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Items: 1 to 20 of 88

1.
R-loops and impaired autophagy trigger cGAS-dependent inflammation via micronuclei formation in Senataxin-deficient cells
Laura Zannini, Miriana Cardano, Giordano Liberi, Giacomo Buscemi
Cell Mol Life Sci. 2024 Dec; 81(1): 339. Published online 2024 Aug 9. doi: 10.1007/s00018-024-05380-3
PMCID:
PMC11335261
AbstractArticlePDF–6.9M
2.
Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein
Xiao Tang, Yang Liu, Jinhui Wang, Teng Long, Bobo Wing Yee Mok, Yan Huang, Ziqing Peng, Qinyu Jia, Chengxi Liu, Pui-Kin So, Sirius Pui-Kam Tse, Cheuk Hei NG, Shiyi Liu, Fei Sun, Shaojun Tang, Zhong-Ping Yao, Honglin Chen, Yusong Guo
J Biol Chem. 2024 Jun; 300(6): 107390. Published online 2024 May 21. doi: 10.1016/j.jbc.2024.107390
PMCID:
PMC11237930
AbstractArticlePDF–3.8M
3.
Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability
YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Carmen Florencia Suarez, Nicolas S Gonzalez-Foutel, Ahmad Malik, Sebastien Martinez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N Al-Zahrani, Lisa Hoeg, Zhen Yuan Lin, Ricky Tsai, Geraldine Mbamalu, Varda Rotter, Patricia Ashton-Prolla, Jason Moffat, Lucia Beatriz Chemes, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek
Mol Syst Biol. 2024 Jun; 20(6): 719–740. Published online 2024 Apr 5. doi: 10.1038/s44320-024-00032-x
PMCID:
PMC11148184
AbstractArticlePDF–8.1M
4.
Senataxin deficiency disrupts proteostasis through nucleolar ncRNA-driven protein aggregation
Xuemei Wen, Hengyi Xu, Phillip R. Woolley, Olivia M. Conway, Jun Yao, Andreas Matouschek, Alan M. Lambowitz, Tanya T. Paull
J Cell Biol. 2024 Jul 1; 223(7): e202309036. Published online 2024 May 8. doi: 10.1083/jcb.202309036
PMCID:
PMC11080644
AbstractArticlePDF–8.7M
5.
Sen1 Architecture: RNA-DNA Hybrid Resolution, Autoregulation, and Insights into SETX Inactivation in AOA2
C. Denise Appel, Oya Bermek, Venkata P. Dandey, Makayla Wood, Elizabeth Viverette, Jason G. Williams, Jonathan Bouvette, Amanda A. Riccio, Juno M. Krahn, Mario J. Borgnia, R. Scott Williams
Mol Cell. Author manuscript; available in PMC 2024 Oct 19.
Published in final edited form as: Mol Cell. 2023 Oct 19; 83(20): 3692–3706.e5. Published online 2023 Oct 12. doi: 10.1016/j.molcel.2023.09.024
PMCID:
PMC10629462
AbstractArticlePDF–3.0M
6.
Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates
Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert
Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644
PMCID:
PMC10565876
AbstractArticlePDF–3.7M
7.
Human senataxin is a bona fide R-loop resolving enzyme and transcription termination factor
Zdenka Hasanova, Veronika Klapstova, Odil Porrua, Richard Stefl, Marek Sebesta
Nucleic Acids Res. 2023 Apr 11; 51(6): 2818–2837. Published online 2023 Mar 2. doi: 10.1093/nar/gkad092
PMCID:
PMC10085699
AbstractArticlePDF–4.2M
8.
The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA
Ellis G. Jaffray, Michael H. Tatham, Barbara Mojsa, Magda Liczmanska, Alejandro Rojas-Fernandez, Yili Yin, Graeme Ball, Ronald T. Hay
J Cell Biol. 2023 Apr 3; 222(4): e202201027. Published online 2023 Feb 28. doi: 10.1083/jcb.202201027
PMCID:
PMC10005898
AbstractArticlePDF–6.7M
9.
HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation
Jingsheng Yuan, Tao Lv, Jian Yang, Zhenru Wu, Lvnan Yan, Jiayin Yang, Yujun Shi, Li Jiang
Cell Mol Gastroenterol Hepatol. 2023; 15(2): 307–325. Published online 2022 Oct 14. doi: 10.1016/j.jcmgh.2022.10.005
PMCID:
PMC9772558
AbstractArticlePDF–8.2M
10.
FANCD2 promotes mitotic rescue from transcription-mediated replication stress in SETX-deficient cancer cells
Maha Said, Viviana Barra, Elisa Balzano, Ibtissam Talhaoui, Franca Pelliccia, Simona Giunta, Valeria Naim
Commun Biol. 2022; 5: 1395. Published online 2022 Dec 21. doi: 10.1038/s42003-022-04360-2
PMCID:
PMC9772326
AbstractArticlePDF–2.4M
11.
