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Select item 109870061.

Autoimmunity-associated allele of tyrosine phosphatase gene PTPN22 enhances anti-viral immunity

Robin C. Orozco, Kristi Marquardt, Isaraphorn Pratumchai, Anam Fatima Shaikh, Kerri Mowen, Alain Domissy, John R. Teijaro, Linda A. Sherman

PLoS Pathog. 2024 Mar; 20(3): e1012095. Published online 2024 Mar 21. doi: 10.1371/journal.ppat.1012095

PMCID:: PMC10987006

Abstract Article PDF–3.7M

Select item 108623532.

Structural basis for a novel, highly specific interaction involving the Csk SH3 domain and its natural ligand

Ranajeet Ghose, Alexander Shekhtman, Michael J. Goger, Hong Ji, David Cowburn

Nat Struct Biol. Author manuscript; available in PMC 2024 Feb 13.

Published in final edited form as: Nat Struct Biol. 2001 Nov; 8(11): 998–1004. doi: 10.1038/nsb1101-998

PMCID:: PMC10862353

Abstract Article PDF–685K

Select item 103477383.

Targeted inhibition of PTPN22 is a novel approach to alleviate osteogenic responses in aortic valve interstitial cells and aortic valve lesions in mice

Shunyi Li, Zichao Luo, Shuwen Su, Liming Wen, Gaopeng Xian, Jing Zhao, Xingbo Xu, Dingli Xu, Qingchun Zeng

BMC Med. 2023; 21: 252. Published online 2023 Jul 13. doi: 10.1186/s12916-023-02888-6

PMCID:: PMC10347738

Abstract Article PDF–14M

Select item 91196774.

Redox regulation of PTPN22 affects the severity of T-cell-dependent autoimmune inflammation

Jaime James, Yifei Chen, Clara M Hernandez, Florian Forster, Markus Dagnell, Qing Cheng, Amir A Saei, Hassan Gharibi, Gonzalo Fernandez Lahore, Annika Åstrand, Rajneesh Malhotra, Bernard Malissen, Roman A Zubarev, Elias SJ Arnér, Rikard Holmdahl

eLife. 2022; 11: e74549. Published online 2022 May 19. doi: 10.7554/eLife.74549

PMCID:: PMC9119677

Abstract Article PDF–2.2M

Select item 89293865.

Targeting Protein Tyrosine Phosphatase 22 Does Not Enhance the Efficacy of Chimeric Antigen Receptor T Cells in Solid Tumors

Xin Du, Phillip K. Darcy, Florian Wiede, Tony Tiganis

Mol Cell Biol. 2022 Mar; 42(3): e00449-21. Prepublished online 2022 Jan 18. Published online 2022 Mar 17. doi: 10.1128/mcb.00449-21

PMCID:: PMC8929386

Abstract Article PDF–3.0M

Select item 87907006.

Mesenchymal Stem Cells Derived Extracellular Vesicles Alleviate Traumatic Hemorrhagic Shock Induced Hepatic Injury via IL-10/PTPN22-Mediated M2 Kupffer Cell Polarization

Yunwei Zhang, Xiaofei Zhang, Hongji Zhang, Peng Song, Wenming Pan, Peng Xu, Guoliang Wang, Ping Hu, Zixuan Wang, Kunpeng Huang, Xiaodong Zhang, Hui Wang, Jinxiang Zhang

Front Immunol. 2021; 12: 811164. Published online 2022 Jan 12. doi: 10.3389/fimmu.2021.811164

PMCID:: PMC8790700

Abstract Article PDF–15M

Select item 84287507.

Proautoimmune Allele of Tyrosine Phosphatase, PTPN22, Enhances Tumor Immunity

Robin C. Orozco, Kristi Marquardt, Kerri Mowen, Linda A. Sherman

J Immunol. 2021 Sep 15; 207(6): 1662–1671. Published online 2021 Sep 15. doi: 10.4049/jimmunol.2100304

PMCID:: PMC8428750

Abstract Article PDF–2.7M

Select item 70656008.

