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Items: 1 to 20 of 107

1.
Antagonistic roles of canonical and alternative-RPA in disease-associated tandem CAG repeat instability
Terence Gall-Duncan, Jennifer Luo, Carla-Marie Jurkovic, Laura A. Fischer, Kyota Fujita, Amit L. Deshmukh, Rachel J. Harding, Stephanie Tran, Mustafa Mehkary, Vanessa Li, David E. Leib, Ran Chen, Hikari Tanaka, Amanda G. Mason, Dominique Lévesque, Mahreen Khan, Mortezaali Razzaghi, Tanya Prasolava, Stella Lanni, Nozomu Sato, Marie-Christine Caron, Gagan B. Panigrahi, Peixiang Wang, Rachel Lau, Arturo López Castel, Jean-Yves Masson, Lynette Tippett, Clinton Turner, Maria Spies, Albert R. La Spada, Eric I. Campos, Maurice A. Curtis, François-Michel Boisvert, Richard L.M. Faull, Beverly L. Davidson, Masayuki Nakamori, Hitoshi Okazawa, Marc S. Wold, Christopher E. Pearson
Cell. Author manuscript; available in PMC 2024 Oct 26.
Published in final edited form as: Cell. 2023 Oct 26; 186(22): 4898–4919.e25. Published online 2023 Oct 11. doi: 10.1016/j.cell.2023.09.008
PMCID:
PMC11209935
AbstractArticlePDF–3.0M
2.
PD1 inhibits PKCθ-dependent phosphorylation of cytoskeleton-related proteins and immune synapse formation
Daniela Chmiest, Silvia Podavini, Kalliopi Ioannidou, David Vallois, Chantal Décaillet, Montserrat Gonzalez, Manfredo Quadroni, Kevin Blackney, Rebekka Schairer, Laurence de Leval, Margot Thome
Blood Adv. 2024 Jun 11; 8(11): 2908–2923. Published online 2024 Mar 26. doi: 10.1182/bloodadvances.2023011901
PMCID:
PMC11176957
AbstractArticlePDF–6.3M
3.
TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing
Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan
Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233
PMCID:
PMC10237422
AbstractArticlePDF–23M
4.
The Peptidyl-Prolyl cis-trans isomerase, Pin1, associates with Protein Kinase C θ via a critical Phospho-Thr-Pro motif in the V3 regulatory domain
Nikhil Ponnoor Anto, Amitha Muraleedharan, Pulak Ranjan Nath, Zuoming Sun, Chen Keasar, Etta Livneh, Alex Braiman, Amnon Altman, Kok-Fai Kong, Noah Isakov
Front Immunol. 2023; 14: 1126464. Published online 2023 Mar 8. doi: 10.3389/fimmu.2023.1126464
PMCID:
PMC10031136
AbstractArticlePDF–5.6M
5.
OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization
Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti
Science. Author manuscript; available in PMC 2022 Sep 11.
Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983
PMCID:
PMC9119736
AbstractArticlePDF–3.3M
6.
Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling
Ilektra Kouranti, Waed Abdel Khalek, Stephani Mazurkiewicz, Irmine Loisel-Ferreira, Alexis M. Gautreau, Lionel Pintard, Xavier Jeunemaitre, Eric Clauser
Int J Mol Sci. 2022 May; 23(9): 5151. Published online 2022 May 5. doi: 10.3390/ijms23095151
PMCID:
PMC9105235
AbstractArticlePDF–5.8M
7.
Unraveling the hidden role of a uORF-encoded peptide as a kinase inhibitor of PKCs
Divya Ram Jayaram, Sigal Frost, Chanan Argov, Vijayasteltar Belsamma Liju, Nikhil Ponnoor Anto, Amitha Muraleedharan, Assaf Ben-Ari, Rose Sinay, Ilan Smoly, Ofra Novoplansky, Noah Isakov, Debra Toiber, Chen Keasar, Moshe Elkabets, Esti Yeger-Lotem, Etta Livneh
Proc Natl Acad Sci U S A. 2021 Oct 5; 118(40): e2018899118. Published online 2021 Sep 30. doi: 10.1073/pnas.2018899118
PMCID:
PMC8501901
AbstractArticlePDF–1.8M
8.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
9.
The Emerging Function of PKCtheta in Cancer
Amandine Nicolle, Ye Zhang, Karine Belguise
Biomolecules. 2021 Feb; 11(2): 221. Published online 2021 Feb 5. doi: 10.3390/biom11020221
PMCID:
PMC7915540
AbstractArticlePDF–881K
10.
Two novel pleiotropic loci associated with osteoporosis and abdominal obesity
Lu Liu, Xiao-Lin Yang, Hong Zhang, Zi-Jia Zhang, Xin-Tong Wei, Gui-Juan Feng, Ju Liu, Hui-Ping Peng, Rong Hai, Hui Shen, Qing Tian, Hong-Wen Deng, Yu-Fang Pei, Lei Zhang
Hum Genet. Author manuscript; available in PMC 2021 Feb 15.
Published in final edited form as: Hum Genet. 2020 Aug; 139(8): 1023–1035. Published online 2020 Apr 1. doi: 10.1007/s00439-020-02155-1
PMCID:
PMC7883472
AbstractArticlePDF–884K
11.
