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Select item 115081811.

Oral Microbiome and CPT1A Function in Fatty Acid Metabolism in Oral Cancer

Zeba Praveen, Sung-Weon Choi, Jong Ho Lee, Joo Yong Park, Hyun Jun Oh, Ik Jae Kwon, Jin Hee Park, Mi Kyung Kim

Int J Mol Sci. 2024 Oct; 25(20): 10890. Published online 2024 Oct 10. doi: 10.3390/ijms252010890

PMCID:: PMC11508181

Abstract Article PDF–4.2M

Select item 112969142.

DSBSO-Based XL-MS Analysis of Breast Cancer PDX Tissues to Delineate Protein Interaction Network in Clinical Samples

Fenglong Jiao, Clinton Yu, Andrew Wheat, Lijun Chen, Tung-Shing Mamie Lih, Hui Zhang, Lan Huang

J Proteome Res. Author manuscript; available in PMC 2024 Aug 3.

Published in final edited form as: J Proteome Res. 2024 Aug 2; 23(8): 3269–3279. Published online 2024 Feb 9. doi: 10.1021/acs.jproteome.3c00832

PMCID:: PMC11296914

Abstract Article PDF–1.7M

Select item 112099353.

Antagonistic roles of canonical and alternative-RPA in disease-associated tandem CAG repeat instability

Terence Gall-Duncan, Jennifer Luo, Carla-Marie Jurkovic, Laura A. Fischer, Kyota Fujita, Amit L. Deshmukh, Rachel J. Harding, Stephanie Tran, Mustafa Mehkary, Vanessa Li, David E. Leib, Ran Chen, Hikari Tanaka, Amanda G. Mason, Dominique Lévesque, Mahreen Khan, Mortezaali Razzaghi, Tanya Prasolava, Stella Lanni, Nozomu Sato, Marie-Christine Caron, Gagan B. Panigrahi, Peixiang Wang, Rachel Lau, Arturo López Castel, Jean-Yves Masson, Lynette Tippett, Clinton Turner, Maria Spies, Albert R. La Spada, Eric I. Campos, Maurice A. Curtis, François-Michel Boisvert, Richard L.M. Faull, Beverly L. Davidson, Masayuki Nakamori, Hitoshi Okazawa, Marc S. Wold, Christopher E. Pearson

Cell. Author manuscript; available in PMC 2024 Oct 26.

Published in final edited form as: Cell. 2023 Oct 26; 186(22): 4898–4919.e25. Published online 2023 Oct 11. doi: 10.1016/j.cell.2023.09.008

PMCID:: PMC11209935

Abstract Article PDF–3.0M

Select item 109502824.

CPT1A mediates the succinylation of SP5 which activates transcription of PDPK1 to promote the viability and glycolysis of prostate cancer cells

Shufeng Liu, Xiaoguang Chen, Liqi Zhang, Bo Lu

Cancer Biol Ther. 2024; 25(1): 2329372. Published online 2024 Mar 17. doi: 10.1080/15384047.2024.2329372

PMCID:: PMC10950282

Abstract Article PDF–18M

Select item 109424675.

Mitochondrial Raf1 Regulates Glutamine Catabolism

Ronald L. Shanderson, Ian D. Ferguson, Zurab Siprashvili, Luca Ducoli, Albert M. Li, Weili Miao, Suhas Srinivasan, Mary Grace Velasco, Yang Li, Jiangbin Ye, Paul A. Khavari

Version 1. bioRxiv. Preprint. 2024 Mar 9. doi: 10.1101/2024.03.08.581297

PMCID:: PMC10942467

Abstract Article PDF–6.5M

Select item 106415246.

Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis

Robert S. Kiss, Jarred Chicoine, Youssef Khalil, Robert Sladek, He Chen, Alessandro Pisaturo, Cyril Martin, Jessica D. Dale, Tegan A. Brudenell, Archith Kamath, Jeffrey Kyei-Boahen, Anouar Hafiane, Girija Daliah, Célia Alecki, Tayah S. Hopes, Martin Heier, Irene A. Aligianis, Jean-Jacques Lebrun, Julie Aspden, Emanuele Paci, Anja Kerksiek, Dieter Lütjohann, Peter Clayton, Jimi C. Wills, Alex von Kriegsheim, Tommy Nilsson, Eamonn Sheridan, Mark T. Handley

J Biol Chem. 2023 Nov; 299(11): 105295. Published online 2023 Sep 28. doi: 10.1016/j.jbc.2023.105295

PMCID:: PMC10641524

Abstract Article PDF–3.8M

Select item 106123627.

