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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 106305212.

Pyruvate dehydrogenase kinase 1 protects against neuronal injury and memory loss in mouse models of diabetes

Yuan Yao, Jiaming Shi, Chunlai Zhang, Wei Gao, Ning Huang, Yaobei Liu, Weiwen Yan, Yingguang Han, Wenjuan Zhou, Liang Kong

Cell Death Dis. 2023 Nov; 14(11): 722. Published online 2023 Nov 7. doi: 10.1038/s41419-023-06249-2

PMCID:: PMC10630521

Abstract Article PDF–5.3M

Select item 103309143.

Sall4 restricts glycolytic metabolism in limb buds through transcriptional regulation of glycolytic enzyme genes

Hiroko Kawakami, Katherine Q. Chen, Ruizhi Zhang, Matthew P. Pappas, Abigail Bailey, Julie A. Reisz, Dylan Corcoran, Ryuichi Nishinakamura, Angelo D’Alessandro, Yasuhiko Kawakami

Dev Biol. Author manuscript; available in PMC 2024 Sep 1.

Published in final edited form as: Dev Biol. 2023 Sep; 501: 28–38. Published online 2023 Jun 8. doi: 10.1016/j.ydbio.2023.06.004

PMCID:: PMC10330914

Abstract Article PDF–1.7M

Select item 103183884.

Pyruvate dehydrogenase kinase regulates vascular inflammation in atherosclerosis and increases cardiovascular risk

Maria J Forteza, Martin Berg, Andreas Edsfeldt, Jangming Sun, Roland Baumgartner, Ilona Kareinen, Felipe Beccaria Casagrande, Ulf Hedin, Song Zhang, Ivan Vuckovic, Petras P Dzeja, Konstantinos A Polyzos, Anton Gisterå, Mette Trauelsen, Thue W Schwartz, Lea Dib, Joerg Herrmann, Claudia Monaco, Ljubica Matic, Isabel Gonçalves, Daniel F J Ketelhuth

Cardiovasc Res. 2023 Jun; 119(7): 1524–1536. Published online 2023 Mar 2. doi: 10.1093/cvr/cvad038

PMCID:: PMC10318388

Abstract Article PDF–83M

Select item 103078525.

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility

Juan Gu, Pingyang Ke, Haokun Guo, Jing Liu, Yan Liu, Xin Tian, Zhuo Huang, Xin Xu, Demei Xu, Yuanlin Ma, Xuefeng Wang, Fei Xiao

Cell Death Differ. 2023 Jul; 30(7): 1726–1741. Published online 2023 May 4. doi: 10.1038/s41418-023-01174-5

PMCID:: PMC10307852

Abstract Article PDF–8.8M

Select item 100426086.

Analysis of a genetic region affecting mouse body weight

Connie L. K. Leung, Subashini Karunakaran, Michael G. Atser, Leyla Innala, Xiaoke Hu, Victor Viau, James D. Johnson, Susanne M. Clee

Physiol Genomics. 2023 Mar 1; 55(3): 132–146. Published online 2023 Jan 30. doi: 10.1152/physiolgenomics.00137.2022

PMCID:: PMC10042608

Abstract Article

Select item 85998647.

TMEM116 is required for lung cancer cell motility and metastasis through PDK1 signaling pathway

Suhong Zhang, Haiting Dai, Wenya Li, Runming Wang, Hanyu Wu, Ming Shen, Ye Hu, Lixin Xie, Yiming Xing

Cell Death Dis. 2021 Dec; 12(12): 1086. Published online 2021 Nov 16. doi: 10.1038/s41419-021-04369-1

PMCID:: PMC8599864

Abstract Article PDF–5.8M

Select item 85893108.

Adhesion G protein–coupled receptor Gpr126/Adgrg6 is essential for placental development

Rebeca Torregrosa-Carrión, Rebeca Piñeiro-Sabarís, Marcos Siguero-Álvarez, Joaquím Grego-Bessa, Luis Luna-Zurita, Vitor Samuel Fernandes, Donal MacGrogan, Didier Y. R. Stainier, José Luis de la Pompa

Sci Adv. 2021 Nov; 7(46): eabj5445. Published online 2021 Nov 12. doi: 10.1126/sciadv.abj5445

PMCID:: PMC8589310

Abstract Article PDF–19M

Select item 84928759.

Pyruvate dehydrogenase kinase 1 and 2 deficiency reduces high-fat diet-induced hypertrophic obesity and inhibits the differentiation of preadipocytes into mature adipocytes

Hyeon-Ji Kang, Byong-Keol Min, Won-Il Choi, Jae-Han Jeon, Dong Wook Kim, Sungmi Park, Yun-Kyung Lee, Hwa-jin Kim, Ju-Eun Byeon, Younghoon Go, Hye Jin Ham, Yong Hyun Jeon, Mi-Jin Kim, Jung Yi Lee, Adam R. Wende, Sung Hee Choi, Robert A. Harris, In-Kyu Lee

Exp Mol Med. 2021 Sep; 53(9): 1390–1401. Published online 2021 Sep 22. doi: 10.1038/s12276-021-00672-1

PMCID:: PMC8492875

Abstract Article PDF–5.5M

Select item 849051610.

