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Items: 1 to 20 of 30

1.
Intrinsically Disordered Membrane Anchors of Rheb, RhoA, and DiRas3 Small GTPases: Molecular Dynamics, Membrane Organization, and Interactions
Chase M. Hutchins, Alemayehu A. Gorfe
J Phys Chem B. Author manuscript; available in PMC 2024 Jul 23.
Published in final edited form as: J Phys Chem B. 2024 Jul 11; 128(27): 6518–6528. Published online 2024 Jun 28. doi: 10.1021/acs.jpcb.4c01876
PMCID:
PMC11265623
AbstractArticlePDF–2.2M
2.
Expression of RASSF1A, DIRAS3, and AKAP9 Genes in Thyroid Lesions: Implications for Differential Diagnosis and Prognosis of Thyroid Carcinomas
Kamila Soboska, Michał Kusiński, Karol Pawelczyk, Monika Migdalska-Sęk, Ewa Brzeziańska-Lasota, Karolina H. Czarnecka-Chrebelska
Int J Mol Sci. 2024 Jan; 25(1): 562. Published online 2024 Jan 1. doi: 10.3390/ijms25010562
PMCID:
PMC10778957
AbstractArticlePDF–1.8M
3.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
4.
Elimination of dormant, autophagic ovarian cancer cells and xenografts through enhanced sensitivity to ALK inhibition
Alicia M. Blessing, Janice M. Santiago-O’Farrill, Weiqun Mao, Lan Pang, Jing Ning, Daewoo Pak, Lakshmi Reddy Bollu, Philip Rask, LaKesla Iles, Samantha Tran, Ezzeddine Elmir, Geoffrey Bartholomeusz, Robert Langley, Zhen Lu, Robert C. Bast, Jr.
Cancer. Author manuscript; available in PMC 2021 Aug 1.
Published in final edited form as: Cancer. 2020 Aug 1; 126(15): 3579–3592. Published online 2020 Jun 2. doi: 10.1002/cncr.32985
PMCID:
PMC7384209
AbstractArticlePDF–2.4M
5.
A risk signature with four autophagy‐related genes for predicting survival of glioblastoma multiforme
Yulin Wang, Weijiang Zhao, Zhe Xiao, Gefei Guan, Xin Liu, Minghua Zhuang
J Cell Mol Med. 2020 Apr; 24(7): 3807–3821. Published online 2020 Feb 17. doi: 10.1111/jcmm.14938
PMCID:
PMC7171404
AbstractArticlePDF–2.6M
6.
A reference map of the human binary protein interactome
Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood
Nature. Author manuscript; available in PMC 2020 Oct 8.
Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x
PMCID:
PMC7169983
AbstractArticlePDF–5.4M
7.
DIRAS3 (ARHI) Blocks RAS/MAPK Signaling by Binding Directly to RAS and Disrupting RAS Clusters
Margie N. Sutton, Zhen Lu, Yao-Cheng Li, Yong Zhou, Tao Huang, Albert S. Reger, Amy M. Hurwitz, Timothy Palzkill, Craig Logsdon, Xiaowen Liang, Joe W. Gray, Xiaolin Nan, John Hancock, Geoffrey M. Wahl, Robert C. Bast, Jr.
Cell Rep. Author manuscript; available in PMC 2020 Jan 8.
Published in final edited form as: Cell Rep. 2019 Dec 10; 29(11): 3448–3459.e6. doi: 10.1016/j.celrep.2019.11.045
PMCID:
PMC6948147
AbstractArticlePDF–2.0M
8.
Epigenetic inhibition of the tumor suppressor ARHI by light at night-induced circadian melatonin disruption mediates STAT3-driven paclitaxel resistance in breast cancer
Shulin Xiang, Robert T. Dauchy, Aaron E. Hoffman, David Pointer, Tripp Frasch, David E. Blask, Steven M. Hill
J Pineal Res. Author manuscript; available in PMC 2020 Sep 1.
Published in final edited form as: J Pineal Res. 2019 Sep; 67(2): e12586. Published online 2019 Jun 9. doi: 10.1111/jpi.12586
PMCID:
PMC6750268
AbstractArticlePDF–1.3M
9.
Oncogenic Ras is downregulated by ARHI and induces autophagy by Ras/AKT/mTOR pathway in glioblastoma
Chen Zhong, Mengting Shu, Junyi Ye, Xiaoxiong Wang, Xin Chen, Zhendong Liu, Wenyang Zhao, Boxian Zhao, Zhixing Zheng, Zhiqin Yin, Ming Gao, Haiqi Zhao, Kaikai Wang, Shiguang Zhao
BMC Cancer. 2019; 19: 441. Published online 2019 May 14. doi: 10.1186/s12885-019-5643-z
PMCID:
PMC6515631
AbstractArticlePDF–13M
10.
Distinct subgroup of the Ras family member 3 (DIRAS3) expression impairs metastasis and induces autophagy of gastric cancer cells in mice
Jingping Qiu, Xiaoting Li, Yingjian He, Dan Sun, Wenhui Li, Yan Xin
J Cancer Res Clin Oncol. 2018; 144(10): 1869–1886. Published online 2018 Jul 24. doi: 10.1007/s00432-018-2708-3
PMCID:
PMC6153597
AbstractArticlePDF–17M
11.
Architecture of the human interactome defines protein communities and disease networks
Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper
Nature. Author manuscript; available in PMC 2017 Nov 17.
Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366
PMCID:
PMC5531611
AbstractArticlePDF–2.7M
12.
Silencing of the small GTPase DIRAS3 induces cellular senescence in human white adipose stromal/progenitor cells
Asim Ejaz, Monika Mattesich, Werner Zwerschke
Aging (Albany NY) 2017 Mar; 9(3): 860–876. Published online 2017 Mar 17. doi: 10.18632/aging.101197
PMCID:
PMC5391236
AbstractArticlePDF–1.1M
13.
