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Items: 1 to 20 of 158

1.
NEMO/NF-κB signaling functions as a double-edged sword in PanIN formation versus progression to pancreatic cancer
Miltiadis Tsesmelis, Ulrike F. G. Büttner, Melanie Gerstenlauer, Uta Manfras, Konstantinos Tsesmelis, Ziwei Du, Nadine Sperb, Stephanie Ellen Weissinger, Peter Möller, Thomas F. E. Barth, Harald J. Maier, Lap Kwan Chan, Thomas Wirth
Mol Cancer. 2024; 23: 103. Published online 2024 May 16. doi: 10.1186/s12943-024-01989-x
PMCID:
PMC11097402
AbstractArticlePDF–8.8M
2.
Damaged mitochondria recruit the effector NEMO to activate NF-κB signaling
Olivia Harding, Elisabeth Holzer, Julia F. Riley, Sascha Martens, Erika L.F. Holzbaur
Mol Cell. Author manuscript; available in PMC 2024 Sep 7.
Published in final edited form as: Mol Cell. 2023 Sep 7; 83(17): 3188–3204.e7. doi: 10.1016/j.molcel.2023.08.005
PMCID:
PMC10510730
AbstractArticlePDF–4.0M
3.
E3 ligase HECTD3 promotes RNA virus replication and virus-induced inflammation via K33-linked polyubiquitination of PKR
Jiaying Huang, Zhou Yu, Xuelian Li, Mingjin Yang, Qian Fang, Zheng Li, Chunmei Wang, Taoyong Chen, Xuetao Cao
Cell Death Dis. 2023 Jul; 14(7): 396. Published online 2023 Jul 4. doi: 10.1038/s41419-023-05923-9
PMCID:
PMC10319860
AbstractArticlePDF–3.7M
4.
DTX3L Enhances Type I Interferon Antiviral Response by Promoting the Ubiquitination and Phosphorylation of TBK1
Jiaqi Huang, Zhengrong Chen, Yunfei Ye, Yu Shao, Peijie Zhu, Xiaoping Li, Yu Ma, Fei Xu, Ji Zhou, Mengyun Wu, Xiu Gao, Yi Yang, Jinping Zhang, Chuangli Hao
J Virol. 2023 Jun; 97(6): e00687-23. Published online 2023 May 31. doi: 10.1128/jvi.00687-23
PMCID:
PMC10308958
AbstractArticlePDF–4.8M
5.
NEMO- and RelA-dependent NF-κB signaling promotes small cell lung cancer
Lioba Koerner, Marcel Schmiel, Tsun-Po Yang, Martin Peifer, Reinhard Buettner, Manolis Pasparakis
Cell Death Differ. 2023 Apr; 30(4): 938–951. Published online 2023 Jan 18. doi: 10.1038/s41418-023-01112-5
PMCID:
PMC10070460
AbstractArticlePDF–7.1M
6.
LncRNA Gm26917 regulates inflammatory response in macrophages by enhancing Annexin A1 ubiquitination in LPS-induced acute liver injury
Qing Zhao, Meng-Fei Sheng, Yao-Yun Wang, Xing-Yu Wang, Wei-Yi Liu, Yuan-Yuan Zhang, Tiao-Ying Ke, Shu Chen, Gao-Zong Pang, Liang Yong, Zhan Ding, Yu-Jun Shen, Yu-Xian Shen, Wei Shao
Front Pharmacol. 2022; 13: 975250. Published online 2022 Nov 1. doi: 10.3389/fphar.2022.975250
PMCID:
PMC9663662
AbstractArticlePDF–4.4M
7.
Smooth muscle cell specific NEMO deficiency inhibits atherosclerosis in ApoE−/− mice
Takashi Imai, Trieu-My Van, Manolis Pasparakis, Apostolos Polykratis
Sci Rep. 2022; 12: 12538. Published online 2022 Jul 22. doi: 10.1038/s41598-022-16737-8
PMCID:
PMC9307802
AbstractArticlePDF–3.1M
8.
p62 Promotes Survival and Hepatocarcinogenesis in Mice with Liver-Specific NEMO Ablation
Vangelis Kondylis, Farina Schneider, Fabian Schorn, Nikos Oikonomou, Beate Katharina Straub, Sabine Werner, Philip Rosenstiel, Manolis Pasparakis
Cancers (Basel) 2022 May; 14(10): 2436. Published online 2022 May 15. doi: 10.3390/cancers14102436
PMCID:
PMC9139637
AbstractArticlePDF–8.6M
9.
