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Select item 107165521.

Chronic AMPK inactivation slows SHH medulloblastoma progression by inhibiting mTORC1 signaling and depleting tumor stem cells

Daniel Shiloh Malawsky, Taylor Dismuke, Hedi Liu, Ethan Castellino, Jay Brenman, Biplab Dasgupta, Andrey Tikunov, Timothy R. Gershon

iScience. 2023 Dec 15; 26(12): 108443. Published online 2023 Nov 14. doi: 10.1016/j.isci.2023.108443

PMCID:: PMC10716552

Abstract Article PDF–5.9M

Select item 86316032.

Protein kinase A drives paracrine crisis and WNT4-dependent testis tumor in Carney complex

Cyril Djari, Isabelle Sahut-Barnola, Amandine Septier, Ingrid Plotton, Nathanaëlle Montanier, Damien Dufour, Adrien Levasseur, James Wilmouth, Jr., Jean-Christophe Pointud, Fabio R. Faucz, Crystal Kamilaris, Antoine-Guy Lopez, Florian Guillou, Amanda Swain, Seppo J. Vainio, Igor Tauveron, Pierre Val, Hervé Lefebvre, Constantine A. Stratakis, Antoine Martinez, Anne-Marie Lefrançois-Martinez

J Clin Invest. 2021 Dec 1; 131(23): e146910. Published online 2021 Dec 1. doi: 10.1172/JCI146910

PMCID:: PMC8631603

Abstract Article PDF–35M

Select item 82332313.

Loss of PKA regulatory subunit 1α aggravates cardiomyocyte necrosis and myocardial ischemia/reperfusion injury

Yuening Liu, Jingrui Chen, Peng Xia, Constantine A. Stratakis, Zhaokang Cheng

J Biol Chem. 2021 Jul; 297(1): 100850. Published online 2021 Jun 1. doi: 10.1016/j.jbc.2021.100850

PMCID:: PMC8233231

Abstract Article PDF–3.5M

Select item 79387704.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 78462885.

Oxidation of Protein Kinase A Regulatory Subunit PKARIα Protects Against Myocardial Ischemia-Reperfusion Injury by Inhibiting Lysosomal-Triggered Calcium Release

Jillian N. Simon, Besarte Vrellaku, Stefania Monterisi, Sandy M. Chu, Nadiia Rawlings, Oliver Lomas, Gerard A. Marchal, Dominic Waithe, Fahima Syeda, Parag R. Gajendragadkar, Raja Jayaram, Rana Sayeed, Keith M. Channon, Larissa Fabritz, Pawel Swietach, Manuela Zaccolo, Philip Eaton, Barbara Casadei

Circulation. 2021 Feb 2; 143(5): 449–465. Published online 2020 Nov 13. doi: 10.1161/CIRCULATIONAHA.120.046761

PMCID:: PMC7846288

Abstract Article PDF–3.7M

Select item 77927126.

Inhibition of cardiac potassium currents by oxidation-activated protein kinase A contributes to early afterdepolarizations in the heart

M. Trum, M. M. T. Islam, S. Lebek, M. Baier, P. Hegner, P. Eaton, L. S. Maier, S. Wagner

Am J Physiol Heart Circ Physiol. 2020 Dec 1; 319(6): H1347–H1357. Published online 2020 Oct 9. doi: 10.1152/ajpheart.00182.2020

PMCID:: PMC7792712

Abstract Article

Select item 75663527.

Prkar1a haploinsufficiency ameliorates the growth hormone excess phenotype in Aip-deficient mice

Marie Helene Schernthaner-Reiter, Giampaolo Trivellin, Thomas Roetzer, Johannes A Hainfellner, Matthew F Starost, Constantine A Stratakis

Hum Mol Genet. 2020 Sep 1; 29(17): 2951–2961. Published online 2020 Aug 21. doi: 10.1093/hmg/ddaa178

PMCID:: PMC7566352

Abstract Article PDF–1.2M

Select item 73944428.

Activation of Protein Kinase A (PKA) signaling mitigates congenital hyperinsulinism associated hypoglycemia in the Sur1^-/- mouse model

Mangala M. Soundarapandian, Christine A. Juliana, Jinghua Chai, Patrick A. Haslett, Kevin Fitzgerald, Diva D. De León

PLoS One. 2020; 15(7): e0236892. Published online 2020 Jul 31. doi: 10.1371/journal.pone.0236892

PMCID:: PMC7394442

Abstract Article PDF–2.0M

Select item 70937529.

PRKAR1A deficiency impedes hypertrophy and reduces heart size

Yuening Liu, Peng Xia, Jingrui Chen, W. Patricia Bandettini, Lawrence S. Kirschner, Constantine A. Stratakis, Zhaokang Cheng

Physiol Rep. 2020 Mar; 8(6): e14405. Published online 2020 Mar 25. doi: 10.14814/phy2.14405

PMCID:: PMC7093752

Abstract Article PDF–1.8M

Select item 687411710.

PKA Activates AMPK Through LKB1 Signaling in Follicular Thyroid Cancer

Suresh Kari, Vasyl V. Vasko, Shivam Priya, Lawrence S. Kirschner

Front Endocrinol (Lausanne) 2019; 10: 769. Published online 2019 Nov 8. doi: 10.3389/fendo.2019.00769

PMCID:: PMC6874117

Abstract Article PDF–2.6M

Select item 679747911.

