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Select item 88849111.

JAGGED1/NOTCH3 activation promotes aortic hypermuscularization and stenosis in elastin deficiency

Jui M. Dave, Raja Chakraborty, Aglaia Ntokou, Junichi Saito, Fatima Z. Saddouk, Zhonghui Feng, Ashish Misra, George Tellides, Robert K. Riemer, Zsolt Urban, Caroline Kinnear, James Ellis, Seema Mital, Robert Mecham, Kathleen A. Martin, Daniel M. Greif

J Clin Invest. 2022 Mar 1; 132(5): e142338. Published online 2022 Mar 1. doi: 10.1172/JCI142338

PMCID:: PMC8884911

Abstract Article PDF–3.3M

Select item 79387702.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 70606623.

Essential requirement for nicastrin in marginal zone and B-1 B cell development

Jin Huk Choi, Jonghee Han, Panayotis C. Theodoropoulos, Xue Zhong, Jianhui Wang, Dawson Medler, Sara Ludwig, Xiaoming Zhan, Xiaohong Li, Miao Tang, Thomas Gallagher, Gang Yu, Bruce Beutler

Proc Natl Acad Sci U S A. 2020 Mar 3; 117(9): 4894–4901. Published online 2020 Feb 18. doi: 10.1073/pnas.1916645117

PMCID:: PMC7060662

Abstract Article PDF–1.7M

Select item 68399464.

Dysregulation of the TET family of epigenetic regulators in lymphoid and myeloid malignancies

Chan-Wang J. Lio, Hiroshi Yuita, Anjana Rao

Blood. 2019 Oct 31; 134(18): 1487–1497. Prepublished online 2019 Aug 29. doi: 10.1182/blood.2019791475

PMCID:: PMC6839946

Abstract Article

Select item 68221685.

Hepatocyte Notch activation induces liver fibrosis in nonalcoholic steatohepatitis

Changyu Zhu, KyeongJin Kim, Xiaobo Wang, Alberto Bartolome, Marcela Salomao, Paola Dongiovanni, Marica Meroni, Mark J. Graham, Katherine P. Yates, Anna Mae Diehl, Robert F. Schwabe, Ira Tabas, Luca Valenti, Joel E. Lavine, Utpal B. Pajvani

Sci Transl Med. Author manuscript; available in PMC 2019 Nov 21.

Published in final edited form as: Sci Transl Med. 2018 Nov 21; 10(468): eaat0344. doi: 10.1126/scitranslmed.aat0344

PMCID:: PMC6822168

Abstract Article PDF–2.3M

Select item 67423296.

Nicastrin Is Required for Assembly of Presenilin/γ-Secretase Complexes to Mediate Notch Signaling and for Processing and Trafficking of β-Amyloid Precursor Protein in Mammals

Tong Li, Guojun Ma, Huaibin Cai, Donald L. Price, Philip C. Wong

J Neurosci. 2003 Apr 15; 23(8): 3272–3277. doi: 10.1523/JNEUROSCI.23-08-03272.2003

PMCID:: PMC6742329

Abstract Article PDF–341K

Select item 67252097.

APH-1a Is the Principal Mammalian APH-1 Isoform Present in γ-Secretase Complexes during Embryonic Development

Guojun Ma, Tong Li, Donald L. Price, Philip C. Wong

J Neurosci. 2005 Jan 5; 25(1): 192–198. doi: 10.1523/JNEUROSCI.3814-04.2005

PMCID:: PMC6725209

Abstract Article PDF–351K

Select item 66728278.

Moderate Reduction of γ-Secretase Attenuates Amyloid Burden and Limits Mechanism-Based Liabilities

Tong Li, Hongjin Wen, Cory Brayton, Fiona M. Laird, Guojun Ma, Shiwen Peng, Lisa Placanica, T. C. Wu, Barbara J. Crain, Donald L. Price, Charles G. Eberhart, Philip C. Wong

J Neurosci. 2007 Oct 3; 27(40): 10849–10859. doi: 10.1523/JNEUROSCI.2152-07.2007

PMCID:: PMC6672827

Abstract Article PDF–665K

Select item 64927839.

Astroglial Activation and Tau Hyperphosphorylation Precede to Neuron Loss in a Neurodegenerative Mouse Model

Jin‐Xing Hou, Shan‐Shan Cheng, Lu Chen, Qi‐Hui Wang, Yun Shi, Yun Xu, Zhen‐Yu Yin, Gui‐Quan Chen

CNS Neurosci Ther. 2016 Mar; 22(3): 244–247. Published online 2016 Jan 25. doi: 10.1111/cns.12509

PMCID:: PMC6492783

Article PDF–572K

Select item 643376210.

Conditional Inactivation of Pen-2 in the Developing Neocortex Leads to Rapid Switch of Apical Progenitors to Basal Progenitors

Shanshan Cheng, Tingting Liu, Yimin Hu, Yingqian Xia, Jinxing Hou, Chaoli Huang, Xiaochuan Zou, Juan Liang, Yun Stone Shi, Yuanlin Zheng, Jun Lu, Guiquan Chen

J Neurosci. 2019 Mar 20; 39(12): 2195–2207. doi: 10.1523/JNEUROSCI.2523-18.2019

PMCID:: PMC6433762

Abstract Article PDF–9.1M

Select item 635442611.

The APMAP interactome reveals new modulators of APP processing and beta-amyloid production that are altered in Alzheimer’s disease

Hermeto Gerber, Sebastien Mosser, Benjamin Boury-Jamot, Michael Stumpe, Alessandra Piersigilli, Christine Goepfert, Joern Dengjel, Urs Albrecht, Fulvio Magara, Patrick C. Fraering

Acta Neuropathol Commun. 2019; 7: 13. Published online 2019 Jan 31. doi: 10.1186/s40478-019-0660-3

PMCID:: PMC6354426

Abstract Article PDF–3.7M

Select item 615985612.

