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Select item 113306441.

Variants of LRP2, encoding a multifunctional cell-surface endocytic receptor, associated with hearing loss and retinal dystrophy

Rabia Faridi, Rizwan Yousaf, Shoujun Gu, Sayaka Inagaki, Amy E. Turriff, Keith Pelstring, Bin Guan, Amelia Naik, Andrew J. Griffith, Samuel Mawuli Adadey, Elvis Twumasi Aboagye, Gordon A. Awandare, Robert J. Morell, Ekaterini Tsilou, Amanda G. Noyes, Laura A. G. Sulmonte, Ambroise Wonkam, Isabelle Schrauwen, Suzanne M. Leal, Hela Azaiez, Carmen C. Brewer, Sheikh Riazuddin, Robert B. Hufnagel, Michael Hoa, Wadih M. Zein, J. Karl de Dios, Thomas B. Friedman

Clin Genet. Author manuscript; available in PMC 2024 Aug 18.

Published in final edited form as: Clin Genet. 2023 Jun; 103(6): 699–703. Published online 2023 Mar 13. doi: 10.1111/cge.14312

PMCID:: PMC11330644

Abstract Article PDF–591K

Select item 111452822.

Cryo-EM structures elucidate the multiligand receptor nature of megalin

Sawako Goto, Akihisa Tsutsumi, Yongchan Lee, Michihiro Hosojima, Hideyuki Kabasawa, Koichi Komochi, Satoru Nagatoishi, Kazuya Takemoto, Kouhei Tsumoto, Tomohiro Nishizawa, Masahide Kikkawa, Akihiko Saito

Proc Natl Acad Sci U S A. 2024 May 28; 121(22): e2318859121. Published online 2024 May 21. doi: 10.1073/pnas.2318859121

PMCID:: PMC11145282

Abstract Article PDF–8.1M

Select item 111367203.

Polymorphisms in LRP2 and CUBN genes and their association with serum vitamin D levels and sleep apnea

Dimitra Anatolou, Paschalis Steiropoulos, Athanasios Zissimopoulos, Konstantina Chadia, Kostas Archontogeorgis, George Kolios, Vangelis G. Manolopoulos, Georgia Ragia

Sleep Breath. 2024; 28(2): 959–966. Published online 2023 Nov 27. doi: 10.1007/s11325-023-02950-w

PMCID:: PMC11136720

Abstract Article PDF–626K

Select item 111057524.

Megalin mediates plasma membrane to mitochondria cross-talk and regulates mitochondrial metabolism

Qingtian Li, Fan Lei, Yi Tang, Jenny Szu-Chin Pan, Qiang Tong, Yuxiang Sun, David Sheikh-Hamad

Cell Mol Life Sci. 2018 Nov; 75(21): 4021–4040. Published online 2018 Jun 9. doi: 10.1007/s00018-018-2847-3

PMCID:: PMC11105752

Abstract Article PDF–7.1M

Select item 107039685.

Human parietal epithelial cells (PECs) and proteinuria in lupus nephritis: a role for ClC-5, megalin, and cubilin?

Monica Ceol, Lisa Gianesello, Hernan Trimarchi, Alberto Migliorini, Giovanna Priante, Claudia M. Radu, Elena Naso, Annalisa Angelini, Lorenzo A. Calò, Franca Anglani, Dorella Del Prete

J Nephrol. 2023; 36(9): 2499–2506. Published online 2023 Aug 18. doi: 10.1007/s40620-023-01725-6

PMCID:: PMC10703968

Abstract Article PDF–3.4M

Select item 101516156.

Cross-linking mass spectrometry discovers, evaluates, and corroborates structures and protein–protein interactions in the human cell

Tara K. Bartolec, Xabier Vázquez-Campos, Alexander Norman, Clement Luong, Marcus Johnson, Richard J. Payne, Marc R. Wilkins, Joel P. Mackay, Jason K. K. Low

Proc Natl Acad Sci U S A. 2023 Apr 25; 120(17): e2219418120. Published online 2023 Apr 18. doi: 10.1073/pnas.2219418120

PMCID:: PMC10151615

Abstract Article PDF–2.9M

Select item 99938427.

