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Select item 115066421.

Cooperative Substructure and Energetics of Allosteric Regulation of the Catalytic Core of the E3 Ubiquitin Ligase Parkin by Phosphorylated Ubiquitin

Xiang Ye, Sravya Kotaru, Rosana Lopes, Shannen Cravens, Mauricio Lasagna, A. Joshua Wand

Biomolecules. 2024 Oct; 14(10): 1338. Published online 2024 Oct 21. doi: 10.3390/biom14101338

PMCID:: PMC11506642

Abstract Article PDF–2.6M

Select item 114129862.

Activation of parkin by a molecular glue

Véronique Sauvé, Eric Stefan, Nathalie Croteau, Thomas Goiran, Rayan Fakih, Nupur Bansal, Adelajda Hadzipasic, Jing Fang, Paramasivam Murugan, Shimin Chen, Edward A. Fon, Warren D. Hirst, Laura F. Silvian, Jean-François Trempe, Kalle Gehring

Nat Commun. 2024; 15: 7707. Published online 2024 Sep 19. doi: 10.1038/s41467-024-51889-3

PMCID:: PMC11412986

Abstract Article PDF–3.0M

Select item 113684013.

Additional feedforward mechanism of Parkin activation via binding of phospho-UBL and RING0 in trans

Dipti Ranjan Lenka, Shakti Virendra Dahe, Odetta Antico, Pritiranjan Sahoo, Alan R Prescott, Miratul MK Muqit, Atul Kumar

eLife. 2024; 13: RP96699. Published online 2024 Sep 2. doi: 10.7554/eLife.96699

PMCID:: PMC11368401

Abstract Article PDF–12M

Select item 113103204.

Naturally occurring hyperactive variants of human parkin

Tahrima Saiha Huq, Jean Luo, Rayan Fakih, Véronique Sauvé, Kalle Gehring

Commun Biol. 2024; 7: 961. Published online 2024 Aug 8. doi: 10.1038/s42003-024-06656-x

PMCID:: PMC11310320

Abstract Article PDF–2.9M

Select item 112982035.

Deciphering the neuroprotective mechanisms of RACK1 in cerebral ischemia‐reperfusion injury: Pioneering insights into mitochondrial autophagy and the PINK1/Parkin axis

Lanqing Zhao, Yu Chen, Hongxi Li, Xiaoxu Ding, Jinwei Li

CNS Neurosci Ther. 2024 Aug; 30(8): e14836. Published online 2024 Aug 4. doi: 10.1111/cns.14836

PMCID:: PMC11298203

Abstract Article PDF–18M

Select item 111055386.

Shedding light on mitophagy in neurons: what is the evidence for PINK1/Parkin mitophagy in vivo?

Nadia Cummins, Jürgen Götz

Cell Mol Life Sci. 2018 Apr; 75(7): 1151–1162. Published online 2017 Oct 30. doi: 10.1007/s00018-017-2692-9

PMCID:: PMC11105538

Abstract Article PDF–816K

Select item 110811817.

PINK1/Park2-Mediated Mitophagy Relieve Non-Alcoholic Fatty Liver Disease

Han HE, Yinhe TANG, Lei ZHUANG, Yihua ZHENG, Xiaming HUANG

Physiol Res. 2024 Apr; 73(2): 253–263. Published online 2024 Apr 30. doi: 10.33549/physiolres.934925

PMCID:: PMC11081181

Abstract Article PDF–1.0M

Select item 110725068.

FKBP51 modulates hippocampal size and function in post-translational regulation of Parkin

Bin Qiu, Zhaohui Zhong, Shawn Righter, Yuxue Xu, Jun Wang, Ran Deng, Chao Wang, Kent E. Williams, Yao-ying Ma, Gavriil Tsechpenakis, Tiebing Liang, Weidong Yong

Cell Mol Life Sci. 2022 Mar; 79(3): 175. Published online 2022 Mar 4. doi: 10.1007/s00018-022-04167-8

PMCID:: PMC11072506

Abstract Article PDF–8.7M

Select item 109327809.

