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Select item 113237871.

Astrocytic lipid metabolism determines susceptibility to diet-induced obesity

Luis Varela, Jae Geun Kim, Pablo Fernández-Tussy, Binod Aryal, Zhong Wu Liu, Carlos Fernández-Hernando, Tamas L. Horvath

Sci Adv. 2021 Dec; 7(50): eabj2814. Published online 2021 Dec 10. doi: 10.1126/sciadv.abj2814

PMCID:: PMC11323787

Abstract Article PDF–11M

Select item 112170812.

Mir22hg facilitates ferritinophagy-mediated ferroptosis in sepsis by recruiting the m6A reader YTHDC1 and enhancing Angptl4 mRNA stability

Wenlong Deng, Liang Zhong, Shupei Ye, Jiajing Luo, Guobin Ren, Junhao Huang, Xiaolei Zhuang

J Bioenerg Biomembr. 2024; 56(4): 405–418. Published online 2024 Jun 6. doi: 10.1007/s10863-024-10022-1

PMCID:: PMC11217081

Abstract Article PDF–6.5M

Select item 109735883.

Characterization of sexual dimorphism in ANGPTL4 levels and function

Mingjuan Deng, Sander Kersten

J Lipid Res. 2024 Apr; 65(4): 100526. Published online 2024 Feb 29. doi: 10.1016/j.jlr.2024.100526

PMCID:: PMC10973588

Abstract Article PDF–5.0M

Select item 109176604.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 107698265.

ANGPTL4 binds to the leptin receptor to regulate ectopic bone formation

Hongling Hu, Sheng Luo, Pinglin Lai, Mingqiang Lai, Linlin Mao, Sheng Zhang, Yuanjun Jiang, Jiaxin Wen, Wu Zhou, Xiaolin Liu, Liang Wang, Minjun Huang, Yanjun Hu, Xiaoyang Zhao, Laixin Xia, Weijie Zhou, Yu Jiang, Zhipeng Zou, Anling Liu, Bin Guo, Xiaochun Bai

Proc Natl Acad Sci U S A. 2024 Jan 2; 121(1): e2310685120. Published online 2023 Dec 26. doi: 10.1073/pnas.2310685120

PMCID:: PMC10769826

Abstract Article PDF–23M

Select item 107162926.

Suppression of angiopoietin-like 4 reprograms endothelial cell metabolism and inhibits angiogenesis

Balkrishna Chaube, Kathryn M. Citrin, Mahnaz Sahraei, Abhishek K. Singh, Diego Saenz de Urturi, Wen Ding, Richard W. Pierce, Raaisa Raaisa, Rebecca Cardone, Richard Kibbey, Carlos Fernández-Hernando, Yajaira Suárez

Nat Commun. 2023; 14: 8251. Published online 2023 Dec 12. doi: 10.1038/s41467-023-43900-0

PMCID:: PMC10716292

Abstract Article PDF–14M

Select item 104480457.

Angiopoietin-like 4 promotes epidermal stem cell proliferation and migration and contributes to cutaneous wound re-epithelialization: ANGPTL4 promotes EpSC proliferation and skin wound healing

Yuan Yang, Chenghao Yu, Yingying Le, Weijuan Gong, Jihui Ju, Guangliang Zhang, Pengxiang Ji, Rui Zuo, Zhe Liu, Ping Zhang, Ruixing Hou, Yi Fu

Acta Biochim Biophys Sin (Shanghai) 2023 Aug 25; 55(8): 1265–1274. Published online 2023 Jul 3. doi: 10.3724/abbs.2023055

PMCID:: PMC10448045

Abstract Article PDF–3.6M

Select item 102569758.

Dual role of ANGPTL4 in inflammation

Yuyue Zuo, Zhen He, Yu Chen, Lei Dai

Inflamm Res. 2023 Jun 10 : 1–11. doi: 10.1007/s00011-023-01753-9 [Epub ahead of print]

PMCID:: PMC10256975

Abstract Article PDF–2.3M

Select item 99816089.

