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Select item 100286691.

Rac1/PAK1 signaling contributes to bone cancer pain by Regulation dendritic spine remodeling in rats

Lingfei Xu, Long Yang, Yan Wu, Xinxin Wan, Xihui Tang, Yuqing Xu, Qingsong Chen, Yuepeng Liu, Su Liu

Mol Pain. 2023; 19: 17448069231161031. Published online 2023 Mar 20. doi: 10.1177/17448069231161031

Correction in:: Mol Pain. 2023; 19: 17448069231182501.

PMCID:: PMC10028669

Abstract Article PDF–2.1M

Select item 69543642.

Up-regulation of P21-activated kinase 1 in osteoarthritis chondrocytes is responsible for osteoarthritic cartilage destruction

Wanli Ma, Xiaohe Wang, Chunhui Wang, Mingzhi Gong, Peng Ren

Biosci Rep. 2020 Jan 31; 40(1): BSR20191017. Published online 2020 Jan 10. doi: 10.1042/BSR20191017

PMCID:: PMC6954364

Abstract Article PDF–2.0M

Select item 67250783.

Deleted in Colorectal Cancer Binding Netrin-1 Mediates Cell Substrate Adhesion and Recruits Cdc42, Rac1, Pak1, and N-WASP into an Intracellular Signaling Complex That Promotes Growth Cone Expansion

Masoud Shekarabi, Simon W. Moore, Nicolas X. Tritsch, Stephen J. Morris, Jean-Francois Bouchard, Timothy E. Kennedy

J Neurosci. 2005 Mar 23; 25(12): 3132–3141. doi: 10.1523/JNEUROSCI.1920-04.2005

PMCID:: PMC6725078

Abstract Article PDF–499K

Select item 57044844.

Ragadeepthi Tunduguru, Jing Zhang, Arianne Aslamy, Vishal A. Salunkhe, Joseph T. Brozinick, Jeffrey S. Elmendorf, Debbie C. Thurmond

J Biol Chem. 2017 Nov 17; 292(46): 19034–19043. Published online 2017 Sep 25. doi: 10.1074/jbc.M117.801340

PMCID:: PMC5704484

Abstract Article PDF–528K

Select item 54654805.

Protein kinase D1 (PKD1) phosphorylation on Ser²⁰³ by type I p21-activated kinase (PAK) regulates PKD1 localization

Jen-Kuan Chang, Yang Ni, Liang Han, James Sinnett-Smith, Rodrigo Jacamo, Osvaldo Rey, Steven H. Young, Enrique Rozengurt

J Biol Chem. 2017 Jun 9; 292(23): 9523–9539. Published online 2017 Apr 13. doi: 10.1074/jbc.M116.771394

PMCID:: PMC5465480

Abstract Article PDF–3.0M

Select item 53863596.

MicroRNA-494 inhibits breast cancer progression by directly targeting PAK1

Meng-Na Zhan, Xiao-Ting Yu, Jun Tang, Ci-Xiang Zhou, Chen-Long Wang, Qian-Qian Yin, Xiu-Feng Gong, Ming He, Jian-Rong He, Guo-Qiang Chen, Qian Zhao

Cell Death Dis. 2017 Jan; 8(1): e2529. Published online 2017 Jan 5. doi: 10.1038/cddis.2016.440

PMCID:: PMC5386359

Abstract Article PDF–4.2M

Select item 50088067.

Tuning PAK Activity to Rescue Abnormal Myelin Permeability in HNPP

Bo Hu, Sezgi Arpag, Xuebao Zhang, Wiebke Möbius, Hauke Werner, Gina Sosinsky, Mark Ellisman, Yang Zhang, Audra Hamilton, Jonathan Chernoff, Jun Li

PLoS Genet. 2016 Sep; 12(9): e1006290. Published online 2016 Sep 1. doi: 10.1371/journal.pgen.1006290

PMCID:: PMC5008806

Abstract Article PDF–11M

Select item 49076988.

p21-activated kinase 1 restricts tonic endocannabinoid signaling in the hippocampus

Shuting Xia, Zikai Zhou, Celeste Leung, Yuehua Zhu, Xingxiu Pan, Junxia Qi, Maria Morena, Matthew N Hill, Wei Xie, Zhengping Jia

eLife. 2016; 5: e14653. Published online 2016 Jun 14. doi: 10.7554/eLife.14653

PMCID:: PMC4907698

Abstract Article PDF–5.8M

Select item 48488059.

Down-regulation of p21-activated serine/threonine kinase 1 is involved in loss of mesencephalic dopamine neurons

Hwanhee Kim, Jun-Young Oh, Sun-Lim Choi, Yeon-Ju Nam, Anna Jo, Ara Kwon, Eun-Young Shin, Eung-Gook Kim, Hyong Kyu Kim

Mol Brain. 2016; 9: 45. Published online 2016 Apr 27. doi: 10.1186/s13041-016-0230-6

PMCID:: PMC4848805

Abstract Article PDF–2.2M

Select item 476109010.

Involvement of Rac1 signalling pathway in the development and maintenance of acute inflammatory pain induced by bee venom injection

Yan Wang, Yun‐Fei Lu, Chun‐Li Li, Wei Sun, Zhen Li, Rui‐Rui Wang, Ting He, Fan Yang, Yan Yang, Xiao‐Liang Wang, Su‐Min Guan, Jun Chen

Br J Pharmacol. 2016 Mar; 173(5): 937–950. Published online 2016 Feb 10. doi: 10.1111/bph.13413

PMCID:: PMC4761090

Abstract Article PDF–2.1M

Select item 468292411.

