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Items: 1 to 20 of 51

1.
TAOK3 Facilitates Esophageal Squamous Cell Carcinoma Progression and Cisplatin Resistance Through Augmenting Autophagy Mediated by IRGM
Mingchuang Sun, Zhaoxing Li, Xiaoyuan Wang, Meirong Zhao, Yuan Chu, Zehua Zhang, Kang Fang, Ziying Zhao, Anqi Feng, Zhuyun Leng, Jianing Shi, Li Zhang, Tao Chen, Meidong Xu
Adv Sci (Weinh) 2023 Oct; 10(29): 2300864. Published online 2023 Sep 13. doi: 10.1002/advs.202300864
PMCID:
PMC10582451
AbstractArticlePDF–6.4M
2.
Race-specific association of an IRGM risk allele with cytokine expression in human subjects
Teminioluwa Ajayi, Prashant Rai, Min Shi, Kristin A. Gabor, Peer W. F. Karmaus, Julie M. Meacham, Kevin Katen, Jennifer H. Madenspacher, Shepherd H. Schurman, Michael B. Fessler
Sci Rep. 2023; 13: 12911. Published online 2023 Aug 9. doi: 10.1038/s41598-023-40313-3
PMCID:
PMC10412543
AbstractArticlePDF–1.4M
3.
Differential Requirement for IRGM Proteins during Tuberculosis Infection in Mice
Kaley M. Wilburn, Rachel K. Meade, Emma M. Heckenberg, Jacob Dockterman, Jörn Coers, Christopher M. Sassetti, Andrew J. Olive, Clare M. Smith
Infect Immun. 2023 Feb; 91(2): e00510-22. Published online 2023 Jan 11. doi: 10.1128/iai.00510-22
PMCID:
PMC9933630
AbstractArticlePDF–1.5M
4.
Selective autophagy of RIPosomes maintains innate immune homeostasis during bacterial infection
Subhash Mehto, Kautilya Kumar Jena, Rina Yadav, Swatismita Priyadarsini, Pallavi Samal, Sivaram Krishna, Kollori Dhar, Ashish Jain, Nishant Ranjan Chauhan, Krushna C Murmu, Ramyasingh Bal, Rinku Sahu, Pundrik Jaiswal, Bhabani Sankar Sahoo, Srinivas Patnaik, Thomas A Kufer, Tor Erik Rusten, Swati Chauhan, Punit Prasad, Santosh Chauhan
EMBO J. 2022 Dec; 41(23): e111289. Published online 2022 Oct 11. doi: 10.15252/embj.2022111289
PMCID:
PMC9713718
AbstractArticlePDF–14M
5.
Inhibition of IRGM establishes a robust antiviral immune state to restrict pathogenic viruses
Parej Nath, Nishant Ranjan Chauhan, Kautilya Kumar Jena, Ankita Datey, Nilima Dinesh Kumar, Subhash Mehto, Saikat De, Tapas Kumar Nayak, Swatismita Priyadarsini, Kshitish Rout, Ramyasingh Bal, Krushna C Murmu, Manjula Kalia, Srinivas Patnaik, Punit Prasad, Fulvio Reggiori, Soma Chattopadhyay, Santosh Chauhan
EMBO Rep. 2021 Nov 4; 22(11): e52948. Published online 2021 Sep 1. doi: 10.15252/embr.202152948
PMCID:
PMC8567234
AbstractArticlePDF–2.6M
6.
IRGM/Irgm1 facilitates macrophage apoptosis through ROS generation and MAPK signal transduction: Irgm1+/- mice display increases atherosclerotic plaque stability
Shaohong Fang, Song Sun, Hengxuan Cai, Xiaoyi Zou, Shanjie Wang, Xinran Hao, Xin Wan, Jiangtian Tian, Zhaoying Li, Zhongze He, Wei Huang, Chenchen Liang, Zhenming Zhang, Liming Yang, Jinwei Tian, Bo Yu, Bo Sun
Theranostics. 2021; 11(19): 9358–9375. Published online 2021 Sep 9. doi: 10.7150/thno.62797
PMCID:
PMC8490524
AbstractArticlePDF–7.2M
7.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
8.
