PMC Links for GEO Profiles (Select 75372314) - PMC

Links from GEO Profiles

Items: 1 to 20 of 282

<< First< Prev

Page of 15

Select item 110835721.

Systemic LPS Administration Stimulates the Activation of Non-Neuronal Cells in an Experimental Model of Spinal Muscular Atrophy

Eleni Karafoulidou, Evangelia Kesidou, Paschalis Theotokis, Chrystalla Konstantinou, Maria-Konstantina Nella, Iliana Michailidou, Olga Touloumi, Eleni Polyzoidou, Ilias Salamotas, Ofira Einstein, Athanasios Chatzisotiriou, Marina-Kleopatra Boziki, Nikolaos Grigoriadis

Cells. 2024 May; 13(9): 785. Published online 2024 May 4. doi: 10.3390/cells13090785

PMCID:: PMC11083572

Abstract Article PDF–4.6M

Select item 110186312.

Improved gene therapy for spinal muscular atrophy in mice using codon-optimized hSMN1 transgene and hSMN1 gene-derived promotor

Qing Xie, Xiupeng Chen, Hong Ma, Yunxiang Zhu, Yijie Ma, Leila Jalinous, Gerald F Cox, Fiona Weaver, Jun Yang, Zachary Kennedy, Alisha Gruntman, Ailing Du, Qin Su, Ran He, Phillip WL Tai, Guangping Gao, Jun Xie

EMBO Mol Med. 2024 Apr; 16(4): 945–965. Published online 2024 Feb 27. doi: 10.1038/s44321-024-00037-x

PMCID:: PMC11018631

Abstract Article PDF–13M

Select item 109455243.

Depletion of SMN protein in mesenchymal progenitors impairs the development of bone and neuromuscular junction in spinal muscular atrophy

Sang-Hyeon Hann, Seon-Yong Kim, Ye Lynne Kim, Young-Woo Jo, Jong-Seol Kang, Hyerim Park, Se-Young Choi, Young-Yun Kong

eLife. 2024; 12: RP92731. Published online 2024 Feb 6. doi: 10.7554/eLife.92731

PMCID:: PMC10945524

Abstract Article PDF–15M

Select item 106436214.

SMN deficiency perturbs monoamine neurotransmitter metabolism in spinal muscular atrophy

Valeria Valsecchi, Francesco Errico, Valentina Bassareo, Carmen Marino, Tommaso Nuzzo, Paola Brancaccio, Giusy Laudati, Antonella Casamassa, Manuela Grimaldi, Adele D’Amico, Manolo Carta, Enrico Bertini, Giuseppe Pignataro, Anna Maria D’Ursi, Alessandro Usiello

Commun Biol. 2023; 6: 1155. Published online 2023 Nov 13. doi: 10.1038/s42003-023-05543-1

PMCID:: PMC10643621

Abstract Article PDF–6.3M

Select item 105740145.

Diaphragm Fatigue in SMNΔ7 Mice and Its Molecular Determinants: An Underestimated Issue

Francesca Cadile, Deborah Recchia, Massimiliano Ansaldo, Paola Rossi, Giorgia Rastelli, Simona Boncompagni, Lorenza Brocca, Maria Antonietta Pellegrino, Monica Canepari

Int J Mol Sci. 2023 Oct; 24(19): 14953. Published online 2023 Oct 6. doi: 10.3390/ijms241914953

PMCID:: PMC10574014

Abstract Article PDF–3.3M

Select item 102931746.

Evaluation of the orally bioavailable 4-phenylbutyrate-tethered trichostatin A analogue AR42 in models of spinal muscular atrophy

Casey J. Lumpkin, Ashlee W. Harris, Andrew J. Connell, Ryan W. Kirk, Joshua A. Whiting, Luciano Saieva, Livio Pellizzoni, Arthur H. M. Burghes, Matthew E. R. Butchbach

Sci Rep. 2023; 13: 10374. Published online 2023 Jun 26. doi: 10.1038/s41598-023-37496-0

PMCID:: PMC10293174

Abstract Article PDF–4.5M

Select item 102700037.

Base editing rescue of spinal muscular atrophy in cells and in mice

Mandana Arbab, Zaneta Matuszek, Kaitlyn M. Kray, Ailing Du, Gregory A. Newby, Anton J. Blatnik, Aditya Raguram, Michelle F. Richter, Kevin T. Zhao, Jonathan M. Levy, Max W. Shen, W. David Arnold, Dan Wang, Jun Xie, Guangping Gao, Arthur H. M. Burghes, David R. Liu

Science. Author manuscript; available in PMC 2023 Jun 15.

