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Select item 95535551.

Identification of Calcium Channel-Related Gene P2RX2 for Prognosis and Immune Infiltration in Prostate Cancer

Qinyu Li, Bili Wu, Motuma Daba, Xintao Gao, Bingliang Chen, Guoda Song, Kai Zeng, Jianping Miao, Xianglin Yuan, Jihong Liu, Zhihua Wang, Bo Liu

Dis Markers. 2022; 2022: 8058160. Published online 2022 Sep 30. doi: 10.1155/2022/8058160

PMCID:: PMC9553555

Abstract Article PDF–5.0M

Select item 93148362.

P2X2 receptor subunit interfaces are missense variant hotspots, where mutations tend to increase apparent ATP affinity

Federica Gasparri, Debayan Sarkar, Sarune Bielickaite, Mette Homann Poulsen, Alexander Sebastian Hauser, Stephan Alexander Pless

Br J Pharmacol. 2022 Jul; 179(14): 3859–3874. Published online 2022 Mar 29. doi: 10.1111/bph.15830

PMCID:: PMC9314836

Abstract Article PDF–13M

Select item 84876803.

Identification of a Novel Stop Loss Mutation in P2RX2 Gene in an Iranian Family with Autosomal Nonsyndromic Hearing Loss

Reza Azizi Malamiri, Javad Mohammadi Asl, Farideh Ghanbari

Iran Biomed J. 2021 Sep; 25(5): 368–373. Published online 2021 Jul 13. doi: 10.52547/ibj.25.5.368

PMCID:: PMC8487680

Abstract Article PDF–878K

Select item 81708434.

Generation and characterization of a P2rx2 V60L mouse model for DFNA41

Xiaoya Chen, Clemer Abad, Zheng-yi Chen, Juan I Young, Channabasavaiah B Gurumurthy, Katherina Walz, Xue Zhong Liu

Hum Mol Genet. 2021 Jun 1; 30(11): 985–995. Published online 2021 Mar 31. doi: 10.1093/hmg/ddab077

PMCID:: PMC8170843

Abstract Article PDF–1.3M

Select item 81650305.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 70083546.

Identification of a distinct desensitisation gate in the ATP-gated P2X2 receptor

Anastasios Stavrou, Richard J. Evans, Ralf Schmid

Biochem Biophys Res Commun. 2020 Feb 26; 523(1): 190–195. doi: 10.1016/j.bbrc.2019.12.028

PMCID:: PMC7008354

Abstract Article

Select item 68426327.

Hearing loss mutations alter the functional properties of human P2X2 receptor channels through distinct mechanisms

Benjamin George, Kenton J. Swartz, Mufeng Li

Proc Natl Acad Sci U S A. 2019 Nov 5; 116(45): 22862–22871. Published online 2019 Oct 21. doi: 10.1073/pnas.1912156116

PMCID:: PMC6842632

Abstract Article PDF–1.9M

Select item 65015878.

Reactive Oxygen Species Potentiate the P2X₂ Receptor Activity through Intracellular Cys⁴³⁰

Claudio Coddou, Juan F. Codocedo, Shuo Li, Juan G. Lillo, Claudio Acuña-Castillo, Paulina Bull, Stanko S. Stojilkovic, J. Pablo Huidobro-Toro

J Neurosci. 2009 Sep 30; 29(39): 12284–12291. doi: 10.1523/JNEUROSCI.2096-09.2009

PMCID:: PMC6501587

Abstract Article PDF–1.5M

Select item 55316119.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 502200110.

P2X-mediated AMPA receptor internalization and synaptic depression is controlled by two CaMKII phosphorylation sites on GluA1 in hippocampal neurons

Johan-Till Pougnet, Benjamin Compans, Audrey Martinez, Daniel Choquet, Eric Hosy, Eric Boué-Grabot

Sci Rep. 2016; 6: 31836. Published online 2016 Sep 14. doi: 10.1038/srep31836

PMCID:: PMC5022001

Abstract Article PDF–1.8M

Select item 493327411.

Modulation of P2X3 and P2X2/3 Receptors by Monoclonal Antibodies

Anatoly Shcherbatko, Davide Foletti, Kris Poulsen, Pavel Strop, Guoyun Zhu, Adela Hasa-Moreno, Jody Melton Witt, Carole Loo, Stellanie Krimm, Ariel Pios, Jessica Yu, Colleen Brown, John K. Lee, Robert Stroud, Arvind Rajpal, David Shelton

J Biol Chem. 2016 Jun 3; 291(23): 12254–12270. Published online 2016 Apr 20. doi: 10.1074/jbc.M116.722330

PMCID:: PMC4933274

Abstract Article PDF–5.0M

Select item 452970612.

Localization of P2X receptor subtypes 2, 3 and 7 in human urinary bladder

Karl Svennersten, Katarina Hallén-Grufman, Petra J. de Verdier, N. Peter Wiklund, Mirjana Poljakovic

BMC Urol. 2015; 15: 81. Published online 2015 Aug 8. doi: 10.1186/s12894-015-0075-9

PMCID:: PMC4529706

Abstract Article PDF–1.8M

Select item 444187113.