Structures of LRP2 reveal a molecular machine for endocytosis

Andrew Beenken, Gabriele Cerutti, Julia Brasch, Yicheng Guo, Zizhang Sheng, Hediye Erdjument-Bromage, Zainab Aziz, Shelief Y Robbins-Juarez, Estefania Y Chavez, Goran Ahlsen, Phinikoula S Katsamba, Thomas A. Neubert, Anthony W.P. Fitzpatrick, Jonathan Barasch, Lawrence Shapiro

Cell. Author manuscript; available in PMC 2023 Mar 8.

Published in final edited form as: Cell. 2023 Feb 16; 186(4): 821–836.e13. Published online 2023 Feb 6. doi: 10.1016/j.cell.2023.01.016

PMCID:: PMC9993842

Abstract Article PDF–3.6M

Select item 99833588.

Regulation of Prostate Androgens by Megalin and 25-hydroxyvitamin D Status: Mechanism for High Prostate Androgens in African American Men

Jason Garcia, Kirsten D. Krieger, Candice Loitz, Lillian M. Perez, Zachary A. Richards, Yves Helou, Steve Kregel, Sasha Celada, Clementina A. Mesaros, Maarten Bosland, Peter H. Gann, Thomas E. Willnow, Donald Vander Griend, Rick Kittles, Gail S. Prins, Trevor Penning, Larisa Nonn

Cancer Res Commun. 2023 Mar; 3(3): 371–382. Published online 2023 Mar 3. doi: 10.1158/2767-9764.CRC-22-0362

PMCID:: PMC9983358

Abstract Article PDF–11M

Select item 93485769.

Chr21 protein–protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer’s disease

Julia Viard, Yann Loe-Mie, Rachel Daudin, Malik Khelfaoui, Christine Plancon, Anne Boland, Francisco Tejedor, Richard L Huganir, Eunjoon Kim, Makoto Kinoshita, Guofa Liu, Volker Haucke, Thomas Moncion, Eugene Yu, Valérie Hindie, Henri Bléhaut, Clotilde Mircher, Yann Herault, Jean-François Deleuze, Jean-Christophe Rain, Michel Simonneau, Aude-Marie Lepagnol-Bestel

Life Sci Alliance. 2022 Dec; 5(12): e202101205. Published online 2022 Aug 1. doi: 10.26508/lsa.202101205

PMCID:: PMC9348576

Abstract Article PDF–3.0M

Select item 917141110.

Physical and functional interactome atlas of human receptor tyrosine kinases

Kari Salokas, Xiaonan Liu, Tiina Öhman, Iftekhar Chowdhury, Lisa Gawriyski, Salla Keskitalo, Markku Varjosalo

EMBO Rep. 2022 Jun; 23(6): e54041. Published online 2022 Apr 5. doi: 10.15252/embr.202154041

PMCID:: PMC9171411

Abstract Article PDF–1.9M

Select item 910523511.

Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling

Ilektra Kouranti, Waed Abdel Khalek, Stephani Mazurkiewicz, Irmine Loisel-Ferreira, Alexis M. Gautreau, Lionel Pintard, Xavier Jeunemaitre, Eric Clauser

Int J Mol Sci. 2022 May; 23(9): 5151. Published online 2022 May 5. doi: 10.3390/ijms23095151

PMCID:: PMC9105235

Abstract Article PDF–5.8M

Select item 906494112.

The disturbed expression of vitamin D and retinoic acid-related orphan receptors α and γ and of megalin in inflammatory skin diseases

Anna A Brozyna, Michał A Żmijewski, Kinga Linowiecka, Tae-Kang Kim, Radomir M Slominski, Andrzej T Slominski

Exp Dermatol. Author manuscript; available in PMC 2023 May 1.

