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Select item 112909691.

A pathologically expanded, clonal lineage of IL-21–producing CD4⁺ T cells drives inflammatory neuropathy

Maryamsadat Seyedsadr, Madison F. Bang, Ethan C. McCarthy, Shirley Zhang, Ho-Chung Chen, Mahnia Mohebbi, Willy Hugo, Jason K. Whitmire, Melissa G. Lechner, Maureen A. Su

J Clin Invest. 2024 Aug 1; 134(15): e178602. Published online 2024 Jun 11. doi: 10.1172/JCI178602

PMCID:: PMC11290969

Abstract Article PDF–6.1M

Select item 110308772.

Combination of IL-21 and IL-15 enhances tumour-specific cytotoxicity and cytokine production of TCR-transduced primary T cells

Nadine Pouw, Elike Treffers-Westerlaken, Jaco Kraan, Floyd Wittink, Timo ten Hagen, Jaap Verweij, Reno Debets

Cancer Immunol Immunother. 2010 Jun; 59(6): 921–931. Published online 2010 Jan 26. doi: 10.1007/s00262-010-0818-0

PMCID:: PMC11030877

Abstract Article PDF–536K

Select item 104878983.

TRIM67 Implicates in Regulating the Homeostasis and Synaptic Development of Mitral Cells in the Olfactory Bulb

Chunyu Cai, Qihui Luo, Lanlan Jia, Yu Xia, Xinting Lan, Xiaoli Wei, Shuai Shi, Yucong Liu, Yao Wang, Zongliang Xiong, Riyi Shi, Chao Huang, Zhengli Chen

Int J Mol Sci. 2023 Sep; 24(17): 13439. Published online 2023 Aug 30. doi: 10.3390/ijms241713439

PMCID:: PMC10487898

Abstract Article PDF–7.5M

Select item 104548454.

T Follicular Helper Cells in Tertiary Lymphoid Structure Contribute to Renal Fibrosis by IL-21

Ran Luo, Dan Chang, Nanhui Zhang, Yichun Cheng, Shuwang Ge, Gang Xu

Int J Mol Sci. 2023 Aug; 24(16): 12535. Published online 2023 Aug 8. doi: 10.3390/ijms241612535

PMCID:: PMC10454845

Abstract Article PDF–11M

Select item 104542395.

IL-21/IL-21R Promotes the Pro-Inflammatory Effects of Macrophages during C. muridarum Respiratory Infection

Shuaini Yang, Jiajia Zeng, Wenlian Hao, Ruoyuan Sun, Yuqing Tuo, Lu Tan, Hong Zhang, Ran Liu, Hong Bai

Int J Mol Sci. 2023 Aug; 24(16): 12557. Published online 2023 Aug 8. doi: 10.3390/ijms241612557

PMCID:: PMC10454239

Abstract Article PDF–7.2M

Select item 103551626.

IL-21 shapes germinal center polarization via light zone B cell selection and cyclin D3 upregulation

Lina Petersone, Chun Jing Wang, Natalie M. Edner, Astrid Fabri, Spyridoula-Angeliki Nikou, Claudia Hinze, Ellen M. Ross, Elisavet Ntavli, Yassin Elfaki, Frank Heuts, Vitalijs Ovcinnikovs, Andrea Rueda Gonzalez, Luke P. Houghton, Hannah M. Li, Yang Zhang, Kai-Michael Toellner, Lucy S.K. Walker

J Exp Med. 2023 Oct 2; 220(10): e20221653. Published online 2023 Jul 19. doi: 10.1084/jem.20221653

PMCID:: PMC10355162

Abstract Article PDF–6.9M

Select item 102475237.

IL-21 and tissue-specific signals instruct Tbet⁺CD11c⁺ B cell development following viral infection

Wenzhi Song, Gina M. Sanchez, Daniel P. Mayer, Holly N. Blackburn, Irene Chernova, Richard A. Flavell, Jason S. Weinstein, Joe Craft

J Immunol. Author manuscript; available in PMC 2024 Jun 15.

