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Select item 108979071.

Cbl-b mitigates the responsiveness of naive CD8⁺ T cells that experience extensive tonic T cell receptor signaling

Joel Eggert, Wendy M. Zinzow-Kramer, Yuesong Hu, Elizabeth M. Kolawole, Yuan-Li Tsai, Arthur Weiss, Brian D. Evavold, Khalid Salaita, Christopher D. Scharer, Byron B. Au-Yeung

Sci Signal. Author manuscript; available in PMC 2024 Mar 6.

Published in final edited form as: Sci Signal. 2024 Feb 6; 17(822): eadh0439. Published online 2024 Feb 6. doi: 10.1126/scisignal.adh0439

PMCID:: PMC10897907

Abstract Article PDF–2.0M

Select item 103379712.

Seven naturally variant loci serve as genetic modifiers of Lamc2^jeb induced non-Herlitz junctional Epidermolysis Bullosa in mice

Thomas J. Sproule, Vivek M. Philip, Nabig A. Chaudhry, Derry C. Roopenian, John P. Sundberg

PLoS One. 2023; 18(7): e0288263. Published online 2023 Jul 12. doi: 10.1371/journal.pone.0288263

PMCID:: PMC10337971

Abstract Article PDF–3.7M

Select item 93990873.

Covalent TCR-peptide-MHC interactions induce T cell activation and redirect T cell fate in the thymus

Christopher Szeto, Pirooz Zareie, Rushika C. Wirasinha, Justin B. Zhang, Andrea T. Nguyen, Alan Riboldi-Tunnicliffe, Nicole L. La Gruta, Stephanie Gras, Stephen R. Daley

Nat Commun. 2022; 13: 4951. Published online 2022 Aug 23. doi: 10.1038/s41467-022-32692-4

PMCID:: PMC9399087

Abstract Article PDF–2.9M

Select item 82929834.

Positive feedback between the T cell kinase Zap70 and its substrate LAT acts as a clustering-dependent signaling switch

Elliot Dine, Ellen H. Reed, Jared E. Toettcher

Cell Rep. Author manuscript; available in PMC 2021 Jul 21.

Published in final edited form as: Cell Rep. 2021 Jun 22; 35(12): 109280. doi: 10.1016/j.celrep.2021.109280

PMCID:: PMC8292983

Abstract Article PDF–2.7M

Select item 81172095.

Cbl-b deficiency prevents functional but not phenotypic T cell anergy

Trang T.T. Nguyen, Zhi-En Wang, Lin Shen, Andrew Schroeder, Walter Eckalbar, Arthur Weiss

J Exp Med. 2021 Jul 5; 218(7): e20202477. Published online 2021 May 11. doi: 10.1084/jem.20202477

PMCID:: PMC8117209

Abstract Article PDF–6.4M

Select item 73403436.

Alternative ZAP70-p38 signals prime a classical p38 pathway through LAT and SOS to support regulatory T cell differentiation

Jesse E. Jun, Kayla R. Kulhanek, Hang Chen, Arup Chakraborty, Jeroen P. Roose

Sci Signal. Author manuscript; available in PMC 2020 Jul 7.

Published in final edited form as: Sci Signal. 2019 Jul 23; 12(591): eaao0736. Published online 2019 Jul 23. doi: 10.1126/scisignal.aao0736

PMCID:: PMC7340343

Abstract Article PDF–2.4M

Select item 71958497.

Phosphotyrosine-dependent interaction between the kinases PKCθ and Zap70 promotes proximal TCR signaling

Jiji Xie, Xuemei Han, Chensi Zhao, Ann J. Canonigo-Balancio, John R. Yates, III, Yingqiu Li, Björn F. Lillemeier, Amnon Altman

Sci Signal. Author manuscript; available in PMC 2020 May 2.

Published in final edited form as: Sci Signal. 2019 Apr 16; 12(577): eaar3349. Published online 2019 Apr 16. doi: 10.1126/scisignal.aar3349

PMCID:: PMC7195849

Abstract Article PDF–2.0M

Select item 69524388.

