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Select item 112818081.

Adenylate cyclase 3: a potential genetic link between obesity and major depressive disorder

Mackenzie Fitzpatrick, Leah C. Solberg Woods

Physiol Genomics. 2024 Jan 1; 56(1): 1–8. Published online 2023 Nov 13. doi: 10.1152/physiolgenomics.00056.2023

PMCID:: PMC11281808

Abstract Article

Select item 109168662.

Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma

Suzannah G. Miller, Maria Hoh, Christopher C. Ebmeier, Jian Wei Tay, Natalie G. Ahn

Mol Biol Cell. 2024 Mar 1; 35(3): ar31. Published online 2024 Jan 29. doi: 10.1091/mbc.E23-06-0255

PMCID:: PMC10916866

Abstract Article PDF–4.7M

Select item 108547903.

Postnatal Dynamic Ciliary ARL13B and ADCY3 Localization in the Mouse Brain

Katlyn K. Brewer, Kathryn M. Brewer, Tiffany T. Terry, Tamara Caspary, Christian Vaisse, Nicolas F. Berbari

Cells. 2024 Feb; 13(3): 259. Published online 2024 Jan 30. doi: 10.3390/cells13030259

PMCID:: PMC10854790

Abstract Article PDF–13M

Select item 86512294.

Molecular modelling of novel ADCY3 variant predicts a molecular target for tackling obesity

Meropi Toumba, Pavlos Fanis, Dimitrios Vlachakis, Vassos Neocleous, Leonidas A. Phylactou, Nicos Skordis, Christos S. Mantzoros, Maria Pantelidou

Int J Mol Med. 2022 Jan; 49(1): 10. Published online 2021 Nov 24. doi: 10.3892/ijmm.2021.5065

PMCID:: PMC8651229

Abstract Article PDF–4.2M

Select item 81650305.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 73220676.

RIG-I regulates myeloid differentiation by promoting TRIM25-mediated ISGylation

Song-Fang Wu, Li Xia, Xiao-Dong Shi, Yu-Jun Dai, Wei-Na Zhang, Jun-Mei Zhao, Wu Zhang, Xiang-Qin Weng, Jing Lu, Huang-Ying Le, Sheng-ce Tao, Jiang Zhu, Zhu Chen, Yue-Ying Wang, Saijuan Chen

Proc Natl Acad Sci U S A. 2020 Jun 23; 117(25): 14395–14404. Published online 2020 Jun 8. doi: 10.1073/pnas.1918596117

PMCID:: PMC7322067

Abstract Article PDF–2.7M

Select item 67579477.

Ko Kobayakawa, Reiko Hayashi, Kenji Morita, Kazunari Miyamichi, Yuichiro Oka, Akio Tsuboi, Hitoshi Sakano

J Neurosci. 2002 Jul 15; 22(14): 5931–5937. doi: 10.1523/JNEUROSCI.22-14-05931.2002

PMCID:: PMC6757947

Abstract Article PDF–655K

Select item 66727058.

Absence of Adenylyl Cyclase 3 Perturbs Peripheral Olfactory Projections in Mice

Dong-Jing Zou, Alexander T. Chesler, Claire E. Le Pichon, Andriy Kuznetsov, Xin Pei, Eugene L. Hwang, Stuart Firestein

J Neurosci. 2007 Jun 20; 27(25): 6675–6683. doi: 10.1523/JNEUROSCI.0699-07.2007

PMCID:: PMC6672705

Abstract Article PDF–605K

Select item 60248019.

Interaction between an ADCY3 Genetic Variant and Two Weight-Lowering Diets Affecting Body Fatness and Body Composition Outcomes Depending on Macronutrient Distribution: A Randomized Trial

Leticia Goni, Jose Ignacio Riezu-Boj, Fermín I. Milagro, Fernando J. Corrales, Lourdes Ortiz, Marta Cuervo, J. Alfredo Martínez

Nutrients. 2018 Jun; 10(6): 789. Published online 2018 Jun 19. doi: 10.3390/nu10060789

PMCID:: PMC6024801

Abstract Article PDF–527K

Select item 582810610.

