PMC Links for GEO Profiles (Select 74015404) - PMC

Select item 111589001.

Human homolog of NOTUM, overexpressed in hepatocellular carcinoma, is regulated transcriptionally by β‐catenin/TCF

Yuichi Torisu, Akira Watanabe, Aya Nonaka, Yutaka Midorikawa, Masatoshi Makuuchi, Takahiro Shimamura, Haruhiko Sugimura, Atsushi Niida, Tetsu Akiyama, Hiroko Iwanari, Tatsuhiko Kodama, Mikio Zeniya, Hiroyuki Aburatani

Cancer Sci. 2008 Jun; 99(6): 1139–1146. Published online 2008 Apr 21. doi: 10.1111/j.1349-7006.2008.00814.x

PMCID:: PMC11158900

Abstract Article PDF–285K

Select item 110909662.

Notum enhances gastric cancer stem-like cell properties through upregulation of Sox2 by PI3K/AKT signaling pathway

Yi Liu, Hui Chen, Lanshu Xiao, Ping Dong, Yanhui Ma, Yunlan Zhou, Junyao Yang, Bingxian Bian, Guohua Xie, Lei Chen, Lisong Shen

Cell Oncol (Dordr) 2024; 47(2): 463–480. Published online 2023 Sep 26. doi: 10.1007/s13402-023-00875-w

PMCID:: PMC11090966

Abstract Article PDF–11M

Select item 88064813.

Notum palmitoleoyl-protein carboxylesterase regulates Fas cell surface death receptor-mediated apoptosis via the Wnt signaling pathway in colon adenocarcinoma

Hua Gong, Qiang Niu, Yi Zhou, YUN-Xia Wang, Xuan-Fu Xu, Ke-Zhu Hou

Bioengineered. 2021; 12(1): 5241–5252. Published online 2021 Aug 17. doi: 10.1080/21655979.2021.1961657

PMCID:: PMC8806481

Abstract Article PDF–1.9M

Select item 81518024.

Paneth cell produced Notum attenuates regeneration of aged intestinal epithelium

Nalle Pentinmikko, Sharif Iqbal, Miyeko Mana, Simon Andersson, III Armand B. Cognetta, Radu M. Suciu, Jatin Roper, Kalle Luopajärvi, Eino Markelin, Swetha Gopalakrishnan, Olli-Pekka Smolander, Santiago Naranjo, Tuure Saarinen, Anne Juuti, Kirsi Pietiläinen, Petri Auvinen, Ari Ristimäki, Nitin Gupta, Tuomas Tammela, Tyler Jacks, David M. Sabatini, Benjamin F. Cravatt, Ömer H. Yilmaz, Pekka Katajisto

Nature. Author manuscript; available in PMC 2021 May 26.

Published in final edited form as: Nature. 2019 Jul; 571(7765): 398–402. Published online 2019 Jul 10. doi: 10.1038/s41586-019-1383-0

PMCID:: PMC8151802

Abstract Article PDF–4.8M

Select item 80102185.

Notum deacylates octanoylated ghrelin

Yuguang Zhao, Laura-Nadine Schuhmacher, Morgan Roberts, Satoshi Kakugawa, Ganka Bineva-Todd, Steve Howell, Nicola O'Reilly, Christine Perret, Ambrosius P. Snijders, Jean-Paul Vincent, E. Yvonne Jones

Mol Metab. 2021 Jul; 49: 101201. Published online 2021 Feb 27. doi: 10.1016/j.molmet.2021.101201

PMCID:: PMC8010218

Abstract Article PDF–2.1M

Select item 76150496.

Apc-mutant cells deploy Notum to bias clonal competition and drive cancer

Dustin J. Flanagan, Nalle Pentinmikko, Kalle Luopajärvi, Nicky J. Willis, Kathryn Gilroy, Alexander P. Raven, Lynn Mcgarry, Johanna I. Englund, Anna Webb, Sandra Scharaw, Nadia Nasreddin, Michael C. Hodder, Rachel A. Ridgway, Emma Minnee, Nathalie Sphyris, Ella Gilchrist, Arafath K. Najumudeen, Beatrice Romagnolo, Christine Perret, Ann C. Williams, Hans Clevers, Pirjo Nummela, Marianne Lähde, Kari Alitalo, Ville Hietakangas, Ann Hedley, William Clark, Colin Nixon, Kristina Kirschner, E. Yvonne Jones, Ari Ristimäki, Simon Leedham, Paul V. Fish, Jean-Paul Vincent, Pekka Katajisto, Owen J. Sansom

Nature. Author manuscript; available in PMC 2023 Sep 7.

Published in final edited form as: Nature. 2021 Jun 1; 594(7863): 430–435. Published online 2021 Jun 2. doi: 10.1038/s41586-021-03525-z

PMCID:: PMC7615049

Abstract Article PDF–3.9M

Select item 71699837.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 70275358.