GM-CSF drives dysregulated hematopoietic stem cell activity and pathogenic extramedullary myelopoiesis in experimental spondyloarthritis

Daniel Regan-Komito, James W. Swann, Philippos Demetriou, E. Suzanne Cohen, Nicole J. Horwood, Stephen N. Sansom, Thibault Griseri

Nat Commun. 2020; 11: 155. Published online 2020 Jan 9. doi: 10.1038/s41467-019-13853-4

PMCID:: PMC6952438

Abstract Article PDF–3.0M

Select item 69387069.

mDia1/3-dependent actin polymerization spatiotemporally controls LAT phosphorylation by Zap70 at the immune synapse

D. Thumkeo, Y. Katsura, Y. Nishimura, P. Kanchanawong, K. Tohyama, T. Ishizaki, S. Kitajima, C. Takahashi, T. Hirata, N. Watanabe, M. F. Krummel, S. Narumiya

Sci Adv. 2020 Jan; 6(1): eaay2432. Published online 2020 Jan 1. doi: 10.1126/sciadv.aay2432

PMCID:: PMC6938706

Abstract Article PDF–3.9M

Select item 680591910.

GTPase-activating protein Rasal1 associates with ZAP-70 of the TCR and negatively regulates T-cell tumor immunity

Youg Raj Thaker, Monika Raab, Klaus Strebhardt, Christopher E. Rudd

Nat Commun. 2019; 10: 4804. Published online 2019 Oct 22. doi: 10.1038/s41467-019-12544-4

PMCID:: PMC6805919

Abstract Article PDF–1.7M

Select item 674491911.

Reporters of TCR signaling identify arthritogenic T cells in murine and human autoimmune arthritis

Judith F. Ashouri, Lih-Yun Hsu, Steven Yu, Dmitry Rychkov, Yiling Chen, Debra A. Cheng, Marina Sirota, Erik Hansen, Lisa Lattanza, Julie Zikherman, Arthur Weiss

Proc Natl Acad Sci U S A. 2019 Sep 10; 116(37): 18517–18527. Published online 2019 Aug 27. doi: 10.1073/pnas.1904271116

PMCID:: PMC6744919

Abstract Article PDF–1.9M

Select item 656261512.

ZAP-70 Regulates Autoimmune Arthritis via Alterations in T Cell Activation and Apoptosis

Réka Kugyelka, Lilla Prenek, Katalin Olasz, Zoltán Kohl, Bálint Botz, Tibor T. Glant, Timea Berki, Ferenc Boldizsár

Cells. 2019 May; 8(5): 504. Published online 2019 May 24. doi: 10.3390/cells8050504

PMCID:: PMC6562615

Abstract Article PDF–1.3M

Select item 648547713.

Innate-like T cells straddle innate and adaptive immunity by revising antigen-receptor responsiveness

Melanie Wencker, Gleb Turchinovich, Rafael Di Marco Barros, Livija Deban, Anett Jandke, Andrew Cope, Adrian C Hayday

Nat Immunol. Author manuscript; available in PMC 2019 Apr 26.

Published in final edited form as: Nat Immunol. 2014 Jan; 15(1): 80–87. Published online 2013 Nov 17. doi: 10.1038/ni.2773

PMCID:: PMC6485477

Abstract Article PDF–2.7M

Select item 620224914.

Lck promotes Zap70-dependent LAT phosphorylation by bridging Zap70 to LAT

Wan-Lin Lo, Neel H. Shah, Nagib Ahsan, Veronika Horkova, Ondrej Stepanek, Arthur R. Salomon, John Kuriyan, Arthur Weiss

Nat Immunol. Author manuscript; available in PMC 2018 Dec 18.

Published in final edited form as: Nat Immunol. 2018 Jul; 19(7): 733–741. Published online 2018 Jun 18. doi: 10.1038/s41590-018-0131-1

PMCID:: PMC6202249

Abstract Article PDF–1.0M

Select item 614340415.

Nod2-deficiency augments Th17-responses and exacerbates autoimmune arthritis

Ruth J. Napier, Ellen J. Lee, Emily E. Vance, Paige Snow, Kimberly A. Samson, Clare E. Dawson, Amy E. Moran, Peter Stenzel, Michael P. Davey, Shimon Sakaguchi, Holly L. Rosenzweig

J Immunol. Author manuscript; available in PMC 2019 Oct 1.

Published in final edited form as: J Immunol. 2018 Oct 1; 201(7): 1889–1898. Published online 2018 Aug 27. doi: 10.4049/jimmunol.1700507

PMCID:: PMC6143404

Abstract Article PDF–884K

Select item 603527816.

Altered thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant ZAP70

Meng Zhao, Mattias N. D. Svensson, Koen Venken, Ashu Chawla, Shu Liang, Isaac Engel, Piotr Mydel, Jeremy Day, Dirk Elewaut, Nunzio Bottini, Mitchell Kronenberg

Nat Commun. 2018; 9: 2627. Published online 2018 Jul 6. doi: 10.1038/s41467-018-05095-7