ANGPTL4 stabilizes atherosclerotic plaques and modulates the phenotypic transition of vascular smooth muscle cells through KLF4 downregulation

Dong Im Cho, Min Joo Ahn, Hyang Hee Cho, Meeyoung Cho, Ju Hee Jun, Bo Gyeong Kang, Soo Yeon Lim, Soo Ji Yoo, Mi Ra Kim, Hyung-Seok Kim, Su-Jin Lee, Le Thanh Dat, Changho Lee, Yong Sook Kim, Youngkeun Ahn

Exp Mol Med. 2023 Feb; 55(2): 426–442. Published online 2023 Feb 13. doi: 10.1038/s12276-023-00937-x

PMCID:: PMC9981608

Abstract Article PDF–11M

Select item 997445910.

Intracapillary LPL levels in brown adipose tissue, visualized with an antibody-based approach, are regulated by ANGPTL4 at thermoneutral temperatures

Wenxin Song, Ye Yang, Patrick Heizer, Yiping Tu, Thomas A. Weston, Joonyoung R. Kim, Priscilla Munguia, Hyesoo Jung, Jared L.-C. Fong, Caitlyn Tran, Michael Ploug, Anne P. Beigneux, Stephen G. Young, Loren G. Fong

Proc Natl Acad Sci U S A. 2023 Feb 21; 120(8): e2219833120. Published online 2023 Feb 14. doi: 10.1073/pnas.2219833120

PMCID:: PMC9974459

Abstract Article PDF–14M

Select item 959520611.

Primary tumor–derived systemic nANGPTL4 inhibits metastasis

Corinne Hübers, Ashik Ahmed Abdul Pari, Denise Grieshober, Martin Petkov, Alexander Schmidt, Tatjana Messmer, Christian Moritz Heyer, Sebastian Schölch, Stephanie S. Kapel, Nicolas Gengenbacher, Mahak Singhal, Benjamin Schieb, Claudine Fricke, Rainer Will, Kim Remans, Jochen Sven Utikal, Christoph Reissfelder, Matthias Schlesner, Kairbaan M. Hodivala-Dilke, Sander Kersten, Sergij Goerdt, Hellmut G. Augustin, Moritz Felcht

J Exp Med. 2023 Jan 2; 220(1): e20202595. Published online 2022 Oct 21. doi: 10.1084/jem.20202595

PMCID:: PMC9595206

Abstract Article PDF–6.3M

Select item 948971612.

Hnrnpk maintains chondrocytes survival and function during growth plate development via regulating Hif1α-glycolysis axis

Yuyu Chen, Jinna Wu, Shun Zhang, Wenjie Gao, Zhiheng Liao, Taifeng Zhou, Yongyong Li, Deying Su, Hengyu Liu, Xiaoming Yang, Peiqiang Su, Caixia Xu

Cell Death Dis. 2022 Sep; 13(9): 803. Published online 2022 Sep 20. doi: 10.1038/s41419-022-05239-0

PMCID:: PMC9489716

Abstract Article PDF–8.5M

Select item 944250313.

Silencing of Angiopoietin-Like Protein 4 (Angptl4) Decreases Inflammation, Extracellular Matrix Degradation, and Apoptosis in Osteoarthritis via the Sirtuin 1/NF-κB Pathway

Chao Jia, Xiucui Li, Jun Pan, Haiwei Ma, Dengying Wu, Hongwei Lu, Wei Wang, Xutong Zhang, Xianhong Yi

Oxid Med Cell Longev. 2022; 2022: 1135827. Published online 2022 Aug 27. doi: 10.1155/2022/1135827

PMCID:: PMC9442503

Abstract Article PDF–4.1M

Select item 931053714.

