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Select item 112099351.

Antagonistic roles of canonical and alternative-RPA in disease-associated tandem CAG repeat instability

Terence Gall-Duncan, Jennifer Luo, Carla-Marie Jurkovic, Laura A. Fischer, Kyota Fujita, Amit L. Deshmukh, Rachel J. Harding, Stephanie Tran, Mustafa Mehkary, Vanessa Li, David E. Leib, Ran Chen, Hikari Tanaka, Amanda G. Mason, Dominique Lévesque, Mahreen Khan, Mortezaali Razzaghi, Tanya Prasolava, Stella Lanni, Nozomu Sato, Marie-Christine Caron, Gagan B. Panigrahi, Peixiang Wang, Rachel Lau, Arturo López Castel, Jean-Yves Masson, Lynette Tippett, Clinton Turner, Maria Spies, Albert R. La Spada, Eric I. Campos, Maurice A. Curtis, François-Michel Boisvert, Richard L.M. Faull, Beverly L. Davidson, Masayuki Nakamori, Hitoshi Okazawa, Marc S. Wold, Christopher E. Pearson

Cell. Author manuscript; available in PMC 2024 Oct 26.

Published in final edited form as: Cell. 2023 Oct 26; 186(22): 4898–4919.e25. Published online 2023 Oct 11. doi: 10.1016/j.cell.2023.09.008

PMCID:: PMC11209935

Abstract Article PDF–3.0M

Select item 111140402.

TPX2: of spindle assembly, DNA damage response, and cancer

Gernot Neumayer, Camille Belzil, Oliver J. Gruss, Minh Dang Nguyen

Cell Mol Life Sci. 2014 Aug; 71(16): 3027–3047. Published online 2014 Feb 21. doi: 10.1007/s00018-014-1582-7

PMCID:: PMC11114040

Abstract Article PDF–1.0M

Select item 111043443.

TPX2 upregulates MMP13 to promote the progression of lipopolysaccharide-induced osteoarthritis

Jingtao Yu, Weiqi Wang, Zenghui Jiang, Huashun Liu

PeerJ. 2024; 12: e17032. Published online 2024 May 17. doi: 10.7717/peerj.17032

PMCID:: PMC11104344

Abstract Article PDF–14M

Select item 109113594.

Integrative analysis confirms TPX2 as a novel biomarker for clinical implication, tumor microenvironment, and immunotherapy response across human solid tumors

Mingxia Zhu, Xiaping Wang, Qing Zhang, Chen Xie, Tongshan Wang, Kai Shen, Lan Zhang, Xin Zhou

Aging (Albany NY) 2024 Feb 15; 16(3): 2563–2590. Published online 2024 Feb 2. doi: 10.18632/aging.205498

PMCID:: PMC10911359

Abstract Article PDF–5.7M

Select item 105107435.

UHRF1 promotes spindle assembly and chromosome congression by catalyzing EG5 polyubiquitination

Xuli Qi, Youhong Liu, Yuchong Peng, Yuxin Fu, Yongming Fu, Linglong Yin, Xiong Li

J Cell Biol. 2023 Nov 6; 222(11): e202210093. Published online 2023 Sep 20. doi: 10.1083/jcb.202210093

PMCID:: PMC10510743

Abstract Article PDF–5.3M

Select item 103232526.

Proximity labelling identifies pro-migratory endocytic recycling cargo and machinery of the Rab4 and Rab11 families

Beverley Wilson, Chloe Flett, Jakub Gemperle, Craig Lawless, Matthew Hartshorn, Eleanor Hinde, Tess Harrison, Megan Chastney, Sarah Taylor, Jennifer Allen, Jim C. Norman, Thomas Zacharchenko, Patrick T. Caswell

J Cell Sci. 2023 Jun 15; 136(12): jcs260468. Published online 2023 Jun 23. doi: 10.1242/jcs.260468

PMCID:: PMC10323252

Abstract Article

Select item 103078927.

TPX2 expression as a negative predictor of gemcitabine efficacy in pancreatic cancer

Michael Guenther, Sai Agash Surendran, Michael Haas, Volker Heinemann, Michael von Bergwelt-Baildon, Jutta Engel, Jens Werner, Stefan Boeck, Steffen Ormanns

Br J Cancer. 2023 Jul 27; 129(1): 175–182. Published online 2023 May 4. doi: 10.1038/s41416-023-02295-x

PMCID:: PMC10307892

Abstract Article PDF–1.1M

Select item 102431168.

Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification

Camila M. Aprosoff, Boris J.A. Dyakov, Vivian H.W. Cheung, Cassandra J. Wong, Mikaela Palandra, Anne-Claude Gingras, Haley D.M. Wyatt

J Proteome Res. 2023 Jun 2; 22(6): 1660–1681. Published online 2023 Apr 18. doi: 10.1021/acs.jproteome.2c00706

PMCID:: PMC10243116

Abstract Article PDF–13M

Select item 102374229.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 1016690010.

TPX2 promotes ovarian tumorigenesis by interacting with Lamin A/C and affecting its stability

Xin Meng, Jiazhen Cao, Hui Zheng, Xiaolu Ma, Yanchun Wang, Ying Tong, Suhong Xie, Renquan Lu, Lin Guo

Cancer Med. 2023 Apr; 12(8): 9738–9748. Published online 2023 Feb 15. doi: 10.1002/cam4.5683

PMCID:: PMC10166900

Abstract Article PDF–33M

Select item 1007290611.

