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Items: 1 to 20 of 41

1.
Extracellular vesicle-derived CircWhsc1 promotes cardiomyocyte proliferation and heart repair by activating TRIM59/STAT3/Cyclin B2 pathway
Guoquan Wei, Chuling Li, Xiaoqian Jia, Jingfang Xie, Zhenquan Tang, Ming Jin, Qiqi Chen, Yili Sun, Sisi He, Xinzhong Li, Yanmei Chen, Hao Zheng, Wangjun Liao, Yulin Liao, Jianping Bin, Senlin Huang
J Adv Res. 2023 Nov; 53: 199–218. Published online 2022 Dec 29. doi: 10.1016/j.jare.2022.12.014
PMCID:
PMC10658329
AbstractArticlePDF–9.9M
2.
Wolf-Hirschhorn syndrome candidate 1 (Whsc1) methyltransferase signals via a Pitx2-miR-23/24 axis to effect tooth development
Dan Su, Steve Eliason, Zhao Sun, Fan Shao, Brad A. Amendt
J Biol Chem. 2023 Nov; 299(11): 105324. Published online 2023 Oct 6. doi: 10.1016/j.jbc.2023.105324
PMCID:
PMC10656234
AbstractArticlePDF–5.0M
3.
Histone methyltransferase Nsd2 ensures maternal–fetal immune tolerance by promoting regulatory T-cell recruitment
Le Zhang, Xuehui Long, Yuye Yin, Jun Wang, Huamin Zhu, Jingjing Chen, Yuliang Wang, Yun Chen, Xiaoming Wang
Cell Mol Immunol. 2022 May; 19(5): 634–643. Published online 2022 Mar 23. doi: 10.1038/s41423-022-00849-2
PMCID:
PMC9061842
AbstractArticlePDF–3.9M
4.
Histone methyltransferase WHSC1 loss dampens MHC-I antigen presentation pathway to impair IFN-γ–stimulated antitumor immunity
Jiale Ren, Ni Li, Siyu Pei, Yannan Lian, Li Li, Yuchong Peng, Qiuli Liu, Jiacheng Guo, Xuege Wang, Ying Han, Guoying Zhang, Hanling Wang, Yaqi Li, Jun Jiang, Qintong Li, Minjia Tan, Junjie Peng, Guohong Hu, Yichuan Xiao, Xiong Li, Moubin Lin, Jun Qin
J Clin Invest. 2022 Apr 15; 132(8): e153167. Published online 2022 Apr 15. doi: 10.1172/JCI153167
PMCID:
PMC9012282
AbstractArticlePDF–4.0M
5.
METTL3 enhances NSD2 mRNA stability to reduce renal impairment and interstitial fibrosis in mice with diabetic nephropathy
Weiming Tang, Yilin Zhao, Hui Zhang, Ying Peng, Zhilian Rui
BMC Nephrol. 2022; 23: 124. Published online 2022 Mar 30. doi: 10.1186/s12882-022-02753-3
PMCID:
PMC8969340
AbstractArticlePDF–12M
6.
PP2Cδ Controls the Differentiation and Function of Dendritic Cells Through Regulating the NSD2/mTORC2/ACLY Pathway
Nianyin Lv, Sufeng Jin, Zihao Liang, Xiaohui Wu, Yanhua Kang, Lan Su, Yeping Dong, Bingwei Wang, Tonghui Ma, Liyun Shi
Front Immunol. 2021; 12: 751409. Published online 2022 Jan 7. doi: 10.3389/fimmu.2021.751409
PMCID:
PMC8777276
AbstractArticlePDF–10M
7.
A histone H3.3K36M mutation in mice causes an imbalance of histone modifications and defects in chondrocyte differentiation
Shusaku Abe, Hiroaki Nagatomo, Hiroyuki Sasaki, Takashi Ishiuchi
Epigenetics. 2021; 16(10): 1123–1134. Published online 2020 Nov 16. doi: 10.1080/15592294.2020.1841873
PMCID:
PMC8510613
AbstractArticlePDF–7.2M
8.
