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Items: 1 to 20 of 219

1.
Molecular mechanism of HNF-1A–mediated HNF4A gene regulation and promoter-driven HNF4A-MODY diabetes
Laura Kind, Janne Molnes, Erling Tjora, Arne Raasakka, Matti Myllykoski, Kevin Colclough, Cécile Saint-Martin, Caroline Adelfalk, Petra Dusatkova, Stepanka Pruhova, Camilla Valtonen-André, Christine Bellanné-Chantelot, Thomas Arnesen, Petri Kursula, Pål Rasmus Njølstad
JCI Insight. 2024 Jun 10; 9(11): e175278. Published online 2024 Jun 10. doi: 10.1172/jci.insight.175278
PMCID:
PMC11382887
AbstractArticlePDF–4.9M
2.
Pan-cancer mapping of single CD8+ T cell profiles reveals a TCF1:CXCR6 axis regulating CD28 co-stimulation and anti-tumor immunity
Katherine Tooley, Livnat Jerby, Giulia Escobar, S. Harsha Krovi, Davide Mangani, Gitanjali Dandekar, Hanning Cheng, Asaf Madi, Ella Goldschmidt, Conner Lambden, Rajesh K. Krishnan, Orit Rozenblatt-Rosen, Aviv Regev, Ana C. Anderson
Cell Rep Med. 2024 Jul 16; 5(7): 101640. Published online 2024 Jul 2. doi: 10.1016/j.xcrm.2024.101640
PMCID:
PMC11293343
AbstractArticlePDF–5.4M
3.
Tripartite motif 8 promotes the progression of hepatocellular carcinoma via mediating ubiquitination of HNF1α
Yu Peng, Hui Qian, Wen-Ping Xu, Meng-Chao Xiao, Chen-Hong Ding, Fang Liu, Huan-Yu Hong, Shu-Qing Liu, Xin Zhang, Wei-Fen Xie
Cell Death Dis. 2024 Jun; 15(6): 416. Published online 2024 Jun 15. doi: 10.1038/s41419-024-06819-y
PMCID:
PMC11180176
AbstractArticlePDF–5.0M
4.
HNF1α maintains pancreatic α and β cell functions in primary human islets
Mollie F. Qian, Romina J. Bevacqua, Vy M.N. Coykendall, Xiong Liu, Weichen Zhao, Charles A. Chang, Xueying Gu, Xiao-Qing Dai, Patrick E. MacDonald, Seung K. Kim
JCI Insight. 2023 Dec 22; 8(24): e170884. Published online 2023 Dec 22. doi: 10.1172/jci.insight.170884
PMCID:
PMC10807710
AbstractArticlePDF–2.3M
5.
Characterisation of HNF1A variants in paediatric diabetes in Norway using functional and clinical investigations to unmask phenotype and monogenic diabetes
Pernille Svalastoga, Alba Kaci, Janne Molnes, Marie H. Solheim, Bente B. Johansson, Lars Krogvold, Torild Skrivarhaug, Eivind Valen, Stefan Johansson, Anders Molven, Jørn V. Sagen, Eirik Søfteland, Lise Bjørkhaug, Erling Tjora, Ingvild Aukrust, Pål R. Njølstad
Diabetologia. 2023; 66(12): 2226–2237. Published online 2023 Oct 5. doi: 10.1007/s00125-023-06012-4
PMCID:
PMC10627920
AbstractArticlePDF–1.5M
6.
Single cell multiomic analysis reveals diabetes-associated β-cell heterogeneity driven by HNF1A
Chen Weng, Anniya Gu, Shanshan Zhang, Leina Lu, Luxin Ke, Peidong Gao, Xiaoxiao Liu, Yuntong Wang, Peinan Hu, Dylan Plummer, Elise MacDonald, Saixian Zhang, Jiajia Xi, Sisi Lai, Konstantin Leskov, Kyle Yuan, Fulai Jin, Yan Li
Nat Commun. 2023; 14: 5400. Published online 2023 Sep 5. doi: 10.1038/s41467-023-41228-3
PMCID:
PMC10480445
AbstractArticlePDF–8.5M
7.
