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Select item 111024551.

Vascular endothelial-derived SPARCL1 exacerbates viral pneumonia through pro-inflammatory macrophage activation

Gan Zhao, Maria E. Gentile, Lulu Xue, Christopher V. Cosgriff, Aaron I. Weiner, Stephanie Adams-Tzivelekidis, Joanna Wong, Xinyuan Li, Sara Kass-Gergi, Nicolas P. Holcomb, Maria C. Basal, Kathleen M. Stewart, Joseph D. Planer, Edward Cantu, Jason D. Christie, Maria M. Crespo, Michael J. Mitchell, Nuala J. Meyer, Andrew E. Vaughan

Nat Commun. 2024; 15: 4235. Published online 2024 May 18. doi: 10.1038/s41467-024-48589-3

PMCID:: PMC11102455

Abstract Article PDF–4.2M

Select item 101740542.

Identifying liver metastasis-related hub genes in breast cancer and characterizing SPARCL1 as a potential prognostic biomarker

Mingkuan Chen, Wenfang Zheng, Lin Fang

PeerJ. 2023; 11: e15311. Published online 2023 May 8. doi: 10.7717/peerj.15311

PMCID:: PMC10174054

Abstract Article PDF–8.0M

Select item 99530083.

The Matricellular Protein Hevin Is Involved in Alcohol Use Disorder

Amaia Nuñez-delMoral, Paula C. Bianchi, Iria Brocos-Mosquera, Augusto Anesio, Paola Palombo, Rosana Camarini, Fabio C. Cruz, Luis F. Callado, Vincent Vialou, Amaia M. Erdozain

Biomolecules. 2023 Feb; 13(2): 234. Published online 2023 Jan 25. doi: 10.3390/biom13020234

PMCID:: PMC9953008

Abstract Article PDF–2.0M

Select item 93485764.

Chr21 protein–protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer’s disease

Julia Viard, Yann Loe-Mie, Rachel Daudin, Malik Khelfaoui, Christine Plancon, Anne Boland, Francisco Tejedor, Richard L Huganir, Eunjoon Kim, Makoto Kinoshita, Guofa Liu, Volker Haucke, Thomas Moncion, Eugene Yu, Valérie Hindie, Henri Bléhaut, Clotilde Mircher, Yann Herault, Jean-François Deleuze, Jean-Christophe Rain, Michel Simonneau, Aude-Marie Lepagnol-Bestel

Life Sci Alliance. 2022 Dec; 5(12): e202101205. Published online 2022 Aug 1. doi: 10.26508/lsa.202101205

PMCID:: PMC9348576

Abstract Article PDF–3.0M

Select item 92759145.

Circular_0086414 induces SPARC like 1 (SPARCL1) production to inhibit esophageal cancer cell proliferation, invasion and glycolysis and induce cell apoptosis by sponging miR-1290

Qingfeng Jiang, Haoran Wang, Dongfeng Yuan, Xin Qian, Xiaochao Ma, Ming Yan, Wenqun Xing

Bioengineered. 2022; 13(5): 12099–12114. Published online 2022 May 13. doi: 10.1080/21655979.2022.2073114

PMCID:: PMC9275914

Abstract Article PDF–8.8M

Select item 90907896.

The KDM6A-SPARCL1 axis blocks metastasis and regulates the tumour microenvironment of gastrointestinal stromal tumours by inhibiting the nuclear translocation of p65

Chaoyong Shen, Luyin Han, Baike Liu, Guixiang Zhang, Zhaolun Cai, Xiaonan Yin, Yuan Yin, Zhixin Chen, Bo Zhang

Br J Cancer. 2022 Jun 1; 126(10): 1457–1469. Published online 2022 Feb 8. doi: 10.1038/s41416-022-01728-3

PMCID:: PMC9090789

Abstract Article PDF–2.7M

Select item 88034257.

SPARCL1 Is a Novel Prognostic Biomarker and Correlates with Tumor Microenvironment in Colorectal Cancer

Hai-Ping Zhang, Jun Wu, Zhi-Feng Liu, Jing-Wen Gao, Shu-Yu Li

Biomed Res Int. 2022; 2022: 1398268. Published online 2022 Jan 24. doi: 10.1155/2022/1398268

PMCID:: PMC8803425

Abstract Article PDF–3.2M

Select item 82547588.

