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Select item 114815941.

METTL3 mediates m6A modification of lncRNA CRNDE to promote ATG10 expression and improve brain ischemia/reperfusion injury through YTHDC1

Zhengtao Yu, Ying Xia, Jiameng Li, Junwen Jiang, You Li, Youjun Li, Liu Wang

Biol Direct. 2024; 19: 92. Published online 2024 Oct 16. doi: 10.1186/s13062-024-00536-4

PMCID:: PMC11481594

Abstract Article PDF–7.9M

Select item 112099352.

Antagonistic roles of canonical and alternative-RPA in disease-associated tandem CAG repeat instability

Terence Gall-Duncan, Jennifer Luo, Carla-Marie Jurkovic, Laura A. Fischer, Kyota Fujita, Amit L. Deshmukh, Rachel J. Harding, Stephanie Tran, Mustafa Mehkary, Vanessa Li, David E. Leib, Ran Chen, Hikari Tanaka, Amanda G. Mason, Dominique Lévesque, Mahreen Khan, Mortezaali Razzaghi, Tanya Prasolava, Stella Lanni, Nozomu Sato, Marie-Christine Caron, Gagan B. Panigrahi, Peixiang Wang, Rachel Lau, Arturo López Castel, Jean-Yves Masson, Lynette Tippett, Clinton Turner, Maria Spies, Albert R. La Spada, Eric I. Campos, Maurice A. Curtis, François-Michel Boisvert, Richard L.M. Faull, Beverly L. Davidson, Masayuki Nakamori, Hitoshi Okazawa, Marc S. Wold, Christopher E. Pearson

Cell. Author manuscript; available in PMC 2024 Oct 26.

Published in final edited form as: Cell. 2023 Oct 26; 186(22): 4898–4919.e25. Published online 2023 Oct 11. doi: 10.1016/j.cell.2023.09.008

PMCID:: PMC11209935

Abstract Article PDF–3.0M

Select item 111451463.

YTHDC1‐dependent m6A modification modulated FOXM1 promotes glycolysis and tumor progression through CENPA in triple‐negative breast cancer

Xi Shen, Jianxin Zhong, Pan Yu, Feng Liu, Haoran Peng, Nianyong Chen

Cancer Sci. 2024 Jun; 115(6): 1881–1895. Published online 2024 Apr 3. doi: 10.1111/cas.16137

PMCID:: PMC11145146

Abstract Article PDF–18M

Select item 111257864.

m⁶A Reader YTHDC1 Impairs Respiratory Syncytial Virus Infection by Downregulating Membrane CX3CR1 Expression

Lucas W. Picavet, Ellen C. N. van Vroonhoven, Rianne C. Scholman, Yesper T. H. Smits, Rupa Banerjee, Sjanna B. Besteman, Mattheus C. Viveen, Michiel M. van der Vlist, Marvin E. Tanenbaum, Robert J. Lebbink, Sebastiaan J. Vastert, Jorg van Loosdregt

Viruses. 2024 May; 16(5): 778. Published online 2024 May 14. doi: 10.3390/v16050778

PMCID:: PMC11125786

Abstract Article PDF–2.5M

Select item 110922625.

KAP1 stabilizes MYCN mRNA and promotes neuroblastoma tumorigenicity by protecting the RNA m⁶A reader YTHDC1 protein degradation

Yi Yang, Yingwen Zhang, Guoyu Chen, Bowen Sun, Fei Luo, Yijin Gao, Haizhong Feng, Yanxin Li

J Exp Clin Cancer Res. 2024; 43: 141. Published online 2024 May 14. doi: 10.1186/s13046-024-03040-9

PMCID:: PMC11092262

Abstract Article PDF–3.7M

Select item 110740426.

Recruitment of PVT1 Enhances YTHDC1-Mediated m6A Modification of IL-33 in Hyperoxia-Induced Lung Injury During Bronchopulmonary Dysplasia

Tianping Bao, Xiangye Liu, Jian Hu, Mengmeng Ma, Jingyan Li, Linxia Cao, Bingrui Yu, Huaiping Cheng, Sai Zhao, Zhaofang Tian

Inflammation. 2024; 47(2): 469–482. Published online 2023 Nov 2. doi: 10.1007/s10753-023-01923-1

PMCID:: PMC11074042

Abstract Article PDF–6.5M

Select item 109950987.