A whole genome CRISPR screen identifies AHR loss as a mechanism of resistance to a PARP7 inhibitor
Huadong Chen, Morgan E. Diolaiti, Patrick C. O’Leary, Ajda Rojc, Nevan J. Krogan, Minkyu Kim, Alan Ashworth
Mol Cancer Ther. Author manuscript; available in PMC 2023 Jan 5.
Published in final edited form as: Mol Cancer Ther. 2022 Jul 5; 21(7): 1076–1089. doi: 10.1158/1535-7163.MCT-21-0841
PMCID:
PMC9769698
AbstractArticlePDF–2.7M
12.
The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers
Martina Oravcová, Minghua Nie, Nicola Zilio, Shintaro Maeda, Yasaman Jami-Alahmadi, Eros Lazzerini-Denchi, James A Wohlschlegel, Helle D Ulrich, Takanori Otomo, Michael N Boddy
eLife. 2022; 11: e79676. Published online 2022 Nov 14. doi: 10.7554/eLife.79676
PMCID:
PMC9708086
AbstractArticlePDF–8.5M
13.
Ovarian tumorB1-mediated heat shock transcription factor 1 deubiquitination is critical for glycolysis and development of endometriosis
Xi Ling, Jiayi Lu, Xiaoyun Wang, Lan Liu, Lu Liu, Yadi Wang, Yujun Sun, Chune Ren, Chao Lu, Zhenhai Yu
iScience. 2022 Nov 18; 25(11): 105363. Published online 2022 Oct 14. doi: 10.1016/j.isci.2022.105363
PMCID:
PMC9626688
AbstractArticlePDF–6.0M
14.
Transcriptional targets of senataxin and E2 promoter binding factors are associated with neuro-degenerative pathways during increased autophagic flux
Aaron E. Casey, Wenjun Liu, Leanne K. Hein, Timothy J. Sargeant, Stephen M. Pederson, Ville-Petteri Mäkinen
Sci Rep. 2022; 12: 17665. Published online 2022 Oct 21. doi: 10.1038/s41598-022-21617-2
PMCID:
PMC9587291
AbstractArticlePDF–1.3M
15.
The in vivo Interaction Landscape of Histones H3.1 and H3.3
Robert Siddaway, Scott Milos, Étienne Coyaud, Hwa Young Yun, Shahir M. Morcos, Sanja Pajovic, Eric I. Campos, Brian Raught, Cynthia Hawkins
Mol Cell Proteomics. 2022 Oct; 21(10): 100411. Published online 2022 Sep 9. doi: 10.1016/j.mcpro.2022.100411
PMCID:
PMC9540345
AbstractArticlePDF–3.9M
16.
Mutation in senataxin alters the mechanism of R-loop resolution in amyotrophic lateral sclerosis 4
Annapoorna Kannan, Juliana Cuartas, Pratik Gangwani, Dana Branzei, Laxman Gangwani
Brain. 2022 Sep; 145(9): 3072–3094. Published online 2022 Jan 19. doi: 10.1093/brain/awab464
PMCID:
PMC9536298
AbstractArticlePDF–3.1M
17.
Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB
Fu‐Long Li, Zhengming Wu, Yong‐Qi Gao, Forrest Z Bowling, J Matthew Franklin, Chongze Hu, Raymond T Suhandynata, Michael A Frohman, Michael V Airola, Huilin Zhou, Kun‐Liang Guan
EMBO J. 2022 Sep; 41(17): e110698. Published online 2022 Jul 17. doi: 10.15252/embj.2022110698
PMCID:
PMC9433938
AbstractArticlePDF–9.3M
18.
OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization
Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti
Science. Author manuscript; available in PMC 2022 Sep 11.
Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983
PMCID:
PMC9119736
AbstractArticlePDF–3.3M
19.
ΔNp63-Senataxin circuit controls keratinocyte differentiation by promoting the transcriptional termination of epidermal genes
Veronica Gatti, Claudia Fierro, Mirco Compagnone, Veronica La Banca, Alessandro Mauriello, Manuela Montanaro, Stefano Scalera, Francesca De Nicola, Eleonora Candi, Francesco Ricci, Luca Fania, Gerry Melino, Angelo Peschiaroli
Proc Natl Acad Sci U S A. 2022 Mar 8; 119(10): e2104718119. Published online 2022 Mar 2. doi: 10.1073/pnas.2104718119
PMCID:
PMC8915885
AbstractArticlePDF–2.0M
20.
Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy
Xin Sun, Yuhan Shu, Guiqin Ye, Caixia Wu, Mengting Xu, Ruilan Gao, Dongsheng Huang, Jianbin Zhang
Acta Pharm Sin B. 2022 Feb; 12(2): 838–852. Published online 2021 Jul 21. doi: 10.1016/j.apsb.2021.07.003
PMCID:
PMC8897022
AbstractArticlePDF–3.0M

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