The kinase PDK1 regulates regulatory T cell survival via controlling redox homeostasis

Peiran Feng, Quanli Yang, Liang Luo, Yadong Sun, Wenkai Lv, Shuo Wan, Zerong Guan, Zhiqiang Xiao, Feng Liu, Zehua Li, Zhongjun Dong, Meixiang Yang

Theranostics. 2021; 11(19): 9503–9518. Published online 2021 Sep 13. doi: 10.7150/thno.63992

PMCID:: PMC8490516

Abstract Article PDF–3.9M

Select item 831323911.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

Select item 793877012.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 790021913.

Activation of amino acid metabolic program in cardiac HIF1-alpha-deficient mice

Ivan Menendez-Montes, Beatriz Escobar, Manuel J. Gomez, Teresa Albendea-Gomez, Beatriz Palacios, Elena Bonzon-Kulichenko, Jose Luis Izquierdo-Garcia, Ana Vanessa Alonso, Alessia Ferrarini, Luis Jesus Jimenez-Borreguero, Jesus Ruiz-Cabello, Jesus Vázquez, Silvia Martin-Puig

iScience. 2021 Feb 19; 24(2): 102124. Published online 2021 Feb 3. doi: 10.1016/j.isci.2021.102124

PMCID:: PMC7900219

Abstract Article PDF–6.0M

Select item 788157014.

PDK1 is a negative regulator of axon regeneration

Hyemin Kim, Jinyoung Lee, Yongcheol Cho

Mol Brain. 2021; 14: 31. Published online 2021 Feb 12. doi: 10.1186/s13041-021-00748-z

PMCID:: PMC7881570

Abstract Article PDF–3.7M

Select item 758952415.

Targeting SKA3 suppresses the proliferation and chemoresistance of laryngeal squamous cell carcinoma via impairing PLK1–AKT axis-mediated glycolysis

Wei Gao, Yuliang Zhang, Hongjie Luo, Min Niu, Xiwang Zheng, Wanglai Hu, Jiajia Cui, Xuting Xue, Yunfeng Bo, Fengsheng Dai, Yan Lu, Dongli Yang, Yujia Guo, Huina Guo, Huizheng Li, Yu Zhang, Tao Yang, Li Li, Linshi Zhang, Rui Hou, Shuxin Wen, Changming An, Teng Ma, Lei Jin, Wei Xu, Yongyan Wu

Cell Death Dis. 2020 Oct; 11(10): 919. Published online 2020 Oct 26. doi: 10.1038/s41419-020-03104-6

PMCID:: PMC7589524

Abstract Article PDF–5.2M

Select item 749303016.

Pyruvate dehydrogenase kinase is a negative regulator of interleukin-10 production in macrophages

Yi Rang Na, Daun Jung, Juha Song, Jong-Wan Park, Jung Joo Hong, Seung Hyeok Seok

J Mol Cell Biol. 2020 Jul; 12(7): 543–555. Published online 2020 Jan 3. doi: 10.1093/jmcb/mjz113

PMCID:: PMC7493030

Abstract Article PDF–1.5M

Select item 726108717.

The PDK1-FoxO1 signaling in adipocytes controls systemic insulin sensitivity through the 5-lipoxygenase–leukotriene B₄ axis

Tetsuya Hosooka, Yusei Hosokawa, Kaku Matsugi, Masakazu Shinohara, Yoko Senga, Yoshikazu Tamori, Chikako Aoki, Sho Matsui, Tsutomu Sasaki, Tadahiro Kitamura, Masashi Kuroda, Hiroshi Sakaue, Kazuhiro Nomura, Kei Yoshino, Yuko Nabatame, Yoshito Itoh, Kanji Yamaguchi, Yoshitake Hayashi, Jun Nakae, Domenico Accili, Takehiko Yokomizo, Susumu Seino, Masato Kasuga, Wataru Ogawa

Proc Natl Acad Sci U S A. 2020 May 26; 117(21): 11674–11684. Published online 2020 May 11. doi: 10.1073/pnas.1921015117

PMCID:: PMC7261087

Abstract Article PDF–1.8M

Select item 719713818.

PDK1 regulates the survival of the developing cortical interneurons

Yongjie Wei, Xiaoning Han, Chunjie Zhao

Mol Brain. 2020; 13: 65. Published online 2020 May 4. doi: 10.1186/s13041-020-00604-6

PMCID:: PMC7197138

Abstract Article PDF–9.2M

Select item 691749419.

Coronary arterial development is regulated by a Dll4-Jag1-EphrinB2 signaling cascade

Stanislao Igor Travisano, Vera Lucia Oliveira, Belén Prados, Joaquim Grego-Bessa, Rebeca Piñeiro-Sabarís, Vanesa Bou, Manuel J Gómez, Fátima Sánchez-Cabo, Donal MacGrogan, José Luis de la Pompa

eLife. 2019; 8: e49977. Published online 2019 Dec 4. doi: 10.7554/eLife.49977

PMCID:: PMC6917494

Abstract Article PDF–19M

Select item 662242620.

Von Hippel-Lindau Acts as a Metabolic Switch Controlling Nephron Progenitor Differentiation

Kasey Cargill, Shelby L. Hemker, Andrew Clugston, Anjana Murali, Elina Mukherjee, Jiao Liu, Daniel Bushnell, Andrew J. Bodnar, Zubaida Saifudeen, Jacqueline Ho, Carlton M. Bates, Dennis Kostka, Eric S. Goetzman, Sunder Sims-Lucas

J Am Soc Nephrol. 2019 Jul; 30(7): 1192–1205. Published online 2019 May 29. doi: 10.1681/ASN.2018111170

PMCID:: PMC6622426

Abstract Article

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