Phosphatase PTPN22 Regulates Dendritic Cell Homeostasis and cDC2 Dependent T Cell Responses

Harriet A. Purvis, Fiona Clarke, Anna B. Montgomery, Chloe Colas, Jack A. Bibby, Georgina H. Cornish, Xuezhi Dai, Diana Dudziak, David J. Rawlings, Rose Zamoyska, Pierre Guermonprez, Andrew P. Cope

Front Immunol. 2020; 11: 376. Published online 2020 Mar 4. doi: 10.3389/fimmu.2020.00376

PMCID:: PMC7065600

Abstract Article PDF–1.0M

Select item 69975469.

PTPN22 Acts in a Cell Intrinsic Manner to Restrict the Proliferation and Differentiation of T Cells Following Antibody Lymphodepletion

Johanna A. Knipper, David Wright, Andrew P. Cope, Bernard Malissen, Rose Zamoyska

Front Immunol. 2020; 11: 52. Published online 2020 Jan 28. doi: 10.3389/fimmu.2020.00052

PMCID:: PMC6997546

Abstract Article PDF–3.6M

Select item 685906610.

Quantitative interactomics in primary T cells unveils TCR signal diversification extent and dynamics

Guillaume Voisinne, Kristof Kersse, Karima Chaoui, Liaoxun Lu, Julie Chaix, Lichen Zhang, Marisa Goncalves Menoita, Laura Girard, Youcef Ounoughene, Hui Wang, Odile Burlet-Schiltz, Hervé Luche, Frédéric Fiore, Marie Malissen, Anne Gonzalez de Peredo, Yinming Liang, Romain Roncagalli, Bernard Malissen

Nat Immunol. Author manuscript; available in PMC 2020 Apr 7.

Published in final edited form as: Nat Immunol. 2019 Nov 1; 20(11): 1530–1541. Published online 2019 Oct 7. doi: 10.1038/s41590-019-0489-8

PMCID:: PMC6859066

Abstract Article PDF–2.9M

Select item 679136611.

The autoimmune risk variant PTPN22 C1858T alters B cell tolerance at discrete checkpoints and differentially shapes the naïve repertoire

Genita Metzler, Xuezhi Dai, Christopher D. Thouvenel, Socheath Khim, Tania Habib, Jane H. Buckner, David J. Rawlings

J Immunol. Author manuscript; available in PMC 2019 Oct 14.

Published in final edited form as: J Immunol. 2017 Oct 1; 199(7): 2249–2260. Published online 2017 Aug 11. doi: 10.4049/jimmunol.1700601

PMCID:: PMC6791366

Abstract Article PDF–1.5M

Select item 677781412.

Deletion of PTPN22 improves effector and memory CD8⁺ T cell responses to tumors

Rebecca J. Brownlie, David Wright, Rose Zamoyska, Robert J. Salmond

JCI Insight. 2019 Aug 22; 4(16): e127847. Published online 2019 Aug 22. doi: 10.1172/jci.insight.127847

PMCID:: PMC6777814

Abstract Article PDF–1.4M

Select item 669397113.

Experimental colitis in IL‐10‐deficient mice ameliorates in the absence of PTPN22

T. Jofra, G. Galvani, I. Cosorich, L. De Giorgi, A. Annoni, A. Vecchione, C. Sorini, M. Falcone, G. Fousteri

Clin Exp Immunol. 2019 Sep; 197(3): 263–275. Published online 2019 Jul 10. doi: 10.1111/cei.13339

PMCID:: PMC6693971

Abstract Article PDF–600K

Select item 654645114.

Protein tyrosine phosphatase non-receptor type 22 modulates colitis in a microbiota-dependent manner

Marianne R. Spalinger, Thomas S.B. Schmidt, Marlene Schwarzfischer, Larissa Hering, Kirstin Atrott, Silvia Lang, Claudia Gottier, Annelies Geirnaert, Christophe Lacroix, Xuezhi Dai, David J. Rawlings, Andrew C. Chan, Christian von Mering, Gerhard Rogler, Michael Scharl

J Clin Invest. 2019 Jun 3; 129(6): 2527–2541. Published online 2019 May 20. doi: 10.1172/JCI123263

PMCID:: PMC6546451

Abstract Article PDF–13M

Select item 619811315.

