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Select item 109836671.

CYLD alleviates NLRP3 inflammasome-mediated pyroptosis in osteoporosis by deubiquitinating WNK1

Guiyong Jiang, Yu Cai, Duo Cheng, Hao Wang, Geyang Deng, Dayong Xiang

J Orthop Surg Res. 2024; 19: 212. Published online 2024 Apr 1. doi: 10.1186/s13018-024-04675-2

PMCID:: PMC10983667

Abstract Article PDF–9.0M

Select item 104850392.

WNK1 is required during male pachynema to sustain fertility

Ru-pin Alicia Chi, Xiaojiang Xu, Jian-Liang Li, Xin Xu, Guang Hu, Paula Brown, Cynthia Willson, Oleksandr Kirsanov, Christopher Geyer, Chou-Long Huang, Marcos Morgan, Francesco DeMayo

iScience. 2023 Sep 15; 26(9): 107616. Published online 2023 Aug 12. doi: 10.1016/j.isci.2023.107616

PMCID:: PMC10485039

Abstract Article PDF–9.5M

Select item 102319913.

WNK1 promotes water homeostasis by acting as a central osmolality sensor for arginine vasopressin release

Xin Jin, Jian Xie, Chia-Wei Yeh, Jen-Chi Chen, Chih-Jen Cheng, Cheng-Chang Lien, Chou-Long Huang

J Clin Invest. 2023 Jun 1; 133(11): e164222. Published online 2023 Jun 1. doi: 10.1172/JCI164222

PMCID:: PMC10231991

Abstract Article PDF–2.3M

Select item 98723284.

B cell–intrinsic requirement for WNK1 kinase in antibody responses in mice

Darryl A. Hayward, Lesley Vanes, Stefanie Wissmann, Sujana Sivapatham, Harald Hartweger, Joshua Biggs O’May, Leonard L. de Boer, Richard Mitter, Robert Köchl, Jens V. Stein, Victor L.J. Tybulewicz

J Exp Med. 2023 Mar 6; 220(3): e20211827. Published online 2023 Jan 20. doi: 10.1084/jem.20211827

PMCID:: PMC9872328

Abstract Article PDF–6.8M

Select item 93353065.

WNK1 collaborates with TGF-β in endothelial cell junction turnover and angiogenesis

Ankita B. Jaykumar, Sakina Plumber, David M. Barry, Derk Binns, Chonlarat Wichaidit, Magdalena Grzemska, Svetlana Earnest, Elizabeth J. Goldsmith, Ondine Cleaver, Melanie H. Cobb

Proc Natl Acad Sci U S A. 2022 Jul 26; 119(30): e2203743119. Published online 2022 Jul 22. doi: 10.1073/pnas.2203743119

PMCID:: PMC9335306

Abstract Article PDF–2.1M

Select item 90156996.

The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery

Kiren Baines, Kazuaki Yoshioka, Yoh Takuwa, Jon D. Lane

Autophagy Rep. 2022; 1(1): 88–118. Published online 2022 Apr 7. doi: 10.1080/27694127.2022.2042054

PMCID:: PMC9015699

Abstract Article PDF–3.3M

Select item 88058107.

Long noncoding RNA Gm44593 attenuates oxidative stress from age-related hearing loss by regulating miR-29b/WNK1

Qian Li, Yanzi Zang, Zhanwei Sun, Wenqi Zhang, Hongjian Liu

Bioengineered. 2022; 13(1): 573–582. Published online 2021 Dec 30. doi: 10.1080/21655979.2021.2012062

PMCID:: PMC8805810

Abstract Article PDF–1.7M

Select item 84246648.

L-WNK1 is required for BK channel activation in intercalated cells

Evan C. Ray, Rolando Carrisoza-Gaytan, Mohammad Al-Bataineh, Allison L. Marciszyn, Lubika J. Nkashama, Jingxin Chen, Aaliyah Winfrey, Shawn Griffiths, Tracey R. Lam, Daniel Flores, Peng Wu, WenHui Wang, Chou-Long Huang, Arohan R. Subramanya, Thomas R. Kleyman, Lisa M. Satlin

Am J Physiol Renal Physiol. 2021 Aug 1; 321(2): F245–F254. Published online 2021 Jul 7. doi: 10.1152/ajprenal.00472.2020

PMCID:: PMC8424664

Abstract Article

Select item 83164919.

Chloride sensing by WNK1 regulates NLRP3 inflammasome activation and pyroptosis

Lindsey Mayes-Hopfinger, Aura Enache, Jian Xie, Chou-Long Huang, Robert Köchl, Victor L. J. Tybulewicz, Teresa Fernandes-Alnemri, Emad S. Alnemri

Nat Commun. 2021; 12: 4546. Published online 2021 Jul 27. doi: 10.1038/s41467-021-24784-4

PMCID:: PMC8316491

Abstract Article PDF–2.6M

Select item 817480910.

Role of KLHL3 and dietary K⁺ in regulating KS-WNK1 expression

Mauricio Ostrosky-Frid, María Chávez-Canales, Jinwei Zhang, Olena Andrukhova, Eduardo R. Argaiz, Fernando Lerdo-de-Tejada, Adrian Murillo-de-Ozores, Andrea Sanchez-Navarro, Lorena Rojas-Vega, Norma A. Bobadilla, Norma Vazquez, María Castañeda-Bueno, Dario R. Alessi, Gerardo Gamba

Am J Physiol Renal Physiol. 2021 May 1; 320(5): F734–F747. Published online 2021 Mar 8. doi: 10.1152/ajprenal.00575.2020

PMCID:: PMC8174809

Abstract Article

Select item 793877011.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 771027512.