Multi-tissue epigenetic analysis identifies distinct associations underlying insulin resistance and Alzheimer’s disease at CPT1A locus

Chloé Sarnowski, Tianxiao Huan, Yiyi Ma, Roby Joehanes, Alexa Beiser, Charles S. DeCarli, Nancy L. Heard-Costa, Daniel Levy, Honghuang Lin, Ching-Ti Liu, Chunyu Liu, James B. Meigs, Claudia L. Satizabal, Jose C. Florez, Marie-France Hivert, Josée Dupuis, Philip L. De Jager, David A. Bennett, Sudha Seshadri, Alanna C. Morrison

Clin Epigenetics. 2023; 15: 173. Published online 2023 Oct 27. doi: 10.1186/s13148-023-01589-4

PMCID:: PMC10612362

Abstract Article PDF–1.4M

Select item 105234548.

CPT1A-mediated fatty acid oxidation confers cancer cell resistance to immune-mediated cytolytic killing

Zheng Liu, Wenjie Liu, Wei Wang, Yibao Ma, Yufeng Wang, David L. Drum, Jinyang Cai, Hallie Blevins, Eun Lee, Syed Shah, Paul B. Fisher, Xinhui Wang, Xianjun Fang, Chunqing Guo, Xiang-Yang Wang

Proc Natl Acad Sci U S A. 2023 Sep 26; 120(39): e2302878120. Published online 2023 Sep 18. doi: 10.1073/pnas.2302878120

PMCID:: PMC10523454

Abstract Article PDF–1.3M

Select item 103986609.

C9orf72 protein quality control by UBR5‐mediated heterotypic ubiquitin chains

Julia Jülg, Dieter Edbauer, Christian Behrends

EMBO Rep. 2023 Aug; 24(8): e55895. Published online 2023 Jun 15. doi: 10.15252/embr.202255895

PMCID:: PMC10398660

Abstract Article PDF–2.4M

Select item 1034845810.

DNA Methylation Near CPT1A and Changes in Triglyceride-rich Lipoproteins in Response to Weight-loss Diet Interventions

Xiang Li, Xiaojian Shao, Qiaochu Xue, Minghao Kou, Catherine M Champagne, Boryana S Koseva, Yoriko Heianza, Elin Grundberg, Lydia A Bazzano, George A Bray, Frank M Sacks, Lu Qi

J Clin Endocrinol Metab. 2023 Aug; 108(8): e542–e549. Published online 2023 Feb 17. doi: 10.1210/clinem/dgad086

PMCID:: PMC10348458

Abstract Article

Select item 1028188811.

NQO1/CPT1A promotes the progression of pancreatic adenocarcinoma via fatty acid oxidation: NQO1/CPT1A promotes PAAD via FAO

Ran Xu, Ying Liu, Liang Ma, Yao Sun, Haifeng Liu, Yang Yang, Tiefeng Jin, Dawei Yang

Acta Biochim Biophys Sin (Shanghai) 2023 May; 55(5): 758–768. Published online 2023 May 29. doi: 10.3724/abbs.2023066

PMCID:: PMC10281888

Abstract Article PDF–4.0M

Select item 1025046912.

Carnitine palmitoyltransferase 1A promotes mitochondrial fission by enhancing MFF succinylation in ovarian cancer

Yaqin Zhu, Yue Wang, Ying Li, Zhongqi Li, Wenhui Kong, Xiaoxuan Zhao, Shuting Chen, Liting Yan, Lenan Wang, Yunli Tong, Huanjie Shao

Commun Biol. 2023; 6: 618. Published online 2023 Jun 8. doi: 10.1038/s42003-023-04993-x

PMCID:: PMC10250469

Abstract Article PDF–1.1M

Select item 1023742213.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 1014884314.

mTORC2 interactome and localization determine aggressiveness of high-grade glioma cells through association with gelsolin

Naphat Chantaravisoot, Piriya Wongkongkathep, Nuttiya Kalpongnukul, Narawit Pacharakullanon, Pornchai Kaewsapsak, Chaiyaboot Ariyachet, Joseph A. Loo, Fuyuhiko Tamanoi, Trairak Pisitkun

Sci Rep. 2023; 13: 7037. Published online 2023 Apr 29. doi: 10.1038/s41598-023-33872-y

PMCID:: PMC10148843

Abstract Article PDF–11M

Select item 990930015.