Hearing loss caused by a P2RX2 mutation identified in a MELAS family with a coexisting mitochondrial 3243AG mutation

Hideaki Moteki, Hela Azaiez, Kevin T Booth, Mitsuru Hattori, Ai Sato, Yoshihiko Sato, Mitsuo Motobayashi, Christina M Sloan, Diana L Kolbe, A Eliot Shearer, Richard J H Smith, Shin-ichi Usami

Ann Otol Rhinol Laryngol. Author manuscript; available in PMC 2015 May 23.

Published in final edited form as: Ann Otol Rhinol Laryngol. 2015 May; 124(1 0): 177S–183S. Published online 2015 Mar 18. doi: 10.1177/0003489415575045

PMCID:: PMC4441871

Abstract Article PDF–442K

Select item 388719014.

Direct Gating of ATP-activated Ion Channels (P2X2 Receptors) by Lipophilic Attachment at the Outer End of the Second Transmembrane Domain

Simon W. Rothwell, Phillip J. Stansfeld, Laricia Bragg, Alexej Verkhratsky, R. Alan North

J Biol Chem. 2014 Jan 10; 289(2): 618–626. Published online 2013 Nov 22. doi: 10.1074/jbc.M113.529099

PMCID:: PMC3887190

Abstract Article PDF–2.1M

Select item 377440815.

P2X Receptor Chimeras Highlight Roles of the Amino Terminus to Partial Agonist Efficacy, the Carboxyl Terminus to Recovery from Desensitization, and Independent Regulation of Channel Transitions

Rebecca C. Allsopp, Louise K. Farmer, Alistair G. Fryatt, Richard J. Evans

J Biol Chem. 2013 Jul 19; 288(29): 21412–21421. Published online 2013 Jun 5. doi: 10.1074/jbc.M113.464651

PMCID:: PMC3774408

Abstract Article PDF–2.3M

Select item 376755016.

Subtype-specific control of P2X receptor channel signaling by ATP and Mg²⁺

Mufeng Li, Shai D. Silberberg, Kenton J. Swartz

Proc Natl Acad Sci U S A. 2013 Sep 3; 110(36): E3455–E3463. Published online 2013 Aug 19. doi: 10.1073/pnas.1308088110

PMCID:: PMC3767550

Abstract Article PDF–4.6M

Select item 373053117.

ROLE OF ATP IN REGULATING RENAL MICROVASCULAR FUNCTION AND IN HYPERTENSION

Zhengrong Guan, Edward W. Inscho

Hypertension. Author manuscript; available in PMC 2013 Aug 1.

Published in final edited form as: Hypertension. 2011 Sep; 58(3): 333–340. Published online 2011 Jul 18. doi: 10.1161/HYPERTENSIONAHA.110.155952

PMCID:: PMC3730531

Abstract Article PDF–1.4M

Select item 358195418.

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins

Rajesh Ghai, Andrea Bugarcic, Huadong Liu, Suzanne J. Norwood, Sune Skeldal, Elizabeth J. Coulson, Shawn Shun-Cheng Li, Rohan D. Teasdale, Brett M. Collins

Proc Natl Acad Sci U S A. 2013 Feb 19; 110(8): E643–E652. Published online 2013 Feb 4. doi: 10.1073/pnas.1216229110

PMCID:: PMC3581954

Abstract Article PDF–2.3M

Select item 356837119.

Mutation of the ATP-gated P2X₂ receptor leads to progressive hearing loss and increased susceptibility to noise

Denise Yan, Yan Zhu, Tom Walsh, Dinghua Xie, Huijun Yuan, Asli Sirmaci, Taro Fujikawa, Ann Chi Yan Wong, Tze L. Loh, Lilin Du, M’hamed Grati, Srdjan M. Vlajkovic, Susan Blanton, Allen F. Ryan, Zheng-Yi Chen, Peter R. Thorne, Bechara Kachar, Mustafa Tekin, Hong-Bo Zhao, Gary D. Housley, Mary-Claire King, Xue Z. Liu

Proc Natl Acad Sci U S A. 2013 Feb 5; 110(6): 2228–2233. Published online 2013 Jan 23. doi: 10.1073/pnas.1222285110

PMCID:: PMC3568371

Abstract Article PDF–1.0M

Select item 352371020.

Regulation of P2X2 Receptors by the Neuronal Calcium Sensor VILIP1

Severine Chaumont, Vincent Compan, Estelle Toulme, Esther Richler, Gary D. Housley, Francois Rassendren, Baljit S. Khakh

Sci Signal. Author manuscript; available in PMC 2012 Dec 17.

Published in final edited form as: Sci Signal. 2008 Oct 14; 1(41): ra8. Published online 2008 Oct 14. doi: 10.1126/scisignal.1162329

PMCID:: PMC3523710

Abstract Article PDF–2.7M

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