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Select item 109058021.

Tight junction protein cingulin variant is associated with cancer susceptibility by overexpressed IQGAP1 and Rac1-dependent epithelial-mesenchymal transition

Yi-Ting Huang, Ya-Ting Hsu, Pei-Ying Wu, Yu-Min Yeh, Peng-Chan Lin, Keng-Fu Hsu, Meng-Ru Shen

J Exp Clin Cancer Res. 2024; 43: 65. Published online 2024 Mar 1. doi: 10.1186/s13046-024-02987-z

PMCID:: PMC10905802

Abstract Article PDF–2.9M

Select item 108792132.

HMGB1 promotes mitochondrial transfer between hepatocellular carcinoma cells through RHOT1 and RAC1 under hypoxia

Mengjia Jing, Xiaofeng Xiong, Xin Mao, Qianben Song, Lumiao Zhang, Yiming Ouyang, Yingzhi Pang, Yu Fu, Wei Yan

Cell Death Dis. 2024 Feb; 15(2): 155. Published online 2024 Feb 20. doi: 10.1038/s41419-024-06536-6

PMCID:: PMC10879213

Abstract Article PDF–6.5M

Select item 108216013.

The Snail signaling branch downstream of the TGF-β/Smad3 pathway mediates Rho activation and subsequent stress fiber formation

Mitsuyoshi Motizuki, Takashi Yokoyama, Masao Saitoh, Keiji Miyazawa

J Biol Chem. 2024 Jan; 300(1): 105580. Published online 2023 Dec 21. doi: 10.1016/j.jbc.2023.105580

PMCID:: PMC10821601

Abstract Article PDF–5.5M

Select item 107893794.

LANCL1, a cell surface protein, promotes liver tumor initiation through FAM49B-Rac1 axis to suppress oxidative stress

Hongyang Huang, Yu-Man Tsui, Daniel Wai-Hung Ho, Clive Yik-Sham Chung, Karen Man-Fong Sze, Eva Lee, Gary Cheuk-Hang Cheung, Vanilla Xin Zhang, Xia Wang, Xueying Lyu, Irene Oi-Lin Ng

Hepatology. 2024 Feb; 79(2): 323–340. Published online 2023 Aug 7. doi: 10.1097/HEP.0000000000000523

PMCID:: PMC10789379

Abstract Article PDF–2.4M

Select item 106929205.

Cell aggregation activates small GTPase Rac1 and induces CD44 cleavage by maintaining lipid raft integrity

Dong Li, Younhee Park, Hami Hemati, Xia Liu

J Biol Chem. 2023 Dec; 299(12): 105377. Published online 2023 Oct 20. doi: 10.1016/j.jbc.2023.105377

PMCID:: PMC10692920

Abstract Article PDF–4.3M

Select item 106176736.

The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation

Xin Gu, Christopher Nardone, Nolan Kamitaki, Aoyue Mao, Stephen J. Elledge, Michael E. Greenberg

Science. Author manuscript; available in PMC 2023 Oct 31.

Published in final edited form as: Science. 2023 Aug 25; 381(6660): eadh5021. Published online 2023 Aug 25. doi: 10.1126/science.adh5021

PMCID:: PMC10617673

Abstract Article PDF–3.6M

Select item 105434197.

Silencing Rac1 and Prex1 Inhibit Epithelial–Mesenchymal Transition in Human Gastric Cancer Cells Induced by Transforming Growth Factor-β1

Xinyan Gao, Xiaoyan Lin, Mengxin Lin, Yanqin Lan, Yao Wang, Riping Wu, Junde Li, Chuanyong Huang, Dongta Zhong

Turk J Gastroenterol. 2023 Sep; 34(9): 975–981. Published online 2023 Sep 1. doi: 10.5152/tjg.2023.23108

PMCID:: PMC10543419

Abstract Article PDF–1.4M

Select item 105140328.

Interfering with Rac1-activation during neonatal monocyte-macrophage differentiation influences the inflammatory responses of M1 macrophages

Hang Fu, Ping Zhang, Xiao-Dong Zhao, Xiao-Yun Zhong

Cell Death Dis. 2023 Sep; 14(9): 619. Published online 2023 Sep 21. doi: 10.1038/s41419-023-06150-y

PMCID:: PMC10514032

Abstract Article PDF–5.2M

Select item 104499669.

MiR-22-3p suppresses NSCLC cell migration and EMT via targeting RAC1 expression

Xuejiao Wang, Xiaobin Wang, Tao Jiang, Zhipei Zhang, Nianlin Xie, Guang Yang

Funct Integr Genomics. 2023; 23(3): 281. Published online 2023 Aug 25. doi: 10.1007/s10142-023-01211-z

PMCID:: PMC10449966

Abstract Article PDF–4.0M

Select item 1032604410.

Clinical profiling of MRD48 and functional characterization of two novel pathogenic RAC1 variants

Manuela Priolo, Erika Zara, Francesca Clementina Radio, Andrea Ciolfi, Francesca Spadaro, Emanuele Bellacchio, Cecilia Mancini, Francesca Pantaleoni, Viviana Cordeddu, Luigi Chiriatti, Marcello Niceta, Emilio Africa, Corrado Mammì, Daniela Melis, Simona Coppola, Marco Tartaglia

Eur J Hum Genet. 2023 Jul; 31(7): 805–814. Published online 2023 Apr 14. doi: 10.1038/s41431-023-01351-7

PMCID:: PMC10326044

Abstract Article PDF–2.4M

Select item 1031702311.