Published in final edited form as: J Immunol. 2023 Jun 15; 210(12): 1861–1865. doi: 10.4049/jimmunol.2300027

PMCID:: PMC10247523

Abstract Article PDF–1.0M

Select item 94423038.

IL‐21 has a critical role in establishing germinal centers by amplifying early B cell proliferation

Alexandra R Dvorscek, Craig I McKenzie, Marcus J Robinson, Zhoujie Ding, Catherine Pitt, Kristy O'Donnell, Dimitra Zotos, Robert Brink, David M Tarlinton, Isaak Quast

EMBO Rep. 2022 Sep; 23(9): e54677. Published online 2022 Jul 8. doi: 10.15252/embr.202254677

PMCID:: PMC9442303

Abstract Article PDF–892K

Select item 92208279.

Blimp-1 molds the epigenetic architecture of IL-21–mediated autoimmune diseases through an autoregulatory circuit

Yu-Wen Liu, Shin-Huei Fu, Ming-Wei Chien, Chao-Yuan Hsu, Ming-Hong Lin, Jia-Ling Dong, Rita Jui-Hsien Lu, Yi-Jing Lee, Pao-Yang Chen, Chih-Hung Wang, Huey-Kang Sytwu

JCI Insight. 2022 Jun 8; 7(11): e151614. Published online 2022 Jun 8. doi: 10.1172/jci.insight.151614

PMCID:: PMC9220827

Abstract Article PDF–7.5M

Select item 892214910.

The Proinflammatory Cytokines IL-18, IL-21, and IFN-γ Differentially Regulate Liver Inflammation and Anti-Mitochondrial Antibody Level in a Murine Model of Primary Biliary Cholangitis

Ya-Fei Xu, Yuan Yao, Min Ma, Shu-Han Yang, Peng Jiang, Jinjun Wang, Koichi Tsuneyama, Chan Wang, Xiangdong Liu, Liang Li, Zhe-Xiong Lian

J Immunol Res. 2022; 2022: 7111445. Published online 2022 Mar 7. doi: 10.1155/2022/7111445

PMCID:: PMC8922149

Abstract Article PDF–2.6M

Select item 867135511.

Neoantigen driven B cell and CD4 T follicular helper cell collaboration promotes anti-tumor CD8 T cell responses

Can Cui, Jiawei Wang, Eric Fagerberg, Ping-Min Chen, Kelli A. Connolly, Martina Damo, Julie F. Cheung, Tianyang Mao, Adnan S. Askari, Shuting Chen, Brittany Fitzgerald, Gena G. Foster, Stephanie C. Eisenbarth, Hongyu Zhao, Joseph Craft, Nikhil S. Joshi

Cell. Author manuscript; available in PMC 2022 Dec 9.

Published in final edited form as: Cell. 2021 Dec 9; 184(25): 6101–6118.e13. Published online 2021 Nov 30. doi: 10.1016/j.cell.2021.11.007

PMCID:: PMC8671355

Abstract Article PDF–1.5M

Select item 866090512.

The concerted change in the distribution of cell cycle phases and zone composition in germinal centers is regulated by IL-21

Dimitra Zotos, Isaak Quast, Connie S. N. Li-Wai-Suen, Craig I. McKenzie, Marcus J. Robinson, Andrey Kan, Gordon K. Smyth, Philip D. Hodgkin, David M. Tarlinton

Nat Commun. 2021; 12: 7160. Published online 2021 Dec 9. doi: 10.1038/s41467-021-27477-0

PMCID:: PMC8660905

Abstract Article PDF–2.3M

Select item 821061613.

Adjuvant-free peptide vaccine targeting Clec9a on dendritic cells can induce robust antitumor immune response through Syk/IL-21 axis

Shanshan Gou, Shuai Wang, Wenwen Liu, Guanyu Chen, Dongyang Zhang, Jiangfeng Du, Zhongyi Yan, Hongfei Wang, Wenjie Zhai, Xinghua Sui, Yahong Wu, Yuanming Qi, Yanfeng Gao

Theranostics. 2021; 11(15): 7308–7321. Published online 2021 May 24. doi: 10.7150/thno.56406

PMCID:: PMC8210616

Abstract Article PDF–1.9M

Select item 806321114.

moDCs differentiate into Bcl6⁺ mature moDCs to promote cyclic di-GMP vaccine adjuvant-induced memory T_H cells in the lung

Samira Mansouri, Divya S Katikaneni, Himanshu Gogoi, Lei Jin

J Immunol. Author manuscript; available in PMC 2022 May 1.