Loss-of-function variants in ADCY3 increase risk of obesity and type 2 diabetes

Niels Grarup, Ida Moltke, Mette K. Andersen, Maria Dalby, Kristoffer Vitting-Seerup, Timo Kern, Yuvaraj Mahendran, Emil Jørsboe, Christina V. L. Larsen, Inger K. Dahl-Petersen, Arthur Gilly, Daniel Suveges, George Dedoussis, Eleftheria Zeggini, Oluf Pedersen, Robin Andersson, Peter Bjerregaard, Marit E. Jørgensen, Anders Albrechtsen, Torben Hansen

Nat Genet. Author manuscript; available in PMC 2018 Jul 8.

Published in final edited form as: Nat Genet. 2018 Feb; 50(2): 172–174. Published online 2018 Jan 8. doi: 10.1038/s41588-017-0022-7

PMCID:: PMC5828106

Abstract Article PDF–546K

Select item 582692611.

VIRMA mediates preferential m⁶A mRNA methylation in 3′UTR and near stop codon and associates with alternative polyadenylation

Yanan Yue, Jun Liu, Xiaolong Cui, Jie Cao, Guanzheng Luo, Zezhou Zhang, Tao Cheng, Minsong Gao, Xiao Shu, Honghui Ma, Fengqin Wang, Xinxia Wang, Bin Shen, Yizhen Wang, Xinhua Feng, Chuan He, Jianzhao Liu

Cell Discov. 2018; 4: 10. Published online 2018 Feb 27. doi: 10.1038/s41421-018-0019-0

PMCID:: PMC5826926

Abstract Article PDF–2.3M

Select item 580564612.

Subcellular localization of MC4R with ADCY3 at neuronal primary cilia underlies a common pathway for genetic predisposition to obesity

Jacqueline E. Siljee, Yi Wang, Adelaide A. Bernard, Baran A. Ersoy, Sumei Zhang, Aaron Marley, Mark Von Zastrow, Jeremy F. Reiter, Christian Vaisse

Nat Genet. Author manuscript; available in PMC 2018 Jul 8.

Published in final edited form as: Nat Genet. 2018 Feb; 50(2): 180–185. Published online 2018 Jan 8. doi: 10.1038/s41588-017-0020-9

PMCID:: PMC5805646

Article PDF–1.5M

Select item 563060013.

Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism

Giulia Antoniali, Fabrizio Serra, Lisa Lirussi, Mikiei Tanaka, Chiara D’Ambrosio, Shiheng Zhang, Slobodanka Radovic, Emiliano Dalla, Yari Ciani, Andrea Scaloni, Mengxia Li, Silvano Piazza, Gianluca Tell

Nat Commun. 2017; 8: 797. Published online 2017 Oct 6. doi: 10.1038/s41467-017-00842-8

PMCID:: PMC5630600

Abstract Article PDF–2.3M

Select item 553161114.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 549522515.

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing

Teng Fei, Yiwen Chen, Tengfei Xiao, Wei Li, Laura Cato, Peng Zhang, Maura B. Cotter, Michaela Bowden, Rosina T. Lis, Shuang G. Zhao, Qiu Wu, Felix Y. Feng, Massimo Loda, Housheng Hansen He, X. Shirley Liu, Myles Brown

Proc Natl Acad Sci U S A. 2017 Jun 27; 114(26): E5207–E5215. Published online 2017 Jun 13. doi: 10.1073/pnas.1617467114

PMCID:: PMC5495225

Abstract Article PDF–1.3M

Select item 526628316.

Adenylate Cyclase Type III Is Not a Ubiquitous Marker for All Primary Cilia during Development

Maria Cristina Antal, Karelle Bénardais, Brigitte Samama, Cyril Auger, Valérie Schini-Kerth, Said Ghandour, Nelly Boehm

PLoS One. 2017; 12(1): e0170756. Published online 2017 Jan 25. doi: 10.1371/journal.pone.0170756

PMCID:: PMC5266283

Abstract Article PDF–1.8M

Select item 461721117.

The BioPlex Network: A Systematic Exploration of the Human Interactome

Edward L. Huttlin, Lily Ting, Raphael J. Bruckner, Fana Gebreab, Melanie P. Gygi, John Szpyt, Stanley Tam, Gabriela Zarraga, Greg Colby, Kurt Baltier, Rui Dong, Virginia Guarani, Laura Pontano Vaites, Alban Ordureau, Ramin Rad, Brian K. Erickson, Martin Wühr, Joel Chick, Bo Zhai, Deepak Kolippakkam, Julian Mintseris, Robert A. Obar, Tim Harris, Spyros Artavanis-Tsakonas, Mathew E. Sowa, Pietro DeCamilli, Joao A. Paulo, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2016 Jul 16.

