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Select item 111848361.

Combined HRAS and NRAS ablation induces a RASopathy phenotype in mice

Rocío Fuentes-Mateos, Rósula García-Navas, Cristina Fernández-Infante, Luis Hernández-Cano, Nuria Calzada-Nieto, Andrea Olarte-San Juan, Carmen Guerrero, Eugenio Santos, Alberto Fernández-Medarde

Cell Commun Signal. 2024; 22: 332. Published online 2024 Jun 17. doi: 10.1186/s12964-024-01717-4

PMCID:: PMC11184836

Abstract Article PDF–2.1M

Select item 107712232.

Deletion of Small GTPase H-Ras Rescues Memory Deficits and Reduces Amyloid Plaque-Associated Dendritic Spine Loss in Transgenic Alzheimer’s Mice

Wenhui Qu, Angela Jeong, Rui Zhong, Josslen S. Thieschafer, Andrea Gram, Ling Li

Mol Neurobiol. Author manuscript; available in PMC 2024 Jan 6.

Published in final edited form as: Mol Neurobiol. 2023 Feb; 60(2): 495–511. Published online 2022 Oct 26. doi: 10.1007/s12035-022-03082-0

PMCID:: PMC10771223

Abstract Article PDF–1.7M

Select item 101451923.

Murine models of HRAS-mediated cutaneous skeletal hypophosphatemia syndrome suggest bone as the FGF23 excess source

Diana Ovejero, Zachary Michel, Christophe Cataisson, Amanda Saikali, Rebeca Galisteo, Stuart H. Yuspa, Michael T. Collins, Luis F. de Castro

J Clin Invest. 2023 May 1; 133(9): e159330. Published online 2023 May 1. doi: 10.1172/JCI159330

PMCID:: PMC10145192

Abstract Article PDF–17M

Select item 101224304.

RAS oncogene signal strength regulates matrisomal gene expression and tumorigenicity of mouse keratinocytes

Christophe Cataisson, Alex J Lee, Ashley M Zhang, Alicia Mizes, Serena Korkmaz, Brandi L Carofino, Thomas J Meyer, Aleksandra M Michalowski, Luowei Li, Stuart H Yuspa

Carcinogenesis. 2022 Dec; 43(12): 1149–1161. Published online 2022 Oct 28. doi: 10.1093/carcin/bgac083

PMCID:: PMC10122430

Abstract Article PDF–24M

Select item 99608965.

Gain-of-Function p53N236S Mutation Drives the Bypassing of HRas^V12-Induced Cellular Senescence via PGC–1α

Hao Yang, Ke Zhang, Yusheng Guo, Xin Guo, Kailong Hou, Jing Hou, Ying Luo, Jing Liu, Shuting Jia

Int J Mol Sci. 2023 Feb; 24(4): 3790. Published online 2023 Feb 14. doi: 10.3390/ijms24043790

PMCID:: PMC9960896

Abstract Article PDF–3.4M

Select item 97508806.

Ras drives malignancy through stem cell crosstalk with the microenvironment

Shaopeng Yuan, Katherine S. Stewart, Yihao Yang, Merve Deniz Abdusselamoglu, S. Martina Parigi, Tamar Y. Feinberg, Karen Tumaneng, Hanseul Yang, John M. Levorse, Lisa Polak, David Ng, Elaine Fuchs

Nature. 2022; 612(7940): 555–563. Published online 2022 Nov 30. doi: 10.1038/s41586-022-05475-6

PMCID:: PMC9750880

Abstract Article PDF–23M

Select item 96241757.

Increased osteoclastogenesis contributes to bone loss in the Costello syndrome Hras G12V mouse model

Sayantan Nandi, Saravanakkumar Chennappan, Yannik Andrasch, Miray Fidan, Melanie Engler, Mubashir Ahmad, Jan P. Tuckermann, Martin Zenker, Ion Cristian Cirstea

Front Cell Dev Biol. 2022; 10: 1000575. Published online 2022 Oct 18. doi: 10.3389/fcell.2022.1000575

PMCID:: PMC9624175

Abstract Article PDF–2.8M

Select item 95330108.

Impaired Proteolysis of Noncanonical RAS Proteins Drives Clonal Hematopoietic Transformation

Sisi Chen, Rahul S. Vedula, Antonio Cuevas-Navarro, Bin Lu, Simon J. Hogg, Eric Wang, Salima Benbarche, Katherine Knorr, Won Jun Kim, Robert F. Stanley, Hana Cho, Caroline Erickson, Michael Singer, Dan Cui, Steven Tittley, Benjamin H. Durham, Tatiana S. Pavletich, Elise Fiala, Michael F. Walsh, Daichi Inoue, Sebastien Monette, Justin Taylor, Neal Rosen, Frank McCormick, R. Coleman Lindsley, Pau Castel, Omar Abdel-Wahab

Cancer Discov. 2022 Oct 5; 12(10): 2434–2453. Published online 2022 Jul 29. doi: 10.1158/2159-8290.CD-21-1631

PMCID:: PMC9533010

Abstract Article PDF–11M

Select item 92917129.

Redox-sensitive small GTPase H-Ras in murine astrocytes, an in vitro study

Candida Zuchegna, Antonio Porcellini, Samantha Messina

Redox Rep. 2022; 27(1): 150–157. Published online 2022 Jul 13. doi: 10.1080/13510002.2022.2094109

Correction in:: Redox Rep. 2022; 27(1): 176.

PMCID:: PMC9291712

Abstract Article PDF–1.5M

Select item 901229310.