Structural characterization of melatonin as an inhibitor of the Wnt deacylase Notum

Yuguang Zhao, Jingshan Ren, James Hillier, Margaret Jones, Weixian Lu, Edith Yvonne Jones

J Pineal Res. 2020 Mar; 68(2): e12630. Published online 2020 Jan 24. doi: 10.1111/jpi.12630

PMCID:: PMC7027535

Abstract Article PDF–1.4M

Select item 67666469.

Osteoblast-derived NOTUM reduces cortical bone mass in mice and the NOTUM locus is associated with bone mineral density in humans

Sofia Movérare-Skrtic, Karin H. Nilsson, Petra Henning, Thomas Funck-Brentano, Maria Nethander, Fernando Rivadeneira, Glaucia Coletto Nunes, Antti Koskela, Juha Tuukkanen, Jan Tuckermann, Christine Perret, Pedro Paulo Chaves Souza, Ulf H. Lerner, Claes Ohlsson

FASEB J. 2019 Oct; 33(10): 11163–11179. Published online 2019 Jul 15. doi: 10.1096/fj.201900707R

PMCID:: PMC6766646

Abstract Article

Select item 632312510.

NOTUM inhibition increases endocortical bone formation and bone strength

Robert Brommage, Jeff Liu, Peter Vogel, Faika Mseeh, Andrea Y. Thompson, David G. Potter, Melanie K. Shadoan, Gwenn M. Hansen, Sabrina Jeter-Jones, Jie Cui, Dawn Bright, Jennifer P. Bardenhagen, Deon D. Doree, Sofia Movérare-Skrtic, Karin H. Nilsson, Petra Henning, Ulf H. Lerner, Claes Ohlsson, Arthur T. Sands, James E. Tarver, David R. Powell, Brian Zambrowicz, Qingyun Liu

Bone Res. 2019; 7: 2. Published online 2019 Jan 8. doi: 10.1038/s41413-018-0038-3

PMCID:: PMC6323125

Abstract Article PDF–1.2M

Select item 629978911.

NOTUM Is Involved in the Progression of Colorectal Cancer

JONG HYUK YOON, DAYEA KIM, JAEYOON KIM, HYEONGJOO LEE, JAEWANG GHIM, BYUNG JUN KANG, PARKYONG SONG, PANN-GHILL SUH, SUNG HO RYU, TAEHOON G LEE

Cancer Genomics Proteomics. 2018 Nov-Dec; 15(6): 485–497. Published online 2018 Nov 3. doi: 10.21873/cgp.20107

PMCID:: PMC6299789

Abstract Article PDF–561K

Select item 474740312.

Novel insights into Notum and glypicans regulation in colorectal cancer

Mariangela De Robertis, Maddalena Arigoni, Luisa Loiacono, Federica Riccardo, Raffaele Adolfo Calogero, Yana Feodorova, Dessislava Tashkova, Vesselin Belovejdov, Victoria Sarafian, Federica Cavallo, Emanuela Signori

Oncotarget. 2015 Dec 1; 6(38): 41237–41257. Published online 2015 Oct 20. doi: 10.18632/oncotarget.5652

PMCID:: PMC4747403

Abstract Article PDF–2.3M

Select item 464794113.

hORFeome v3.1: A resource of human open reading frames representing over 10,000 human genes

Philippe Lamesch, Ning Li, Stuart Milstein, Changyu Fan, Tong Hao, Gabor Szabo, Zhenjun Hu, Kavitha Venkatesan, Graeme Bethel, Paul Martin, Jane Rogers, Stephanie Lawlor, Stuart McLaren, Amélie Dricot, Heather Borick, Michael E. Cusick, Jean Vandenhaute, Ian Dunham, David E. Hill, Marc Vidal

Genomics. 2007 Mar; 89(3): 307–315. doi: 10.1016/j.ygeno.2006.11.012

PMCID:: PMC4647941

Abstract Article

Select item 437648914.

Notum deacylates Wnts to suppress signalling activity

Satoshi Kakugawa, Paul F. Langton, Matthias Zebisch, Steve Howell, Tao-Hsin Chang, Yan Liu, Ten Feizi, Ganka Bineva, Nicola O’Reilly, Ambrosius P. Snijders, E. Yvonne Jones, Jean-Paul Vincent

Nature. Author manuscript; available in PMC 2015 Sep 12.

Published in final edited form as: Nature. 2015 Mar 12; 519(7542): 187–192. Published online 2015 Feb 25. doi: 10.1038/nature14259

PMCID:: PMC4376489

Abstract Article PDF–5.0M

Select item 317805915.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 13924116.

Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences

Mammalian Gene Collection (MGC) Program Team

Proc Natl Acad Sci U S A. 2002 Dec 24; 99(26): 16899–16903. Published online 2002 Dec 11. doi: 10.1073/pnas.242603899

PMCID:: PMC139241

Abstract Article PDF–118K

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