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Items: 1 to 20 of 77

1.
Endothelial EGLN3-PKM2 signaling induces the formation of acute astrocytic barrier to alleviate immune cell infiltration after subarachnoid hemorrhage
Mingxu Duan, Xufang Ru, Jiru Zhou, Yuanshu Li, Peiwen Guo, Wenbo Kang, Wenyan Li, Zhi Chen, Hua Feng, Yujie Chen
Fluids Barriers CNS. 2024; 21: 42. Published online 2024 May 16. doi: 10.1186/s12987-024-00550-8
PMCID:
PMC11100217
AbstractArticlePDF–23M
2.
Low nuclear expression of HIF‐hydroxylases PHD2/EGLN1 and PHD3/EGLN3 are associated with poor recurrence‐free survival in clear cell renal cell carcinoma
Lassi Luomala, Kalle Mattila, Paula Vainio, Harry Nisén, Teijo Pellinen, Jouni Lohi, Teemu D. Laajala, Petrus Järvinen, Anna‐Riina Koskenniemi, Panu Jaakkola, Tuomas Mirtti
Cancer Med. 2024 Feb; 13(3): e6998. Published online 2024 Feb 24. doi: 10.1002/cam4.6998
PMCID:
PMC10891444
AbstractArticlePDF–1.9M
3.
Assessment of community efforts to advance network-based prediction of protein–protein interactions
Xu-Wen Wang, Lorenzo Madeddu, Kerstin Spirohn, Leonardo Martini, Adriano Fazzone, Luca Becchetti, Thomas P. Wytock, István A. Kovács, Olivér M. Balogh, Bettina Benczik, Mátyás Pétervári, Bence Ágg, Péter Ferdinandy, Loan Vulliard, Jörg Menche, Stefania Colonnese, Manuela Petti, Gaetano Scarano, Francesca Cuomo, Tong Hao, Florent Laval, Luc Willems, Jean-Claude Twizere, Marc Vidal, Michael A. Calderwood, Enrico Petrillo, Albert-László Barabási, Edwin K. Silverman, Joseph Loscalzo, Paola Velardi, Yang-Yu Liu
Nat Commun. 2023; 14: 1582. Published online 2023 Mar 22. doi: 10.1038/s41467-023-37079-7
PMCID:
PMC10033937
AbstractArticlePDF–1.5M
4.
Inactivation of EGLN3 hydroxylase facilitates Erk3 degradation via autophagy and impedes lung cancer growth
Ying Jin, Yamu Pan, Shuang Zheng, Yao Liu, Jie Xu, Yazhi Peng, Zemei Zhang, Yadong Wang, Yulian Xiong, Lei Xu, Kaiyu Mu, Suwen Chen, Fei Zheng, Ye Yuan, Jian Fu
Oncogene. 2022; 41(12): 1752–1766. Published online 2022 Feb 5. doi: 10.1038/s41388-022-02203-2
PMCID:
PMC8933280
AbstractArticlePDF–8.6M
5.
CFTR interactome mapping using the mammalian membrane two‐hybrid high‐throughput screening system
Sang Hyun Lim, Jamie Snider, Liron Birimberg‐Schwartz, Wan Ip, Joana C Serralha, Hugo M Botelho, Miquéias Lopes‐Pacheco, Madalena C Pinto, Mohamed Taha Moutaoufik, Mara Zilocchi, Onofrio Laselva, Mohsen Esmaeili, Max Kotlyar, Anna Lyakisheva, Priscilla Tang, Lucía López Vázquez, Indira Akula, Farzaneh Aboualizadeh, Victoria Wong, Ingrid Grozavu, Teuta Opacak‐Bernardi, Zhong Yao, Meg Mendoza, Mohan Babu, Igor Jurisica, Tanja Gonska, Christine E Bear, Margarida D Amaral, Igor Stagljar
Mol Syst Biol. 2022 Feb; 18(2): e10629. Published online 2022 Feb 14. doi: 10.15252/msb.202110629
PMCID:
PMC8842165
AbstractArticlePDF–3.0M
6.
