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Select item 105757371.

SPTAN1/NUMB axis senses cell density to restrain cell growth and oncogenesis through Hippo signaling

Dongxue Su, Yuxi Li, Weiji Zhang, Huan Gao, Yao Cheng, Yongqiang Hou, Junhong Li, Yi Ye, Zhangjian Lai, Zhe Li, Haitao Huang, Jiaxin Li, Jinhuan Li, Mengyu Cheng, Cheng Nian, Na Wu, Zhien Zhou, Yunzhi Xing, Yu Zhao, He Liu, Jiayu Tang, Qinghua Chen, Lixin Hong, Wengang Li, Zhihai Peng, Bin Zhao, Randy L. Johnson, Pingguo Liu, Wanjin Hong, Lanfen Chen, Dawang Zhou

J Clin Invest. 2023 Oct 16; 133(20): e168888. Published online 2023 Oct 16. doi: 10.1172/JCI168888

PMCID:: PMC10575737

Abstract Article PDF–11M

Select item 95814852.

Numb regulates Tau levels and prevents neurodegeneration in tauopathy mouse models

Marine Lacomme, Sarah C. Hales, Thomas W. Brown, Katarina Stevanovic, Christine Jolicoeur, Jenny Cai, Therence Bois, Melissa Desrosiers, Deniz Dalkara, Michel Cayouette

Sci Adv. 2022 Oct; 8(42): eabm4295. Published online 2022 Oct 19. doi: 10.1126/sciadv.abm4295

PMCID:: PMC9581485

Abstract Article PDF–12M

Select item 88033383.

Numb and Numblike regulate sarcomere assembly and maintenance

Baolei Wang, Min Yang, Shujuan Li

J Clin Invest. 2022 Feb 1; 132(3): e139420. Published online 2022 Feb 1. doi: 10.1172/JCI139420

Correction in:: J Clin Invest. 2022 Jul 15; 132(14): e162883.

PMCID:: PMC8803338

Abstract Article PDF–12M

Select item 84711364.

The Spatiotemporal Expression of Notch1 and Numb and Their Functional Interaction during Cardiac Morphogenesis

Lianjie Miao, Yangyang Lu, Anika Nusrat, Hala Y. Abdelnasser, Sayantap Datta, Bin Zhou, Robert J. Schwartz, Mingfu Wu

Cells. 2021 Sep; 10(9): 2192. Published online 2021 Aug 25. doi: 10.3390/cells10092192

PMCID:: PMC8471136

Abstract Article PDF–8.0M

Select item 81877925.

Depletion of Numb and Numblike in Murine Lung Epithelial Cells Ameliorates Bleomycin-Induced Lung Fibrosis by Inhibiting the β-Catenin Signaling Pathway

Alessandro Ianni, Michael Hofmann, Poonam Kumari, Shahriar Tarighi, Hamza M Al-Tamari, André Görgens, Bernd Giebel, Hendrik Nolte, Marcus Krüger, Isabelle Salwig, Soni Savai Pullamsetti, Andreas Günther, André Schneider, Thomas Braun

Front Cell Dev Biol. 2021; 9: 639162. Published online 2021 May 26. doi: 10.3389/fcell.2021.639162

PMCID:: PMC8187792

Abstract Article PDF–9.4M

Select item 79387706.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 67685627.

EGFR Signaling Termination via Numb Trafficking in Ependymal Progenitors Controls Postnatal Neurogenic Niche Differentiation

Khadar Abdi, Gabriel Neves, Joon Pyun, Emre Kiziltug, Angelica Ahrens, Chay T. Kuo

Cell Rep. Author manuscript; available in PMC 2019 Sep 30.

Published in final edited form as: Cell Rep. 2019 Aug 20; 28(8): 2012–2022.e4. doi: 10.1016/j.celrep.2019.07.056

PMCID:: PMC6768562

Abstract Article PDF–2.2M

Select item 67201118.

Exosomal microRNA transport from salivary mesenchyme regulates epithelial progenitor expansion during organogenesis.

Toru Hayashi, Isabelle M.A. Lombaert, Belinda R. Hauser, Vaishali N. Patel, Matthew P. Hoffman

Dev Cell. Author manuscript; available in PMC 2019 Sep 3.

Published in final edited form as: Dev Cell. 2017 Jan 9; 40(1): 95–103. Published online 2016 Dec 29. doi: 10.1016/j.devcel.2016.12.001

PMCID:: PMC6720111

Abstract Article PDF–773K

Select item 66817369.

Cardiomyocyte orientation modulated by the Numb family proteins–N-cadherin axis is essential for ventricular wall morphogenesis

Lianjie Miao, Jingjing Li, Jian Li, Yangyang Lu, David Shieh, Joseph E. Mazurkiewicz, Margarida Barroso, John J. Schwarz, Hong-Bo Xin, Harold A. Singer, Peter A. Vincent, Weimin Zhong, Glenn L. Radice, Leo Q. Wan, Zhen-Chuan Fan, Guoying Huang, Mingfu Wu

Proc Natl Acad Sci U S A. 2019 Jul 30; 116(31): 15560–15569. Published online 2019 Jul 12. doi: 10.1073/pnas.1904684116

PMCID:: PMC6681736

Abstract Article PDF–3.6M

Select item 592471710.

β1-integrin Is a Cell-Autonomous Factor Mediating the Numb Pathway for Cardiac Progenitor Maintenance

Brian Gibbs, Lincoln Shenje, Peter Andersen, Matthew Miyamoto, Chulan Kwon

Biochem Biophys Res Commun. Author manuscript; available in PMC 2019 Jun 2.