Rer1-mediated quality control system is required for neural stem cell maintenance during cerebral cortex development

Taichi Hara, Ikuko Maejima, Tomoko Akuzawa, Rika Hirai, Hisae Kobayashi, Satoshi Tsukamoto, Mika Tsunoda, Aguri Ono, Shota Yamakoshi, Satoshi Oikawa, Ken Sato

PLoS Genet. 2018 Sep; 14(9): e1007647. Published online 2018 Sep 27. doi: 10.1371/journal.pgen.1007647

PMCID:: PMC6159856

Abstract Article PDF–13M

Select item 588472913.

Gamma-secretase inhibition lowers plasma triglyceride-rich lipoproteins by stabilizing the LDL receptor

KyeongJin Kim, Ira J. Goldberg, Mark J. Graham, Meenakshi Sundaram, Enrico Bertaggia, Samuel Lee, Li Qiang, Rebecca A. Haeusler, Daniel Metzger, Pierre Chambon, Zemin Yao, Henry N. Ginsberg, Utpal B. Pajvani

Cell Metab. Author manuscript; available in PMC 2019 Apr 3.

Published in final edited form as: Cell Metab. 2018 Apr 3; 27(4): 816–827.e4. Published online 2018 Mar 22. doi: 10.1016/j.cmet.2018.02.010

PMCID:: PMC5884729

Abstract Article PDF–1.1M

Select item 538122614.

Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function

Tingting Zhang, Wei Du, Andrew F. Wilson, Satoshi H. Namekawa, Paul R. Andreassen, Amom Ruhikanta Meetei, Qishen Pang

Sci Rep. 2017; 7: 45626. Published online 2017 Apr 5. doi: 10.1038/srep45626

PMCID:: PMC5381226

Abstract Article PDF–1.4M

Select item 488243415.

Loss of Nicastrin from Oligodendrocytes Results in Hypomyelination and Schizophrenia with Compulsive Behavior

Daniel R. Dries, Yi Zhu, Mieu M. Brooks, Diego A. Forero, Megumi Adachi, Basar Cenik, James M. West, Yu-Hong Han, Cong Yu, Jennifer Arbella, Annelie Nordin, Rolf Adolfsson, Jurgen Del-Favero, Q. Richard Lu, Patrick Callaerts, Shari G. Birnbaum, Gang Yu

J Biol Chem. 2016 May 27; 291(22): 11647–11656. Published online 2016 Mar 23. doi: 10.1074/jbc.M116.715078

PMCID:: PMC4882434

Abstract Article PDF–2.1M

Select item 466029716.

Physiologically generated presenilin 1 lacking exon 8 fails to rescue brain PS1−/− phenotype and forms complexes with wildtype PS1 and nicastrin

Hannah Brautigam, Cesar L. Moreno, John W. Steele, Alexey Bogush, Dara L. Dickstein, John B.J. Kwok, Peter R. Schofield, Gopal Thinakaran, Paul M. Mathews, Patrick R. Hof, Sam Gandy, Michelle E. Ehrlich

Sci Rep. 2015; 5: 17042. Published online 2015 Nov 26. doi: 10.1038/srep17042

PMCID:: PMC4660297

Abstract Article PDF–2.4M

Select item 440525217.

Presenilins regulate the cellular level of the tumor suppressor PTEN

Han Zhang, Runzhong Liu, Ruishan Wang, Shuigen Hong, Huaxi Xu, Yun-wu Zhang

Neurobiol Aging. Author manuscript; available in PMC 2015 Apr 21.

Published in final edited form as: Neurobiol Aging. 2008 May; 29(5): 653–660. Published online 2007 Jan 12. doi: 10.1016/j.neurobiolaging.2006.11.020

PMCID:: PMC4405252

Abstract Article PDF–1.6M

Select item 438690418.

Modeling bladder cancer in mice: opportunities and challenges

Takashi Kobayashi, Tomasz B. Owczarek, James M. McKiernan, Cory Abate-Shen

Nat Rev Cancer. Author manuscript; available in PMC 2015 Jul 1.

Published in final edited form as: Nat Rev Cancer. 2015 Jan; 15(1): 42–54. doi: 10.1038/nrc3858

PMCID:: PMC4386904

Abstract Article PDF–785K

Select item 435881219.

Presenilin-1 knockin mice reveal loss-of-function mechanism for familial Alzheimer’s disease

Dan Xia, Hirotaka Watanabe, Bei Wu, Sang Hun Lee, Yan Li, Evgeny Tsvetkov, Vadim Y. Bolshakov, Jie Shen, Raymond J. Kelleher, III

Neuron. Author manuscript; available in PMC 2016 Mar 4.

Published in final edited form as: Neuron. 2015 Mar 4; 85(5): 967–981. doi: 10.1016/j.neuron.2015.02.010

PMCID:: PMC4358812

Abstract Article PDF–2.5M

Select item 432864720.

An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease

Yasuhiko Kizuka, Shinobu Kitazume, Reiko Fujinawa, Takashi Saito, Nobuhisa Iwata, Takaomi C Saido, Miyako Nakano, Yoshiki Yamaguchi, Yasuhiro Hashimoto, Matthias Staufenbiel, Hiroyuki Hatsuta, Shigeo Murayama, Hiroshi Manya, Tamao Endo, Naoyuki Taniguchi

EMBO Mol Med. 2015 Feb; 7(2): 175–189. Published online 2015 Jan 15. doi: 10.15252/emmm.201404438

PMCID:: PMC4328647

Abstract Article PDF–2.3M

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