Annexin A5 is essential for PKCθ translocation during T-cell activation
Zhaoqing Hu, Lin Li, Banghui Zhu, Yi Huang, Xinran Wang, Xiaolei Lin, Maoxia Li, Peipei Xu, Xuerui Zhang, Jing Zhang, Zichun Hua
J Biol Chem. 2020 Oct 9; 295(41): 14214–14221. Published online 2020 Aug 12. doi: 10.1074/jbc.RA120.015143
PMCID:
PMC7549025
AbstractArticlePDF–3.4M
12.
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases
Marija Buljan, Rodolfo Ciuffa, Audrey van Drogen, Anton Vichalkovski, Martin Mehnert, George Rosenberger, Sohyon Lee, Markku Varjosalo, Lucia Espona Pernas, Vincent Spegg, Berend Snijder, Ruedi Aebersold, Matthias Gstaiger
Mol Cell. 2020 Aug 6; 79(3): 504–520.e9. doi: 10.1016/j.molcel.2020.07.001
PMCID:
PMC7427327
AbstractArticle
13.
PRKCQ inhibition enhances chemosensitivity of triple-negative breast cancer by regulating Bim
Jessica H. Byerly, Elisa R. Port, Hanna Y. Irie
Breast Cancer Res. 2020; 22: 72. Published online 2020 Jun 29. doi: 10.1186/s13058-020-01302-w
PMCID:
PMC7322866
AbstractArticlePDF–1.3M
14.
PKCθ-JunB axis via upregulation of VEGFR3 expression mediates hypoxia-induced pathological retinal neovascularization
Raj Kumar, Arul M. Mani, Nikhlesh K. Singh, Gadiparthi N. Rao
Cell Death Dis. 2020 May; 11(5): 325. Published online 2020 May 7. doi: 10.1038/s41419-020-2522-0
PMCID:
PMC7206019
AbstractArticlePDF–16M
15.
Phosphotyrosine-dependent interaction between the kinases PKCθ and Zap70 promotes proximal TCR signaling
Jiji Xie, Xuemei Han, Chensi Zhao, Ann J. Canonigo-Balancio, John R. Yates, III, Yingqiu Li, Björn F. Lillemeier, Amnon Altman
Sci Signal. Author manuscript; available in PMC 2020 May 2.
Published in final edited form as: Sci Signal. 2019 Apr 16; 12(577): eaar3349. Published online 2019 Apr 16. doi: 10.1126/scisignal.aar3349
PMCID:
PMC7195849
AbstractArticlePDF–2.0M
16.
Targeting the glycans of glycoproteins: a novel paradigm for antiviral therapy
Jan Balzarini
Nat Rev Microbiol. 2007; 5(8): 583–597. doi: 10.1038/nrmicro1707
PMCID:
PMC7098186
AbstractArticlePDF–1.1M
17.
Structural determinants of phorbol ester binding activity of the C1a and C1b domains of protein kinase C theta
Agnes Czikora, Satyabrata Pany, Youngki You, Amandeep S. Saini, Nancy E. Lewin, Gary A. Mitchell, Adelle Abramovitz, Noemi Kedei, Peter M. Blumberg, Joydip Das
Biochim Biophys Acta Biomembr. Author manuscript; available in PMC 2020 Jan 13.
Published in final edited form as: Biochim Biophys Acta Biomembr. 2018 May; 1860(5): 1046–1056. Published online 2018 Jan 6. doi: 10.1016/j.bbamem.2018.01.007
PMCID:
PMC6957261
AbstractArticlePDF–1.3M
18.
PRKCQ rs4750316 is associated with Vogt-Koyanagi-Harada syndrome in a Han Chinese population
Lei Xu, Tingting Zhao, Gangxiang Yuan, Shengping Hou, Wenxin Zeng, Feilan Chen
Mol Vis. 2019; 25: 834–842. Published online 2019 Dec 2.
PMCID:
PMC6925663
AbstractArticlePDF–594K
19.
PLEKHA4/kramer Attenuates Dishevelled Ubiquitination to Modulate Wnt and Planar Cell Polarity Signaling
Adnan Shami Shah, Alex G. Batrouni, Dongsung Kim, Amith Punyala, Wendy Cao, Chun Han, Michael L. Goldberg, Marcus B. Smolka, Jeremy M. Baskin
Cell Rep. Author manuscript; available in PMC 2019 Jun 26.
Published in final edited form as: Cell Rep. 2019 May 14; 27(7): 2157–2170.e8. doi: 10.1016/j.celrep.2019.04.060
PMCID:
PMC6594551
AbstractArticlePDF–1.4M
20.
BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression
Lei Yu, Natee Jearawiriyapaisarn, Mary P. Lee, Tomonori Hosoya, Qingqing Wu, Greggory Myers, Kim-Chew Lim, Ryo Kurita, Yukio Nakamura, Anne B. Vojtek, Jean-François Rual, James Douglas Engel
Genes Dev. 2018 Dec 1; 32(23-24): 1537–1549. doi: 10.1101/gad.318436.118
PMCID:
PMC6295165
AbstractArticlePDF–3.5M

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