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Select item 114656881.

Systematic perturbations of SETD2, NSD1, NSD2, NSD3, and ASH1L reveal their distinct contributions to H3K36 methylation

Gerry A. Shipman, Reinnier Padilla, Cynthia Horth, Bo Hu, Eric Bareke, Francisca N. Vitorino, Joanna M. Gongora, Benjamin A. Garcia, Chao Lu, Jacek Majewski

Genome Biol. 2024; 25: 263. Published online 2024 Oct 10. doi: 10.1186/s13059-024-03415-3

PMCID:: PMC11465688

Article PDF–6.0M

Select item 107819972.

H3K36 methyltransferase NSD1 protects against osteoarthritis through regulating chondrocyte differentiation and cartilage homeostasis

Rui Shao, Jinlong Suo, Zhong Zhang, Mingxiang Kong, Yiyang Ma, Yang Wen, Mengxue Liu, Lenan Zhuang, Kai Ge, Qing Bi, Changqing Zhang, Weiguo Zou

Cell Death Differ. 2024 Jan; 31(1): 106–118. Published online 2023 Nov 27. doi: 10.1038/s41418-023-01244-8

PMCID:: PMC10781997

Article PDF–11M

Select item 105269803.

Targeting KDM2A Enhances T Cell Infiltration in NSD1-Deficient Head and Neck Squamous Cell Carcinoma

Chen Chen, June Ho Shin, Zhuoqing Fang, Kevin Brennan, Nina B. Horowitz, Kathleen L. Pfaff, Emma L. Welsh, Scott J. Rodig, Olivier Gevaert, Or Gozani, Ravindra Uppaluri, John B. Sunwoo

Cancer Res. Author manuscript; available in PMC 2024 Feb 15.

Published in final edited form as: Cancer Res. 2023 Aug 15; 83(16): 2645–2655. doi: 10.1158/0008-5472.CAN-22-3114

PMCID:: PMC10526980

Article PDF–1.6M

Select item 102307554.

NSD1 deposits histone H3 lysine 36 dimethylation to pattern non-CG DNA methylation in neurons

Nicole Hamagami, Dennis Y. Wu, Adam W. Clemens, Sabin A. Nettles, Aidan Li, Harrison W. Gabel

Mol Cell. Author manuscript; available in PMC 2024 May 4.

Published in final edited form as: Mol Cell. 2023 May 4; 83(9): 1412–1428.e7. Published online 2023 Apr 24. doi: 10.1016/j.molcel.2023.04.001

PMCID:: PMC10230755

Article PDF–2.4M

Select item 97507915.

H3K36 methyltransferase NSD1 is essential for normal B1 and B2 cell development and germinal center formation

Sulan Zhai, Min Cao, Han Zhou, Huamin Zhu, Tongchang Xu, Yuliang Wang, Xiaoming Wang, Zhenming Cai

Front Immunol. 2022; 13: 959021. Published online 2022 Nov 30. doi: 10.3389/fimmu.2022.959021

PMCID:: PMC9750791

Article PDF–3.2M

Select item 95886796.

Histone methylation antagonism drives tumor immune evasion in squamous cell carcinomas

Yinglu Li, Elizabeth M. Goldberg, Xiao Chen, Xinjing Xu, John T. McGuire, Giuseppe Leuzzi, Dimitris Karagiannis, Tiffany Tate, Nargess Farhangdoost, Cynthia Horth, Esther Dai, Zhiming Li, Zhiguo Zhang, Benjamin Izar, Jianwen Que, Alberto Ciccia, Jacek Majewski, Angela J. Yoon, Laurie Ailles, Cathy Lee Mendelsohn, Chao Lu

Mol Cell. Author manuscript; available in PMC 2023 Oct 20.

Published in final edited form as: Mol Cell. 2022 Oct 20; 82(20): 3901–3918.e7. Published online 2022 Oct 6. doi: 10.1016/j.molcel.2022.09.007

PMCID:: PMC9588679

Article PDF–4.5M

Select item 92653447.

Mitoribosomal Deregulation Drives Senescence via TPP1-Mediated Telomere Deprotection

Seongki Min, So Mee Kwon, Jiwon Hong, Young-Kyoung Lee, Tae Jun Park, Su Bin Lim, Gyesoon Yoon

Cells. 2022 Jul; 11(13): 2079. Published online 2022 Jun 30. doi: 10.3390/cells11132079

PMCID:: PMC9265344

Article PDF–6.4M

Select item 91340118.

Analysis of a miR-148a Targetome in B Cell Central Tolerance

Fengge Ma, Yating Zhan, Rocío Bartolomé-Cabrero, Wei Ying, Masahide Asano, Zhe Huang, Changchun Xiao, Alicia González-Martín

Front Immunol. 2022; 13: 861655. Published online 2022 May 12. doi: 10.3389/fimmu.2022.861655

PMCID:: PMC9134011

Article PDF–4.4M

Select item 85482619.

Differential impact of a dyskeratosis congenita mutation in TPP1 on mouse hematopoiesis and germline

Jacqueline V Graniel, Kamlesh Bisht, Ann Friedman, James White, Eric Perkey, Ashley Vanderbeck, Alina Moroz, Léolène J Carrington, Joshua D Brandstadter, Frederick Allen, Adrienne Niederriter Shami, Peedikayil Thomas, Aniela Crayton, Mariel Manzor, Anna Mychalowych, Jennifer Chase, Saher S Hammoud, Catherine E Keegan, Ivan Maillard, Jayakrishnan Nandakumar

Life Sci Alliance. 2022 Jan; 5(1): e202101208. Published online 2021 Oct 13. doi: 10.26508/lsa.202101208

PMCID:: PMC8548261

Article PDF–3.5M

Select item 851061310.

