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Items: 1 to 20 of 426

1.
Impact of RANGAP1 SUMOylation on Smad4 nuclear export by bioinformatic analysis and cell assays
Feng Zhang, Jun Yang, Yifei Cheng
Biomol Biomed. 2024 Dec 1; 24(6): 1620–1636. Published online 2024 Dec 1. doi: 10.17305/bb.2024.10443
PMCID:
PMC11496865
AbstractArticlePDF–4.0M
2.
SMAD4 mutations causing Myhre syndrome are under positive selection in the male germline
Katherine A. Wood, R Spencer Tong, Marialetizia Motta, Viviana Cordeddu, Eleanor R. Scimone, Stephen J. Bush, Dale W. Maxwell, Eleni Giannoulatou, Viviana Caputo, Alice Traversa, Cecilia Mancini, Giovanni B. Ferrero, Francesco Benedicenti, Paola Grammatico, Daniela Melis, Katharina Steindl, Nicola Brunetti-Pierri, Eva Trevisson, Andrew OM. Wilkie, Angela E. Lin, Valerie Cormier-Daire, Stephen RF. Twigg, Marco Tartaglia, Anne Goriely
Am J Hum Genet. 2024 Sep 5; 111(9): 1953–1969. Published online 2024 Aug 7. doi: 10.1016/j.ajhg.2024.07.006
PMCID:
PMC11444041
AbstractArticlePDF–3.0M
3.
Clinical and Molecular Characterization of SMAD4 Splicing Variants in Patients with Juvenile Polyposis Syndrome
Giovanna Forte, Antonia Lucia Buonadonna, Candida Fasano, Paola Sanese, Filomena Cariola, Andrea Manghisi, Anna Filomena Guglielmi, Martina Lepore Signorile, Katia De Marco, Valentina Grossi, Vittoria Disciglio, Cristiano Simone
Int J Mol Sci. 2024 Jul; 25(14): 7939. Published online 2024 Jul 20. doi: 10.3390/ijms25147939
PMCID:
PMC11276957
AbstractArticlePDF–1.7M
4.
Antagonistic roles of canonical and alternative-RPA in disease-associated tandem CAG repeat instability
Terence Gall-Duncan, Jennifer Luo, Carla-Marie Jurkovic, Laura A. Fischer, Kyota Fujita, Amit L. Deshmukh, Rachel J. Harding, Stephanie Tran, Mustafa Mehkary, Vanessa Li, David E. Leib, Ran Chen, Hikari Tanaka, Amanda G. Mason, Dominique Lévesque, Mahreen Khan, Mortezaali Razzaghi, Tanya Prasolava, Stella Lanni, Nozomu Sato, Marie-Christine Caron, Gagan B. Panigrahi, Peixiang Wang, Rachel Lau, Arturo López Castel, Jean-Yves Masson, Lynette Tippett, Clinton Turner, Maria Spies, Albert R. La Spada, Eric I. Campos, Maurice A. Curtis, François-Michel Boisvert, Richard L.M. Faull, Beverly L. Davidson, Masayuki Nakamori, Hitoshi Okazawa, Marc S. Wold, Christopher E. Pearson
Cell. Author manuscript; available in PMC 2024 Oct 26.
Published in final edited form as: Cell. 2023 Oct 26; 186(22): 4898–4919.e25. Published online 2023 Oct 11. doi: 10.1016/j.cell.2023.09.008
PMCID:
PMC11209935
AbstractArticlePDF–3.0M
5.
SMAD4 depletion contributes to endocrine resistance by integrating ER and ERBB signaling in HR + HER2− breast cancer
Kang Li, Dan Shu, Han Li, Ailin Lan, Wenjie Zhang, Zhaofu Tan, Man Huang, Maria Lauda Tomasi, Aishun Jin, Haochen Yu, Meiying Shen, Shengchun Liu
Cell Death Dis. 2024 Jun; 15(6): 444. Published online 2024 Jun 24. doi: 10.1038/s41419-024-06838-9
PMCID:
PMC11196642
AbstractArticlePDF–5.8M
6.
Promoter‐wide analysis of Smad4 binding sites in human epithelial cells
Daizo Koinuma, Shuichi Tsutsumi, Naoko Kamimura, Takeshi Imamura, Hiroyuki Aburatani, Kohei Miyazono
Cancer Sci. 2009 Nov; 100(11): 2133–2142. Published online 2009 Jul 23. doi: 10.1111/j.1349-7006.2009.01299.x
PMCID:
PMC11159945
AbstractArticlePDF–670K
7.