ANGPTL4 influences the therapeutic response of patients with neovascular age-related macular degeneration by promoting choroidal neovascularization

Yu Qin, Aumreetam Dinabandhu, Xuan Cao, Jaron Castillo Sanchez, Kathleen Jee, Murilo Rodrigues, Chuanyu Guo, Jing Zhang, Jordan Vancel, Deepak Menon, Noore-Sabah Khan, Tao Ma, Stephany Y. Tzeng, Yassine Daoud, Jordan J. Green, Gregg L. Semenza, Silvia Montaner, Akrit Sodhi

JCI Insight. 2022 Jul 8; 7(13): e157896. Published online 2022 Jul 8. doi: 10.1172/jci.insight.157896

PMCID:: PMC9310537

Abstract Article PDF–3.6M

Select item 927941415.

A SOX17-PDGFB signaling axis regulates aortic root development

Pengfei Lu, Ping Wang, Bingruo Wu, Yidong Wang, Yang Liu, Wei Cheng, Xuhui Feng, Xinchun Yuan, Miriam M. Atteya, Haleigh Ferro, Yukiko Sugi, Grant Rydquist, Mahdi Esmaily, Jonathan T. Butcher, Ching-Pin Chang, Jack Lenz, Deyou Zheng, Bin Zhou

Nat Commun. 2022; 13: 4065. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31815-1

PMCID:: PMC9279414

Abstract Article PDF–11M

Select item 904809816.

Angiopoietin-like 4 governs diurnal lipoprotein lipase activity in brown adipose tissue

Robin van Eenige, Wietse In het Panhuis, Milena Schönke, Céline Jouffe, Thomas H. Devilee, Ricky Siebeler, Trea C.M. Streefland, Hetty C.M. Sips, Amanda C.M. Pronk, Ruben H.P. Vorderman, Hailiang Mei, Jan Bert van Klinken, Michel van Weeghel, Nina H. Uhlenhaut, Sander Kersten, Patrick C.N. Rensen, Sander Kooijman

Mol Metab. 2022 Jun; 60: 101497. Published online 2022 Apr 10. doi: 10.1016/j.molmet.2022.101497

PMCID:: PMC9048098

Abstract Article PDF–3.6M

Select item 887336417.

Single-cell analysis of skin immune cells reveals an Angptl4-ifi20b axis that regulates monocyte differentiation during wound healing

Wei Kiat Jonathan Wee, Zun Siong Low, Chin Kiat Ooi, Benjamin Patrana Henategala, Zhi Guang Ridley Lim, Yun Sheng Yip, Marcus Ivan Gerard Vos, William Wei Ren Tan, Hong Sheng Cheng, Nguan Soon Tan

Cell Death Dis. 2022 Feb; 13(2): 180. Published online 2022 Feb 24. doi: 10.1038/s41419-022-04638-7

PMCID:: PMC8873364

Abstract Article PDF–2.6M

Select item 866635518.

Role and mechanism of the action of angiopoietin-like protein ANGPTL4 in plasma lipid metabolism

Sander Kersten

J Lipid Res. 2021; 62: 100150. Published online 2021 Nov 18. doi: 10.1016/j.jlr.2021.100150

PMCID:: PMC8666355

Abstract Article PDF–1.1M

Select item 856038019.

Chronic high-fat feeding and prolonged fasting in liver-specific ANGPTL4 knockout mice

Kathryn M. Spitler, Shwetha K. Shetty, Emily M. Cushing, Kelli L. Sylvers-Davie, Brandon S. J. Davies

Am J Physiol Endocrinol Metab. 2021 Oct 1; 321(4): E464–E478. Published online 2021 Aug 16. doi: 10.1152/ajpendo.00144.2021

PMCID:: PMC8560380

Abstract Article

Select item 848843820.

Weighted Gene Co-Expression Network Analysis Identifies ANGPTL4 as a Key Regulator in Diabetic Cardiomyopathy via FAK/SIRT3/ROS Pathway in Cardiomyocyte

Lei Dai, Yang Xie, Wenjun Zhang, Xiaodan Zhong, Mengwen Wang, Hongcheng Jiang, Zhen He, Xiaolei Liu, Hesong Zeng, Hongjie Wang

Front Endocrinol (Lausanne) 2021; 12: 705154. Published online 2021 Sep 20. doi: 10.3389/fendo.2021.705154

PMCID:: PMC8488438

Abstract Article PDF–3.5M

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