A histone H3.3K36M mutation in mice causes an imbalance of histone modifications and defects in chondrocyte differentiation

Shusaku Abe, Hiroaki Nagatomo, Hiroyuki Sasaki, Takashi Ishiuchi

Epigenetics. 2021; 16(10): 1123–1134. Published online 2020 Nov 16. doi: 10.1080/15592294.2020.1841873

PMCID:: PMC8510613

Article PDF–7.2M

Select item 844873511.

Distinct functions of POT1 proteins contribute to the regulation of telomerase recruitment to telomeres

Peili Gu, Shuting Jia, Taylor Takasugi, Valerie M. Tesmer, Jayakrishnan Nandakumar, Yong Chen, Sandy Chang

Nat Commun. 2021; 12: 5514. Published online 2021 Sep 17. doi: 10.1038/s41467-021-25799-7

PMCID:: PMC8448735

Article PDF–8.7M

Select item 833387112.

Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox Gene Temporal Collinear Activation for Body Axial Patterning in Mice

Feng Zhang, Xiong Zhao, Runmin Jiang, Yuying Wang, Xinli Wang, Yu Gu, Longyong Xu, Jing Ye, Charlie Degui Chen, Shuangping Guo, Dawei Zhang, Daqing Zhao

Front Cell Dev Biol. 2021; 9: 642931. Published online 2021 Jul 21. doi: 10.3389/fcell.2021.642931

PMCID:: PMC8333871

Article PDF–1.4M

Select item 826233713.

TPP1 mutagenesis screens unravel shelterin interfaces and functions in hematopoiesis

Sherilyn Grill, Shilpa Padmanaban, Ann Friedman, Eric Perkey, Frederick Allen, Valerie M. Tesmer, Jennifer Chase, Rami Khoriaty, Catherine E. Keegan, Ivan Maillard, Jayakrishnan Nandakumar

JCI Insight. 2021 May 10; 6(9): e138059. Published online 2021 May 10. doi: 10.1172/jci.insight.138059

PMCID:: PMC8262337

Article PDF–2.7M

Select item 821645714.

The H3K36me2 methyltransferase NSD1 modulates H3K27ac at active enhancers to safeguard gene expression

Yuan Fang, Yin Tang, Yanjun Zhang, Yixin Pan, Junqi Jia, Zhongxing Sun, Weiwu Zeng, Jiaqi Chen, Ying Yuan, Dong Fang

Nucleic Acids Res. 2021 Jun 21; 49(11): 6281–6295. Published online 2021 Jun 9. doi: 10.1093/nar/gkab473

PMCID:: PMC8216457

Article PDF–3.9M

Select item 796892515.

TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation

Xiaochen Fan, V Pragathi Masamsetti, Jane QJ Sun, Kasper Engholm-Keller, Pierre Osteil, Joshua Studdert, Mark E Graham, Nicolas Fossat, Patrick PL Tam

eLife. 2021; 10: e62873. Published online 2021 Feb 8. doi: 10.7554/eLife.62873

PMCID:: PMC7968925

Article PDF–4.0M

Select item 793877016.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Article PDF–2.0M

Select item 729331017.

Nuclear interacting SET domain protein 1 inactivation impairs GATA1-regulated erythroid differentiation and causes erythroleukemia

Katharina Leonards, Marwa Almosailleakh, Samantha Tauchmann, Frederik Otzen Bagger, Cécile Thirant, Sabine Juge, Thomas Bock, Hélène Méreau, Matheus F. Bezerra, Alexandar Tzankov, Robert Ivanek, Régine Losson, Antoine H. F. M. Peters, Thomas Mercher, Juerg Schwaller

Nat Commun. 2020; 11: 2807. Published online 2020 Jun 12. doi: 10.1038/s41467-020-16179-8

PMCID:: PMC7293310

Article PDF–4.4M

Select item 695961018.

ATRX affects the repair of telomeric DSBs by promoting cohesion and a DAXX-dependent activity

Courtney A. Lovejoy, Kaori Takai, Michael S. Huh, David J. Picketts, Titia de Lange

PLoS Biol. 2020 Jan; 18(1): e3000594. Published online 2020 Jan 2. doi: 10.1371/journal.pbio.3000594

PMCID:: PMC6959610

Article PDF–5.0M

Select item 618618419.

High-throughput gene expression analysis identifies p53-dependent and -independent pathways contributing to the adrenocortical dysplasia (acd) phenotype

Ceren Sucularli, Peedikayil Thomas, Hande Kocak, James S. White, Bridget C. O’Connor, Catherine E. Keegan

Gene. Author manuscript; available in PMC 2019 Dec 30.

Published in final edited form as: Gene. 2018 Dec 30; 679: 219–231. Published online 2018 Sep 4. doi: 10.1016/j.gene.2018.09.002

PMCID:: PMC6186184

Article PDF–2.5M

Select item 581531220.

The N Terminus of the OB Domain of Telomere Protein TPP1 Is Critical for Telomerase Action

Sherilyn Grill, Valerie M. Tesmer, Jayakrishnan Nandakumar

Cell Rep. Author manuscript; available in PMC 2018 Feb 16.

Published in final edited form as: Cell Rep. 2018 Jan 30; 22(5): 1132–1140. doi: 10.1016/j.celrep.2018.01.012

PMCID:: PMC5815312

Article PDF–1.3M

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