Interplay between hevin, SPARC, and MDGAs: modulators of neurexin-neuroligin trans-synaptic bridges.

Shanghua Fan, Shanti Pal Gangwar, Mischa Machius, Gabby Rudenko

Structure. Author manuscript; available in PMC 2022 Jul 1.

Published in final edited form as: Structure. 2021 Jul 1; 29(7): 664–678.e6. Published online 2021 Feb 2. doi: 10.1016/j.str.2021.01.003

PMCID:: PMC8254758

Abstract Article PDF–3.2M

Select item 81650309.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 724172610.

Species-, organ- and cell-type-dependent expression of SPARCL1 in human and mouse tissues

Anika Klingler, Daniela Regensburger, Clara Tenkerian, Nathalie Britzen-Laurent, Arndt Hartmann, Michael Stürzl, Elisabeth Naschberger

PLoS One. 2020; 15(5): e0233422. Published online 2020 May 21. doi: 10.1371/journal.pone.0233422

PMCID:: PMC7241726

Abstract Article PDF–3.4M

Select item 648153911.

Modulation of SPARC/Hevin Proteins in Alzheimer’s Disease Brain Injury

Maximilian Strunz, Juliet T. Jarrell, David S. Cohen, Eric R. Rosin, Charles R. Vanderburg, Xudong Huang

J Alzheimers Dis. 2019; 68(2): 695–710. Prepublished online 2019 Mar 11. Published online 2019 Mar 29. doi: 10.3233/JAD-181032

PMCID:: PMC6481539

Abstract Article PDF–3.0M

Select item 648038812.

Methylation of SPARCL1 Is Associated with Oncologic Outcome of Advanced Upper Urinary Tract Urothelial Carcinoma

Hao-Lun Luo, Po-Huang Chiang, Chun-Chieh Huang, Yu-Li Su, Min-Tse Sung, Eing-Mei Tsai, Chang-Shen Lin, Po-Hui Chiang

Int J Mol Sci. 2019 Apr; 20(7): 1653. Published online 2019 Apr 3. doi: 10.3390/ijms20071653

PMCID:: PMC6480388

Abstract Article PDF–2.2M

Select item 593475313.

SPARCL1 Accelerates Symptom Onset in Alzheimer’s Disease and Influences Brain Structure and Function During Aging

Sahba Seddighi, Vijay R. Varma, Yang An, Sudhir Varma, Lori L. Beason-Held, Toshiko Tanaka, Melissa H. Kitner-Triolo, Michael A. Kraut, Christos Davatzikos, Madhav Thambisetty

J Alzheimers Dis. Author manuscript; available in PMC 2018 May 4.

Published in final edited form as: J Alzheimers Dis. 2018; 61(1): 401–414. doi: 10.3233/JAD-170557

PMCID:: PMC5934753

Abstract Article PDF–598K

Select item 585111314.

SPARCL1 suppresses osteosarcoma metastasis and recruits macrophages by activation of canonical WNT/β-catenin signaling through stabilization of the WNT–receptor complex

S-J Zhao, Y-Q Jiang, N-W Xu, Q Li, Q Zhang, S-Y Wang, J Li, Y-H Wang, Y-L Zhang, S-H Jiang, Y-J Wang, Y-J Huang, X-X Zhang, G-A Tian, C-C Zhang, Y-Y Lv, M Dai, F Liu, R Zhang, D Zhou, Z-G Zhang

Oncogene. 2018 Feb 22; 37(8): 1049–1061. Published online 2017 Oct 30. doi: 10.1038/onc.2017.403

PMCID:: PMC5851113

Abstract Article PDF–4.8M

Select item 509691615.

Matricellular protein SPARCL1 regulates tumor microenvironment–dependent endothelial cell heterogeneity in colorectal carcinoma

Elisabeth Naschberger, Andrea Liebl, Vera S. Schellerer, Manuela Schütz, Nathalie Britzen-Laurent, Patrick Kölbel, Ute Schaal, Lisa Haep, Daniela Regensburger, Thomas Wittmann, Ludger Klein-Hitpass, Tilman T. Rau, Barbara Dietel, Valérie S. Méniel, Alan R. Clarke, Susanne Merkel, Roland S. Croner, Werner Hohenberger, Michael Stürzl

J Clin Invest. 2016 Nov 1; 126(11): 4187–4204. Published online 2016 Oct 10. doi: 10.1172/JCI78260

PMCID:: PMC5096916

Abstract Article PDF–6.6M

Select item 487287916.