HRAS germline mutations impair LKB1/AMPK signaling and mitochondrial homeostasis in Costello syndrome models

Laetitia Dard, Christophe Hubert, Pauline Esteves, Wendy Blanchard, Ghina Bou About, Lyla Baldasseroni, Elodie Dumon, Chloe Angelini, Mégane Delourme, Véronique Guyonnet-Dupérat, Stéphane Claverol, Laura Fontenille, Karima Kissa, Pierre-Emmanuel Séguéla, Jean-Benoît Thambo, Lévy Nicolas, Yann Herault, Nadège Bellance, Nivea Dias Amoedo, Frédérique Magdinier, Tania Sorg, Didier Lacombe, Rodrigue Rossignol

J Clin Invest. 2022 Apr 15; 132(8): e131053. Published online 2022 Apr 15. doi: 10.1172/JCI131053

PMCID:: PMC9012293

Abstract Article PDF–14M

Select item 861731111.

MEK-inhibitor-mediated rescue of skeletal myopathy caused by activating Hras mutation in a Costello syndrome mouse model

William E. Tidyman, Alice F. Goodwin, Yoshiko Maeda, Ophir D. Klein, Katherine A. Rauen

Dis Model Mech. 2022 Feb 1; 15(2): dmm049166. Published online 2021 Nov 19. doi: 10.1242/dmm.049166

PMCID:: PMC8617311

Abstract Article

Select item 849231912.

Targeting CDK4 overcomes EMT-mediated tumor heterogeneity and therapeutic resistance in KRAS-mutant lung cancer

Aparna Padhye, Jessica M. Konen, B. Leticia Rodriguez, Jared J. Fradette, Joshua K. Ochieng, Lixia Diao, Jing Wang, Wei Lu, Luisa S. Solis, Harsh Batra, Maria G. Raso, Michael D. Peoples, Rosalba Minelli, Alessandro Carugo, Christopher A. Bristow, Don L. Gibbons

JCI Insight. 2021 Sep 8; 6(17): e148392. Published online 2021 Sep 8. doi: 10.1172/jci.insight.148392

PMCID:: PMC8492319

Abstract Article PDF–7.9M

Select item 844884613.

Pericyte-derived fibrotic scarring is conserved across diverse central nervous system lesions

David O. Dias, Jannis Kalkitsas, Yildiz Kelahmetoglu, Cynthia P. Estrada, Jemal Tatarishvili, Daniel Holl, Linda Jansson, Shervin Banitalebi, Mahmood Amiry-Moghaddam, Aurélie Ernst, Hagen B. Huttner, Zaal Kokaia, Olle Lindvall, Lou Brundin, Jonas Frisén, Christian Göritz

Nat Commun. 2021; 12: 5501. Published online 2021 Sep 17. doi: 10.1038/s41467-021-25585-5

PMCID:: PMC8448846

Abstract Article PDF–23M

Select item 835389314.

Generation of combined hepatocellular‐cholangiocarcinoma through transdifferentiation and dedifferentiation in p53‐knockout mice

Yang Liu, Bing Xin, Masahiro Yamamoto, Masanori Goto, Takako Ooshio, Yuki Kamikokura, Hiroki Tanaka, Lingtong Meng, Yoko Okada, Yusuke Mizukami, Yuji Nishikawa

Cancer Sci. 2021 Aug; 112(8): 3111–3124. Published online 2021 Jun 27. doi: 10.1111/cas.14996

PMCID:: PMC8353893

Abstract Article PDF–3.3M

Select item 831323915.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

Select item 799392116.

Selective translation of cell fate regulators mediates tolerance to broad oncogenic stress

Elise Y. Cai, Megan N. Kufeld, Samantha Schuster, Sonali Arora, Madeline Larkin, Alexandre A. Germanos, Andrew C. Hsieh, Slobodan Beronja

Cell Stem Cell. Author manuscript; available in PMC 2021 Aug 6.

Published in final edited form as: Cell Stem Cell. 2020 Aug 6; 27(2): 270–283.e7. Published online 2020 Jun 8. doi: 10.1016/j.stem.2020.05.007

PMCID:: PMC7993921

Abstract Article PDF–1.2M

Select item 793877017.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 781717318.

Interplay of opposing fate choices stalls oncogenic growth in murine skin epithelium

Madeline Sandoval, Zhe Ying, Slobodan Beronja

eLife. 2021; 10: e54618. Published online 2021 Jan 4. doi: 10.7554/eLife.54618

PMCID:: PMC7817173

Abstract Article PDF–6.0M

Select item 771827619.

Epigenetic activation of a RAS/MYC axis in H3.3K27M-driven cancer

Sanja Pajovic, Robert Siddaway, Taylor Bridge, Javal Sheth, Patricia Rakopoulos, Byungjin Kim, Scott Ryall, Sameer Agnihotri, Lauren Phillips, Man Yu, Christopher Li, Scott Milos, Palak Patel, Dilakshan Srikanthan, Annie Huang, Cynthia Hawkins

Nat Commun. 2020; 11: 6216. Published online 2020 Dec 4. doi: 10.1038/s41467-020-19972-7

PMCID:: PMC7718276

Abstract Article PDF–2.5M

Select item 742686920.

Costello syndrome model mice with a Hras^G12S/+ mutation are susceptible to develop house dust mite-induced atopic dermatitis

Yu Katata, Shin-ichi Inoue, Atsuko Asao, Shuhei Kobayashi, Hitoshi Terui, Aya Inoue-Shibui, Taiki Abe, Tetsuya Niihori, Setsuya Aiba, Naoto Ishii, Shigeo Kure, Yoko Aoki

Cell Death Dis. 2020 Aug; 11(8): 617. Published online 2020 Aug 13. doi: 10.1038/s41419-020-02845-8

PMCID:: PMC7426869

Abstract Article PDF–3.5M

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