Wolf–Hirschhorn syndrome candidate 1 facilitates alveolar macrophage pyroptosis in sepsis-induced acute lung injury through NEK7-mediated NLRP3 inflammasome activation
Caixia Liu, Benlong Cai, Dan Li, Yuan Yao
Innate Immun. 2021 Aug; 27(6): 437–447. Published online 2021 Aug 25. doi: 10.1177/17534259211035426
PMCID:
PMC8504266
AbstractArticlePDF–2.0M
9.
Inhibition of WHSC1 Allows for Reprogramming of the Immune Compartment in Prostate Cancer
Muzamil Y. Want, Ellen Karasik, Bryan Gillard, A. J. Robert McGray, Sebastiano Battaglia
Int J Mol Sci. 2021 Aug; 22(16): 8742. Published online 2021 Aug 14. doi: 10.3390/ijms22168742
PMCID:
PMC8395944
AbstractArticlePDF–2.4M
10.
Whsc1 links pluripotency exit with mesendoderm specification
Tian V. Tian, Bruno Di Stefano, Grégoire Stik, Maria Vila-Casadesús, José Luis Sardina, Enrique Vidal, Alessandro Dasti, Carolina Segura Morales, Luisa De Andres Aguayo, Antonio Gomez, Johanna Goldmann, Rudolf Jaenisch, Thomas Graf
Nat Cell Biol. Author manuscript; available in PMC 2021 Apr 5.
Published in final edited form as: Nat Cell Biol. 2019 Jul; 21(7): 824–834. Published online 2019 Jun 24. doi: 10.1038/s41556-019-0342-1
PMCID:
PMC8020485
AbstractArticlePDF–2.3M
11.
TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation
Xiaochen Fan, V Pragathi Masamsetti, Jane QJ Sun, Kasper Engholm-Keller, Pierre Osteil, Joshua Studdert, Mark E Graham, Nicolas Fossat, Patrick PL Tam
eLife. 2021; 10: e62873. Published online 2021 Feb 8. doi: 10.7554/eLife.62873
PMCID:
PMC7968925
AbstractArticlePDF–4.0M
12.
The catalytic domain of the histone methyltransferase NSD2/MMSET is required for the generation of B1 cells in mice
Marc-Werner Dobenecker, Jonas Marcello, Annette Becker, Eugene Rudensky, Natarajan V. Bhanu, Thomas Carrol, Benjamin A. Garcia, Rabinder Prinjha, Vyacheslav Yurchenko, Alexander Tarakhovsky
FEBS Lett. Author manuscript; available in PMC 2021 Oct 1.
Published in final edited form as: FEBS Lett. 2020 Oct; 594(20): 3324–3337. Published online 2020 Aug 29. doi: 10.1002/1873-3468.13903
PMCID:
PMC7722058
AbstractArticlePDF–873K
13.
H3K36 dimethylation by MMSET promotes classical non-homologous end-joining at unprotected telomeres
Inge de Krijger, Jaco van der Torre, Marieke H. Peuscher, Mathias Eder, Jacqueline J. L. Jacobs
Oncogene. 2020; 39(25): 4814–4827. Published online 2020 May 29. doi: 10.1038/s41388-020-1334-0
PMCID:
PMC7299843
AbstractArticlePDF–1.7M
14.
Histone methyltransferase Nsd2 is required for follicular helper T cell differentiation
Xuehui Long, Le Zhang, Yang Zhang, Min Min, Bichun Lin, Jingjing Chen, Xiaojie Ma, Sulan Zhai, Zhenming Cai, Yingxia Liu, Yanlai Lu, Nan Che, Wenfeng Tan, Jun Qin, Xiaoming Wang
J Exp Med. 2020 Jan 6; 217(1): e20190832. Published online 2019 Oct 21. doi: 10.1084/jem.20190832
PMCID:
PMC7037247
AbstractArticlePDF–5.9M
15.