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins

Javier Barallobre-Barreiro, Rahmi Oklu, Marc Lynch, Marika Fava, Ferheen Baig, Xiaoke Yin, Temo Barwari, David N. Potier, Hassan Albadawi, Marjan Jahangiri, Karen E. Porter, Michael T. Watkins, Sanjay Misra, Julianne Stoughton, Manuel Mayr

Cardiovasc Res. 2016 Jun 1; 110(3): 419–430. Published online 2016 Apr 11. doi: 10.1093/cvr/cvw075

PMCID:: PMC4872879

Abstract Article PDF–1.1M

Select item 460926217.

Androgen Regulated SPARCL1 in the Tumor Microenvironment Inhibits Metastatic Progression

Paula J. Hurley, Robert M. Hughes, Brian W. Simons, Jessie Huang, Rebecca M. Miller, Brian Shinder, Michael C. Haffner, David Esopi, Yasunori Kimura, Javaneh Jabbari, Ashley E. Ross, Nicholas Erho, Ismael A. Vergara, Sheila F. Faraj, Elai Davicioni, George J. Netto, Srinivasan Yegnasubramanian, Steven S. An, Edward M. Schaeffer

Cancer Res. Author manuscript; available in PMC 2016 Oct 15.

Published in final edited form as: Cancer Res. 2015 Oct 15; 75(20): 4322–4334. Published online 2015 Aug 20. doi: 10.1158/0008-5472.CAN-15-0024

PMCID:: PMC4609262

Abstract Article PDF–927K

Select item 384011518.

A Genome-Wide Association Study Identifies New Susceptibility Loci for Esophageal Adenocarcinoma and Barrett’s Esophagus

David M. Levine, Weronica E. Ek, Rui Zhang, Xinxue Liu, Lynn Onstad, Cassandra Sather, Pierre Lao-Sirieix, Marilie D. Gammon, Douglas A. Corley, Nicholas J. Shaheen, Nigel C. Bird, Laura J. Hardie, Liam J. Murray, Brian J. Reid, Wong-Ho Chow, Harvey A. Risch, Olof Nyrén, Weimin Ye, Geoffrey Liu, Yvonne Romero, Leslie Bernstein, Anna H. Wu, Alan G. Casson, Stephen Chanock, Patricia Harrington, Isabel Caldas, Irene Debiram-Beecham, Carlos Caldas, Nicholas K. Hayward, Paul Pharoah, Rebecca Fitzgerald, Stuart MacGregor, David C. Whiteman, Thomas L. Vaughan

Nat Genet. Author manuscript; available in PMC 2014 Jun 1.

Published in final edited form as: Nat Genet. 2013 Dec; 45(12): 1487–1493. Published online 2013 Oct 13. doi: 10.1038/ng.2796

PMCID:: PMC3840115

Article PDF–1.5M

Select item 383849119.

SPARCL1 suppresses metastasis in prostate cancer

Yuzhu Xiang, Qingchao Qiu, Ming Jiang, Renjie Jin, Brian D. Lehmann, Douglas W. Strand, Bojana Jovanovic, David J. DeGraff, Yi Zheng, Dina A. Yousif, Christine Q. Simmons, Thomas C. Case, Jia Yi, Justin M. Cates, John Virostko, Xiusheng He, Xunbo Jin, Simon W. Hayward, Robert J. Matusik, Alfred L. George, Jr., Yajun Yi

Mol Oncol. 2013 Dec; 7(6): 1019–1030. Published online 2013 Jul 20. doi: 10.1016/j.molonc.2013.07.008

PMCID:: PMC3838491

Abstract Article PDF–2.0M

Select item 364276920.

A BAC Transgenic Mouse Model to Analyze the Function of Astroglial SPARCL1 (SC1) in the Central Nervous System

Jill M. Weimer, Amelia Stanco, Jr-Gang Cheng, Ana C. Vargo, Santhi Voora, E. S. Anton

Glia. Author manuscript; available in PMC 2013 May 3.

Published in final edited form as: Glia. 2008 Jul; 56(9): 935–941. doi: 10.1002/glia.20666

PMCID:: PMC3642769

Abstract Article PDF–2.4M

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