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Select item 81650301.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 80940532.

Genetic Analysis of Hyperpolarization‐Activated Cyclic Nucleotide‐Gated Cation Channels in Sudden Unexpected Death in Epilepsy Cases

Emily Tu, Louise Waterhouse, Johan Duflou, Richard D. Bagnall, Christopher Semsarian

Brain Pathol. 2011 Nov; 21(6): 692–698. Published online 2011 Aug 16. doi: 10.1111/j.1750-3639.2011.00500.x

PMCID:: PMC8094053

Abstract Article PDF–332K

Select item 66238333.

Recessive Loss-of-Function Mutation in the Pacemaker HCN2 Channel Causing Increased Neuronal Excitability in a Patient with Idiopathic Generalized Epilepsy

Jacopo C. DiFrancesco, Andrea Barbuti, Raffaella Milanesi, Stefania Coco, Annalisa Bucchi, Georgia Bottelli, Carlo Ferrarese, Silvana Franceschetti, Benedetta Terragni, Mirko Baruscotti, Dario DiFrancesco

J Neurosci. 2011 Nov 30; 31(48): 17327–17337. doi: 10.1523/JNEUROSCI.3727-11.2011

PMCID:: PMC6623833

Abstract Article PDF–2.6M

Select item 61666824.

Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei

Domenico Fasci, Hugo van Ingen, Richard A. Scheltema, Albert J. R. Heck

Mol Cell Proteomics. 2018 Oct; 17(10): 2018–2033. Published online 2018 Jul 18. doi: 10.1074/mcp.RA118.000924

PMCID:: PMC6166682

Abstract Article PDF–3.8M

Select item 56638795.

Mechanism for the inhibition of the cAMP dependence of HCN ion channels by the auxiliary subunit TRIP8b

John R. Bankston, Hannah A. DeBerg, Stefan Stoll, William N. Zagotta

J Biol Chem. 2017 Oct 27; 292(43): 17794–17803. Published online 2017 Sep 1. doi: 10.1074/jbc.M117.800722

PMCID:: PMC5663879

Abstract Article PDF–1.5M

Select item 54902536.

HCN2/SkM1 Gene Transfer Into Canine Left Bundle Branch Induces Stable, Autonomically Responsive Biological Pacing at Physiological Heart Rates

Gerard J. J. Boink, Lian Duan, Bruce D. Nearing, Iryna N. Shlapakova, Eugene A. Sosunov, Evgeny P. Anyukhovsky, Eugene Bobkov, Yelena Kryukova, Nazira Ozgen, Peter Danilo, Jr, Ira S. Cohen, Richard L. Verrier, Richard B. Robinson, Michael R. Rosen

J Am Coll Cardiol. Author manuscript; available in PMC 2017 Jun 29.

Published in final edited form as: J Am Coll Cardiol. 2013 Mar 19; 61(11): 1192–1201. Published online 2013 Feb 6. doi: 10.1016/j.jacc.2012.12.031

PMCID:: PMC5490253

Abstract Article PDF–1.1M

Select item 49020707.

Identification of methylated genes in salivary gland adenoid cystic carcinoma xenografts using global demethylation and methylation microarray screening

SHIZHANG LING, ELENI M. RETTIG, MARIETTA TAN, XIAOFEI CHANG, ZHIMING WANG, MARIANA BRAIT, JUSTIN A. BISHOP, ELANA J. FERTIG, MICHAEL CONSIDINE, MICHAEL J. WICK, PATRICK K. HA

Int J Oncol. 2016 Jul; 49(1): 225–234. Published online 2016 May 18. doi: 10.3892/ijo.2016.3532

PMCID:: PMC4902070

Abstract Article PDF–496K

Select item 49018758.

Autism-Associated SHANK3 Haploinsufficiency Causes I_h-Channelopathy in Human Neurons

Fei Yi, Tamas Danko, Salome Calado Botelho, Christopher Patzke, ChangHui Pak, Marius Wernig, Thomas C. Südhof

Science. Author manuscript; available in PMC 2016 Jun 10.

