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Select item 113995911.

CYYR1 promotes the degradation of the E3 ubiquitin ligase WWP1 and is associated with favorable prognosis in breast cancer

Tiphaine Perron, Mathieu Boissan, Ivan Bièche, Laura Courtois, Florent Dingli, Damarys Loew, Mouna Chouchène, Sabrina Colasse, Laurence Levy, Céline Prunier

J Biol Chem. 2024 Sep; 300(9): 107601. Published online 2024 Jul 24. doi: 10.1016/j.jbc.2024.107601

PMCID:: PMC11399591

Abstract Article PDF–2.8M

Select item 111148912.

WWP1: a versatile ubiquitin E3 ligase in signaling and diseases

Xu Zhi, Ceshi Chen

Cell Mol Life Sci. 2012 May; 69(9): 1425–1434. Published online 2011 Nov 4. doi: 10.1007/s00018-011-0871-7

PMCID:: PMC11114891

Abstract Article PDF–866K

Select item 109457073.

Comparative interactome analysis of α-arrestin families in human and Drosophila

Kyung-Tae Lee, Inez KA Pranoto, Soon-Young Kim, Hee-Joo Choi, Ngoc Bao To, Hansong Chae, Jeong-Yeon Lee, Jung-Eun Kim, Young V Kwon, Jin-Wu Nam

eLife. 2024; 12: RP88328. Published online 2024 Jan 25. doi: 10.7554/eLife.88328

PMCID:: PMC10945707

Abstract Article PDF–2.8M

Select item 101740914.

Cytoplasmic YAP1‐mediated ESCRT‐III assembly promotes autophagic cell death and is ubiquitinated by NEDD4L in breast cancer

Yan Guo, Yuqing Cui, Yangyang Li, Xiaoying Jin, Dandan Wang, Mengxia Lei, Fengzhi Chen, Yali Liu, Jinwen Xu, Guanyu Yao, Guangchun Zeng, Xuesong Chen

Cancer Commun (Lond) 2023 May; 43(5): 582–612. Published online 2023 Apr 2. doi: 10.1002/cac2.12417

PMCID:: PMC10174091

Abstract Article PDF–22M

Select item 99865205.

Lysosomal trafficking of the glucose transporter GLUT1 requires sequential regulation by TXNIP and ubiquitin

Susan J. Qualls-Histed, Casey P. Nielsen, Jason A. MacGurn

iScience. 2023 Mar 17; 26(3): 106150. Published online 2023 Feb 6. doi: 10.1016/j.isci.2023.106150

PMCID:: PMC9986520

Abstract Article PDF–9.6M

Select item 94754626.

ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold

Wenjing Yang, Beili Wang, Qian Yu, Te Liu, Tong Li, Tongtong Tian, Anli Jin, Lin Ding, Wei Chen, Hao Wang, Jingrong Xian, Baishen Pan, Jian Zhou, Jia Fan, Xinrong Yang, Wei Guo

Theranostics. 2022; 12(14): 6189–6206. Published online 2022 Aug 21. doi: 10.7150/thno.72134

PMCID:: PMC9475462

Abstract Article PDF–4.6M

Select item 92626147.

A dual-activity topoisomerase complex regulates mRNA translation and turnover

Shuaikun Su, Yutong Xue, Alexei Sharov, Yongqing Zhang, Seung Kyu Lee, Jennifer L Martindale, Wen Li, Wai Lim Ku, Keji Zhao, Supriyo De, Weiping Shen, Payel Sen, Myriam Gorospe, Dongyi Xu, Weidong Wang

Nucleic Acids Res. 2022 Jul 8; 50(12): 7013–7033. Published online 2022 Jun 24. doi: 10.1093/nar/gkac538

PMCID:: PMC9262614

Abstract Article PDF–3.6M

Select item 91197368.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 90428229.

Cul3-KLHL20 E3 ubiquitin ligase plays a key role in the arms race between HIV-1 Nef and host SERINC5 restriction

Sunan Li, Rongrong Li, Iqbal Ahmad, Xiaomeng Liu, Silas F. Johnson, Liangliang Sun, Yong-Hui Zheng

Nat Commun. 2022; 13: 2242. Published online 2022 Apr 26. doi: 10.1038/s41467-022-30026-y

PMCID:: PMC9042822

Abstract Article PDF–7.5M

Select item 895155610.