YTHDC1 promotes the malignant progression of gastric cancer by promoting ROD1 translocation to the nucleus

Danhong Dong, Jiangpeng Wei, Weidong Wang, Haikun Zhou, Liu Hong, Gang Ji, Xisheng Yang

Cell Biol Toxicol. 2024; 40(1): 19. Published online 2024 Apr 4. doi: 10.1007/s10565-024-09859-4

PMCID:: PMC10995098

Abstract Article PDF–8.7M

Select item 107649588.

TRIM28-mediated nucleocapsid protein SUMOylation enhances SARS-CoV-2 virulence

Jiang Ren, Shuai Wang, Zhi Zong, Ting Pan, Sijia Liu, Wei Mao, Huizhe Huang, Xiaohua Yan, Bing Yang, Xin He, Fangfang Zhou, Long Zhang

Nat Commun. 2024; 15: 244. Published online 2024 Jan 4. doi: 10.1038/s41467-023-44502-6

PMCID:: PMC10764958

Abstract Article PDF–4.4M

Select item 107334059.

YTHDC1 as a tumor progression suppressor through modulating FSP1-dependent ferroptosis suppression in lung cancer

Shuai Yuan, Shu Xi, Hong Weng, Meng-Meng Guo, Jin-Hui Zhang, Zhi-Ping Yu, Haozhe Zhang, Zhaojun Yu, Zengzhen Xing, Meng-Yang Liu, Dao-Jing Ming, Rajiv Kumar Sah, Yi Zhou, Gang Li, Tao Zeng, Xin Hong, Yafei Li, Xian-Tao Zeng, Hailiang Hu

Cell Death Differ. 2023 Dec; 30(12): 2477–2490. Published online 2023 Oct 30. doi: 10.1038/s41418-023-01234-w

PMCID:: PMC10733405

Abstract Article PDF–5.7M

Select item 1068425810.

YTHDC1-Modified m6A Methylation of Hsa_circ_0102678 Promotes Keratinocyte Inflammation Induced by Cutibacterium acnes Biofilm through Regulating miR-146a/TRAF6 and IRAK1 Axis

Meng Zhou, Yuzhen Liu, Haoxiang Xu, Xu Chen, Nana Zheng, Zhimin Duan, Yiping Ge, Dongqing Li, Tong Lin, Rong Zeng, Qing Chen, Min Li

J Innate Immun. 2023 Jan-Dec; 15(1): 822–835. Published online 2023 Oct 30. doi: 10.1159/000534704

PMCID:: PMC10684258

Abstract Article PDF–1.7M

Select item 1061798111.

SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9

Nora Schmidt, Sabina Ganskih, Yuanjie Wei, Alexander Gabel, Sebastian Zielinski, Hasmik Keshishian, Caleb A. Lareau, Liv Zimmermann, Jana Makroczyova, Cadence Pearce, Karsten Krey, Thomas Hennig, Sebastian Stegmaier, Lambert Moyon, Marc Horlacher, Simone Werner, Jens Aydin, Marco Olguin-Nava, Ramya Potabattula, Anuja Kibe, Lars Dölken, Redmond P. Smyth, Neva Caliskan, Annalisa Marsico, Christine Krempl, Jochen Bodem, Andreas Pichlmair, Steven A. Carr, Petr Chlanda, Florian Erhard, Mathias Munschauer

Cell. 2023 Oct 26; 186(22): 4834–4850.e23. doi: 10.1016/j.cell.2023.09.002

PMCID:: PMC10617981

Abstract Article

Select item 1056587612.

Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates

Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert

Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644

PMCID:: PMC10565876

Abstract Article PDF–3.7M

Select item 1053570713.

