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Select item 115117501.

Solid-state NMR assignment of α-synuclein polymorph prepared from helical intermediate

Sahil Ahlawat, Surabhi Mehra, Chandrakala M. Gowda, Samir K Maji, Vipin Agarwal

Biomol NMR Assign. 2024; 18(2): 193–200. Published online 2024 Jul 4. doi: 10.1007/s12104-024-10188-0

PMCID:: PMC11511750

Abstract Article PDF–4.0M

Select item 114963192.

Mitophagy Upregulation Occurs Early in the Neurodegenerative Process Mediated by α-Synuclein

Sarah Hui, Jimmy George, Minesh Kapadia, Hien Chau, Zahn Bariring, Rebecca Earnshaw, Kashfia Shafiq, Lorraine V. Kalia, Suneil K. Kalia

Mol Neurobiol. 2024; 61(11): 9032–9042. Published online 2024 Apr 6. doi: 10.1007/s12035-024-04131-6

PMCID:: PMC11496319

Abstract Article PDF–1.3M

Select item 114469543.

Analysis and comparison of post-translational modifications of α-synuclein filaments in multiple system atrophy and dementia with Lewy bodies

Fuyuki Kametani, Marina Tahira, Masaki Takao, Tomoyasu Matsubara, Kazuko Hasegawa, Mari Yoshida, Yuko Saito, Shigeo Murayama, Masato Hasegawa

Sci Rep. 2024; 14: 22892. Published online 2024 Oct 2. doi: 10.1038/s41598-024-74130-z

PMCID:: PMC11446954

Abstract Article PDF–3.7M

Select item 114010344.

Proximity labeling reveals dynamic changes in the SQSTM1 protein network

Alejandro N. Rondón-Ortiz, Lushuang Zhang, Peter E.A. Ash, Avik Basu, Sambhavi Puri, Sophie J.F. van der Spek, Zihan Wang, Luke Dorrian, Andrew Emili, Benjamin Wolozin

J Biol Chem. 2024 Sep; 300(9): 107621. Published online 2024 Aug 3. doi: 10.1016/j.jbc.2024.107621

PMCID:: PMC11401034

Abstract Article PDF–5.4M

Select item 113776745.

Immune responses to oligomeric α-synuclein in Parkinson’s disease peripheral blood mononuclear cells

Ana Florencia Vega-Benedetti, Clara Porcedda, Tommaso Ercoli, Giuliana Fusco, Chiara Burgaletto, Rita Pillai, Francesca Palmas, Anna Flavia Cantone, Fabrizio Angius, Paolo Solla, Alfonso De Simone, Giuseppina Cantarella, Cesarina Giallongo, Valeria Sogos, Giovanni Defazio, Anna R. Carta

J Neurol. 2024; 271(9): 5916–5929. Published online 2024 Jul 10. doi: 10.1007/s00415-024-12554-3

PMCID:: PMC11377674

Abstract Article PDF–3.1M

Select item 113613486.

Interfering with aggregated α-synuclein in advanced melanoma leads to a major upregulation of MHC class II proteins

Claudia Fokken, Ivan Silbern, Orr Shomroni, Kuan-Ting Pan, Sergey Ryazanov, Andrei Leonov, Nadine Winkler, Henning Urlaub, Christian Griesinger, Dorothea Becker

Melanoma Res. 2024 Oct; 34(5): 393–407. Published online 2024 Jul 2. doi: 10.1097/CMR.0000000000000982

PMCID:: PMC11361348

Abstract Article PDF–1.7M

Select item 113361287.

RXR nuclear receptor signaling modulates lipid metabolism and triggers lysosomal clearance of alpha-synuclein in neuronal models of synucleinopathy

Arati Tripathi, Heba Alnakhala, Lisa Brontesi, Dennis Selkoe, Ulf Dettmer

Cell Mol Life Sci. 2024 Dec; 81(1): 362. Published online 2024 Aug 20. doi: 10.1007/s00018-024-05373-2

PMCID:: PMC11336128

Abstract Article PDF–3.4M

Select item 113311698.