Published in final edited form as: Science. 2023 Apr 21; 380(6642): eadg6518. Published online 2023 Apr 14. doi: 10.1126/science.adg6518

PMCID:: PMC10270003

Abstract Article PDF–1.7M

Select item 101641308.

A spinal muscular atrophy modifier implicates the SMN protein in SNARE complex assembly at neuromuscular synapses

Jeong-Ki Kim, Narendra N. Jha, Tomoyuki Awano, Charlotte Caine, Kishore Gollapalli, Emily Welby, Seung-Soo Kim, Andrea Fuentes-Moliz, Xueyong Wang, Zhihua Feng, Fusako Sera, Taishi Takeda, Shunichi Homma, Chien-Ping Ko, Lucia Tabares, Allison D. Ebert, Mark M. Rich, Umrao R. Monani

Neuron. Author manuscript; available in PMC 2024 May 3.

Published in final edited form as: Neuron. 2023 May 3; 111(9): 1423–1439.e4. Published online 2023 Mar 1. doi: 10.1016/j.neuron.2023.02.004

PMCID:: PMC10164130

Abstract Article PDF–3.4M

Select item 101467809.

Nifedipine Ameliorates Cellular Differentiation Defects of Smn-Deficient Motor Neurons and Enhances Neuromuscular Transmission in SMA Mice

Rocio Tejero, Mohammad Alsakkal, Luisa Hennlein, Ana M. Lopez-Cabello, Sibylle Jablonka, Lucia Tabares

Int J Mol Sci. 2023 Apr; 24(8): 7648. Published online 2023 Apr 21. doi: 10.3390/ijms24087648

PMCID:: PMC10146780

Abstract Article PDF–2.3M

Select item 1009048910.

MiR34 contributes to spinal muscular atrophy and AAV9-mediated delivery of MiR34a ameliorates the motor deficits in SMA mice

Tai-Heng Chen, Shih-Hsin Chang, Yu-Fu Wu, Ya-Ping Yen, Fang-Yu Hsu, Yen-Chung Chen, Yang Ming, Ho-Chiang Hsu, Yi-Ching Su, Sheng-Tang Wong, Jui-Hung Hung, Shih-Hwa Chiou, Yuh-Jyh Jong, Jun-An Chen

Mol Ther Nucleic Acids. 2023 Jun 13; 32: 144–160. Published online 2023 Mar 15. doi: 10.1016/j.omtn.2023.03.005

PMCID:: PMC10090489

Abstract Article PDF–3.7M

Select item 1007747511.

DG9-conjugated morpholino rescues phenotype in SMA mice by reaching the CNS via a subcutaneous administration

Tejal Aslesh, Esra Erkut, Jun Ren, Kenji Rowel Q. Lim, Stanley Woo, Susan Hatlevig, Hong M. Moulton, Simon Gosgnach, John Greer, Rika Maruyama, Toshifumi Yokota

JCI Insight. 2023 Mar 8; 8(5): e160516. Published online 2023 Mar 8. doi: 10.1172/jci.insight.160516

PMCID:: PMC10077475

Abstract Article PDF–9.0M

Select item 996175212.

Long-Term SMN- and Ncald-ASO Combinatorial Therapy in SMA Mice and NCALD-ASO Treatment in hiPSC-Derived Motor Neurons Show Protective Effects

Anixa Muiños-Bühl, Roman Rombo, Karen K. Ling, Eleonora Zilio, Frank Rigo, C. Frank Bennett, Brunhilde Wirth

Int J Mol Sci. 2023 Feb; 24(4): 4198. Published online 2023 Feb 20. doi: 10.3390/ijms24044198

PMCID:: PMC9961752

Abstract Article PDF–7.9M

Select item 992628113.

Agonist of growth hormone-releasing hormone improves the disease features of spinal muscular atrophy mice

Marina Boido, Iacopo Gesmundo, Anna Caretto, Francesca Pedrolli, Roberta Schellino, Sheila Leone, Renzhi Cai, Wei Sha, Ezio Ghigo, Andrew V. Schally, Alessandro Vercelli, Riccarda Granata

Proc Natl Acad Sci U S A. 2023 Jan 10; 120(2): e2216814120. Published online 2023 Jan 5. doi: 10.1073/pnas.2216814120

PMCID:: PMC9926281

Abstract Article PDF–2.5M

Select item 983466214.