Published in final edited form as: Cell. 2015 Jul 16; 162(2): 425–440. doi: 10.1016/j.cell.2015.06.043

PMCID:: PMC4617211

Abstract Article PDF–2.2M

Select item 429478018.

Sustained signalling by PTH modulates IP₃ accumulation and IP₃ receptors through cyclic AMP junctions

Abha Meena, Stephen C. Tovey, Colin W. Taylor

J Cell Sci. 2015 Jan 15; 128(2): 408–420. doi: 10.1242/jcs.163071

PMCID:: PMC4294780

Abstract Article

Select item 426520719.

Genome-wide association study of height-adjusted BMI in childhood identifies functional variant in ADCY3

Evangelia Stergiakouli, Romy Gaillard, Jeremy M Tavaré, Nina Balthasar, Ruth J Loos, Hendrik R Taal, David M Evans, Fernando Rivadeneira, Beate St Pourcain, André G Uitterlinden, John P Kemp, Albert Hofman, Susan M Ring, Tim J Cole, Vincent WV Jaddoe, George Davey Smith, Nicholas J Timpson

Obesity (Silver Spring) 2014 Oct; 22(10): 2252–2259. Published online 2014 Jul 21. doi: 10.1002/oby.20840

PMCID:: PMC4265207

Abstract Article PDF–578K

Select item 416882020.

Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index

Wanqing Wen, Wei Zheng, Yukinori Okada, Fumihiko Takeuchi, Yasuharu Tabara, Joo-Yeon Hwang, Rajkumar Dorajoo, Huaixing Li, Fuu-Jen Tsai, Xiaobo Yang, Jiang He, Ying Wu, Meian He, Yi Zhang, Jun Liang, Xiuqing Guo, Wayne Huey-Herng Sheu, Ryan Delahanty, Xingyi Guo, Michiaki Kubo, Ken Yamamoto, Takayoshi Ohkubo, Min Jin Go, Jian Jun Liu, Wei Gan, Ching-Chu Chen, Yong Gao, Shengxu Li, Nanette R. Lee, Chen Wu, Xueya Zhou, Huaidong Song, Jie Yao, I-Te Lee, Jirong Long, Tatsuhiko Tsunoda, Koichi Akiyama, Naoyuki Takashima, Yoon Shin Cho, Rick TH Ong, Ling Lu, Chien-Hsiun Chen, Aihua Tan, Treva K Rice, Linda S. Adair, Lixuan Gui, Matthew Allison, Wen-Jane Lee, Qiuyin Cai, Minoru Isomura, Satoshi Umemura, Young Jin Kim, Mark Seielstad, James Hixson, Yong-Bing Xiang, Masato Isono, Bong-Jo Kim, Xueling Sim, Wei Lu, Toru Nabika, Juyoung Lee, Wei-Yen Lim, Yu-Tang Gao, Ryoichi Takayanagi, Dae-Hee Kang, Tien Yin Wong, Chao Agnes Hsiung, I-Chien Wu, Jyh-Ming Jimmy Juang, Jiajun Shi, Bo Youl Choi, Tin Aung, Frank Hu, Mi Kyung Kim, Wei Yen Lim, Tzung-Dao Wang, Min-Ho Shin, Jeannette Lee, Bu-Tian Ji, Young-Hoon Lee, Terri L. Young, Dong Hoon Shin, Byung-Yeol Chun, Myeong-Chan Cho, Bok-Ghee Han, Chii-Min Hwu, Themistocles L. Assimes, Devin Absher, Xiaofei Yan, Eric Kim, Jane Z. Kuo, Soonil Kwon, Kent D. Taylor, Yii-Der I. Chen, Jerome I. Rotter, Lu Qi, Dingliang Zhu, Tangchun Wu, Karen L. Mohlke, Dongfeng Gu, Zengnan Mo, Jer-Yuarn Wu, Xu Lin, Tetsuro Miki, E. Shyong Tai, Jong-Young Lee, Norihiro Kato, Xiao-Ou Shu, Toshihiro Tanaka

Hum Mol Genet. 2014 Oct 15; 23(20): 5492–5504. Published online 2014 May 26. doi: 10.1093/hmg/ddu248

PMCID:: PMC4168820

Abstract Article PDF–791K

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