USP9X promotes apoptosis in cholangiocarcinoma by modulation expression of KIF1Bβ via deubiquitinating EGLN3
Weiqian Chen, Jingjing Song, Siyu Liu, Bufu Tang, Lin Shen, Jinyu Zhu, Shiji Fang, Fazong Wu, Liyun Zheng, Rongfang Qiu, Chunmiao Chen, Yang Gao, Jianfei Tu, Zhongwei Zhao, Jiansong Ji
J Biomed Sci. 2021; 28: 44. Published online 2021 Jun 10. doi: 10.1186/s12929-021-00738-2
PMCID:
PMC8191029
AbstractArticlePDF–2.7M
7.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
8.
PHD3 loss promotes exercise capacity and fat oxidation in skeletal muscle
Haejin Yoon, Jessica B. Spinelli, Elma Zaganjor, Samantha J. Wong, Natalie J. German, Elizabeth C. Randall, Afsah Dean, Allen Clermont, Joao A. Paulo, Daniel Garcia, Hao Li, Olivia Rombold, Nathalie Y. R. Agar, Laurie J. Goodyear, Reuben J. Shaw, Steven P. Gygi, Johan Auwerx, Marcia C. Haigis
Cell Metab. Author manuscript; available in PMC 2021 Apr 24.
Published in final edited form as: Cell Metab. 2020 Aug 4; 32(2): 215–228.e7. Published online 2020 Jul 13. doi: 10.1016/j.cmet.2020.06.017
PMCID:
PMC8065255
AbstractArticlePDF–1.3M
9.
Prolyl Hydroxylase 3 Knockdown Accelerates VHL-Mutant Kidney Cancer Growth In Vivo
Niki M. Zacharias, Lei Wang, Tapati Maity, Li Li, Steven W. Millward, Jose A. Karam, Christopher G. Wood, Neema Navai
Int J Mol Sci. 2021 Mar; 22(6): 2849. Published online 2021 Mar 11. doi: 10.3390/ijms22062849
PMCID:
PMC8001211
AbstractArticlePDF–3.2M
10.
Development of a colorimetric α-ketoglutarate detection assay for prolyl hydroxylase domain (PHD) proteins
Samantha J. Wong, Alison E. Ringel, William Yuan, Joao A. Paulo, Haejin Yoon, Mark A. Currie, Marcia C. Haigis
J Biol Chem. 2021 Jan-Jun; 296: 100397. Published online 2021 Feb 8. doi: 10.1016/j.jbc.2021.100397
PMCID:
PMC7961094
AbstractArticlePDF–1.4M
11.
TET is targeted for proteasomal degradation by the PHD-pVHL pathway to reduce DNA hydroxymethylation
Sijia Fan, Jing Wang, Guangqing Yu, Fangjing Rong, Dawei Zhang, Chenxi Xu, Juan Du, Zhi Li, Gang Ouyang, Wuhan Xiao
J Biol Chem. 2020 Nov 27; 295(48): 16299–16313. Published online 2020 Sep 22. doi: 10.1074/jbc.RA120.014538
PMCID:
PMC7705310
AbstractArticlePDF–2.8M
12.
Label-free Interactome Analysis Revealed an Essential Role of CUL3-KEAP1 Complex in Mediating the Ubiquitination and Degradation of PHD2
Ang Luo, Yue Chen
J Proteome Res. Author manuscript; available in PMC 2020 Aug 9.
Published in final edited form as: J Proteome Res. 2020 Jan 3; 19(1): 260–268. Published online 2019 Dec 6. doi: 10.1021/acs.jproteome.9b00513
PMCID:
PMC7415006
AbstractArticlePDF–1.2M
13.
A reference map of the human binary protein interactome
Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood
Nature. Author manuscript; available in PMC 2020 Oct 8.
Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x
PMCID:
PMC7169983
AbstractArticlePDF–5.4M
14.
Abrogation of esophageal carcinoma development in miR-31 knockout rats
Louise Y. Fong, Cristian Taccioli, Alexey Palamarchuk, Guidantonio Malagoli Tagliazucchi, Ruiyan Jing, Karl J. Smalley, Sili Fan, Joseph Altemus, Oliver Fiehn, Kay Huebner, John L. Farber, Carlo M. Croce
Proc Natl Acad Sci U S A. 2020 Mar 17; 117(11): 6075–6085. Published online 2020 Mar 2. doi: 10.1073/pnas.1920333117
PMCID:
PMC7084137
AbstractArticlePDF–2.7M
15.
Whole-Genome Sequencing Identifies the Egl Nine Homologue 3 (egln3/phd3) and Protein Phosphatase 1 Regulatory Inhibitor Subunit 2 (PPP1R2P1) Associated with High-Altitude Polycythemia in Tibetans at High Altitude
Luobu Gesang, Lamu Gusang, Ciren Dawa, Gawa Gesang, Kang Li
Dis Markers. 2019; 2019: 5946461. Published online 2019 Nov 7. doi: 10.1155/2019/5946461
PMCID:
PMC6881591
AbstractArticlePDF–446K
16.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations
Robert Fragoza, Jishnu Das, Shayne D. Wierbowski, Jin Liang, Tina N. Tran, Siqi Liang, Juan F. Beltran, Christen A. Rivera-Erick, Kaixiong Ye, Ting-Yi Wang, Li Yao, Matthew Mort, Peter D. Stenson, David N. Cooper, Xiaomu Wei, Alon Keinan, John C. Schimenti, Andrew G. Clark, Haiyuan Yu
Nat Commun. 2019; 10: 4141. Published online 2019 Sep 12. doi: 10.1038/s41467-019-11959-3
PMCID:
PMC6742646
AbstractArticlePDF–1.2M
17.
Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates
Matthew E Cockman, Kerstin Lippl, Ya-Min Tian, Hamish B Pegg, William D Figg, Jnr, Martine I Abboud, Raphael Heilig, Roman Fischer, Johanna Myllyharju, Christopher J Schofield, Peter J Ratcliffe
eLife. 2019; 8: e46490. Published online 2019 Sep 10. doi: 10.7554/eLife.46490
PMCID:
PMC6739866
AbstractArticlePDF–4.0M
18.
Targeted and Interactome Proteomics Revealed the Role of PHD2 in Regulating BRD4 Proline Hydroxylation
Luke Erber, Ang Luo, Yue Chen
Mol Cell Proteomics. 2019 Sep; 18(9): 1772–1781. Published online 2019 Jun 25. doi: 10.1074/mcp.RA119.001535
PMCID:
PMC6731074
AbstractArticlePDF–1.4M
19.
Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance
Matthew F Pech, Linda E Fong, Jacqueline E Villalta, Leanne JG Chan, Samir Kharbanda, Jonathon J O'Brien, Fiona E McAllister, Ari J Firestone, Calvin H Jan, Jeffrey Settleman
eLife. 2019; 8: e47362. Published online 2019 Aug 27. doi: 10.7554/eLife.47362
PMCID:
PMC6713475
AbstractArticlePDF–4.6M
20.
Prolyl hydroxylase 3 stabilizes the p53 tumor suppressor by inhibiting the p53–MDM2 interaction in a hydroxylase-independent manner
Yiming Xu, Qiang Gao, Yaqian Xue, Xiuxiu Li, Liang Xu, Chenwei Li, Yanqing Qin, Jing Fang
J Biol Chem. 2019 Jun 21; 294(25): 9949–9958. Published online 2019 May 15. doi: 10.1074/jbc.RA118.007181
PMCID:
PMC6597825
AbstractArticlePDF–2.5M

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