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Items: 1 to 20 of 148

1.
IL-2Rα KO mice exhibit maternal microchimerism and reveal nuclear localization of IL-2Rα in lymphoid and non-lymphoid cells
Victoria A. Wong, Kristie N. Dinh, Guangchun Chen, Lucile E. Wrenshall
Front Immunol. 2024; 15: 1369818. Published online 2024 May 15. doi: 10.3389/fimmu.2024.1369818
PMCID:
PMC11133634
AbstractArticlePDF–2.6M
2.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
3.
Distinct use of super-enhancer elements controls cell-type specific CD25 transcription and function
Rosanne Spolski, Peng Li, Vivek Chandra, Boyoung Shin, Shubham Goel, Keiko Sakamoto, Chengyu Liu, Jangsuk Oh, Min Ren, Yutaka Enomoto, Erin E. West, Stephen M. Christensen, Edwin C.K. Wan, Meili Ge, Jian-Xin Lin, Bingyu Yan, Majid Kazemian, Zu-Xi Yu, Keisuke Nagao, Pandurangan Vijayanand, Ellen V. Rothenberg, Warren J. Leonard
Sci Immunol. Author manuscript; available in PMC 2024 Feb 1.
Published in final edited form as: Sci Immunol. 2023 Nov 3; 8(89): eadi8217. Published online 2023 Nov 3. doi: 10.1126/sciimmunol.adi8217
PMCID:
PMC10832512
AbstractArticlePDF–2.6M
4.
CD4 Effector TCR Avidity for Peptide on APC Determines the Level of Memory Generated
Michael C. Jones, Catherine Castonguay, Padma P. Nanaware, Grant C. Weaver, Brian Stadinski, Olivia A. Kugler-Umana, Eric S. Huseby, Lawrence J. Stern, Karl Kai McKinstry, Tara M. Strutt, Priyadharshini Devarajan, Susan L. Swain
J Immunol. Author manuscript; available in PMC 2024 Jun 15.
Published in final edited form as: J Immunol. 2023 Jun 15; 210(12): 1950–1961. doi: 10.4049/jimmunol.2200337
PMCID:
PMC10247507
AbstractArticlePDF–2.5M
5.
The metalloprotease ADAM10 generates soluble interleukin-2 receptor alpha (sCD25) in vivo
Sophia Kirschke, Ireti Ogunsulire, Balachandar Selvakumar, Neele Schumacher, Tanya Sezin, Stefan Rose-John, Alexander Scheffold, Christoph Garbers, Juliane Lokau
J Biol Chem. 2022 Jun; 298(6): 101910. Published online 2022 Apr 7. doi: 10.1016/j.jbc.2022.101910
PMCID:
PMC9127578
AbstractArticlePDF–1.3M
6.
T cell receptor and IL-2 signaling strength control memory CD8+ T cell functional fitness via chromatin remodeling
Shu Shien Chin, Erik Guillen, Laurent Chorro, Sooraj Achar, Karina Ng, Susanne Oberle, Francesca Alfei, Dietmar Zehn, Grégoire Altan-Bonnet, Fabien Delahaye, Grégoire Lauvau
Nat Commun. 2022; 13: 2240. Published online 2022 Apr 26. doi: 10.1038/s41467-022-29718-2
PMCID:
PMC9042912
AbstractArticlePDF–2.9M
7.
Lymph node fibroblastic reticular cells regulate differentiation and function of CD4 T cells via CD25
Dongeon Kim, Mingyo Kim, Tae Woo Kim, Yong-ho Choe, Hae Sook Noh, Hyun Min Jeon, HyunSeok Kim, Youngeun Lee, Gayeong Hur, Kyung-Mi Lee, Kihyuk Shin, Sang-il Lee, Seung-Hyo Lee
J Exp Med. 2022 May 2; 219(5): e20200795. Published online 2022 Mar 22. doi: 10.1084/jem.20200795
PMCID:
PMC8943836
AbstractArticlePDF–4.8M
8.