Published in final edited form as: Science. 2016 May 6; 352(6286): aaf2669. Published online 2016 Mar 10. doi: 10.1126/science.aaf2669

PMCID:: PMC4901875

Abstract Article PDF–1.9M

Select item 46182389.

Molecular Mapping of Sinoatrial Node HCN Channel Expression in the Human Heart

Ning Li, Thomas A. Csepe, Brian J. Hansen, Halina Dobrzynski, Robert S.D. Higgins, Ahmet Kilic, Peter J. Mohler, Paul M.L. Janssen, Michael R. Rosen, Brandon J. Biesiadecki, Vadim V. Fedorov

Circ Arrhythm Electrophysiol. Author manuscript; available in PMC 2016 Oct 1.

Published in final edited form as: Circ Arrhythm Electrophysiol. 2015 Oct; 8(5): 1219–1227. Published online 2015 Aug 24. doi: 10.1161/CIRCEP.115.003070

PMCID:: PMC4618238

Abstract Article PDF–2.1M

Select item 458589110.

Isoform dependent regulation of human HCN channels by cholesterol

Oliver Fürst, Nazzareno D’Avanzo

Sci Rep. 2015; 5: 14270. Published online 2015 Sep 25. doi: 10.1038/srep14270

PMCID:: PMC4585891

Abstract Article PDF–1.5M

Select item 452603211.

Altered expression of hyperpolarization-activated cyclic nucleotide-gated channels and microRNA-1 and -133 in patients with age-associated atrial fibrillation

YAO-DONG LI, YI-FAN HONG, YUEERGULI YUSUFUAJI, BAO-PENG TANG, XIAN-HUI ZHOU, GUO-JUN XU, JIN-XIN LI, LIN SUN, JIANG-HUA ZHANG, QIANG XIN, JIAN XIONG, YU-TONG JI, YU ZHANG

Mol Med Rep. 2015 Sep; 12(3): 3243–3248. Published online 2015 May 25. doi: 10.3892/mmr.2015.3831

PMCID:: PMC4526032

Abstract Article PDF–587K

Select item 421002212.

Structural basis for the mutual antagonism of cAMP and TRIP8b in regulating HCN channel function

Andrea Saponaro, Sofia R. Pauleta, Francesca Cantini, Manolis Matzapetakis, Christian Hammann, Chiara Donadoni, Lei Hu, Gerhard Thiel, Lucia Banci, Bina Santoro, Anna Moroni

Proc Natl Acad Sci U S A. 2014 Oct 7; 111(40): 14577–14582. Published online 2014 Sep 2. doi: 10.1073/pnas.1410389111

PMCID:: PMC4210022

Abstract Article PDF–1.0M

Select item 385145513.

Novel HCN2 Mutation Contributes to Febrile Seizures by Shifting the Channel's Kinetics in a Temperature-Dependent Manner

Yuki Nakamura, Xiuyu Shi, Tomohiro Numata, Yasuo Mori, Ryuji Inoue, Christoph Lossin, Tallie Z. Baram, Shinichi Hirose

PLoS One. 2013; 8(12): e80376. Published online 2013 Dec 4. doi: 10.1371/journal.pone.0080376

PMCID:: PMC3851455

Abstract Article PDF–703K

Select item 338300714.

Augmented Currents of an HCN2 Variant in Patients with Febrile Seizure Syndromes

Leanne M. Dibbens, Christopher A. Reid, Bree Hodgson, Evan A. Thomas, Alison M. Phillips, Elena Gazina, Brett A. Cromer, Alison L. Clarke, Tallie Z. Baram, Ingrid E. Scheffer, Samuel F. Berkovic, Steven Petrou

Ann Neurol. Author manuscript; available in PMC 2012 Jun 26.

Published in final edited form as: Ann Neurol. 2010 Apr; 67(4): 542–546. doi: 10.1002/ana.21909

PMCID:: PMC3383007

Abstract Article PDF–510K

Select item 324799715.