Calcium influx: An essential process by which α-Synuclein regulates morphology of erythrocytes

Ying Yang, Min Shi, Xiaodan Liu, Qiaoyun Zhu, Zhi Xu, Genliang Liu, Tao Feng, Tessandra Stewart, Jing Zhang

J Adv Res. 2024 Aug; 62: 187–198. Published online 2023 Sep 13. doi: 10.1016/j.jare.2023.09.009

Correction in:: J Adv Res. 2024 Sep 23

PMCID:: PMC11331169

Abstract Article PDF–3.6M

Select item 113232489.

Wild-Type α-Synuclein Structure and Aggregation: A Comprehensive Coarse-Grained and All-Atom Molecular Dynamics Study

Gabriel F. Martins, Nuno Galamba

J Chem Inf Model. 2024 Aug 12; 64(15): 6115–6131. Published online 2024 Jul 24. doi: 10.1021/acs.jcim.4c00965

PMCID:: PMC11323248

Abstract Article PDF–9.5M

Select item 1129612110.

Human α‐synuclein overexpression upregulates SKOR1 in a rat model of simulated nigrostriatal ageing

Noelia Morales‐Prieto, Rebekah Bevans, Adam O'Mahony, Aaron Barron, Conor Giles Doran, Erin McCarthy, Ruth M. Concannon, Susan R. Goulding, Cathal M. McCarthy, Louise M. Collins, Aideen M. Sullivan, Gerard W. O'Keeffe

Aging Cell. 2024 Jun; 23(6): e14155. Published online 2024 Mar 26. doi: 10.1111/acel.14155

PMCID:: PMC11296121

Abstract Article PDF–2.5M

Select item 1125868011.

Mechanistic Insight into Intestinal α-Synuclein Aggregation in Parkinson’s Disease Using a Laser-Printed Electrochemical Sensor

Julia M. Balsamo, Keren Zhou, Vinay Kammarchedu, Aida Ebrahimi, Elizabeth N. Bess

ACS Chem Neurosci. 2024 Jul 17; 15(14): 2623–2632. Published online 2024 Jul 3. doi: 10.1021/acschemneuro.4c00106

PMCID:: PMC11258680

Abstract Article PDF–4.5M

Select item 1123586212.

Misfolded alpha‐synuclein in amyotrophic lateral sclerosis: Implications for diagnosis and treatment

Richard Smith, Hanna Hovren, Robert Bowser, Nadine Bakkar, Ralph Garruto, Albert Ludolph, John Ravits, Lia Gaertner, Davan Murphy, Russ Lebovitz

Eur J Neurol. 2024 Apr; 31(4): e16206. Published online 2024 Jan 25. doi: 10.1111/ene.16206

PMCID:: PMC11235862

Abstract Article PDF–2.6M

Select item 1120993513.

Antagonistic roles of canonical and alternative-RPA in disease-associated tandem CAG repeat instability

Terence Gall-Duncan, Jennifer Luo, Carla-Marie Jurkovic, Laura A. Fischer, Kyota Fujita, Amit L. Deshmukh, Rachel J. Harding, Stephanie Tran, Mustafa Mehkary, Vanessa Li, David E. Leib, Ran Chen, Hikari Tanaka, Amanda G. Mason, Dominique Lévesque, Mahreen Khan, Mortezaali Razzaghi, Tanya Prasolava, Stella Lanni, Nozomu Sato, Marie-Christine Caron, Gagan B. Panigrahi, Peixiang Wang, Rachel Lau, Arturo López Castel, Jean-Yves Masson, Lynette Tippett, Clinton Turner, Maria Spies, Albert R. La Spada, Eric I. Campos, Maurice A. Curtis, François-Michel Boisvert, Richard L.M. Faull, Beverly L. Davidson, Masayuki Nakamori, Hitoshi Okazawa, Marc S. Wold, Christopher E. Pearson

Cell. Author manuscript; available in PMC 2024 Oct 26.