Efficient IL-2R signaling differentially affects the stability, function, and composition of the regulatory T-cell pool
Marc Permanyer, Berislav Bošnjak, Silke Glage, Michaela Friedrichsen, Stefan Floess, Jochen Huehn, Gwendolyn E. Patzer, Ivan Odak, Nadine Eckert, Razieh Zargari, Laura Ospina-Quintero, Hristo Georgiev, Reinhold Förster
Cell Mol Immunol. 2021 Feb; 18(2): 398–414. Published online 2021 Jan 6. doi: 10.1038/s41423-020-00599-z
PMCID:
PMC8027001
AbstractArticlePDF–5.7M
9.
Divergent Role for STAT5 in the Adaptive Responses of Natural Killer Cells
Gabriela M. Wiedemann, Simon Grassmann, Colleen M. Lau, Moritz Rapp, Alejandro V. Villarino, Christin Friedrich, Georg Gasteiger, John J. O’Shea, Joseph C. Sun
Cell Rep. Author manuscript; available in PMC 2020 Dec 30.
Published in final edited form as: Cell Rep. 2020 Dec 15; 33(11): 108498. doi: 10.1016/j.celrep.2020.108498
PMCID:
PMC7773031
AbstractArticlePDF–1.7M
10.
T cell signaling and Treg dysfunction correlate to disease kinetics in IL-2Rα-KO autoimmune mice
Genevieve N. Mullins, Kristen M. Valentine, Mufadhal Al-Kuhlani, Dan Davini, Kirk D. C. Jensen, Katrina K. Hoyer
Sci Rep. 2020; 10: 21994. Published online 2020 Dec 15. doi: 10.1038/s41598-020-78975-y
PMCID:
PMC7738527
AbstractArticlePDF–6.2M
11.
CD25-targeted IL-2 signals promote improved outcomes of influenza infection and boost memory CD4 T cell formation
Fahmida Alam, Ayushi Singh, Valeria Flores-Malavet, Stewart Sell, Andrea M. Cooper, Susan L. Swain, K. Kai McKinstry, Tara M. Strutt
J Immunol. Author manuscript; available in PMC 2021 Jun 15.
Published in final edited form as: J Immunol. 2020 Jun 15; 204(12): 3307–3314. Published online 2020 May 6. doi: 10.4049/jimmunol.2000205
PMCID:
PMC7327712
AbstractArticlePDF–978K
12.
IFN-γ and CD25 drive distinct pathological features during hemophagocytic lymphohistiocytosis
Stéphanie Humblet-Baron, Dean Franckaert, James Dooley, Fatima Ailal, Aziz Bousfiha, Caroline Deswarte, Carmen Oleaga-Quintas, Jean-Laurent Casanova, Jacinta Bustamante, Adrian Liston
J Allergy Clin Immunol. Author manuscript; available in PMC 2020 Jun 1.
Published in final edited form as: J Allergy Clin Immunol. 2019 Jun; 143(6): 2215–2226.e7. Published online 2018 Dec 19. doi: 10.1016/j.jaci.2018.10.068
PMCID:
PMC7117880
AbstractArticlePDF–1.8M
13.
Dosage effect of multiple genes accounts for multisystem disorder of myotonic dystrophy type 1
Qi Yin, Hongye Wang, Na Li, Yifu Ding, Zhenfei Xie, Lifang Jin, Yan Li, Qiong Wang, Xinyi Liu, Liuqing Xu, Qing Li, Yongjian Ma, Yanbo Cheng, Kai Wang, Cuiqing Zhong, Qian Yu, Wei Tang, Wanjin Chen, Wenjun Yang, Fan Zhang, Chen Ding, Lan Bao, Bin Zhou, Ping Hu, Jinsong Li
Cell Res. 2020 Feb; 30(2): 133–145. Published online 2019 Dec 18. doi: 10.1038/s41422-019-0264-2
PMCID:
PMC7015062
AbstractArticlePDF–5.5M
14.