Tetramerization Dynamics of C-terminal Domain Underlies Isoform-specific cAMP Gating in Hyperpolarization-activated Cyclic Nucleotide-gated Channels

Marco Lolicato, Marco Nardini, Sabrina Gazzarrini, Stefan Möller, Daniela Bertinetti, Friedrich W. Herberg, Martino Bolognesi, Holger Martin, Marina Fasolini, Jay A. Bertrand, Cristina Arrigoni, Gerhard Thiel, Anna Moroni

J Biol Chem. 2011 Dec 30; 286(52): 44811–44820. Published online 2011 Oct 17. doi: 10.1074/jbc.M111.297606

PMCID:: PMC3247997

Abstract Article PDF–1.5M

Select item 317805916.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 310080717.

Enhanced Expression of a Specific Hyperpolarization-Activated Cyclic Nucleotide-Gated Cation Channel (HCN) in Surviving Dentate Gyrus Granule Cells of Human and Experimental Epileptic Hippocampus

Roland A. Bender, Sheila V. Soleymani, Amy L. Brewster, Snow T. Nguyen, Heinz Beck, Gary W. Mathern, Tallie Z. Baram

J Neurosci. 2003 Jul 30; 23(17): 6826–6836. doi: 10.1523/JNEUROSCI.23-17-06826.2003

PMCID:: PMC3100807

Abstract Article PDF–637K

Select item 294516818.

Variation at the NFATC2 Locus Increases the Risk of Thiazolidinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study

Swneke D. Bailey, Changchun Xie, Ron Do, Alexandre Montpetit, Rafael Diaz, Viswanathan Mohan, Bernard Keavney, Salim Yusuf, Hertzel C. Gerstein, James C. Engert, Sonia Anand, on behalf of the DREAM investigators

Diabetes Care. 2010 Oct; 33(10): 2250–2253. Published online 2010 Jul 13. doi: 10.2337/dc10-0452

PMCID:: PMC2945168

Abstract Article PDF–153K

Select item 277583219.

Gene-centric Association Signals for Lipids and Apolipoproteins Identified via the HumanCVD BeadChip

Philippa J. Talmud, Fotios Drenos, Sonia Shah, Tina Shah, Jutta Palmen, Claudio Verzilli, Tom R. Gaunt, Jacky Pallas, Ruth Lovering, Kawah Li, Juan Pablo Casas, Reecha Sofat, Meena Kumari, Santiago Rodriguez, Toby Johnson, Stephen J. Newhouse, Anna Dominiczak, Nilesh J. Samani, Mark Caulfield, Peter Sever, Alice Stanton, Denis C. Shields, on behalf of the ASCOT investigators, Sandosh Padmanabhan, Olle Melander, Claire Hastie, Christian Delles, on behalf of the NORDIL investigators, Shah Ebrahim, Michael G. Marmot, George Davey Smith, Debbie A. Lawlor, Patricia B. Munroe, for the BRIGHT Consortium, Ian N. Day, Mika Kivimaki, John Whittaker, Steve E. Humphries, Aroon D. Hingorani

Am J Hum Genet. 2009 Nov 13; 85(5): 628–642. doi: 10.1016/j.ajhg.2009.10.014

PMCID:: PMC2775832

Abstract Article PDF–2.8M

Select item 270921020.

Mutation analysis of the hyperpolarization-activated cyclic nucleotide-gated channels HCN1 and HCN2 in idiopathic generalized epilepsy

Bin Tang, Thomas Sander, Kimberley B. Craven, Anne Hempelmann, Andrew Escayg

Neurobiol Dis. Author manuscript; available in PMC 2009 Jul 13.

Published in final edited form as: Neurobiol Dis. 2008 Jan; 29(1): 59–70. Published online 2007 Aug 24. doi: 10.1016/j.nbd.2007.08.006

PMCID:: PMC2709210

Abstract Article PDF–1.2M

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