SMN promotes mitochondrial metabolic maturation during myogenesis by regulating the MYOD-miRNA axis

Akihiro Ikenaka, Yohko Kitagawa, Michiko Yoshida, Chuang-Yu Lin, Akira Niwa, Tatsutoshi Nakahata, Megumu K Saito

Life Sci Alliance. 2023 Mar; 6(3): e202201457. Published online 2023 Jan 5. doi: 10.26508/lsa.202201457

PMCID:: PMC9834662

Abstract Article PDF–4.2M

Select item 982753015.

Plastin 3 rescues cell surface translocation and activation of TrkB in spinal muscular atrophy

Luisa Hennlein, Hanaa Ghanawi, Florian Gerstner, Eduardo Palominos García, Ezgi Yildirim, Lena Saal-Bauernschubert, Mehri Moradi, Chunchu Deng, Teresa Klein, Silke Appenzeller, Markus Sauer, Michael Briese, Christian Simon, Michael Sendtner, Sibylle Jablonka

J Cell Biol. 2023 Mar 6; 222(3): e202204113. Published online 2023 Jan 6. doi: 10.1083/jcb.202204113

PMCID:: PMC9827530

Abstract Article PDF–8.9M

Select item 981374516.

Survival motor neuron protein and neurite degeneration are regulated by Gemin3 in spinal muscular atrophy motoneurons

Maria P. Miralles, Alba Sansa, Maria Beltran, Rosa M. Soler, Ana Garcera

Front Cell Neurosci. 2022; 16: 1054270. Published online 2022 Dec 22. doi: 10.3389/fncel.2022.1054270

PMCID:: PMC9813745

Abstract Article PDF–1.9M

Select item 967694117.

p53-dependent c-Fos expression is a marker but not executor for motor neuron death in spinal muscular atrophy mouse models

Jannik M. Buettner, Leonie Sowoidnich, Florian Gerstner, Beatriz Blanco-Redondo, Stefan Hallermann, Christian M. Simon

Front Cell Neurosci. 2022; 16: 1038276. Published online 2022 Nov 7. doi: 10.3389/fncel.2022.1038276

PMCID:: PMC9676941

Abstract Article PDF–10M

Select item 962112818.

Microvasculopathy in spinal muscular atrophy is driven by a reversible autonomous endothelial cell defect

Haiyan Zhou, Ying Hong, Mariacristina Scoto, Alison Thomson, Emma Pead, Tom MacGillivray, Elena Hernandez-Gerez, Francesco Catapano, Jinhong Meng, Qiang Zhang, Gillian Hunter, Hannah K. Shorrock, Thomas K. Ng, Abedallah Hamida, Mathilde Sanson, Giovanni Baranello, Kevin Howell, Thomas H. Gillingwater, Paul Brogan, Dorothy A. Thompson, Simon H. Parson, Francesco Muntoni

J Clin Invest. 2022 Nov 1; 132(21): e153430. Published online 2022 Nov 1. doi: 10.1172/JCI153430

PMCID:: PMC9621128

Abstract Article PDF–10M

Select item 959909319.

SMN Is Physiologically Downregulated at Wild-Type Motor Nerve Terminals but Aggregates Together with Neurofilaments in SMA Mouse Models

Julio Franco-Espin, Alaó Gatius, José Ángel Armengol, Saravanan Arumugam, Mehri Moradi, Michael Sendtner, Jordi Calderó, Lucia Tabares

Biomolecules. 2022 Oct; 12(10): 1524. Published online 2022 Oct 20. doi: 10.3390/biom12101524

PMCID:: PMC9599093

Abstract Article PDF–8.7M

Select item 955528620.

Counteracting chromatin effects of a splicing-correcting antisense oligonucleotide improves its therapeutic efficacy in spinal muscular atrophy

Luciano E. Marasco, Gwendal Dujardin, Rui Sousa-Luís, Ying Hsiu Liu, José Stigliano, Tomoki Nomakuchi, Nick J. Proudfoot, Adrian R. Krainer, Alberto R. Kornblihtt

Cell. Author manuscript; available in PMC 2023 Jun 9.

Published in final edited form as: Cell. 2022 Jun 9; 185(12): 2057–2070.e15. doi: 10.1016/j.cell.2022.04.031

PMCID:: PMC9555286

Abstract Article PDF–2.0M

PMC

Result Filters

Article attributes

Text availability

Publication date

Custom date range

Research Funder

Additional filters

Display Settings:

Send to:

Links from GEO Profiles

Items: 1 to 20 of 282

Display Settings:

Send to:

Supplemental Content

Find related data

Recent activity