Published in final edited form as: Exp Dermatol. 2022 May; 31(5): 781–788. Published online 2022 Jan 13. doi: 10.1111/exd.14521

PMCID:: PMC9064941

Abstract Article PDF–931K

Select item 903755413.

C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy

Bing-Ru Yan, Taoyingnan Li, Etienne Coyaud, Estelle M. N. Laurent, Jonathan St-Germain, Yuhuan Zhou, Peter K. Kim, Brian Raught, John H. Brumell

Autophagy. 2022; 18(4): 829–840. Published online 2021 Aug 25. doi: 10.1080/15548627.2021.1960116

PMCID:: PMC9037554

Abstract Article PDF–4.1M

Select item 895660414.

CRISPR activation screen identifies BCL-2 proteins and B3GNT2 as drivers of cancer resistance to T cell-mediated cytotoxicity

Julia Joung, Paul C. Kirchgatterer, Ankita Singh, Jang H. Cho, Suchita P. Nety, Rebecca C. Larson, Rhiannon K. Macrae, Rebecca Deasy, Yuen-Yi Tseng, Marcela V. Maus, Feng Zhang

Nat Commun. 2022; 13: 1606. Published online 2022 Mar 25. doi: 10.1038/s41467-022-29205-8

PMCID:: PMC8956604

Abstract Article PDF–3.9M

Select item 882889515.

Human transcription factor protein interaction networks

Helka Göös, Matias Kinnunen, Kari Salokas, Zenglai Tan, Xiaonan Liu, Leena Yadav, Qin Zhang, Gong-Hong Wei, Markku Varjosalo

Nat Commun. 2022; 13: 766. Published online 2022 Feb 9. doi: 10.1038/s41467-022-28341-5

PMCID:: PMC8828895

Abstract Article PDF–1.7M

Select item 864741416.

Expanding the phenotypic spectrum of mutations in LRP2: a novel candidate gene of non-syndromic familial comitant strabismus

Yue Wang, Xuejuan Chen, Tao Jiang, Yayun Gu, Xiaohan Zhang, Wenwen Yuan, Andi Zhao, Rui Li, Zijin Wang, Zhibin Hu, Hu Liu

J Transl Med. 2021; 19: 495. Published online 2021 Dec 6. doi: 10.1186/s12967-021-03155-z

PMCID:: PMC8647414

Abstract Article PDF–5.3M

Select item 855290717.

SARS‐CoV‐2–host proteome interactions for antiviral drug discovery

Xiaonan Liu, Sini Huuskonen, Tuomo Laitinen, Taras Redchuk, Mariia Bogacheva, Kari Salokas, Ina Pöhner, Tiina Öhman, Arun Kumar Tonduru, Antti Hassinen, Lisa Gawriyski, Salla Keskitalo, Maria K Vartiainen, Vilja Pietiäinen, Antti Poso, Markku Varjosalo

Mol Syst Biol. 2021 Nov; 17(11): e10396. Published online 2021 Oct 28. doi: 10.15252/msb.202110396

PMCID:: PMC8552907

Abstract Article PDF–3.9M

Select item 816503018.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 799085119.

Expression profiles of metallothionein-I/II and megalin/LRP-2 in uterine cervical squamous lesions

Hrvoje Jakovac, Nikola Stašić, Maja Krašević, Nives Jonjić, Biserka Radošević-Stašić

Virchows Arch. 2021; 478(4): 735–746. Published online 2020 Oct 21. doi: 10.1007/s00428-020-02947-w

PMCID:: PMC7990851

Abstract Article PDF–15M

Select item 786343020.

Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation

Xiaoqing Fan, Haoran Yang, Chenggang Zhao, Lizhu Hu, Delong Wang, Ruiting Wang, Zhiyou Fang, Xueran Chen

Stem Cell Res Ther. 2021; 12: 107. Published online 2021 Feb 4. doi: 10.1186/s13287-021-02175-2

PMCID:: PMC7863430

Abstract Article PDF–6.5M

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