Autoimmunity gene IRGM suppresses cGAS‐STING and RIG‐I‐MAVS signaling to control interferon response
Kautilya Kumar Jena, Subhash Mehto, Parej Nath, Nishant Ranjan Chauhan, Rinku Sahu, Kollori Dhar, Saroj Kumar Das, Srinivasa Prasad Kolapalli, Krushna C Murmu, Ashish Jain, Sivaram Krishna, Bhabani Sankar Sahoo, Soma Chattopadhyay, Tor Erik Rusten, Punit Prasad, Swati Chauhan, Santosh Chauhan
EMBO Rep. 2020 Sep 3; 21(9): e50051. Published online 2020 Jul 27. doi: 10.15252/embr.202050051
PMCID:
PMC7507369
AbstractArticlePDF–2.7M
9.
Mammalian Atg8 proteins and autophagy factor IRGM control mTOR and TFEB at a regulatory node critical for response to pathogens
Suresh Kumar, Ashish Jain, Seong Won Choi, Gustavo Peixoto Duarte da Silva, Lee Allers, Michal H. Mudd, Ryan Scott Peters, Jan Haug Anonsen, Tor-Erik Rusten, Michael Lazarou, Vojo Deretic
Nat Cell Biol. Author manuscript; available in PMC 2021 Feb 3.
Published in final edited form as: Nat Cell Biol. 2020 Aug; 22(8): 973–985. Published online 2020 Aug 3. doi: 10.1038/s41556-020-0549-1
Correction in:
Nat Cell Biol. 2020 Aug 12
PMCID:
PMC7482486
AbstractArticlePDF–6.0M
10.
The Immunity-related GTPase M rs13361189 variant does not increase the risk for prevalent or incident steatosis; results from the Framingham Heart Study
DR. Tracey G. Simon, Xuan Deng, Ching-Ti Liu, Raymond T. Chung, DR. Michelle T. Long
Liver Int. Author manuscript; available in PMC 2020 Jun 1.
Published in final edited form as: Liver Int. 2019 Jun; 39(6): 1022–1026. Published online 2019 Feb 17. doi: 10.1111/liv.14039
PMCID:
PMC6535115
AbstractArticlePDF–312K
11.
Crohn’s disease IRGM risk alleles are associated with altered gene expression in human tissues
Teminioluwa A. Ajayi, Cynthia L. Innes, Sara A. Grimm, Prashant Rai, Ryan Finethy, Jörn Coers, Xuting Wang, Douglas A. Bell, John A. McGrath, Shepherd H. Schurman, Michael B. Fessler
Am J Physiol Gastrointest Liver Physiol. 2019 Jan 1; 316(1): G95–G105. Published online 2018 Oct 18. doi: 10.1152/ajpgi.00196.2018
PMCID:
PMC6383377
AbstractArticle
12.
The Crohn’s Disease Risk Factor IRGM Limits NLRP3 Inflammasome Activation by Impeding Its Assembly and by Mediating Its Selective Autophagy
Subhash Mehto, Kautilya Kumar Jena, Parej Nath, Swati Chauhan, Srinivasa Prasad Kolapalli, Saroj Kumar Das, Pradyumna Kumar Sahoo, Ashish Jain, Gregory A. Taylor, Santosh Chauhan
Mol Cell. 2019 Feb 7; 73(3): 429–445.e7. doi: 10.1016/j.molcel.2018.11.018
PMCID:
PMC6372082
AbstractArticlePDF–4.9M
13.
IRGM Gene Variants Modify the Relationship Between Visceral Adipose Tissue and NAFLD in Patients With Crohn’s Disease
Tracey G Simon, Kimberley W J Van Der Sloot, Samantha B Chin, Amit D Joshi, Paul Lochhead, Ashwin N Ananthakrishnan, Ramnik Xavier, Raymond T Chung, Hamed Khalili
Inflamm Bowel Dis. 2018 Oct; 24(10): 2247–2257. Published online 2018 May 18. doi: 10.1093/ibd/izy128
PMCID:
PMC6230523
AbstractArticlePDF–517K
14.
Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei
Domenico Fasci, Hugo van Ingen, Richard A. Scheltema, Albert J. R. Heck
Mol Cell Proteomics. 2018 Oct; 17(10): 2018–2033. Published online 2018 Jul 18. doi: 10.1074/mcp.RA118.000924
PMCID:
PMC6166682
AbstractArticlePDF–3.8M
15.
Polymorphisms in Autophagy-Related Gene IRGM Are Associated with Susceptibility to Autoimmune Thyroid Diseases
Qiu-ming Yao, Yuan-feng Zhu, Wen Wang, Zhen-yu Song, Xiao-qing Shao, Ling Li, Rong-hua Song, Xiao-fei An, Qiu Qin, Qian Li, Jin-an Zhang
Biomed Res Int. 2018; 2018: 7959707. Published online 2018 Jun 11. doi: 10.1155/2018/7959707
PMCID:
PMC6016217
AbstractArticlePDF–701K
16.
Mechanism of Stx17 recruitment to autophagosomes via IRGM and mammalian Atg8 proteins
Suresh Kumar, Ashish Jain, Farzin Farzam, Jingyue Jia, Yuexi Gu, Seong Won Choi, Michal H. Mudd, Aurore Claude-Taupin, Michael J. Wester, Keith A. Lidke, Tor-Erik Rusten, Vojo Deretic
J Cell Biol. 2018 Mar 5; 217(3): 997–1013. doi: 10.1083/jcb.201708039
PMCID:
PMC5839791
AbstractArticlePDF–2.5M
17.
Association between IRGM polymorphisms and tuberculosis risk: A meta-analysis
Haojun Xie, Chufang Li, Mincong Zhang, Nanshan Zhong, Ling Chen
Medicine (Baltimore) 2017 Oct; 96(43): e8189. Published online 2017 Oct 27. doi: 10.1097/MD.0000000000008189
PMCID:
PMC5671819
AbstractArticlePDF–1.2M
18.
Hepatitis C virus triggers Golgi fragmentation and autophagy through the immunity-related GTPase M
Marianne D. Hansen, Ingvild B. Johnsen, Kim A. Stiberg, Tatyana Sherstova, Takaji Wakita, Gabriel Mary Richard, Richard K. Kandasamy, Eliane F. Meurs, Marit W. Anthonsen
Proc Natl Acad Sci U S A. 2017 Apr 25; 114(17): E3462–E3471. Published online 2017 Apr 7. doi: 10.1073/pnas.1616683114
PMCID:
PMC5410803
AbstractArticlePDF–1.6M
19.
Role of autophagy genetic variants for the risk of Candida infections
Diana C. Rosentul, Theo S. Plantinga, Marius Farcas, Marije Oosting, Omar J.M. Hamza, William K. Scott, Barbara D. Alexander, John C. Yang, Gregory M. Laird, Leo A.B. Joosten, Jos W. M. van der Meer, John R. Perfect, Bart-Jan Kullberg, Andre J.A.M. van der Ven, Melissa D. Johnson, Mihai G. Netea
Med Mycol. Author manuscript; available in PMC 2015 Dec 22.
Published in final edited form as: Med Mycol. 2014 May; 52(4): 333–341. Published online 2014 Apr 8. doi: 10.1093/mmy/myt035
PMCID:
PMC4687479
AbstractArticlePDF–489K
20.
IRGM governs the core autophagy machinery to conduct antimicrobial defense
Santosh Chauhan, Michael A. Mandell, Vojo Deretic
Mol Cell. Author manuscript; available in PMC 2016 May 7.
Published in final edited form as: Mol Cell. 2015 May 7; 58(3): 507–521. Published online 2015 Apr 16. doi: 10.1016/j.molcel.2015.03.020
PMCID:
PMC4427528
AbstractArticlePDF–2.6M

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