Association between copy number variations in parkin (PRKN) and schizophrenia and autism spectrum disorder: A case–control study

Tzuyao Lo, Itaru Kushima, Hiroki Kimura, Branko Aleksic, Takashi Okada, Hidekazu Kato, Toshiya Inada, Yoshihiro Nawa, Youta Torii, Maeri Yamamoto, Ryo Kimura, Yasuko Funabiki, Hirotaka Kosaka, Shusuke Numata, Kiyoto Kasai, Tsukasa Sasaki, Shigeru Yokoyama, Toshio Munesue, Ryota Hashimoto, Yuka Yasuda, Michiko Fujimoto, Masahide Usami, Masanari Itokawa, Makoto Arai, Kazutaka Ohi, Toshiyuki Someya, Yuichiro Watanabe, Jun Egawa, Tsutomu Takahashi, Michio Suzuki, Hidenori Yamasue, Nakao Iwata, Masashi Ikeda, Norio Ozaki

Neuropsychopharmacol Rep. 2024 Mar; 44(1): 42–50. Published online 2023 Nov 1. doi: 10.1002/npr2.12370

PMCID:: PMC10932780

Abstract Article PDF–801K

Select item 1092871810.

Ubiquitin Ligase Parkin Regulates the Stability of SARS-CoV-2 Main Protease and Suppresses Viral Replication

Li Zhou, Ruochuan Liu, Heather Pathak, Xiaoyu Wang, Geon H. Jeong, Pratima Kumari, Mukesh Kumar, Jun Yin

ACS Infect Dis. 2024 Mar 8; 10(3): 879–889. Published online 2024 Feb 22. doi: 10.1021/acsinfecdis.3c00418

PMCID:: PMC10928718

Abstract Article PDF–4.9M

Select item 1090475511.

Parkin inhibits proliferation and migration of bladder cancer via ubiquitinating Catalase

Renjie Zhang, Wenyu Jiang, Gang Wang, Yi Zhang, Wei Liu, Mingxing Li, Jingtian Yu, Xin Yan, Fenfang Zhou, Wenzhi Du, Kaiyu Qian, Yu Xiao, Tongzu Liu, Lingao Ju, Xinghuan Wang

Commun Biol. 2024; 7: 245. Published online 2024 Feb 29. doi: 10.1038/s42003-024-05935-x

PMCID:: PMC10904755

Abstract Article PDF–3.0M

Select item 1084304712.

Long-read sequencing resolves a complex structural variant in PRKN Parkinson’s disease

Kensuke Daida, Manabu Funayama, Kimberley J Billingsley, Laksh Malik, Abigail Miano-Burkhardt, Hampton L. Leonard, Mary B. Makarious, Hirotaka Iwaki, Jinhui Ding, J. Raphael Gibbs, Mayu Ishiguro, Hiroyo Yoshino, Kotaro Ogaki, Genko Oyama, Kenya Nishioka, Risa Nonaka, Wado Akamatsu, Cornelis Blauwendraat, Nobutaka Hattori

Mov Disord. Author manuscript; available in PMC 2024 Dec 1.

Published in final edited form as: Mov Disord. 2023 Dec; 38(12): 2249–2257. Published online 2023 Nov 5. doi: 10.1002/mds.29610

PMCID:: PMC10843047

Abstract Article PDF–815K

Select item 1079171113.

Pregnancy, fertile life factors, and associated clinical course in PRKN early-onset Parkinson’s disease

Roberta Bovenzi, Matteo Conti, Giulia Rebecca Degoli, Rocco Cerroni, Carlo Alberto Artusi, Mariangela Pierantozzi, Alessandro Stefani, Nicola Biagio Mercuri, Tommaso Schirinzi

Neurol Sci. 2024; 45(2): 591–599. Published online 2023 Sep 2. doi: 10.1007/s10072-023-07029-8

PMCID:: PMC10791711

Abstract Article PDF–553K

Select item 1070656414.