HBO1 determines SMAD action in pluripotency and mesendoderm specification
Cong Zhang, Yongli Shan, Huaisong Lin, Yanqi Zhang, Qi Xing, Jinmin Zhu, Tiancheng Zhou, Aiping Lin, Qianyu Chen, Junwei Wang, Guangjin Pan
Nucleic Acids Res. 2024 May 22; 52(9): 4935–4949. Published online 2024 Feb 29. doi: 10.1093/nar/gkae158
PMCID:
PMC11109972
AbstractArticlePDF–4.1M
8.
Epidermal Growth Factor‐Like Repeats and Discoidin I‐Like Domains 3 Deficiency Attenuates Dilated Cardiomyopathy by Inhibiting Ubiquitin Specific Peptidase 10 Dependent Smad4 Deubiquitination
Mengmeng Zhao, Zihui Zheng, Shanshan Peng, Yao Xu, Jishou Zhang, Jianfang Liu, Wei Pan, Zheng Yin, Shuwan Xu, Cheng Wei, Menglong Wang, Jun Wan, Juan‐Juan Qin
J Am Heart Assoc. 2024 Mar 19; 13(6): e031283. Published online 2024 Mar 8. doi: 10.1161/JAHA.123.031283
PMCID:
PMC11010021
AbstractArticlePDF–14M
9.
FLRT3 and TGF‐β/SMAD4 signalling: Impacts on apoptosis, autophagy and ion channels in supraventricular tachycardia
Yang Pang, Ye Xu, Qingxing Chen, Kuan Cheng, Yunlong Ling, Jun Jang, Junbo Ge, Wenqing Zhu
J Cell Mol Med. 2024 Apr; 28(7): e18237. Published online 2024 Mar 20. doi: 10.1111/jcmm.18237
PMCID:
PMC10955158
AbstractArticlePDF–5.5M
10.
LINC00909 up-regulates pluripotency factors and promotes cancer stemness and metastasis in pancreatic ductal adenocarcinoma by targeting SMAD4
Zhenchong Li, Zuyi Ma, Shujie Wang, Qian Yan, Hongkai Zhuang, Zixuan Zhou, Chunsheng Liu, Yubin Chen, Mingqian Han, Zelong Wu, Shanzhou Huang, Qi Zhou, Baohua Hou, Chuanzhao Zhang
Biol Direct. 2024; 19: 24. Published online 2024 Mar 19. doi: 10.1186/s13062-024-00463-4
PMCID:
PMC10949730
AbstractArticlePDF–11M
11.
Functional filter for whole-genome sequencing data identifies HHT and stress-associated non-coding SMAD4 polyadenylation site variants >5 kb from coding DNA
Sihao Xiao, Zhentian Kai, Daniel Murphy, Dongyang Li, Dilip Patel, Adrianna M. Bielowka, Maria E. Bernabeu-Herrero, Awatif Abdulmogith, Andrew D. Mumford, Sarah K. Westbury, Micheala A. Aldred, Neil Vargesson, Mark J. Caulfield, Genomics England Research Consortium, Claire L. Shovlin
Am J Hum Genet. 2023 Nov 2; 110(11): 1903–1918. Published online 2023 Oct 9. doi: 10.1016/j.ajhg.2023.09.005
PMCID:
PMC10645545
AbstractArticlePDF–4.6M
12.
Loss of SETD2 aggravates colorectal cancer progression caused by SMAD4 deletion through the RAS/ERK signalling pathway
Chunxiao Ma, Min Liu, Wenxin Feng, Hanyu Rao, Wei Zhang, Changwei Liu, Yue Xu, Ziyi Wang, Yan Teng, Xiao Yang, Li Ni, Jin Xu, Wei‐Qiang Gao, Bing Lu, Li Li
Clin Transl Med. 2023 Nov; 13(11): e1475. Published online 2023 Nov 14. doi: 10.1002/ctm2.1475
PMCID:
PMC10644329
AbstractArticlePDF–2.7M
13.
