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Select item 106252631.

Expanding the clinical spectrum of cytosolic phosphoenolpyruvate carboxykinase deficiency: novel PCK1 variants in four Arabian Gulf families

Marwa Al Busaidi, Feda E. Mohamed, Eiman Al-Ajmi, Nadia Al Hashmi, Khalid Al-Thihli, Amna Al Futaisi, Watfa Al Mamari, Fathiya Al-Murshedi, Fatma Al-Jasmi

Orphanet J Rare Dis. 2023; 18: 344. Published online 2023 Nov 3. doi: 10.1186/s13023-023-02946-5

PMCID:: PMC10625263

Abstract Article PDF–1.2M

Select item 105426472.

Suppression of SLC39A6‐CREB1 axis in liver cancer causes PCK1‐mediated mitochondrial dysfunction

Ze Yu, Cheng Chen, Hongpeng Gu, Jinliang Dong, Yingjie Zhang, Jie Wang, Haijie Ma, Guoqiang Zhang

Cell Prolif. 2023 Oct; 56(10): e13527. Published online 2023 Jul 12. doi: 10.1111/cpr.13527

PMCID:: PMC10542647

Article PDF–1.5M

Select item 104033163.

Structure of the human UBR5 E3 ubiquitin ligase

Feng Wang, Qing He, Wenhu Zhan, Ziqi Yu, Efrat Finkin-Groner, Xiaojing Ma, Gang Lin, Huilin Li

Structure. Author manuscript; available in PMC 2023 Aug 4.

Published in final edited form as: Structure. 2023 May 4; 31(5): 541–552.e4. Published online 2023 Apr 10. doi: 10.1016/j.str.2023.03.010

PMCID:: PMC10403316

Abstract Article PDF–1.7M

Select item 103133624.

Gluconeogenic enzyme PCK1 supports S-adenosylmethionine biosynthesis and promotes H3K9me3 modification to suppress hepatocellular carcinoma progression

Dongmei Gou, Rui Liu, Xiaoqun Shan, Haijun Deng, Chang Chen, Jin Xiang, Yi Liu, Qingzhu Gao, Zhi Li, Ailong Huang, Kai Wang, Ni Tang

J Clin Invest. 2023 Jul 3; 133(13): e161713. Published online 2023 Jul 3. doi: 10.1172/JCI161713

PMCID:: PMC10313362

Abstract Article PDF–26M

Select item 88887535.

PCK1 regulates neuroendocrine differentiation in a positive feedback loop of LIF/ZBTB46 signalling in castration-resistant prostate cancer

Yu-Ching Wen, Chien-Liang Liu, Hsiu-Lien Yeh, Wei-Hao Chen, Kuo-Ching Jiang, Van Thi Ngoc Tram, Michael Hsiao, Jiaoti Huang, Wei-Yu Chen, Yen-Nien Liu

Br J Cancer. 2022 Mar 23; 126(5): 778–790. Published online 2021 Nov 24. doi: 10.1038/s41416-021-01631-3

PMCID:: PMC8888753

Abstract Article PDF–3.2M

Select item 82624736.

Gluconeogenic enzyme PCK1 deficiency promotes CHK2 O-GlcNAcylation and hepatocellular carcinoma growth upon glucose deprivation

Jin Xiang, Chang Chen, Rui Liu, Dongmei Gou, Lei Chang, Haijun Deng, Qingzhu Gao, Wanjun Zhang, Lin Tuo, Xuanming Pan, Li Liang, Jie Xia, Luyi Huang, Ke Yao, Bohong Wang, Zeping Hu, Ailong Huang, Kai Wang, Ni Tang

J Clin Invest. 2021 Apr 15; 131(8): e144703. Published online 2021 Apr 15. doi: 10.1172/JCI144703

PMCID:: PMC8262473

Abstract Article PDF–17M

Select item 81904787.

Phosphoenolpyruvate carboxykinase in cell metabolism: Roles and mechanisms beyond gluconeogenesis

Shuo Yu, Simin Meng, Meixiang Xiang, Hong Ma

Mol Metab. 2021 Nov; 53: 101257. Published online 2021 May 18. doi: 10.1016/j.molmet.2021.101257

PMCID:: PMC8190478

Abstract Article PDF–3.1M

Select item 81650308.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 79484139.

Self-acetylation at the active site of phosphoenolpyruvate carboxykinase (PCK1) controls enzyme activity

Pedro Latorre-Muro, Josue Baeza, Ramon Hurtado-Guerrero, Thomas Hicks, Ignacio Delso, Cristina Hernández-Ruiz, Adrian Velázquez-Campoy, Alexis J. Lawton, Jesús Angulo, John M. Denu, José A. Carrodeguas

J Biol Chem. 2021 Jan-Jun; 296: 100205. Published online 2021 Jan 21. doi: 10.1074/jbc.RA120.015103

PMCID:: PMC7948413

Abstract Article PDF–3.0M

Select item 729934010.

PCK1 and DHODH drive colorectal cancer liver metastatic colonization and hypoxic growth by promoting nucleotide synthesis

Norihiro Yamaguchi, Ethan M Weinberg, Alexander Nguyen, Maria V Liberti, Hani Goodarzi, Yelena Y Janjigian, Philip B Paty, Leonard B Saltz, T Peter Kingham, Jia Min Loo, Elisa de Stanchina, Sohail F Tavazoie

eLife. 2019; 8: e52135. Published online 2019 Dec 16. doi: 10.7554/eLife.52135

PMCID:: PMC7299340

Abstract Article PDF–3.1M

Select item 636324111.