ATP spreads inflammation to other limbs through crosstalk between sensory neurons and interneurons
Rie Hasebe, Kaoru Murakami, Masaya Harada, Nada Halaka, Hiroshi Nakagawa, Fuminori Kawano, Yoshinobu Ohira, Tadafumi Kawamoto, Fiona E. Yull, Timothy S. Blackwell, Junko Nio-Kobayashi, Toshihiko Iwanaga, Masahiko Watanabe, Nobuhiro Watanabe, Harumi Hotta, Toshihide Yamashita, Daisuke Kamimura, Yuki Tanaka, Masaaki Murakami
J Exp Med. 2022 Jun 6; 219(6): e20212019. Published online 2022 May 17. doi: 10.1084/jem.20212019
PMCID:
PMC9117706
AbstractArticlePDF–7.0M
10.
Functional genomic landscape of cancer-intrinsic evasion of killing by T cells
Keith A. Lawson, Cristovão M. Sousa, Xiaoyu Zhang, Eiru Kim, Rummy Akthar, Joseph J. Caumanns, Yuxi Yao, Nicholas Mikolajewicz, Catherine Ross, Kevin R. Brown, Abdelrahman Abou Zid, Zi Peng Fan, Shirley Hui, Jordan A. Krall, Donald M. Simons, Chloe J. Slater, Victor De Jesus, Lujia Tang, Richa Singh, Joshua E. Goldford, Sarah Martin, Qian Huang, Elizabeth A. Francis, Andrea Habsid, Ryan Climie, David Tieu, Jiarun Wei, Ren Li, Amy Hin Yan Tong, Michael Aregger, Katherine S. Chan, Hong Han, Xiaowei Wang, Patricia Mero, John H. Brumell, Antonio Finelli, Laurie Ailles, Gary Bader, Gromoslaw A. Smolen, Gillian A. Kingsbury, Traver Hart, Charles Kung, Jason Moffat
Nature. Author manuscript; available in PMC 2022 Apr 18.
Published in final edited form as: Nature. 2020 Oct; 586(7827): 120–126. Published online 2020 Sep 23. doi: 10.1038/s41586-020-2746-2
PMCID:
PMC9014559
AbstractArticlePDF–6.6M
11.
Nemo-dependent, ATM-mediated signals from RAG DNA breaks at Igk feedback inhibit Vk recombination to enforce Igκ allelic exclusion
Rebecca A. Glynn, Craig H. Bassing
J Immunol. Author manuscript; available in PMC 2023 Jan 15.
Published in final edited form as: J Immunol. 2022 Jan 15; 208(2): 371–383. Published online 2021 Dec 29. doi: 10.4049/jimmunol.2100696
PMCID:
PMC8756740
AbstractArticlePDF–1.6M
12.
A functional cerebral endothelium is necessary to protect against cognitive decline
Lianne J Trigiani, Miled Bourourou, María Lacalle-Aurioles, Clotilde Lecrux, Amy Hynes, Shoshana Spring, Darren J Fernandes, John G Sled, Frédéric Lesage, Markus Schwaninger, Edith Hamel
J Cereb Blood Flow Metab. 2022 Jan; 42(1): 74–89. Published online 2021 Sep 13. doi: 10.1177/0271678X211045438
PMCID:
PMC8721775
AbstractArticlePDF–2.0M
13.
The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells
Jan Wenzel, Josephine Lampe, Helge Müller-Fielitz, Raphael Schuster, Marietta Zille, Kristin Müller, Markus Krohn, Jakob Körbelin, Linlin Zhang, Ümit Özorhan, Vanessa Neve, Julian U. G. Wagner, Denisa Bojkova, Mariana Shumliakivska, Yun Jiang, Anke Fähnrich, Fabian Ott, Valentin Sencio, Cyril Robil, Susanne Pfefferle, Florent Sauve, Caio Fernando Ferreira Coêlho, Jonas Franz, Frauke Spiecker, Beate Lembrich, Sonja Binder, Nina Feller, Peter König, Hauke Busch, Ludovic Collin, Roberto Villaseñor, Olaf Jöhren, Hermann C. Altmeppen, Manolis Pasparakis, Stefanie Dimmeler, Jindrich Cinatl, Klaus Püschel, Matija Zelic, Dimitry Ofengeim, Christine Stadelmann, François Trottein, Ruben Nogueiras, Rolf Hilgenfeld, Markus Glatzel, Vincent Prevot, Markus Schwaninger
Nat Neurosci. 2021; 24(11): 1522–1533. Published online 2021 Oct 21. doi: 10.1038/s41593-021-00926-1
PMCID:
PMC8553622
AbstractArticlePDF–7.6M
14.