SMAD4 regulates the progression of cholangiocarcinoma by modulating the expression of STING1
An‐da Shi, Li‐ming Zhao, Guo‐li Sheng, Ge‐ning Zhang, Yong‐chang Tang, Kang‐shuai Li, Zong‐li Zhang
J Cell Mol Med. 2023 Sep; 27(17): 2547–2561. Published online 2023 Jul 24. doi: 10.1111/jcmm.17857
PMCID:
PMC10468663
AbstractArticlePDF–8.1M
14.
Myhre syndrome is caused by dominant-negative dysregulation of SMAD4 and other co-factors
Dimuthu Alankarage, Annabelle Enriquez, Robert D Steine, Cathy Raggio, Megan Higgins, Di Milnes, David T Humphreys, Emma L Duncan, Duncan B Sparrow, Philip F Giampietro, Gavin Chapman, Sally L Dunwoodie
Differentiation. Author manuscript; available in PMC 2023 Aug 22.
Published in final edited form as: Differentiation. 2022 Nov-Dec; 128: 1–12. Published online 2022 Sep 24. doi: 10.1016/j.diff.2022.09.002
PMCID:
PMC10442510
AbstractArticlePDF–1.6M
15.
KRAS mutation-induced EndMT of brain arteriovenous malformation is mediated through the TGF-β/BMP-SMAD4 pathway
Hongyuan Xu, Ran Huo, Hao Li, Yuming Jiao, Jiancong Weng, Jie Wang, Zihan Yan, Junze Zhang, Shaozhi Zhao, Qiheng He, Yingfan Sun, Shuo Wang, Yong Cao
Stroke Vasc Neurol. 2023 Jun; 8(3): 197–206. Published online 2022 Nov 23. doi: 10.1136/svn-2022-001700
PMCID:
PMC10359780
AbstractArticlePDF–3.5M
16.
Deubiquitinase USP13 promotes extracellular matrix expression by stabilizing Smad4 in lung fibroblast cells
XINXIN LIAO, YANHUI LI, JIA LIU, YINGZE ZHANG, JIANGNING TAN, DANIEL J. KASS, MAURICIO ROJAS, RAMA K. MALLAMPALLI, JING ZHAO, YUTONG ZHAO
Transl Res. Author manuscript; available in PMC 2023 Jun 6.
Published in final edited form as: Transl Res. 2020 Sep; 223: 15–24. Published online 2020 May 17. doi: 10.1016/j.trsl.2020.05.004
PMCID:
PMC10243371
AbstractArticlePDF–1.2M
17.
TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing
Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan
Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233
PMCID:
PMC10237422
AbstractArticlePDF–23M
18.
SMAD4 Expression in Monocytes as a Potential Biomarker for Atherosclerosis Risk in Patients with Obstructive Sleep Apnea
Elena Díaz-García, Aldara García-Sánchez, David Sánz-Rubio, Enrique Alfaro, Cristina López-Fernández, Raquel Casitas, Eva Mañas Baena, Irene Cano-Pumarega, Pablo Cubero, Marta Marin-Oto, Eduardo López-Collazo, José María Marin, Francisco García-Río, Carolina Cubillos-Zapata
Int J Mol Sci. 2023 May; 24(9): 7900. Published online 2023 Apr 26. doi: 10.3390/ijms24097900
PMCID:
PMC10178665
AbstractArticlePDF–1.2M
19.
SUMOylation mediates the disassembly of the Smad4 nuclear export complex via RanGAP1 in KELOIDS
Xiaohu Lin, Qianqian Pang, Jie Hu, Jiaqi Sun, Siya Dai, Yijia Yu, Jinghong Xu
J Cell Mol Med. 2023 Apr; 27(8): 1045–1055. Published online 2023 Mar 14. doi: 10.1111/jcmm.17216
PMCID:
PMC10098277
AbstractArticlePDF–2.1M
20.
Hypomorph mutation-directed small-molecule protein-protein interaction inducers to restore mutant SMAD4-suppressed TGF-β signaling
Cong Tang, Mo Xiulei, Qiankun Niu, Alafate Wahafu, Xuan Yang, Min Qui, Andrey A. Ivanov, Yuhong Du, Haian Fu
Cell Chem Biol. Author manuscript; available in PMC 2023 Mar 29.
Published in final edited form as: Cell Chem Biol. 2021 May 20; 28(5): 636–647.e5. Published online 2020 Dec 15. doi: 10.1016/j.chembiol.2020.11.010
PMCID:
PMC10053325
AbstractArticlePDF–1.9M

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