Endothelial PKA activity regulates angiogenesis by limiting autophagy through phosphorylation of ATG16L1

Xiaocheng Zhao, Pavel Nedvetsky, Fabio Stanchi, Anne-Clemence Vion, Oliver Popp, Kerstin Zühlke, Gunnar Dittmar, Enno Klussmann, Holger Gerhardt

eLife. 2019; 8: e46380. Published online 2019 Oct 3. doi: 10.7554/eLife.46380

Correction in:: eLife. 2020; 9: e58195.

PMCID:: PMC6797479

Abstract Article PDF–6.6M

Select item 631150412.

Parathyroid hormone(1–34) and its analogs differentially modulate osteoblastic Rankl expression via PKA/SIK2/SIK3 and PP1/PP2A–CRTC3 signaling

Florante R. Ricarte, Carole Le Henaff, Victoria G. Kolupaeva, Thomas J. Gardella, Nicola C. Partridge

J Biol Chem. 2018 Dec 28; 293(52): 20200–20213. Published online 2018 Oct 30. doi: 10.1074/jbc.RA118.004751

PMCID:: PMC6311504

Abstract Article PDF–2.3M

Select item 624418313.

Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells

Sunyuan Zhang, Nicholas A. Williamson, Marie A. Bogoyevitch

Sci Data. 2018; 5: 180262. Published online 2018 Nov 20. doi: 10.1038/sdata.2018.262

PMCID:: PMC6244183

Abstract Article PDF–753K

Select item 619481314.

Alterations in Sod2-Induced Oxidative Stress Affect Endocrine Cancer Progression

Amruta Ashtekar, Danielle Huk, Alexa Magner, Krista M D La Perle, Laura Boucai, Lawrence S Kirschner

J Clin Endocrinol Metab. 2018 Nov; 103(11): 4135–4145. Published online 2018 Aug 24. doi: 10.1210/jc.2018-01039

PMCID:: PMC6194813

Abstract Article

Select item 615445515.

Deletion of Rap1b, but not Rap1a or Epac1, Reduces Protein Kinase A–Mediated Thyroid Cancer

Danielle J. Huk, Amruta Ashtekar, Alexa Magner, Krista La Perle, Lawrence S. Kirschner

Thyroid. 2018 Sep 1; 28(9): 1153–1161. Published online 2018 Sep 11. doi: 10.1089/thy.2017.0528

PMCID:: PMC6154455

Abstract Article PDF–1.2M

Select item 612364716.

SPATC1L maintains the integrity of the sperm head‐tail junction

Jihye Kim, Jun Tae Kwon, Juri Jeong, Jaehwan Kim, Seong Hyeon Hong, Jinyoung Kim, Zee Yong Park, Kyung Hwun Chung, Edward M Eddy, Chunghee Cho

EMBO Rep. 2018 Sep; 19(9): e45991. Published online 2018 Jul 19. doi: 10.15252/embr.201845991

PMCID:: PMC6123647

Abstract Article PDF–5.7M

Select item 607483817.

Age-dependent effects of Armc5 haploinsufficiency on adrenocortical function

A. Berthon, F.R. Faucz, S. Espiard, L. Drougat, J. Bertherat, C.A. Stratakis

Hum Mol Genet. 2017 Sep 15; 26(18): 3495–3507. Published online 2017 Jun 20. doi: 10.1093/hmg/ddx235

PMCID:: PMC6074838

Abstract Article PDF–2.2M

Select item 599360418.

Anxiety-like behavior and other consequences of early life stress in mice with increased protein kinase A activity

Maddalena Ugolini, Margaret F. Keil, Enrica Paradiso, John Wu, Constantine A. Stratakis

Behav Brain Res. Author manuscript; available in PMC 2019 Aug 1.

Published in final edited form as: Behav Brain Res. 2018 Aug 1; 348: 22–30. Published online 2018 Apr 3. doi: 10.1016/j.bbr.2018.04.001

PMCID:: PMC5993604

Abstract Article PDF–892K

Select item 582898619.

Elevated aggressive behavior in male mice with thyroid-specific Prkar1a and global Epac1 gene deletion

Kathryn L.G. Russart, Danielle Huk, Randy J. Nelson, Lawrence S. Kirschner

Horm Behav. Author manuscript; available in PMC 2019 Feb 1.

Published in final edited form as: Horm Behav. 2018 Feb; 98: 121–129. Published online 2018 Jan 3. doi: 10.1016/j.yhbeh.2017.12.012

PMCID:: PMC5828986

Abstract Article PDF–473K

Select item 582121320.

PKA signaling drives reticularis differentiation and sexually dimorphic adrenal cortex renewal

Typhanie Dumontet, Isabelle Sahut-Barnola, Amandine Septier, Nathanaëlle Montanier, Ingrid Plotton, Florence Roucher-Boulez, Véronique Ducros, Anne-Marie Lefrançois-Martinez, Jean-Christophe Pointud, Mohamad Zubair, Ken-Ichirou Morohashi, David T. Breault, Pierre Val, Antoine Martinez

JCI Insight. 2018 Jan 25; 3(2): e98394. Published online 2018 Jan 25. doi: 10.1172/jci.insight.98394

PMCID:: PMC5821213

Abstract Article PDF–3.9M

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