History of Parkinson’s Disease-Associated Gene, Parkin: Research over a Quarter Century in Quest of Finding the Physiological Substrate

Tohru Kitada, Mustafa T. Ardah, M. Emdadul Haque

Int J Mol Sci. 2023 Dec; 24(23): 16734. Published online 2023 Nov 24. doi: 10.3390/ijms242316734

PMCID:: PMC10706564

Abstract Article PDF–871K

Select item 1061873715.

Parkin Deficiency Suppresses Antigen Presentation to Promote Tumor Immune Evasion and Immunotherapy Resistance

Renzo Perales-Linares, Nektaria Maria Leli, Hesham Mohei, Silvia Beghi, Osvaldo D. Rivera, Nektarios Kostopoulos, Andrea Giglio, Subin S. George, Mireia Uribe-Herranz, Francesca Costabile, Stefano Pierini, Sergei Pustylnikov, Giorgos Skoufos, Yoseph Barash, Artemis G. Hatzigeorgiou, Constantinos Koumenis, Amit Maity, Michael T. Lotze, Andrea Facciabene

Cancer Res. 2023 Nov 1; 83(21): 3562–3576. Published online 2023 Aug 14. doi: 10.1158/0008-5472.CAN-22-2499

PMCID:: PMC10618737

Abstract Article PDF–7.9M

Select item 1061807616.

Tumor suppressor Parkin induces p53-mediated cell cycle arrest in human lung and colorectal cancer cells

Byung Chul Jung, Sung Hoon Kim, Yoonjung Cho, Yoon Suk Kim

BMB Rep. 2023 Oct 31; 56(10): 557–562. Published online 2023 Sep 6. doi: 10.5483/BMBRep.2023-0134

PMCID:: PMC10618076

Abstract Article PDF–6.7M

Select item 1059927817.

Parkin regulates IGF2BP3 through ubiquitination in the tumourigenesis of cervical cancer

Xin Sun, Guiqin Ye, Jiuzhou Li, Huafeng Shou, Gongxun Bai, Jianbin Zhang

Clin Transl Med. 2023 Oct; 13(10): e1457. Published online 2023 Oct 25. doi: 10.1002/ctm2.1457

PMCID:: PMC10599278

Abstract Article PDF–8.2M

Select item 1057324018.

Parkin-Mediated Mitophagy by TGF-β Is Connected with Hepatic Stellate Cell Activation

Ji Hyun Lee, Kyu Min Kim, Eun Hee Jung, Hye Rim Lee, Ji Hye Yang, Sam Seok Cho, Sung Hwan Ki

Int J Mol Sci. 2023 Oct; 24(19): 14826. Published online 2023 Oct 2. doi: 10.3390/ijms241914826

PMCID:: PMC10573240

Abstract Article PDF–2.9M

Select item 1046704119.

Alpha‐synuclein‐associated changes in PINK1‐PRKN‐mediated mitophagy are disease context dependent

Xu Hou, Taylor Hsuan‐Yu Chen, Shunsuke Koga, Jenny M. Bredenberg, Ayman H. Faroqi, Marion Delenclos, Guojun Bu, Zbigniew K. Wszolek, Jonathan A. Carr, Owen A. Ross, Pamela J. McLean, Melissa E. Murray, Dennis W. Dickson, Fabienne C. Fiesel, Wolfdieter Springer

Brain Pathol. 2023 Sep; 33(5): e13175. Published online 2023 May 31. doi: 10.1111/bpa.13175

PMCID:: PMC10467041

Abstract Article PDF–2.9M

Select item 1039273220.

Hypoxia-induced GPCPD1 depalmitoylation triggers mitophagy via regulating PRKN-mediated ubiquitination of VDAC1

Ying Liu, Hanwen Zhang, Yiwei Liu, Siyue Zhang, Peng Su, Lijuan Wang, Yaming Li, Yiran Liang, Xiaolong Wang, Weijing Zhao, Bing Chen, Dan Luo, Ning Zhang, Qifeng Yang

Autophagy. 2023; 19(9): 2443–2463. Published online 2023 Mar 1. doi: 10.1080/15548627.2023.2182482

PMCID:: PMC10392732

Abstract Article PDF–10M

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