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong

Mol Cell. Author manuscript; available in PMC 2023 Apr 4.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015

PMCID:: PMC10072906

Abstract Article PDF–4.2M

Select item 996687512.

Nuclear High Mobility Group A2 (HMGA2) Interactome Revealed by Biotin Proximity Labeling

Antoine Gaudreau-Lapierre, Thomas Klonisch, Hannah Nicolas, Thatchawan Thanasupawat, Laura Trinkle-Mulcahy, Sabine Hombach-Klonisch

Int J Mol Sci. 2023 Feb; 24(4): 4246. Published online 2023 Feb 20. doi: 10.3390/ijms24044246

PMCID:: PMC9966875

Abstract Article PDF–2.4M

Select item 995044713.

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma

Yu-Fei Cao, Lei Xie, Bei-Bei Tong, Man-Yu Chu, Wen-Qi Shi, Xiang Li, Jian-Zhong He, Shao-Hong Wang, Zhi-Yong Wu, Dan-Xia Deng, Ya-Qi Zheng, Zhi-Mao Li, Xiu-E Xu, Lian-Di Liao, Yin-Wei Cheng, Li-Yan Li, Li-Yan Xu, En-Min Li

Cell Death Differ. 2023 Feb; 30(2): 527–543. Published online 2022 Dec 16. doi: 10.1038/s41418-022-01104-x

PMCID:: PMC9950447

Abstract Article PDF–8.4M

Select item 993616214.

AurkA nuclear localization is promoted by TPX2 and counteracted by protein degradation

Italia Anna Asteriti, Federica Polverino, Venturina Stagni, Valentina Sterbini, Camilla Ascanelli, Francesco Davide Naso, Anna Mastrangelo, Alessandro Rosa, Alessandro Paiardini, Catherine Lindon, Giulia Guarguaglini

Life Sci Alliance. 2023 May; 6(5): e202201726. Published online 2023 Feb 16. doi: 10.26508/lsa.202201726

PMCID:: PMC9936162

Abstract Article PDF–2.6M

Select item 989828815.

TPX2 prompts mitotic survival via the induction of BCL2L1 through YAP1 protein stabilization in human embryonic stem cells

Yun-Jeong Kim, Young-Hyun Go, Ho-Chang Jeong, Eun-Ji Kwon, Seong-Min Kim, Hyun Sub Cheong, Wantae Kim, Hyoung Doo Shin, Haeseung Lee, Hyuk-Jin Cha

Exp Mol Med. 2023 Jan; 55(1): 32–42. Published online 2023 Jan 4. doi: 10.1038/s12276-022-00907-9

PMCID:: PMC9898288

Abstract Article PDF–4.0M

Select item 988348216.

TPX2 enhances the transcription factor activation of PXR and enhances the resistance of hepatocellular carcinoma cells to antitumor drugs

Hongbo Wang, Fang Chu, Xiao-feng Zhang, Peng Zhang, Li-xin Li, Yun-long Zhuang, Xiao-feng Niu, Xi He, Zhi-jie Li, Ying Bai, Da Mao, Zhen-wen Liu, Da-li Zhang, Bo-an Li

Cell Death Dis. 2023 Jan; 14(1): 64. Published online 2023 Jan 27. doi: 10.1038/s41419-022-05537-7

PMCID:: PMC9883482

Abstract Article PDF–4.4M

Select item 979798817.

TBK1 posphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1

Jianwen Zhou, Nikoline Lander Rasmussen, Hallvard Lauritz Olsvik, Vyacheslav Akimov, Zehan Hu, Gry Evjen, Stéphanie Kaeser-Pebernard, Devanarayanan Siva Sankar, Carole Roubaty, Pauline Verlhac, Nicole van de Beek, Fulvio Reggiori, Yakubu Princely Abudu, Blagoy Blagoev, Trond Lamark, Terje Johansen, Jörn Dengjel

J Cell Biol. 2023 Feb 6; 222(2): e202108144. Published online 2022 Dec 27. doi: 10.1083/jcb.202108144

PMCID:: PMC9797988

Abstract Article PDF–6.9M

Select item 977255818.

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation

Jingsheng Yuan, Tao Lv, Jian Yang, Zhenru Wu, Lvnan Yan, Jiayin Yang, Yujun Shi, Li Jiang

Cell Mol Gastroenterol Hepatol. 2023; 15(2): 307–325. Published online 2022 Oct 14. doi: 10.1016/j.jcmgh.2022.10.005

PMCID:: PMC9772558

Abstract Article PDF–8.2M

Select item 976969819.

A whole genome CRISPR screen identifies AHR loss as a mechanism of resistance to a PARP7 inhibitor

Huadong Chen, Morgan E. Diolaiti, Patrick C. O’Leary, Ajda Rojc, Nevan J. Krogan, Minkyu Kim, Alan Ashworth

Mol Cancer Ther. Author manuscript; available in PMC 2023 Jan 5.

Published in final edited form as: Mol Cancer Ther. 2022 Jul 5; 21(7): 1076–1089. doi: 10.1158/1535-7163.MCT-21-0841

PMCID:: PMC9769698

Abstract Article PDF–2.7M

Select item 970808620.

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers

Martina Oravcová, Minghua Nie, Nicola Zilio, Shintaro Maeda, Yasaman Jami-Alahmadi, Eros Lazzerini-Denchi, James A Wohlschlegel, Helle D Ulrich, Takanori Otomo, Michael N Boddy

eLife. 2022; 11: e79676. Published online 2022 Nov 14. doi: 10.7554/eLife.79676

PMCID:: PMC9708086

Abstract Article PDF–8.5M

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