Low expression of m6A reader YTHDC1 promotes progression of ovarian cancer via PIK3R1/STAT3/GANAB axis

Xiaogang Wang, Qianyu Chen, Ziqian Bing, Shizhen Zhou, Zhen Xu, Yayi Hou, Yue Zhao, Shuli Zhao, Tingting Wang

Int J Biol Sci. 2023; 19(14): 4672–4688. Published online 2023 Aug 28. doi: 10.7150/ijbs.81595

PMCID:: PMC10535707

Abstract Article PDF–13M

Select item 1033427514.

YTHDC1 positively regulates PTEN expression and plays a critical role in cisplatin resistance of bladder cancer

Yinjie Su, Bo Wang, Jian Huang, Ming Huang, Tianxin Lin

Cell Prolif. 2023 Jul; 56(7): e13404. Published online 2023 Apr 17. doi: 10.1111/cpr.13404

PMCID:: PMC10334275

Abstract Article PDF–8.5M

Select item 1031808315.

The YTHDC1/GLUT3/RNF183 axis forms a positive feedback loop that modulates glucose metabolism and bladder cancer progression

Bin Yan, Xurui Li, Mou Peng, Yali Zuo, Yinhuai Wang, Pian Liu, Weigang Ren, Xin Jin

Exp Mol Med. 2023 Jun; 55(6): 1145–1158. Published online 2023 Jun 1. doi: 10.1038/s12276-023-00997-z

PMCID:: PMC10318083

Abstract Article PDF–7.3M

Select item 1023742216.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 1014656917.

N⁶-methyladenosine reader protein YTHDC1 regulates influenza A virus NS segment splicing and replication

Yinxing Zhu, Ruifang Wang, Jiahui Zou, Shan Tian, Luyao Yu, Yuanbao Zhou, Ying Ran, Meilin Jin, Huanchun Chen, Hongbo Zhou

PLoS Pathog. 2023 Apr; 19(4): e1011305. Published online 2023 Apr 13. doi: 10.1371/journal.ppat.1011305

PMCID:: PMC10146569

Abstract Article PDF–3.0M

Select item 995044718.

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma

Yu-Fei Cao, Lei Xie, Bei-Bei Tong, Man-Yu Chu, Wen-Qi Shi, Xiang Li, Jian-Zhong He, Shao-Hong Wang, Zhi-Yong Wu, Dan-Xia Deng, Ya-Qi Zheng, Zhi-Mao Li, Xiu-E Xu, Lian-Di Liao, Yin-Wei Cheng, Li-Yan Li, Li-Yan Xu, En-Min Li

Cell Death Differ. 2023 Feb; 30(2): 527–543. Published online 2022 Dec 16. doi: 10.1038/s41418-022-01104-x

PMCID:: PMC9950447

Abstract Article PDF–8.4M

Select item 993580919.

The Effect of N6-Methyladenosine Regulators and m6A Reader YTHDC1-Mediated N6-Methyladenosine Modification Is Involved in Oxidative Stress in Human Aortic Dissection

Fanxing Yin, Kun Liu, Wanfu Peng, Deying Jiang, Hao Zhang, Panpan Guo, Yinhao Wu, Xiaoxu Zhang, Chenxi Sun, Yaxuan Wang, Hecheng Wang, Yanshuo Han

Oxid Med Cell Longev. 2023; 2023: 3918393. Published online 2023 Feb 9. doi: 10.1155/2023/3918393

PMCID:: PMC9935809

Abstract Article PDF–1.7M

Select item 979798820.

TBK1 posphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1

Jianwen Zhou, Nikoline Lander Rasmussen, Hallvard Lauritz Olsvik, Vyacheslav Akimov, Zehan Hu, Gry Evjen, Stéphanie Kaeser-Pebernard, Devanarayanan Siva Sankar, Carole Roubaty, Pauline Verlhac, Nicole van de Beek, Fulvio Reggiori, Yakubu Princely Abudu, Blagoy Blagoev, Trond Lamark, Terje Johansen, Jörn Dengjel

J Cell Biol. 2023 Feb 6; 222(2): e202108144. Published online 2022 Dec 27. doi: 10.1083/jcb.202108144

PMCID:: PMC9797988

Abstract Article PDF–6.9M

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