NSD2 promotes ventricular remodelling mediated by the regulation of H3K36me2
Xue‐liang Zhou, Rong‐rong Zhu, Xia Wu, Hua Xu, Yun‐yun Li, Qi‐rong Xu, Sheng Liu, Huang Huang, Xinping Xu, Li Wan, Qi‐cai Wu, Ji‐chun Liu
J Cell Mol Med. 2019 Jan; 23(1): 568–575. Published online 2018 Oct 18. doi: 10.1111/jcmm.13961
PMCID:
PMC6307761
AbstractArticlePDF–1.0M
16.
NSD2 is a conserved driver of metastatic prostate cancer progression
Alvaro Aytes, Arianna Giacobbe, Antonina Mitrofanova, Katia Ruggero, Joanna Cyrta, Juan Arriaga, Luis Palomero, Sonia Farran-Matas, Mark A. Rubin, Michael M. Shen, Andrea Califano, Cory Abate-Shen
Nat Commun. 2018; 9: 5201. Published online 2018 Dec 5. doi: 10.1038/s41467-018-07511-4
PMCID:
PMC6281610
AbstractArticlePDF–3.1M
17.
Depletion of Nsd2-mediated histone H3K36 methylation impairs adipose tissue development and function
Lenan Zhuang, Younghoon Jang, Young-Kwon Park, Ji-Eun Lee, Shalini Jain, Eugene Froimchuk, Aaron Broun, Chengyu Liu, Oksana Gavrilova, Kai Ge
Nat Commun. 2018; 9: 1796. Published online 2018 May 4. doi: 10.1038/s41467-018-04127-6
PMCID:
PMC5935725
AbstractArticlePDF–3.0M
18.
Histone methyltransferase MMSET promotes AID-mediated DNA breaks at the donor switch region during class switch recombination
Hai Vu Nguyen, Junchao Dong, Rohit A. Panchakshari, Vipul Kumar, Frederick W. Alt, Jean-Christophe Bories
Proc Natl Acad Sci U S A. 2017 Dec 5; 114(49): E10560–E10567. Published online 2017 Nov 20. doi: 10.1073/pnas.1701366114
PMCID:
PMC5724247
AbstractArticlePDF–1.4M
19.
Wolf-Hirschhorn Syndrome Candidate-1 is necessary for correct hematopoietic and B cell development
Elena Campos-Sanchez, Nerea Deleyto-Seldas, Veronica Dominguez, Enrique Carrillo-de-Santa-Pau, Kiyoe Ura, Pedro P. Rocha, JungHyun Kim, Arafat Aljoufi, Anna Esteve-Codina, Marc Dabad, Marta Gut, Holger Heyn, Yasufumi Kaneda, Keisuke Nimura, Jane A. Skok, Maria Luisa Martinez-Frias, Cesar Cobaleda
Cell Rep. Author manuscript; available in PMC 2018 May 23.
Published in final edited form as: Cell Rep. 2017 May 23; 19(8): 1586–1601. doi: 10.1016/j.celrep.2017.04.069
PMCID:
PMC5510986
AbstractArticlePDF–3.5M
20.
AKT-mediated stabilization of histone methyltransferase WHSC1 promotes prostate cancer metastasis
Ni Li, Wei Xue, Huairui Yuan, Baijun Dong, Yufeng Ding, Yongfeng Liu, Min Jiang, Shan Kan, Tongyu Sun, Jiale Ren, Qiang Pan, Xiang Li, Peiyuan Zhang, Guohong Hu, Yan Wang, Xiaoming Wang, Qintong Li, Jun Qin
J Clin Invest. 2017 Apr 3; 127(4): 1284–1302. Published online 2017 Mar 20. doi: 10.1172/JCI91144
PMCID:
PMC5373871
AbstractArticlePDF–6.6M

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