WNK1 regulates uterine homeostasis and its ability to support pregnancy

Ru-pin Alicia Chi, Tianyuan Wang, Chou-Long Huang, San-pin Wu, Steven L. Young, John P. Lydon, Francesco J. DeMayo

JCI Insight. 2020 Nov 19; 5(22): e141832. Published online 2020 Nov 19. doi: 10.1172/jci.insight.141832

PMCID:: PMC7710275

Abstract Article PDF–70M

Select item 768573013.

Mutation affecting the conserved acidic WNK1 motif causes inherited hyperkalemic hyperchloremic acidosis

Hélène Louis-Dit-Picard, Ilektra Kouranti, Chloé Rafael, Irmine Loisel-Ferreira, Maria Chavez-Canales, Waed Abdel-Khalek, Eduardo R. Argaiz, Stéphanie Baron, Sarah Vacle, Tiffany Migeon, Richard Coleman, Marcio Do Cruzeiro, Marguerite Hureaux, Nirubiah Thurairajasingam, Stéphane Decramer, Xavier Girerd, Kevin O’Shaugnessy, Paolo Mulatero, Gwenaëlle Roussey, Ivan Tack, Robert Unwin, Rosa Vargas-Poussou, Olivier Staub, Richard Grimm, Paul A. Welling, Gerardo Gamba, Eric Clauser, Juliette Hadchouel, Xavier Jeunemaitre

J Clin Invest. 2020 Dec 1; 130(12): 6379–6394. Published online 2020 Oct 26. doi: 10.1172/JCI94171

PMCID:: PMC7685730

Abstract Article PDF–4.5M

Select item 759126014.

Critical role of WNK1 in MYC-dependent early mouse thymocyte development

Robert Köchl, Lesley Vanes, Miriam Llorian Sopena, Probir Chakravarty, Harald Hartweger, Kathryn Fountain, Andrea White, Jennifer Cowan, Graham Anderson, Victor LJ Tybulewicz

eLife. 2020; 9: e56934. Published online 2020 Oct 14. doi: 10.7554/eLife.56934

PMCID:: PMC7591260

Abstract Article PDF–2.2M

Select item 721947715.

Developmentally regulated KCC2 phosphorylation is essential for dynamic GABA-mediated inhibition and survival

Miho Wantanabe, Jinwei Zhang, M. Shahid Mansuri, Jingjing Duan, Jason K. Karimy, Eric Delpire, Seth L. Alper, Richard P. Lifton, Atsuo Fukuda, Kristopher T. Kahle

Sci Signal. Author manuscript; available in PMC 2020 May 13.

Published in final edited form as: Sci Signal. 2019 Oct 15; 12(603): eaaw9315. Published online 2019 Oct 15. doi: 10.1126/scisignal.aaw9315

PMCID:: PMC7219477

Abstract Article PDF–2.1M

Select item 662911616.

Potassium acts through mTOR to regulate its own secretion

Mads Vaarby Sørensen, Bidisha Saha, Iben Skov Jensen, Peng Wu, Niklas Ayasse, Catherine E. Gleason, Samuel Levi Svendsen, Wen-Hui Wang, David Pearce

JCI Insight. 2019 Jun 6; 4(11): e126910. Published online 2019 Jun 6. doi: 10.1172/jci.insight.126910

PMCID:: PMC6629116

Abstract Article PDF–4.4M

Select item 660230017.

New roles for the de-ubiquitylating enzyme OTUD4 in an RNA–protein network and RNA granules

Richa Das, Lukas Schwintzer, Stanislav Vinopal, Eva Aguado Roca, Marc Sylvester, Ana-Maria Oprisoreanu, Susanne Schoch, Frank Bradke, Meike Broemer

J Cell Sci. 2019 Jun 15; 132(12): jcs229252. Published online 2019 Jun 17. doi: 10.1242/jcs.229252

PMCID:: PMC6602300

Abstract Article

Select item 637896618.

Regulation of erythrocyte Na⁺/K⁺/2Cl⁻ cotransport by an oxygen-switched kinase cascade

Suilan Zheng, Nathan A. Krump, Mary M. McKenna, Yen-Hsing Li, Anke Hannemann, Lisa J. Garrett, John S. Gibson, David M. Bodine, Philip S. Low

J Biol Chem. 2019 Feb 15; 294(7): 2519–2528. Published online 2018 Dec 18. doi: 10.1074/jbc.RA118.006393

PMCID:: PMC6378966

Abstract Article PDF–2.3M

Select item 626277719.

LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow

Hui-yuan Tseng, Anna V. Samarelli, Patricia Kammerer, Sarah Scholze, Tilman Ziegler, Roland Immler, Roy Zent, Markus Sperandio, Charles R. Sanders, Reinhard Fässler, Ralph T. Böttcher

J Cell Sci. 2018 Nov 15; 131(22): jcs218214. Published online 2018 Nov 21. doi: 10.1242/jcs.218214

PMCID:: PMC6262777

Abstract Article

Select item 613952320.

Role of WNK4 and kidney-specific WNK1 in mediating the effect of high dietary K⁺ intake on ROMK channel in the distal convoluted tubule

Peng Wu, Zhong-Xiuzi Gao, Xiao-Tong Su, David H. Ellison, Juliette Hadchouel, Jacques Teulon, Wen-Hui Wang

Am J Physiol Renal Physiol. 2018 Aug 1; 315(2): F223–F230. Published online 2018 Apr 18. doi: 10.1152/ajprenal.00050.2018

PMCID:: PMC6139523

Abstract Article

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