Subthalamic Neurons Coordinate Basal Ganglia Function through Differential Neural Pathways
Yasunobu Yasoshima, Nobuyuki Kai, Shigetaka Yoshida, Sadao Shiosaka, Yoshimasa Koyama, Yukihiko Kayama, Kazuto Kobayashi
J Neurosci. 2005 Aug 24; 25(34): 7743–7753. doi: 10.1523/JNEUROSCI.1904-05.2005
PMCID:
PMC6725250
AbstractArticlePDF–888K
15.
BCL6 corepressor contributes to Th17 cell formation by inhibiting Th17 fate suppressors
Jessica A. Kotov, Dmitri I. Kotov, Jonathan L. Linehan, Vivian J. Bardwell, Micah D. Gearhart, Marc K. Jenkins
J Exp Med. 2019 Jun 3; 216(6): 1450–1464. Published online 2019 May 3. doi: 10.1084/jem.20182376
PMCID:
PMC6547868
AbstractArticlePDF–3.1M
16.
TCR affinity biases Th cell differentiation by regulating CD25, Eef1e1, and Gbp2
Dmitri I. Kotov, Jason S. Mitchell, Thomas Pengo, Christiane Ruedl, Sing Sing Way, Ryan A. Langlois, Brian T. Fife, Marc K. Jenkins
J Immunol. Author manuscript; available in PMC 2020 May 1.
Published in final edited form as: J Immunol. 2019 May 1; 202(9): 2535–2545. Published online 2019 Mar 11. doi: 10.4049/jimmunol.1801609
PMCID:
PMC6478541
AbstractArticlePDF–1.7M
17.
Essential and non-overlapping IL-2Rα-dependent processes for thymic development and peripheral homeostasis of regulatory T cells
Kevin H. Toomer, Jen Bon Lui, Norman H. Altman, Yuguang Ban, Xi Chen, Thomas R. Malek
Nat Commun. 2019; 10: 1037. Published online 2019 Mar 4. doi: 10.1038/s41467-019-08960-1
PMCID:
PMC6399264
AbstractArticlePDF–2.8M
18.
Interleukin 2 modulates thymic-derived regulatory T cell epigenetic landscape
Laurent Chorro, Masako Suzuki, Shu Shien Chin, Tere M. Williams, Erik L. Snapp, Livia Odagiu, Nathalie Labrecque, Grégoire Lauvau
Nat Commun. 2018; 9: 5368. Published online 2018 Dec 18. doi: 10.1038/s41467-018-07806-6
PMCID:
PMC6299086
AbstractArticlePDF–3.6M
19.
Differential Roles of IL-2 Signaling in Developing versus Mature Tregs
Martin Y. Fan, Jun Siong Low, Naoki Tanimine, Kelsey K. Finn, Bhavana Priyadharshini, Sharon K. Germana, Susan M. Kaech, Laurence A. Turka
Cell Rep. Author manuscript; available in PMC 2018 Dec 11.
Published in final edited form as: Cell Rep. 2018 Oct 30; 25(5): 1204–1213.e4. doi: 10.1016/j.celrep.2018.10.002
PMCID:
PMC6289175
AbstractArticlePDF–1.0M
20.
IL-2 is required for the generation of viral-specific CD4+ Th1 Trms cells and B cells are essential for maintenance in the lung
Brian D. Hondowicz, Karen S. Kim, Mikel J. Ruterbusch, Gladys J. Keitany, Marion Pepper
Eur J Immunol. Author manuscript; available in PMC 2019 Jan 1.
Published in final edited form as: Eur J Immunol. 2018 Jan; 48(1): 80–86. Published online 2017 Oct 13. doi: 10.1002/eji.201746928
PMCID:
PMC6215361
AbstractArticlePDF–950K

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