Relationships of SLC2A4, RBP4, PCK1, and PI3K Gene Polymorphisms with Gestational Diabetes Mellitus in a Chinese Population

Shimin Hu, Shujuan Ma, Xun Li, Zhengwen Tian, Huiling Liang, Junxia Yan, Mengshi Chen, Hongzhuan Tan

Biomed Res Int. 2019; 2019: 7398063. Published online 2019 Jan 20. doi: 10.1155/2019/7398063

PMCID:: PMC6363241

Abstract Article PDF–721K

Select item 636069612.

PCK1 negatively regulates cell cycle progression and hepatoma cell proliferation via the AMPK/p27^Kip1 axis

Lin Tuo, Jin Xiang, Xuanming Pan, Jieli Hu, Hua Tang, Li Liang, Jie Xia, Yuan Hu, Wenlu Zhang, Ailong Huang, Kai Wang, Ni Tang

J Exp Clin Cancer Res. 2019; 38: 50. Published online 2019 Feb 4. doi: 10.1186/s13046-019-1029-y

PMCID:: PMC6360696

Abstract Article PDF–7.4M

Select item 631088413.

Characterization of interaction and ubiquitination of phosphoenolpyruvate carboxykinase by E3 ligase UBR5

Qingya Shen, Zhiyu Qiu, Wenping Wu, Jimin Zheng, Zongchao Jia

Biol Open. 2018 Dec 15; 7(12): bio037366. Published online 2018 Dec 15. doi: 10.1242/bio.037366

PMCID:: PMC6310884

Abstract Article PDF–1.4M

Select item 618866914.

Dynamic acetylation of cytosolic phosphoenolpyruvate carboxykinase toggles enzyme activity between gluconeogenic and anaplerotic reactions

Pedro Latorre-Muro, Josue Baeza, Eric A. Armstrong, Ramón Hurtado-Guerrero, Francisco Corzana, Lindsay E. Wu, David A. Sinclair, Pascual López-Buesa, José A. Carrodeguas, John M. Denu

Mol Cell. Author manuscript; available in PMC 2019 Sep 6.

Published in final edited form as: Mol Cell. 2018 Sep 6; 71(5): 718–732.e9. doi: 10.1016/j.molcel.2018.07.031

PMCID:: PMC6188669

Abstract Article PDF–3.4M

Select item 586093015.

Metabolic reprogramming by PCK1 promotes TCA cataplerosis, oxidative stress and apoptosis in liver cancer cells and suppresses hepatocellular carcinoma

Meng-Xi Liu, Lei Jin, Si-Jia Sun, Peng Liu, Xu Feng, Zhou-Li Cheng, Wei-Ren Liu, Kun-Liang Guan, Ying-Hong Shi, Hai-Xin Yuan, Yue Xiong

Oncogene. Author manuscript; available in PMC 2018 Jul 16.

Published in final edited form as: Oncogene. 2018 Mar; 37(12): 1637–1653. Published online 2018 Jan 16. doi: 10.1038/s41388-017-0070-6

PMCID:: PMC5860930

Abstract Article PDF–2.2M

Select item 553161116.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 548248117.

O-GlcNAcylation mediates the control of cytosolic phosphoenolpyruvate carboxykinase activity via Pgc1α

Pedro Latorre, Luis Varona, Carmen Burgos, José A. Carrodeguas, Pascual López-Buesa

PLoS One. 2017; 12(6): e0179988. Published online 2017 Jun 23. doi: 10.1371/journal.pone.0179988

Correction in:: PLoS One. 2017; 12(8): e0183566.

Correction in:: PLoS One. 2017; 12(8): e0183735.

PMCID:: PMC5482481

Abstract Article PDF–3.4M

Select item 533336318.

Nur77 suppresses hepatocellular carcinoma via switching glucose metabolism toward gluconeogenesis through attenuating phosphoenolpyruvate carboxykinase sumoylation

Xue-li Bian, Hang-zi Chen, Peng-bo Yang, Ying-ping Li, Fen-na Zhang, Jia-yuan Zhang, Wei-jia Wang, Wen-xiu Zhao, Sheng Zhang, Qi-tao Chen, Yu Zheng, Xiao-yu Sun, Xiao-min Wang, Kun-Yi Chien, Qiao Wu

Nat Commun. 2017; 8: 14420. Published online 2017 Feb 27. doi: 10.1038/ncomms14420

PMCID:: PMC5333363

Abstract Article PDF–3.0M

Select item 505412319.

Identification of Conserved Regulatory Elements in Mammalian Promoter Regions: A Case Study Using the PCK1 Promoter

George E. Liu, Matthew T. Weirauch, Curtis P. Van Tassell, Robert W. Li, Tad S. Sonstegard, Lakshmi K. Matukumalli, Erin E. Connor, Richard W. Hanson, Jianqi Yang

Genomics Proteomics Bioinformatics. 2008; 6(3-4): 129–143. Published online 2009 Mar 27. doi: 10.1016/S1672-0229(09)60001-2

PMCID:: PMC5054123

Abstract Article PDF–678K

Select item 463137520.

Mixed Inhibition of cPEPCK by Genistein, Using an Extended Binding Site Located Adjacent to Its Catalytic Cleft

Shashank Prakash Katiyar, Arpit Jain, Jaspreet Kaur Dhanjal, Durai Sundar

PLoS One. 2015; 10(11): e0141987. Published online 2015 Nov 3. doi: 10.1371/journal.pone.0141987

PMCID:: PMC4631375

Abstract Article PDF–4.3M

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