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Select item 84348001.

Induction of the endogenous sialoglycan ligand for eosinophil death receptor Siglec-8 in chronic rhinosinusitis with hyperplastic nasal polyposis

Hyun Sil Lee, Anabel Gonzalez-Gil, Virginia Drake, T August Li, Ronald L Schnaar, Jean Kim

Glycobiology. 2021 Aug; 31(8): 1026–1036. Published online 2021 Mar 20. doi: 10.1093/glycob/cwab018

PMCID:: PMC8434800

Abstract Article PDF–806K

Select item 79227942.

First Evidence for a Role of Siglec-8 in Breast Cancer

Anna Trebo, Nina Ditsch, Tom Degenhardt, Christina Kuhn, Martina Rahmeh, Elisa Schmoeckel, Doris Mayr, Bastian Czogalla, Thomas Kolben, Sarah Meister, Sven Mahner, Udo Jeschke, Anna Hester

Int J Mol Sci. 2021 Feb; 22(4): 2000. Published online 2021 Feb 18. doi: 10.3390/ijms22042000

PMCID:: PMC7922794

Abstract Article PDF–3.1M

Select item 65564243.

Siglec-8 in eosinophilic disorders: receptor expression and targeting using chimeric antibodies

Fanny Legrand, Yun Cao, Joshua Wechsler, Xiang Zhu, Nives Zimmermann, Shakuntala Rampertaap, Joseph Monsale, Kimberly Romito, Bradford A. Youngblood, Emily C. Brock, Michelle Makiya, Nenad Tomasevic, Christopher Bebbington, Irina Maric, Dean D. Metcalfe, Bruce S. Bochner, Amy D. Klion

J Allergy Clin Immunol. Author manuscript; available in PMC 2020 Jun 1.

Published in final edited form as: J Allergy Clin Immunol. 2019 Jun; 143(6): 2227–2237.e10. Published online 2018 Dec 10. doi: 10.1016/j.jaci.2018.10.066

PMCID:: PMC6556424

Abstract Article PDF–2.4M

Select item 64456444.

Leveraging Siglec-8 endocytic mechanisms to kill human eosinophils and malignant mast cells

Jeremy A. O’Sullivan, Daniela J. Carroll, Yun Cao, Adriano N. Salicru, Bruce S. Bochner

J Allergy Clin Immunol. Author manuscript; available in PMC 2019 Apr 2.

Published in final edited form as: J Allergy Clin Immunol. 2018 May; 141(5): 1774–1785.e7. Published online 2017 Jul 20. doi: 10.1016/j.jaci.2017.06.028

PMCID:: PMC6445644

Abstract Article PDF–1.8M

Select item 58399295.

Siglec-8 is an activating receptor mediating ß2 integrin-dependent function in human eosinophils

Daniela J. Carroll, Jeremy A. O’Sullivan, David B. Nix, Yun Cao, Michael Tiemeyer, Bruce S. Bochner

J Allergy Clin Immunol. Author manuscript; available in PMC 2019 Jun 1.

Published in final edited form as: J Allergy Clin Immunol. 2018 Jun; 141(6): 2196–2207. Published online 2017 Sep 6. doi: 10.1016/j.jaci.2017.08.013

PMCID:: PMC5839929

Abstract Article PDF–1.5M

Select item 48110406.

Regulation of airway inflammation by Siglec-8 and Siglec-9 sialoglycan ligand expression

Robert P. Schleimer, Ronald L. Schnaar, Bruce S. Bochner

Curr Opin Allergy Clin Immunol. Author manuscript; available in PMC 2017 Feb 1.

Published in final edited form as: Curr Opin Allergy Clin Immunol. 2016 Feb; 16(1): 24–30. doi: 10.1097/ACI.0000000000000234

PMCID:: PMC4811040

Abstract Article PDF–344K

Select item 43555807.

Expression of ligands for Siglec-8 and Siglec-9 in human airways and airway cells

Yi Jia, Huifeng Yu, Steve M. Fernandes, Yadong Wei, Anabel Gonzalez-Gil, Mary G. Motari, Katarina Vajn, Whitney W. Stevens, Anju T. Peters, Bruce S. Bochner, Robert C. Kern, Robert P. Schleimer, Ronald L. Schnaar

J Allergy Clin Immunol. Author manuscript; available in PMC 2016 Mar 1.

Published in final edited form as: J Allergy Clin Immunol. 2015 Mar; 135(3): 799–810.e7. doi: 10.1016/j.jaci.2015.01.004

PMCID:: PMC4355580

Abstract Article PDF–2.3M

Select item 40420618.

Mechanism of Siglec-8-mediated Cell Death in IL-5-activated Eosinophils: Role for ROS-enhanced MEK/ERK Activation

Gen Kano, Maha Almanan, Bruce S. Bochner, Nives Zimmermann

J Allergy Clin Immunol. Author manuscript; available in PMC 2014 Aug 1.

Published in final edited form as: J Allergy Clin Immunol. 2013 Aug; 132(2): 437–445. Published online 2013 May 16. doi: 10.1016/j.jaci.2013.03.024

PMCID:: PMC4042061

Abstract Article PDF–1.3M

Select item 34118569.