Protein tyrosine phosphatase PTPN22 regulates LFA-1 dependent Th1 responses

Cristina Sanchez-Blanco, Fiona Clarke, Georgina H. Cornish, David Depoil, Stephen J. Thompson, Xuezhi Dai, David J. Rawlings, Michael L. Dustin, Rose Zamoyska, Andrew P. Cope, Harriet A. Purvis

J Autoimmun. 2018 Nov; 94: 45–55. doi: 10.1016/j.jaut.2018.07.008

PMCID:: PMC6198113

Abstract Article PDF–1.7M

Select item 610755116.

The protein tyrosine phosphatase PTPN22 negatively regulates presentation of immune complex derived antigens

Fiona Clarke, Harriet A. Purvis, Cristina Sanchez-Blanco, Enrique Gutiérrez-Martinez, Georgina H. Cornish, Rose Zamoyska, Pierre Guermonprez, Andrew P. Cope

Sci Rep. 2018; 8: 12692. Published online 2018 Aug 23. doi: 10.1038/s41598-018-31179-x

PMCID:: PMC6107551

Abstract Article PDF–1.9M

Select item 585994817.

Protein tyrosine phosphatase PTPN22 regulates IL‐1β dependent Th17 responses by modulating dectin‐1 signaling in mice

Harriet A Purvis, Fiona Clarke, Christine K Jordan, Cristina Sanchez Blanco, Georgina H Cornish, Xuezhi Dai, David J Rawlings, Rose Zamoyska, Andrew P Cope

Eur J Immunol. 2018 Feb; 48(2): 306–315. Published online 2017 Oct 20. doi: 10.1002/eji.201747092

PMCID:: PMC5859948

Abstract Article PDF–1.8M

Select item 583699918.

Lack of PTPN22 increases LFA-1-dependent adhesion of Murine Regulatory T Cells improving their regulatory Function

Rebecca J Brownlie, Lisa A Miosge, Demetrios Vassilakos, Lena M Svensson, Andrew Cope, Rose Zamoyska

Sci Signal. Author manuscript; available in PMC 2018 Mar 5.

Published in final edited form as: Sci Signal. 2012 Nov 27; 5(252): ra87. Published online 2012 Nov 27. doi: 10.1126/scisignal.2003365

PMCID:: PMC5836999

Abstract Article PDF–2.5M

Select item 569790019.

The A946T variant IFIH1 RNA sensor mediates an interferon program that limits viral infection but increases the risk for autoimmunity

Jacquelyn A. Gorman, Christian Hundhausen, John S. Errett, Amy E. Stone, Eric J. Allenspach, Yan Ge, Tanvi Arkatkar, Courtnee Clough, Xuezhi Dai, Socheath Khim, Kathleen Pestal, Denny Liggitt, Karen Cerosaletti, Daniel B. Stetson, Richard G. James, Mohamed Oukka, Patrick Concannon, Michael Gale, Jr., Jane H. Buckner, David J. Rawlings

Nat Immunol. Author manuscript; available in PMC 2017 Nov 29.

Published in final edited form as: Nat Immunol. 2017 Jul; 18(7): 744–752. Published online 2017 May 29. doi: 10.1038/ni.3766

PMCID:: PMC5697900

Abstract Article PDF–1.0M

Select item 567684220.

Resistance to TGFβ suppression and improved anti-tumor responses in CD8⁺ T cells lacking PTPN22

Rebecca J. Brownlie, Celine Garcia, Mate Ravasz, Dietmar Zehn, Robert J. Salmond, Rose Zamoyska

Nat Commun. 2017; 8: 1343. Published online 2017 Nov 7. doi: 10.1038/s41467-017-01427-1

PMCID:: PMC5676842

Abstract Article PDF–1.1M

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