High-fat diet plus HNF1A variant promotes polyps by activating β-catenin in early-onset colorectal cancer
Heyu Song, Ricky A. Sontz, Matthew J. Vance, Julia M. Morris, Sulaiman Sheriff, Songli Zhu, Suzann Duan, Jiping Zeng, Erika Koeppe, Ritu Pandey, Curtis A. Thorne, Elena M. Stoffel, Juanita L. Merchant
JCI Insight. 2023 Jul 10; 8(13): e167163. Published online 2023 Jul 10. doi: 10.1172/jci.insight.167163
PMCID:
PMC10371337
AbstractArticlePDF–7.8M
8.
Molecular characterization and re-interpretation of HNF1A variants identified in Indian MODY subjects towards precision medicine
Babu Kavitha, Sampathkumar Ranganathan, Sundaramoorthy Gopi, Umashankar Vetrivel, Nagarajan Hemavathy, Viswanathan Mohan, Venkatesan Radha
Front Endocrinol (Lausanne) 2023; 14: 1177268. Published online 2023 Jun 16. doi: 10.3389/fendo.2023.1177268
PMCID:
PMC10313120
AbstractArticlePDF–3.3M
9.
HNF1A binds and regulates the expression of SLC51B to facilitate the uptake of estrone sulfate in human renal proximal tubule epithelial cells
Jun Wei Chan, Claire Wen Ying Neo, Soumita Ghosh, Hyungwon Choi, Su Chi Lim, E. Shyong Tai, Adrian Kee Keong Teo
Cell Death Dis. 2023 May; 14(5): 302. Published online 2023 May 3. doi: 10.1038/s41419-023-05827-8
PMCID:
PMC10156747
AbstractArticlePDF–4.2M
10.
Pharmacological disruption of mSWI/SNF complex activity restricts SARS-CoV-2 infection
Jin Wei, Ajinkya Patil, Clayton K. Collings, Mia Madel Alfajaro, Yu Liang, Wesley L. Cai, Madison S. Strine, Renata B. Filler, Peter C. DeWeirdt, Ruth E. Hanna, Bridget L. Menasche, Arya Ökten, Mario A. Peña-Hernández, Jon Klein, Andrew McNamara, Romel Rosales, Briana L. McGovern, M. Luis Rodriguez, Adolfo García-Sastre, Kris M. White, Yiren Qin, John G. Doench, Qin Yan, Akiko Iwasaki, Thomas P. Zwaka, Jun Qi, Cigall Kadoch, Craig B. Wilen
Nat Genet. 2023; 55(3): 471–483. Published online 2023 Mar 9. doi: 10.1038/s41588-023-01307-z
PMCID:
PMC10011139
AbstractArticlePDF–21M
11.
HNF1A regulates the crosstalk between innate immune responses and MAFLD by mediating autophagic degradation of TBK1
Yunfei Qin, Dongbo Qiu, Qi Zhang
Autophagy. 2023; 19(3): 1026–1027. Published online 2022 Aug 11. doi: 10.1080/15548627.2022.2110728
PMCID:
PMC9980577
AbstractArticlePDF–362K
12.
Integrated Transcriptomic and Proteomic Analysis Identifies Plasma Biomarkers of Hepatocellular Failure in Alcohol-Associated Hepatitis
Josepmaria Argemi, Komal Kedia, Marina A. Gritsenko, Ana Clemente-Sanchez, Aliya Asghar, Jose M. Herranz, Zhang-Xu Liu, Stephen R. Atkinson, Richard D. Smith, Trina M. Norden-Krichmar, Le Z. Day, Andrew Stolz, John A. Tayek, Ramon Bataller, Timothy R. Morgan, Jon M. Jacobs, the Southern California Alcoholic Hepatitis Consortium and the InTeam Consortium
Am J Pathol. 2022 Dec; 192(12): 1658–1669. doi: 10.1016/j.ajpath.2022.08.009
PMCID:
PMC9765311
AbstractArticlePDF–2.8M
13.