Published in final edited form as: Biochem Biophys Res Commun. 2018 Jun 2; 500(2): 256–260. Published online 2018 Apr 13. doi: 10.1016/j.bbrc.2018.04.054

PMCID:: PMC5924717

Abstract Article PDF–848K

Select item 564508211.

Spatio-temporal profile of postynaptic interactomes integrates components of complex brain disorders

Jing Li, Wangshu Zhang, Hui Yang, Daniel P. Howrigan, Brent Wilkinson, Tade Souaiaia, Oleg V. Evgrafov, Giulio Genovese, Veronica A. Clementel, Jennifer C. Tudor, Ted Abel, James A. Knowles, Benjamin M. Neale, Kai Wang, Fengzhu Sun, Marcelo P. Coba

Nat Neurosci. Author manuscript; available in PMC 2018 Aug 1.

Published in final edited form as: Nat Neurosci. 2017 Aug; 20(8): 1150–1161. Published online 2017 Jun 26. doi: 10.1038/nn.4594

PMCID:: PMC5645082

Abstract Article PDF–2.3M

Select item 562674912.

NUMBL Interacts with TAK1, TRAF6 and NEMO to Negatively Regulate NF-κB Signaling During Osteoclastogenesis

Gaurav Swarnkar, Tim Hung-Po Chen, Manoj Arra, Amjad M. Nasir, Gabriel Mbalaviele, Yousef Abu-Amer

Sci Rep. 2017; 7: 12600. Published online 2017 Oct 3. doi: 10.1038/s41598-017-12707-7

PMCID:: PMC5626749

Abstract Article PDF–3.8M

Select item 550974013.

Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling

Brent Wilkinson, Jing Li, Marcelo P. Coba

Sci Rep. 2017; 7: 5272. Published online 2017 Jul 13. doi: 10.1038/s41598-017-05588-3

PMCID:: PMC5509740

Abstract Article PDF–4.6M

Select item 545084914.

Numb regulates somatic cell lineage commitment during early gonadogenesis in mice

Yi-Tzu Lin, Lindsey Barske, Tony DeFalco, Blanche Capel

Development. 2017 May 1; 144(9): 1607–1618. doi: 10.1242/dev.149203

PMCID:: PMC5450849

Abstract Article

Select item 527219015.

Adaptor proteins NUMB and NUMBL promote cell cycle withdrawal by targeting ERBB2 for degradation

Maretoshi Hirai, Yoh Arita, C. Jane McGlade, Kuo-Fen Lee, Ju Chen, Sylvia M. Evans

J Clin Invest. 2017 Feb 1; 127(2): 569–582. Published online 2017 Jan 9. doi: 10.1172/JCI91081

PMCID:: PMC5272190

Abstract Article PDF–6.4M

Select item 465032916.

Numb is Required for the Production of Terminal Asymmetric Cell Divisions in the Developing Mouse Retina

Amel Kechad, Christine Jolicoeur, Adele Tufford, Pierre Mattar, Renee W.Y. Chow, William A. Harris, Michel Cayouette

J Neurosci. 2012 Nov 28; 32(48): 17197–17210. doi: 10.1523/JNEUROSCI.4127-12.2012

PMCID:: PMC4650329

Abstract Article PDF–5.7M

Select item 463979817.

Numb is required to prevent p53-dependent senescence following skeletal muscle injury

Isabelle Le Roux, Julie Konge, Laurent Le Cam, Patricia Flamant, Shahragim Tajbakhsh

Nat Commun. 2015; 6: 8528. Published online 2015 Oct 27. doi: 10.1038/ncomms9528

PMCID:: PMC4639798

Abstract Article PDF–3.8M

Select item 457757118.

Numb Regulates the Polarized Delivery of Cyclic Nucleotide-Gated Ion Channels in Rod Photoreceptor Cilia

Vasanth Ramamurthy, Christine Jolicoeur, Demetra Koutroumbas, Johanna Mühlhans, Yun-Zheng Le, William W. Hauswirth, Andreas Giessl, Michel Cayouette

J Neurosci. 2014 Oct 15; 34(42): 13976–13987. doi: 10.1523/JNEUROSCI.1938-14.2014

Correction in:: J Neurosci. 2015 Apr 15; 35(15): 6254.

PMCID:: PMC4577571

Abstract Article PDF–5.3M

Select item 429167719.

Osteopetrosis in TAK1-deficient mice owing to defective NF-κB and NOTCH signaling

Gaurav Swarnkar, Kannan Karuppaiah, Gabriel Mbalaviele, Tim (Hung-Po) Chen, Yousef Abu-Amer

Proc Natl Acad Sci U S A. 2015 Jan 6; 112(1): 154–159. Published online 2014 Dec 22. doi: 10.1073/pnas.1415213112

PMCID:: PMC4291677

Abstract Article PDF–1.3M

Select item 400720620.

Precardiac deletion of Numb and Numblike reveals renewal of cardiac progenitors

Lincoln T Shenje, Peter Andersen, Hideki Uosaki, Laviel Fernandez, Peter P Rainer, Gun-sik Cho, Dong-ik Lee, Weimin Zhong, Richard P Harvey, David A Kass, Chulan Kwon

eLife. 2014; 3: e02164. Published online 2014 Apr 24. doi: 10.7554/eLife.02164

PMCID:: PMC4007206

Abstract Article PDF–4.2M

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