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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 108507862.

SELENOK-dependent CD36 palmitoylation regulates microglial functions and Aβ phagocytosis

Pei Ouyang, Zhiyu Cai, Jiaying Peng, Shujing Lin, Xiaochun Chen, Changbin Chen, Ziqi Feng, Lin Wang, Guoli Song, Zhonghao Zhang

Redox Biol. 2024 Apr; 70: 103064. Published online 2024 Feb 1. doi: 10.1016/j.redox.2024.103064

PMCID:: PMC10850786

Abstract Article PDF–17M

Select item 101128053.

Selenoprotein K enhances STING oligomerization to facilitate antiviral response

Lin Lv, Li Chai, Jie Wang, Mengge Wang, Danhui Qin, Hui Song, Yue Fu, Chunyuan Zhao, Jihui Jia, Wei Zhao, Mutian Jia

PLoS Pathog. 2023 Apr; 19(4): e1011314. Published online 2023 Apr 6. doi: 10.1371/journal.ppat.1011314

PMCID:: PMC10112805

Abstract Article PDF–3.0M

Select item 88448314.

Selenoprotein K protects skeletal muscle from damage and is required for satellite cells-mediated myogenic differentiation

Shengchen Wang, Xia Zhao, Qingqing Liu, Yue Wang, Shu Li, Shiwen Xu

Redox Biol. 2022 Apr; 50: 102255. Published online 2022 Feb 4. doi: 10.1016/j.redox.2022.102255

PMCID:: PMC8844831

Abstract Article PDF–15M

Select item 84951755.

Selenoprotein K deficiency-induced apoptosis: A role for calpain and the ERS pathway

Shi-Zheng Jia, Xin-Wen Xu, Zhong-Hao Zhang, Chen Chen, Yu-Bin Chen, Shao-Ling Huang, Qiong Liu, Peter R. Hoffmann, Guo-Li Song

Redox Biol. 2021 Nov; 47: 102154. Published online 2021 Sep 29. doi: 10.1016/j.redox.2021.102154

PMCID:: PMC8495175

Abstract Article PDF–5.4M

Select item 83132396.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

Select item 64595107.

Mouse screen reveals multiple new genes underlying mouse and human hearing loss

Neil J. Ingham, Selina A. Pearson, Valerie E. Vancollie, Victoria Rook, Morag A. Lewis, Jing Chen, Annalisa Buniello, Elisa Martelletti, Lorenzo Preite, Chi Chung Lam, Felix D. Weiss, Zӧe Powis, Pim Suwannarat, Christopher J. Lelliott, Sally J. Dawson, Jacqueline K. White, Karen P. Steel

PLoS Biol. 2019 Apr; 17(4): e3000194. Published online 2019 Apr 11. doi: 10.1371/journal.pbio.3000194

PMCID:: PMC6459510

Abstract Article PDF–5.1M

Select item 52958218.

High-throughput discovery of novel developmental phenotypes

Mary E. Dickinson, Ann M. Flenniken, Xiao Ji, Lydia Teboul, Michael D. Wong, Jacqueline K. White, Terrence F. Meehan, Wolfgang J. Weninger, Henrik Westerberg, Hibret Adissu, Candice N. Baker, Lynette Bower, James M. Brown, L. Brianna Caddle, Francesco Chiani, Dave Clary, James Cleak, Mark J. Daly, James M. Denegre, Brendan Doe, Mary E. Dolan, Sarah M. Edie, Helmut Fuchs, Valerie Gailus-Durner, Antonella Galli, Alessia Gambadoro, Juan Gallegos, Shiying Guo, Neil R. Horner, Chih-wei Hsu, Sara J. Johnson, Sowmya Kalaga, Lance C. Keith, Louise Lanoue, Thomas N. Lawson, Monkol Lek, Manuel Mark, Susan Marschall, Jeremy Mason, Melissa L. McElwee, Susan Newbigging, Lauryl M.J. Nutter, Kevin A. Peterson, Ramiro Ramirez-Solis, Douglas J. Rowland, Edward Ryder, Kaitlin E. Samocha, John R. Seavitt, Mohammed Selloum, Zsombor Szoke-Kovacs, Masaru Tamura, Amanda G Trainor, Ilinca Tudose, Shigeharu Wakana, Jonathan Warren, Olivia Wendling, David B. West, Leeyean Wong, Atsushi Yoshiki, The International Mouse Phenotyping Consortium, Daniel G. MacArthur, Glauco P. Tocchini-Valentini, Xiang Gao, Paul Flicek, Allan Bradley, William C. Skarnes, Monica J. Justice, Helen E. Parkinson, Mark Moore, Sara Wells, Robert E. Braun, Karen L. Svenson, Martin Hrabe de Angelis, Yann Herault, Tim Mohun, Ann-Marie Mallon, R. Mark Henkelman, Steve D.M. Brown, David J. Adams, K.C. Kent Lloyd, Colin McKerlie, Arthur L. Beaudet, Maja Bucan, Stephen A. Murray

Nature. Author manuscript; available in PMC 2017 Mar 14.

Published in final edited form as: Nature. 2016 Sep 22; 537(7621): 508–514. Published online 2016 Sep 14. doi: 10.1038/nature19356

Correction in:: Nature. 2017 Nov 16; 551(7680): 398.

PMCID:: PMC5295821

Abstract Article PDF–3.0M

Select item 52359049.