Published in final edited form as: J Immunol. 2021 May 1; 206(9): 2233–2245. Published online 2021 Apr 19. doi: 10.4049/jimmunol.2001347

PMCID:: PMC8063211

Abstract Article PDF–2.7M

Select item 803862815.

Characterization of Type I Interferon-Associated Chemokines and Cytokines in Lacrimal Glands of Nonobese Diabetic Mice

Merri-Grace Allred, Michael S. Chimenti, Ashley E. Ciecko, Yi-Guang Chen, Scott M. Lieberman

Int J Mol Sci. 2021 Apr; 22(7): 3767. Published online 2021 Apr 5. doi: 10.3390/ijms22073767

PMCID:: PMC8038628

Abstract Article PDF–3.3M

Select item 789841916.

IL-21 promotes intestinal memory IgA responses

Xiangsheng Huang, Wenjing Yang, Suxia Yao, Anthony J. Bilotta, Yao Lu, Zheng Zhou, Pawan Kumar, Sara M. Dann, Yingzi Cong

J Immunol. Author manuscript; available in PMC 2021 Oct 1.

Published in final edited form as: J Immunol. 2020 Oct 1; 205(7): 1944–1952. Published online 2020 Aug 28. doi: 10.4049/jimmunol.1900766

PMCID:: PMC7898419

Abstract Article PDF–1.6M

Select item 772146617.

IL-21 from high-affinity CD4 T cells drives differentiation of brain-resident CD8 T cells during persistent viral infection

Heather M. Ren, E. Motunrayo Kolawole, Mingqiang Ren, Ge Jin, Colleen S. Netherby-Winslow, Quinn Wade, Shwetank, Ziaur S. M. Rahman, Brian D. Evavold, Aron E. Lukacher

Sci Immunol. Author manuscript; available in PMC 2021 Mar 18.

Published in final edited form as: Sci Immunol. 2020 Sep 18; 5(51): eabb5590. doi: 10.1126/sciimmunol.abb5590

PMCID:: PMC7721466

Abstract Article PDF–2.0M

Select item 755635918.

CD11c+ T-bet+ B cells require IL-21 and IFN-γ from T_FH1 cells, and intrinsic Bcl-6 expression, but develop normally in the absence of T-bet

Russell C. Levack, Krista L. Newell, Maria Popescu, Berenice Cabrera-Martinez, Gary M. Winslow

J Immunol. Author manuscript; available in PMC 2021 Feb 15.

Published in final edited form as: J Immunol. 2020 Aug 15; 205(4): 1050–1058. Published online 2020 Jul 17. doi: 10.4049/jimmunol.2000206

PMCID:: PMC7556359

Abstract Article PDF–1.4M

Select item 748573919.

IL-21 mediates microRNA-423-5p /claudin-5 signal pathway and intestinal barrier function in inflammatory bowel disease

Mu Wang, Jian Guo, Yi-Qing Zhao, Jun-Ping Wang

Aging (Albany NY) 2020 Aug 31; 12(16): 16099–16110. Published online 2020 Aug 28. doi: 10.18632/aging.103566

PMCID:: PMC7485739

Abstract Article PDF–1.8M

Select item 730805220.

T cells expressing the lupus susceptibility allele Pbx1d enhance autoimmunity and atherosclerosis in dyslipidemic mice

Wei Li, Ahmed S. Elshikha, Caleb Cornaby, Xiangyu Teng, Georges Abboud, Josephine Brown, Xueyang Zou, Leilani Zeumer-Spataro, Brian Robusto, Seung-Chul Choi, Kristianna Fredenburg, Amy Major, Laurence Morel

JCI Insight. 2020 Jun 4; 5(11): e138274. Published online 2020 Jun 4. doi: 10.1172/jci.insight.138274