Published in final edited form as: Cell. 2023 Oct 26; 186(22): 4898–4919.e25. Published online 2023 Oct 11. doi: 10.1016/j.cell.2023.09.008

PMCID:: PMC11209935

Abstract Article PDF–3.0M

Select item 1120425514.

Downregulation of Protease Cathepsin D and Upregulation of Pathologic α-Synuclein Mediate Paucity of DNAJC6-Induced Degeneration of Dopaminergic Neurons

Ching-Chi Chiu, Ying-Ling Chen, Yi-Hsin Weng, Shu-Yu Liu, Hon-Lun Li, Tu-Hsueh Yeh, Hung-Li Wang

Int J Mol Sci. 2024 Jun; 25(12): 6711. Published online 2024 Jun 18. doi: 10.3390/ijms25126711

PMCID:: PMC11204255

Abstract Article PDF–9.0M

Select item 1118156915.

Alpha-synuclein-induced stress sensitivity renders the Parkinson’s disease brain susceptible to neurodegeneration

Modestos Nakos Bimpos, Katerina Karali, Christine Antoniou, Dionysios Palermos, Maria Fouka, Anastasios Delis, Iason Tzieras, George Panagiotis Chrousos, Yassemi Koutmani, Leonidas Stefanis, Alexia Polissidis

Acta Neuropathol Commun. 2024; 12: 100. Published online 2024 Jun 17. doi: 10.1186/s40478-024-01797-w

PMCID:: PMC11181569

Abstract Article PDF–7.4M

Select item 1118018516.

Disease progression modelling reveals heterogeneity in trajectories of Lewy-type α-synuclein pathology

Sophie E. Mastenbroek, Jacob W. Vogel, Lyduine E. Collij, Geidy E. Serrano, Cécilia Tremblay, Alexandra L. Young, Richard A. Arce, Holly A. Shill, Erika D. Driver-Dunckley, Shyamal H. Mehta, Christine M. Belden, Alireza Atri, Parichita Choudhury, Frederik Barkhof, Charles H. Adler, Rik Ossenkoppele, Thomas G. Beach, Oskar Hansson

Nat Commun. 2024; 15: 5133. Published online 2024 Jun 15. doi: 10.1038/s41467-024-49402-x

PMCID:: PMC11180185

Abstract Article PDF–2.7M

Select item 1114058617.

Elevated ApoE, ApoJ and lipoprotein-bound α-synuclein levels in cerebrospinal fluid from Parkinson’s disease patients – Validation in the BioFIND cohort

Wojciech Paslawski, Per Svenningsson

Parkinsonism Relat Disord. Author manuscript; available in PMC 2024 May 31.

Published in final edited form as: Parkinsonism Relat Disord. 2023 Nov; 116: 105765. Published online 2023 Jul 12. doi: 10.1016/j.parkreldis.2023.105765

PMCID:: PMC11140586

Abstract Article PDF–1.2M

Select item 1113177418.

Synphilin-1 isoforms in Parkinson’s disease: regulation by phosphorylation and ubiquitylation

R. Szargel, R. Rott, S. Engelender

Cell Mol Life Sci. 2008 Jan; 65(1): 80–88. Published online 2007 Nov 5. doi: 10.1007/s00018-007-7343-0

PMCID:: PMC11131774

Abstract Article PDF–898K

Select item 1113164819.

Mitochondrial association of alpha-synuclein causes oxidative stress

M. S. Parihar, A. Parihar, M. Fujita, M. Hashimoto, P. Ghafourifar

Cell Mol Life Sci. 2008 Apr; 65(7-8): 1272–1284. Published online 2008 Feb 25. doi: 10.1007/s00018-008-7589-1

PMCID:: PMC11131648

Abstract Article PDF–2.8M

Select item 1111484120.

Synphilin-1 inhibits alpha-synuclein degradation by the proteasome

Beatriz Alvarez-Castelao, José G. Castaño

Cell Mol Life Sci. 2011 Aug; 68(15): 2643–2654. Published online 2010 Nov 20. doi: 10.1007/s00018-010-0592-3

PMCID:: PMC11114841

Abstract Article PDF–595K

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