A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins

Danielle G. May, Laura Martin-Sancho, Valesca Anschau, Sophie Liu, Rachel J. Chrisopulos, Kelsey L. Scott, Charles T. Halfmann, Ramon Díaz Peña, Dexter Pratt, Alexandre R. Campos, Kyle J. Roux

Viruses. 2022 Mar; 14(3): 611. Published online 2022 Mar 15. doi: 10.3390/v14030611

PMCID:: PMC8951556

Abstract Article PDF–4.4M

Select item 890611911.

WWP1 upregulation predicts poor prognosis and promotes tumor progression by regulating ubiquitination of NDFIP1 in intrahepatic cholangiocarcinoma

Yongjian Li, Qian Cheng, Jie Gao, Zhuomiaoyu Chen, Jingheng Guo, Zuyin Li, Lingyu Tian, Chao Zhang, Yuzi Li, Jiaxi Zheng, Zhao Li, Jiye Zhu

Cell Death Discov. 2022; 8: 107. Published online 2022 Mar 9. doi: 10.1038/s41420-022-00882-0

PMCID:: PMC8906119

Abstract Article PDF–6.1M

Select item 889702212.

Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy

Xin Sun, Yuhan Shu, Guiqin Ye, Caixia Wu, Mengting Xu, Ruilan Gao, Dongsheng Huang, Jianbin Zhang

Acta Pharm Sin B. 2022 Feb; 12(2): 838–852. Published online 2021 Jul 21. doi: 10.1016/j.apsb.2021.07.003

PMCID:: PMC8897022

Abstract Article PDF–3.0M

Select item 877155113.

α-Catulin promotes cancer stemness by antagonizing WWP1-mediated KLF5 degradation in lung cancer

Chia-Hao Tung, Meng-Fan Huang, Chen-Hsien Liang, Yi-Ying Wu, Jia-En Wu, Cheng-Lung Hsu, Yuh-Ling Chen, Tse-Ming Hong

Theranostics. 2022; 12(3): 1173–1186. Published online 2022 Jan 1. doi: 10.7150/thno.63627

PMCID:: PMC8771551

Abstract Article PDF–2.4M

Select item 867084614.

WWP1 inactivation enhances efficacy of PI3K inhibitors while suppressing their toxicities in breast cancer models

Takahiro Kishikawa, Hiroshi Higuchi, Limei Wang, Nivedita Panch, Valerie Maymi, Sachem Best, Samuel Lee, Genso Notoya, Alex Toker, Lydia E. Matesic, Gerburg M. Wulf, Wenyi Wei, Motoyuki Otsuka, Kazuhiko Koike, John G. Clohessy, Yu-Ru Lee, Pier Paolo Pandolfi

J Clin Invest. 2021 Dec 15; 131(24): e140436. Published online 2021 Dec 15. doi: 10.1172/JCI140436

PMCID:: PMC8670846

Abstract Article PDF–3.0M

Select item 861639015.

Fluctuations in AKT and PTEN Activity Are Linked by the E3 Ubiquitin Ligase cCBL

Manuel Olazábal-Morán, Miriam Sánchez-Ortega, Laura Martínez-Muñoz, Carmen Hernández, Manuel S. Rodríguez, Mario Mellado, Ana C. Carrera

Cells. 2021 Nov; 10(11): 2803. Published online 2021 Oct 20. doi: 10.3390/cells10112803

PMCID:: PMC8616390

Abstract Article PDF–4.6M

Select item 849374216.

Mutant NPM1-regulated lncRNA HOTAIRM1 promotes leukemia cell autophagy and proliferation by targeting EGR1 and ULK3

Yipei Jing, Xueke Jiang, Li Lei, Meixi Peng, Jun Ren, Qiaoling Xiao, Yao Tao, Yonghong Tao, Junpeng Huang, Lu Wang, Yuting Tang, Zailin Yang, Zesong Yang, Ling Zhang

J Exp Clin Cancer Res. 2021; 40: 312. Published online 2021 Oct 6. doi: 10.1186/s13046-021-02122-2