Induction of autophagy by ARHI (DIRAS3) alters fundamental metabolic pathways in ovarian cancer models
Argentina Ornelas, Christopher R. McCullough, Zhen Lu, Niki M. Zacharias, Lindsay E. Kelderhouse, Joshua Gray, Hailing Yang, Brian J. Engel, Yan Wang, Weiqun Mao, Margie N. Sutton, Pratip K. Bhattacharya, Robert C. Bast, Jr., Steven W. Millward
BMC Cancer. 2016; 16: 824. Published online 2016 Oct 26. doi: 10.1186/s12885-016-2850-8
PMCID:
PMC5080741
AbstractArticlePDF–1.6M
14.
Transcriptional silencing of long noncoding RNA GNG12-AS1 uncouples its transcriptional and product-related functions
Lovorka Stojic, Malwina Niemczyk, Arturo Orjalo, Yoko Ito, Anna Elisabeth Maria Ruijter, Santiago Uribe-Lewis, Nimesh Joseph, Stephen Weston, Suraj Menon, Duncan T. Odom, John Rinn, Fanni Gergely, Adele Murrell
Nat Commun. 2016; 7: 10406. Published online 2016 Feb 2. doi: 10.1038/ncomms10406
PMCID:
PMC4740813
AbstractArticlePDF–1.6M
15.
LOH at 1p31 (ARHI) and Proliferation in Lymph Node-Negative Breast Cancer
Emiel A. M. Janssen, Irene T. Øvestad, Ivar Skaland, Håvard Søiland, Einar Gudlaugsson, Kjell H. Kjellevold, Arne Nysted, Jon-Arne Søreide, Jan P. A. Baak
Cell Oncol. 2009; 31(5): 335–343. Published online 2009 Sep 16. doi: 10.3233/CLO-2009-0479
PMCID:
PMC4619107
AbstractPDF–271K
16.
The BioPlex Network: A Systematic Exploration of the Human Interactome
Edward L. Huttlin, Lily Ting, Raphael J. Bruckner, Fana Gebreab, Melanie P. Gygi, John Szpyt, Stanley Tam, Gabriela Zarraga, Greg Colby, Kurt Baltier, Rui Dong, Virginia Guarani, Laura Pontano Vaites, Alban Ordureau, Ramin Rad, Brian K. Erickson, Martin Wühr, Joel Chick, Bo Zhai, Deepak Kolippakkam, Julian Mintseris, Robert A. Obar, Tim Harris, Spyros Artavanis-Tsakonas, Mathew E. Sowa, Pietro DeCamilli, Joao A. Paulo, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2016 Jul 16.
Published in final edited form as: Cell. 2015 Jul 16; 162(2): 425–440. doi: 10.1016/j.cell.2015.06.043
PMCID:
PMC4617211
AbstractArticlePDF–2.2M
17.
ARHI (DIRAS3)-mediated autophagy-associated cell death enhances chemosensitivity to cisplatin in ovarian cancer cell lines and xenografts
M N Washington, G Suh, A F Orozco, M N Sutton, H Yang, Y Wang, W Mao, S Millward, A Ornelas, N Atkinson, W Liao, R C Bast, Jr, Z Lu
Cell Death Dis. 2015 Aug; 6(8): e1836. Published online 2015 Aug 6. doi: 10.1038/cddis.2015.208
PMCID:
PMC4558501
AbstractArticlePDF–3.6M
18.
DIRAS3 regulates the autophagosome initiation complex in dormant ovarian cancer cells
Zhen Lu, Maria T Baquero, Hailing Yang, Maojie Yang, Albert S Reger, Choel Kim, Douglas A Levine, Charlotte H Clarke, Warren S-L Liao, Robert C Bast Jr
Autophagy. 2014 Jun 1; 10(6): 1071–1092. Published online 2014 Apr 10. doi: 10.4161/auto.28577
Correction in:
Autophagy. 2014 Aug 1; 10(8): 1482.
PMCID:
PMC4091169
AbstractArticlePDF–12M
19.
ARHI (DIRAS3) induces autophagy in ovarian cancer cells by downregulating the epidermal growth factor receptor, inhibiting PI3K and Ras/MAP signaling and activating the FOXo3a-mediated induction of Rab7
Z Lu, H Yang, M N Sutton, M Yang, C H Clarke, W S-L Liao, R C Bast, Jr
Cell Death Differ. 2014 Aug; 21(8): 1275–1289. Published online 2014 Apr 25. doi: 10.1038/cdd.2014.48
PMCID:
PMC4085535
AbstractArticlePDF–7.6M
20.
A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities
Franco J Vizeacoumar, Roland Arnold, Frederick S Vizeacoumar, Megha Chandrashekhar, Alla Buzina, Jordan T F Young, Julian H M Kwan, Azin Sayad, Patricia Mero, Steffen Lawo, Hiromasa Tanaka, Kevin R Brown, Anastasia Baryshnikova, Anthony B Mak, Yaroslav Fedyshyn, Yadong Wang, Glauber C Brito, Dahlia Kasimer, Taras Makhnevych, Troy Ketela, Alessandro Datti, Mohan Babu, Andrew Emili, Laurence Pelletier, Jeff Wrana, Zev Wainberg, Philip M Kim, Robert Rottapel, Catherine A O’Brien, Brenda Andrews, Charles Boone, Jason Moffat
Mol Syst Biol. 2013; 9: 696. Published online 2013 Oct 8. doi: 10.1038/msb.2013.54
PMCID:
PMC3817404
AbstractArticlePDF–13M

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