Inhibition of Nischarin Expression Promotes Neurite Outgrowth through Regulation of PAK Activity

Yuemin Ding, Yuying Li, Lingchao Lu, Ruyi Zhang, Linghui Zeng, Linlin Wang, Xiong Zhang

PLoS One. 2015; 10(12): e0144948. Published online 2015 Dec 15. doi: 10.1371/journal.pone.0144948

PMCID:: PMC4682924

Abstract Article PDF–1.1M

Select item 441852412.

Signaling of the p21-activated kinase (PAK1) coordinates insulin-stimulated actin remodeling and glucose uptake in skeletal muscle cells

Ragadeepthi Tunduguru, Tim T. Chiu, Latha Ramalingam, Jeffrey S. Elmendorf, Amira Klip, Debbie C. Thurmond

Biochem Pharmacol. Author manuscript; available in PMC 2015 May 4.

Published in final edited form as: Biochem Pharmacol. 2014 Nov 15; 92(2): 380–388. Published online 2014 Sep 6. doi: 10.1016/j.bcp.2014.08.033

PMCID:: PMC4418524

Abstract Article PDF–771K

Select item 438592813.

PAK1 regulates RUFY3-mediated gastric cancer cell migration and invasion

G Wang, Q Zhang, Y Song, X Wang, Q Guo, J Zhang, J Li, Y Han, Z Miao, F Li

Cell Death Dis. 2015 Mar; 6(3): e1682. Published online 2015 Mar 12. doi: 10.1038/cddis.2015.50

PMCID:: PMC4385928

Abstract Article PDF–4.2M

Select item 421330014.

Social learning and amygdala disruptions in Nf1 mice are rescued by blocking p21-activated kinase

Andrei I. Molosh, Philip L. Johnson, John P. Spence, David Arendt, Lauren M. Federici, Cristian Bernabe, Steven P. Janasik, Zaneer M. Segu, Rajesh Khanna, Chirayu Goswami, Weiguo Zhu, Su-Jung Park, Lang Li, Yehia S. Mechref, D. Wade Clapp, Anantha Shekhar

Nat Neurosci. Author manuscript; available in PMC 2015 May 1.

Published in final edited form as: Nat Neurosci. 2014 Nov; 17(11): 1583–1590. Published online 2014 Sep 21. doi: 10.1038/nn.3822

PMCID:: PMC4213300

Abstract Article PDF–1.8M

Select item 415776615.

Microtubule Dynamics Control HGF-Induced Lung Endothelial Barrier Enhancement

Xinyong Tian, Yufeng Tian, Nurgul Moldobaeva, Nicolene Sarich, Anna A. Birukova

PLoS One. 2014; 9(9): e105912. Published online 2014 Sep 8. doi: 10.1371/journal.pone.0105912

PMCID:: PMC4157766

Abstract Article PDF–6.8M

Select item 411724716.

Rho GTPases in insulin-stimulated glucose uptake

Takaya Satoh

Small GTPases. 2014; 5: e28102. Published online 2014 Mar 10. doi: 10.4161/sgtp.28102

PMCID:: PMC4117247

Abstract Article PDF–865K

Select item 408361817.

A Trio-Rac1-PAK1 signaling axis drives invadopodia disassembly

Yasmin Moshfegh, Jose Javier Bravo-Cordero, Veronika Miskolci, John Condeelis, Louis Hodgson

Nat Cell Biol. Author manuscript; available in PMC 2014 Dec 1.

Published in final edited form as: Nat Cell Biol. 2014 Jun; 16(6): 574–586. Published online 2014 May 25. doi: 10.1038/ncb2972

Correction in:: Nat Cell Biol. 2015 Mar; 17(3): 350.

PMCID:: PMC4083618

Abstract Article PDF–1.2M

Select item 388516018.

Novel role of Pyk2 in vascular wall remodeling following balloon injury

Ravisekhar Gadepalli, Nikhlesh K. Singh, Venkatesh Kundumani-Sridharan, Mark R. Heckle, Gadiparthi N. Rao

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2014 Jan 8.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2012 Nov; 32(11): 10.1161/ATVBAHA.112.253112. Published online 2012 Aug 23. doi: 10.1161/ATVBAHA.112.253112

PMCID:: PMC3885160

Abstract Article PDF–7.0M

Select item 361930219.

Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486

Bridget M. Dolan, Sergio G. Duron, David A. Campbell, Benedikt Vollrath, B. S. Shankaranarayana Rao, Hui-Yeon Ko, Gregory G. Lin, Arvind Govindarajan, Se-Young Choi, Susumu Tonegawa

Proc Natl Acad Sci U S A. 2013 Apr 2; 110(14): 5671–5676. Published online 2013 Mar 18. doi: 10.1073/pnas.1219383110

PMCID:: PMC3619302

Abstract Article PDF–454K

Select item 355479320.

MORC2 Signaling Facilitates Phosphorylation-dependent, ATPase-coupled Chromatin Remodeling during the DNA Damage Response

Da-Qiang Li, Sujit S. Nair, Kazufumi Ohshiro, Anupam Kumar, Vasudha S. Nair, Suresh B. Pakala, Sirigiri Divijendra Natha Reddy, Rajendra P. Gajula, Jeyanthy Eswaran, L. Aravind, Rakesh Kumar

Cell Rep. Author manuscript; available in PMC 2013 Jan 24.

Published in final edited form as: Cell Rep. 2012 Dec 27; 2(6): 1657–1669. doi: 10.1016/j.celrep.2012.11.018