TIAM1–RAC1 signalling axis-mediated activation of NADPH oxidase-2 initiates mitochondrial damage in the development of diabetic retinopathy

Renu A. Kowluru, Anjaneyulu Kowluru, Rajakrishnan Veluthakal, Ghulam Mohammad, Ismail Syed, Julia M. Santos, Manish Mishra

Diabetologia. Author manuscript; available in PMC 2023 Jul 3.

Published in final edited form as: Diabetologia. 2014 May; 57(5): 1047–1056. Published online 2014 Feb 20. doi: 10.1007/s00125-014-3194-z

PMCID:: PMC10317023

Abstract Article PDF–1.3M

Select item 1029721312.

Spatiotemporal Coordination of Rac1 and Cdc42 at the Whole Cell Level during Cell Ruffling

Siarhei Hladyshau, Jorik P. Stoop, Kosei Kamada, Shuyi Nie, Denis Tsygankov

Cells. 2023 Jun; 12(12): 1638. Published online 2023 Jun 15. doi: 10.3390/cells12121638

PMCID:: PMC10297213

Abstract Article PDF–7.7M

Select item 1028411713.

Exploring an Alternative Cysteine-Reactive Chemistry to Enable Proteome-Wide PPI Analysis by Cross-Linking Mass Spectrometry

Fenglong Jiao, Leah J. Salituro, Clinton Yu, Craig B. Gutierrez, Scott D. Rychnovsky, Lan Huang

Anal Chem. Author manuscript; available in PMC 2023 Jun 21.

Published in final edited form as: Anal Chem. 2023 Jan 31; 95(4): 2532–2539. Published online 2023 Jan 18. doi: 10.1021/acs.analchem.2c04986

PMCID:: PMC10284117

Abstract Article PDF–2.5M

Select item 1023742214.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 1019583415.

Identification of RAC1 in promoting brain metastasis of lung adenocarcinoma using single-cell transcriptome sequencing

Mingyu Chen, Hanyue Li, Xiaolin Xu, Xunxia Bao, Lei Xue, Xinghao Ai, Jian Xu, Ming Xu, Yong Shi, Timing Zhen, Jie Li, Yi Yang, Yang Ji, Zhiliang Fu, Kaichen Xing, Tao Qing, Qiubo Wang, Ping Zhong, Sibo Zhu

Cell Death Dis. 2023 May; 14(5): 330. Published online 2023 May 18. doi: 10.1038/s41419-023-05823-y

PMCID:: PMC10195834

Abstract Article PDF–5.8M

Select item 1019162616.

ERK3/MAPK6 dictates CDC42/RAC1 activity and ARP2/3-dependent actin polymerization

Katarzyna Bogucka-Janczi, Gregory Harms, Marie-May Coissieux, Mohamed Bentires-Alj, Bernd Thiede, Krishnaraj Rajalingam

eLife. 2023; 12: e85167. Published online 2023 Apr 14. doi: 10.7554/eLife.85167

PMCID:: PMC10191626

Abstract Article PDF–30M

Select item 1016736917.

SAMHD1-induced endosomal FAK signaling promotes human renal clear cell carcinoma metastasis by activating Rac1-mediated lamellipodia protrusion

Sunho An, Tam Thuy Lu Vo, Taekwon Son, Hoon Choi, Jinyoung Kim, Juyeon Lee, Byung Hoon Kim, Misun Choe, Eunyoung Ha, Young-Joon Surh, Kyu-Won Kim, Ji Hae Seo

Exp Mol Med. 2023 Apr; 55(4): 779–793. Published online 2023 Apr 3. doi: 10.1038/s12276-023-00961-x

PMCID:: PMC10167369

Abstract Article PDF–4.7M

Select item 1007694818.

A distinct pattern of growth and RAC1 signaling in melanoma brain metastasis cells

Ioana Stejerean-Todoran, Phyllis A Gimotty, Andrea Watters, Patricia Brafford, Clemens Krepler, Tetiana Godok, Haiyin Li, Zuriñe Bonilla del Rio, Anke Zieseniss, Dörthe M Katschinski, Sinem M Sertel, Silvio O Rizzoli, Bradley Garman, Katherine L Nathanson, Xiaowei Xu, Qing Chen, Jack H Oswald, Michal Lotem, Gordon B Mills, Michael A Davies, Michael P Schön, Ivan Bogeski, Meenhard Herlyn, Adina Vultur

Neuro Oncol. 2023 Apr; 25(4): 674–686. Published online 2022 Sep 2. doi: 10.1093/neuonc/noac212

PMCID:: PMC10076948

Abstract Article PDF–40M

Select item 1005340319.

Git1-PGK1 interaction achieves self-protection against spinal cord ischemia-reperfusion injury by modulating Keap1/Nrf2 signaling

Tao Xu, Peng Gao, Yifan Huang, Mengyuan Wu, Jiang Yi, Zheng Zhou, Xuan Zhao, Tao Jiang, Hao Liu, Tao Qin, Zhenqi Yang, Xiaowei Wang, Tianyi Bao, Jian Chen, Shujie Zhao, Guoyong Yin

Redox Biol. 2023 Jun; 62: 102682. Published online 2023 Mar 20. doi: 10.1016/j.redox.2023.102682

PMCID:: PMC10053403

Abstract Article PDF–12M

Select item 1001457520.

Pals1 functions in redundancy with SMAP1 to inhibit Arf6 in order to prevent Rac1-dependent colorectal cancer cell migration and invasion

Julia Harms, Simona Mareike Lüttgenau, Christin Emming, Justine Guske, Katrin Weber, Thomas Wagner, Larissa Schowe, Pavel Nedvetsky, Michael P. Krahn

Cancer Gene Ther. 2023; 30(3): 497–506. Published online 2022 Dec 9. doi: 10.1038/s41417-022-00570-2

PMCID:: PMC10014575

Abstract Article PDF–5.0M

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