Cerebral angiogenesis ameliorates pathological disorders in Nemo-deficient mice with small-vessel disease
Yun Jiang, Kristin Müller, Mahtab A. Khan, Julian C. Assmann, Josephine Lampe, Knut Kilau, Marius Richter, Maximilian Kleint, Dirk A Ridder, Norbert Hübner, Marc Schmidt-Supprian, Jan Wenzel, Markus Schwaninger
J Cereb Blood Flow Metab. 2021 Feb; 41(2): 219–235. Published online 2020 Mar 9. doi: 10.1177/0271678X20910522
PMCID:
PMC8369998
AbstractArticlePDF–2.9M
15.
SENP1 modulates microglia‐mediated neuroinflammation toward intermittent hypoxia‐induced cognitive decline through the de‐SUMOylation of NEMO
Hongwei Wang, Tianyun Yang, Jinyuan Sun, Sisen Zhang, Song Liu
J Cell Mol Med. 2021 Jul; 25(14): 6841–6854. Published online 2021 Jun 13. doi: 10.1111/jcmm.16689
PMCID:
PMC8278079
AbstractArticlePDF–1.9M
16.
NEMO, a transcriptional target of estrogen and progesterone, is linked to tumor suppressor PML in breast cancer
Kelli E. Valdez, Hanan S. Elsarraj, Yan Hong, Sandra L. Grimm, Lawrence R. Ricci, Fang Fan, Ossama Tawfik, Lisa May, Therese Cusick, Marc Inciardi, Mark Redick, Jason Gatewood, Onalisa Winblad, Susan Hilsenbeck, Dean P. Edwards, Christy Hagan, Andrew K. Godwin, Carol Fabian, Fariba Behbod
Cancer Res. Author manuscript; available in PMC 2021 Jun 28.
Published in final edited form as: Cancer Res. 2017 Jul 15; 77(14): 3802–3813. Published online 2017 May 17. doi: 10.1158/0008-5472.CAN-16-2794
PMCID:
PMC8236416
AbstractArticlePDF–2.4M
17.
Genomic locus proteomic screening identifies the NF-κB signaling pathway components NFκB1 and IKBKG as transcriptional regulators of Ripk3 in endothelial cells
Siqi Gao, Matthew Menendez, Katarzyna Kurylowicz, Courtney T. Griffin
PLoS One. 2021; 16(6): e0253519. Published online 2021 Jun 21. doi: 10.1371/journal.pone.0253519
PMCID:
PMC8216549
AbstractArticlePDF–1.5M
18.
Persistent NF-κB activation in muscle stem cells induces proliferation-independent telomere shortening
Elisia D. Tichy, Nuoying Ma, David Sidibe, Emanuele Loro, Jacob Kocan, Delia Z. Chen, Tejvir S. Khurana, Paul Hasty, Foteini Mourkioti
Cell Rep. Author manuscript; available in PMC 2021 Jun 7.
Published in final edited form as: Cell Rep. 2021 May 11; 35(6): 109098. doi: 10.1016/j.celrep.2021.109098
PMCID:
PMC8183356
AbstractArticlePDF–2.5M
19.
N4BP1 negatively regulates NF-κB by binding and inhibiting NEMO oligomerization
Hexin Shi, Lei Sun, Ying Wang, Aijie Liu, Xiaoming Zhan, Xiaohong Li, Miao Tang, Priscilla Anderton, Sara Hildebrand, Jiexia Quan, Sara Ludwig, Eva Marie Y. Moresco, Bruce Beutler
Nat Commun. 2021; 12: 1379. Published online 2021 Mar 2. doi: 10.1038/s41467-021-21711-5
PMCID:
PMC7925594
AbstractArticlePDF–2.5M
20.
TRIM41 is required to innate antiviral response by polyubiquitinating BCL10 and recruiting NEMO
Zhou Yu, Xuelian Li, Mingjin Yang, Jiaying Huang, Qian Fang, Jianjun Jia, Zheng Li, Yan Gu, Taoyong Chen, Xuetao Cao
Signal Transduct Target Ther. 2021; 6: 90. Published online 2021 Feb 28. doi: 10.1038/s41392-021-00477-8
PMCID:
PMC7914255
AbstractArticlePDF–4.7M

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