Selenoprotein K regulation of palmitoylation and calpain cleavage of ASAP2 is required for efficient FcγR-mediated phagocytosis

Robert L. Norton, Gregory J. Fredericks, Zhi Huang, Jeffrey D. Fay, FuKun W. Hoffmann, Peter R. Hoffmann

J Leukoc Biol. 2017 Feb; 101(2): 439–448. Published online 2016 Sep 6. doi: 10.1189/jlb.2A0316-156RR

PMCID:: PMC5235904

Abstract Article

Select item 510492910.

Selenoprotein Gene Nomenclature

Vadim N. Gladyshev, Elias S. Arnér, Marla J. Berry, Regina Brigelius-Flohé, Elspeth A. Bruford, Raymond F. Burk, Bradley A. Carlson, Sergi Castellano, Laurent Chavatte, Marcus Conrad, Paul R. Copeland, Alan M. Diamond, Donna M. Driscoll, Ana Ferreiro, Leopold Flohé, Fiona R. Green, Roderic Guigó, Diane E. Handy, Dolph L. Hatfield, John Hesketh, Peter R. Hoffmann, Arne Holmgren, Robert J. Hondal, Michael T. Howard, Kaixun Huang, Hwa-Young Kim, Ick Young Kim, Josef Köhrle, Alain Krol, Gregory V. Kryukov, Byeong Jae Lee, Byung Cheon Lee, Xin Gen Lei, Qiong Liu, Alain Lescure, Alexei V. Lobanov, Joseph Loscalzo, Matilde Maiorino, Marco Mariotti, K. Sandeep Prabhu, Margaret P. Rayman, Sharon Rozovsky, Gustavo Salinas, Edward E. Schmidt, Lutz Schomburg, Ulrich Schweizer, Miljan Simonović, Roger A. Sunde, Petra A. Tsuji, Susan Tweedie, Fulvio Ursini, Philip D. Whanger, Yan Zhang

J Biol Chem. 2016 Nov 11; 291(46): 24036–24040. Published online 2016 Sep 19. doi: 10.1074/jbc.M116.756155

PMCID:: PMC5104929

Abstract Article PDF–140K

Select item 506516211.

Coordinately Co-opted Multiple Transposable Elements Constitute an Enhancer for wnt5a Expression in the Mammalian Secondary Palate

Hidenori Nishihara, Naoki Kobayashi, Chiharu Kimura-Yoshida, Kuo Yan, Olga Bormuth, Qiong Ding, Akiko Nakanishi, Takeshi Sasaki, Mika Hirakawa, Kenta Sumiyama, Yasuhide Furuta, Victor Tarabykin, Isao Matsuo, Norihiro Okada

PLoS Genet. 2016 Oct; 12(10): e1006380. Published online 2016 Oct 14. doi: 10.1371/journal.pgen.1006380

PMCID:: PMC5065162

Abstract Article PDF–3.4M

Select item 470600912.

Selenoprotein S-dependent Selenoprotein K Binding to p97(VCP) Protein Is Essential for Endoplasmic Reticulum-associated Degradation

Jea Hwang Lee, Ki Jun Park, Jun Ki Jang, Yeong Ha Jeon, Kwan Young Ko, Joon Hyun Kwon, Seung-Rock Lee, Ick Young Kim

J Biol Chem. 2015 Dec 11; 290(50): 29941–29952. Published online 2015 Oct 26. doi: 10.1074/jbc.M115.680215

PMCID:: PMC4706009

Abstract Article PDF–2.4M

Select item 459900913.

A Novel GLP1 Receptor Interacting Protein ATP6ap2 Regulates Insulin Secretion in Pancreatic Beta Cells

Feihan F. Dai, Alpana Bhattacharjee, Ying Liu, Battsetseg Batchuluun, Ming Zhang, Xinye Serena Wang, Xinyi Huang, Lemieux Luu, Dan Zhu, Herbert Gaisano, Michael B. Wheeler

J Biol Chem. 2015 Oct 9; 290(41): 25045–25061. Published online 2015 Aug 13. doi: 10.1074/jbc.M115.648592

PMCID:: PMC4599009

Abstract Article PDF–2.7M

Select item 424627514.

Stable expression and function of the inositol 1,4,5-triphosphate receptor requires palmitoylation by a DHHC6/selenoprotein K complex

Gregory J. Fredericks, FuKun W. Hoffmann, Aaron H. Rose, Hanna J. Osterheld, Franz M. Hess, Frederic Mercier, Peter R. Hoffmann

Proc Natl Acad Sci U S A. 2014 Nov 18; 111(46): 16478–16483. Published online 2014 Nov 3. doi: 10.1073/pnas.1417176111

PMCID:: PMC4246275

Abstract Article PDF–1.1M

Select item 362944215.

Selenoprotein K is required for palmitoylation of CD36 in macrophages: implications in foam cell formation and atherogenesis

Svenja Meiler, Yvonne Baumer, Zhi Huang, Fukun W. Hoffmann, Gregory J. Fredericks, Aaron H. Rose, Robert L. Norton, Peter R. Hoffmann, William A. Boisvert

J Leukoc Biol. 2013 May; 93(5): 771–780. doi: 10.1189/jlb.1212647

PMCID:: PMC3629442

Abstract Article

Select item 357241016.

A conditional knockout resource for the genome–wide study of mouse gene function

William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley

Nature. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163