Biomarkers of Eosinophil Involvement in Allergic and Eosinophilic Diseases: review of phenotypic and serum markers including a novel assay to quantify levels of soluble Siglec-8

Ho Jeong Na, Robert G. Hamilton, Amy D. Klion, Bruce S. Bochner

J Immunol Methods. Author manuscript; available in PMC 2013 Sep 28.

Published in final edited form as: J Immunol Methods. 2012 Sep 28; 383(1-2): 39–46. Published online 2012 Jun 6. doi: 10.1016/j.jim.2012.05.017

PMCID:: PMC3411856

Abstract Article PDF–1.0M

Select item 332987010.

Developmental, Malignancy-Related, and Cross-Species Analysis of Eosinophil, Mast Cell, and Basophil Siglec-8 Expression

Sherry A. Hudson, Harald Herrmann, Jian Du, Paul Cox, El-Bdaoui Haddad, Barbara Butler, Paul R. Crocker, Steven J. Ackerman, Peter Valent, Bruce S. Bochner

J Clin Immunol. Author manuscript; available in PMC 2012 Dec 1.

Published in final edited form as: J Clin Immunol. 2011 Dec; 31(6): 1045–1053. Published online 2011 Sep 22. doi: 10.1007/s10875-011-9589-4

PMCID:: PMC3329870

Abstract Article PDF–2.2M

Select item 328230111.

IL-33 enhances Siglec-8 mediated apoptosis of human eosinophils

Ho Jeong Na, Sherry A. Hudson, Bruce S. Bochner

Cytokine. Author manuscript; available in PMC 2013 Jan 1.

Published in final edited form as: Cytokine. 2012 Jan; 57(1): 169–174. Published online 2011 Nov 12. doi: 10.1016/j.cyto.2011.10.007

PMCID:: PMC3282301

Abstract Article PDF–868K

Select item 317805912.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 298734813.

Polymorphisms in the sialic acid-binding immunoglobulin-like lectin-8 (Siglec-8) gene are associated with susceptibility to asthma

Pei-Song Gao, Kenichi Shimizu, Audrey V Grant, Nicholas Rafaels, Lin-Fu Zhou, Sherry A Hudson, Satoshi Konno, Nives Zimmermann, Maria I Araujo, Eduardo V Ponte, Alvaro A Cruz, Masaharu Nishimura, Song-Nan Su, Nobuyuki Hizawa, Terry H Beaty, Rasika A Mathias, Marc E Rothenberg, Kathleen C Barnes, Bruce S Bochner

Eur J Hum Genet. 2010 Jun; 18(6): 713–719. Published online 2010 Jan 20. doi: 10.1038/ejhg.2009.239

PMCID:: PMC2987348

Abstract Article PDF–458K

Select item 274262214.

Siglec-8 on human eosinophils and mast cells, and Siglec-F on murine eosinophils, are functionally related inhibitory receptors

Bruce S. Bochner

Clin Exp Allergy. Author manuscript; available in PMC 2010 Mar 1.

Published in final edited form as: Clin Exp Allergy. 2009 Mar; 39(3): 317–324. doi: 10.1111/j.1365-2222.2008.03173.x

PMCID:: PMC2742622

Abstract Article PDF–152K

Select item 271309315.

Eosinophil-Selective Binding and Proapoptotic Effect in Vitro of a Synthetic Siglec-8 Ligand, Polymeric 6′-Sulfated Sialyl Lewis X

Sherry A. Hudson, Nicolai V. Bovin, Ronald L. Schnaar, Paul R. Crocker, Bruce S. Bochner

J Pharmacol Exp Ther. 2009 Aug; 330(2): 608–612. Published online 2009 May 19. doi: 10.1124/jpet.109.152439

PMCID:: PMC2713093

Abstract Article PDF–157K

Select item 217612816.

Interleukin-5 Priming of Human Eosinophils Alters Siglec-8–Mediated Apoptosis Pathways

Esra Nutku-Bilir, Sherry A. Hudson, Bruce S. Bochner

Am J Respir Cell Mol Biol. 2008 Jan; 38(1): 121–124. Published online 2007 Aug 9. doi: 10.1165/rcmb.2007-0154OC

PMCID:: PMC2176128

Abstract Article PDF–133K

Select item 135612917.

Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes

Kouichi Kimura, Ai Wakamatsu, Yutaka Suzuki, Toshio Ota, Tetsuo Nishikawa, Riu Yamashita, Jun-ichi Yamamoto, Mitsuo Sekine, Katsuki Tsuritani, Hiroyuki Wakaguri, Shizuko Ishii, Tomoyasu Sugiyama, Kaoru Saito, Yuko Isono, Ryotaro Irie, Norihiro Kushida, Takahiro Yoneyama, Rie Otsuka, Katsuhiro Kanda, Takahide Yokoi, Hiroshi Kondo, Masako Wagatsuma, Katsuji Murakawa, Shinichi Ishida, Tadashi Ishibashi, Asako Takahashi-Fujii, Tomoo Tanase, Keiichi Nagai, Hisashi Kikuchi, Kenta Nakai, Takao Isogai, Sumio Sugano

Genome Res. 2006 Jan; 16(1): 55–65. doi: 10.1101/gr.4039406