The contribution of functional HNF1A variants and polygenic susceptibility to risk of type 2 diabetes in ancestrally diverse populations
Lauren A. Stalbow, Michael H. Preuss, Roelof A. J. Smit, Nathalie Chami, Lise Bjørkhaug, Ingvild Aukrust, Anna L. Gloyn, Ruth J. F. Loos
Diabetologia. 2023; 66(1): 116–126. Published online 2022 Oct 11. doi: 10.1007/s00125-022-05806-2
PMCID:
PMC9729131
AbstractArticlePDF–1.2M
14.
The HASTER lncRNA promoter is a cis-acting transcriptional stabilizer of HNF1A
Anthony Beucher, Irene Miguel-Escalada, Diego Balboa, Matías G. De Vas, Miguel Angel Maestro, Javier Garcia-Hurtado, Aina Bernal, Roser Gonzalez-Franco, Pierfrancesco Vargiu, Holger Heyn, Philippe Ravassard, Sagrario Ortega, Jorge Ferrer
Nat Cell Biol. 2022; 24(10): 1528–1540. Published online 2022 Oct 6. doi: 10.1038/s41556-022-00996-8
PMCID:
PMC9586874
AbstractArticlePDF–15M
15.
Decreased TCF1 and BCL11B expression predicts poor prognosis for patients with chronic lymphocytic leukemia
Taotao Liang, Xiaojiao Wang, Yanyan Liu, Hao Ai, Qian Wang, Xianwei Wang, Xudong Wei, Yongping Song, Qingsong Yin
Front Immunol. 2022; 13: 985280. Published online 2022 Sep 23. doi: 10.3389/fimmu.2022.985280
PMCID:
PMC9539190
AbstractArticlePDF–7.2M
16.
Genome‐wide association of individual vulnerability with alcohol‐associated liver disease: A Korean genome and epidemiology study
Kwang Yoon Kim, Jung Oh Kim, Young‐Sang Kim, Ja‐Eun Choi, Jae‐Min Park, Kunhee Han, Da‐Hyun Park, Yon Chul Park, Bom Taeck Kim, Kyung‐Won Hong
Hepatology. 2022 Feb; 75(2): 391–402. Published online 2021 Dec 6. doi: 10.1002/hep.32115
PMCID:
PMC9300105
AbstractArticlePDF–726K
17.
Structural and biophysical characterization of transcription factor HNF-1A as a tool to study MODY3 diabetes variants
Laura Kind, Arne Raasakka, Janne Molnes, Ingvild Aukrust, Lise Bjørkhaug, Pål Rasmus Njølstad, Petri Kursula, Thomas Arnesen
J Biol Chem. 2022 Apr; 298(4): 101803. Published online 2022 Mar 4. doi: 10.1016/j.jbc.2022.101803
PMCID:
PMC8988010
AbstractArticlePDF–3.1M
18.
HNF1A POU Domain Mutations Found in Japanese Liver Cancer Patients Cause Downregulation of HNF4A Promoter Activity with Possible Disruption in Transcription Networks
Effi Haque, Aamir Salam Teeli, Dawid Winiarczyk, Masahiko Taguchi, Shun Sakuraba, Hidetoshi Kono, Paweł Leszczyński, Mariusz Pierzchała, Hiroaki Taniguchi
Genes (Basel) 2022 Mar; 13(3): 413. Published online 2022 Feb 24. doi: 10.3390/genes13030413
PMCID:
PMC8949677
AbstractArticlePDF–3.7M
19.
HNF1A Mutations and Beta Cell Dysfunction in Diabetes
Yasutaka Miyachi, Takashi Miyazawa, Yoshihiro Ogawa
Int J Mol Sci. 2022 Mar; 23(6): 3222. Published online 2022 Mar 16. doi: 10.3390/ijms23063222
PMCID:
PMC8948720
AbstractArticlePDF–772K
20.
HNF1A：From Monogenic Diabetes to Type 2 Diabetes and Gestational Diabetes Mellitus
Li-Mei Li, Bei-Ge Jiang, Liang-Liang Sun
Front Endocrinol (Lausanne) 2022; 13: 829565. Published online 2022 Mar 1. doi: 10.3389/fendo.2022.829565
PMCID:
PMC8921476
AbstractArticlePDF–2.5M

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