Overexpression CPT1A reduces lipid accumulation via PPARα/CD36 axis to suppress the cell proliferation in ccRCC: CPT1A inhibits ccRCC cell proliferation via PPARα/CD36 axis

Hui Yang, Hongbo Zhao, Zhongkun Ren, Xiaojia Yi, Qiao Zhang, Zhe Yang, Yingmin Kuang, Yuechun Zhu

Acta Biochim Biophys Sin (Shanghai) 2022 Feb; 54(2): 220–231. Published online 2021 Dec 23. doi: 10.3724/abbs.2021023

PMCID:: PMC9909300

Abstract Article PDF–16M

Select item 989754116.

The impact of variance in carnitine palmitoyltransferase-1 expression on breast cancer prognosis is stratified by clinical and anthropometric factors

Ryan Liu, Shyryn Ospanova, Rachel J. Perry

PLoS One. 2023; 18(2): e0281252. Published online 2023 Feb 3. doi: 10.1371/journal.pone.0281252

PMCID:: PMC9897541

Abstract Article PDF–1.1M

Select item 985197317.

A comprehensive SARS-CoV-2–human protein–protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets

Yadi Zhou, Yuan Liu, Shagun Gupta, Mauricio I. Paramo, Yuan Hou, Chengsheng Mao, Yuan Luo, Julius Judd, Shayne Wierbowski, Marta Bertolotti, Mriganka Nerkar, Lara Jehi, Nir Drayman, Vlad Nicolaescu, Haley Gula, Savaş Tay, Glenn Randall, Peihui Wang, John T. Lis, Cédric Feschotte, Serpil C. Erzurum, Feixiong Cheng, Haiyuan Yu

Nat Biotechnol. Author manuscript; available in PMC 2023 Jan 20.

Published in final edited form as: Nat Biotechnol. 2023 Jan; 41(1): 128–139. Published online 2022 Oct 10. doi: 10.1038/s41587-022-01474-0

PMCID:: PMC9851973

Abstract Article PDF–4.0M

Select item 976969818.

A whole genome CRISPR screen identifies AHR loss as a mechanism of resistance to a PARP7 inhibitor

Huadong Chen, Morgan E. Diolaiti, Patrick C. O’Leary, Ajda Rojc, Nevan J. Krogan, Minkyu Kim, Alan Ashworth

Mol Cancer Ther. Author manuscript; available in PMC 2023 Jan 5.

Published in final edited form as: Mol Cancer Ther. 2022 Jul 5; 21(7): 1076–1089. doi: 10.1158/1535-7163.MCT-21-0841

PMCID:: PMC9769698

Abstract Article PDF–2.7M

Select item 974797619.

Neutrophil trafficking to the site of infection requires Cpt1a-dependent fatty acid β-oxidation

Ly Pham, Padmini Komalavilas, Alex M. Eddie, Timothy E. Thayer, Dalton L. Greenwood, Ken H. Liu, Jaclyn Weinberg, Andrew Patterson, Joshua P. Fessel, Kelli L. Boyd, Jenny C. Schafer, Jamie L. Kuck, Aaron C. Shaver, David K. Flaherty, Brittany K. Matlock, Christiaan D. M. Wijers, C. Henrique Serezani, Dean P. Jones, Evan L. Brittain, Jeffrey C. Rathmell, Michael J. Noto

Commun Biol. 2022; 5: 1366. Published online 2022 Dec 13. doi: 10.1038/s42003-022-04339-z

PMCID:: PMC9747976

Abstract Article PDF–2.6M

Select item 969204320.

CPT1A promotes anoikis resistance in esophageal squamous cell carcinoma via redox homeostasis

Tian Tian, Yunxin Lu, Jinfei Lin, Miao Chen, Huijuan Qiu, Wancui Zhu, Haohui Sun, Jinsheng Huang, Han Yang, Wuguo Deng

Redox Biol. 2022 Dec; 58: 102544. Published online 2022 Nov 15. doi: 10.1016/j.redox.2022.102544

PMCID:: PMC9692043

Abstract Article PDF–13M

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