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Items: 1 to 20 of 40

1.
Fructose Induced KHK-C Can Increase ER Stress Independent of its Effect on Lipogenesis to Drive Liver Disease in Diet-Induced and Genetic Models of NAFLD
Se-Hyung Park, Robert N. Helsley, Taghreed Fadhul, Jennifer L.S. Willoughby, Leila Noetzli, Ho-Chou Tu, Marie H. Solheim, Shiho Fujisaka, Hui Pan, Jonathan M. Dreyfuss, Joanna Bons, Jacob Rose, Christina D. King, Birgit Schilling, Aldons J. Lusis, Calvin Pan, Manoj Gupta, Rohit N. Kulkarni, Kevin Fitzgerald, Philip A. Kern, Senad Divanovic, C. Ronald Kahn, Samir Softic
Metabolism. Author manuscript; available in PMC 2024 Aug 1.
Published in final edited form as: Metabolism. 2023 Aug; 145: 155591. Published online 2023 May 23. doi: 10.1016/j.metabol.2023.155591
PMCID:
PMC10752375
AbstractArticlePDF–3.2M
2.
Ketohexokinase-C regulates global protein acetylation to decrease carnitine palmitoyltransferase 1a-mediated fatty acid oxidation
Robert N. Helsley, Se-Hyung Park, Hemendra J. Vekaria, Patrick G. Sullivan, Lindsey R. Conroy, Ramon C. Sun, María del Mar Romero, Laura Herrero, Joanna Bons, Christina D. King, Jacob Rose, Jesse G. Meyer, Birgit Schilling, C. Ronald Kahn, Samir Softic
J Hepatol. Author manuscript; available in PMC 2023 Nov 27.
Published in final edited form as: J Hepatol. 2023 Jul; 79(1): 25–42. Published online 2023 Feb 21. doi: 10.1016/j.jhep.2023.02.010
PMCID:
PMC10679901
AbstractArticlePDF–2.8M
3.
Genetic ablation of ketohexokinase C isoform impairs pancreatic cancer development
Ilaria Guccini, Guanghui Tang, Trang Thuy To, Laura Di Rito, Solange Le Blanc, Oliver Strobel, Mariantonietta D’Ambrosio, Emiliano Pasquini, Marco Bolis, Pamuditha Silva, Hasan Ali Kabakci, Svenja Godbersen, Andrea Alimonti, Gerald Schwank, Markus Stoffel
iScience. 2023 Aug 18; 26(8): 107368. Published online 2023 Jul 13. doi: 10.1016/j.isci.2023.107368
PMCID:
PMC10407955
AbstractArticlePDF–6.2M
4.
High Fructose Corn Syrup Accelerates Kidney Disease and Mortality in Obese Mice with Metabolic Syndrome
Ana Andres-Hernando, David J. Orlicky, Christina Cicerchi, Masanari Kuwabara, Gabriela E. Garcia, Takahiko Nakagawa, Laura Gabriela Sanchez-Lozada, Richard J. Johnson, Miguel A. Lanaspa
Biomolecules. 2023 May; 13(5): 780. Published online 2023 Apr 30. doi: 10.3390/biom13050780
PMCID:
PMC10216360
AbstractArticlePDF–3.3M
5.
Ketohexokinase-mediated fructose metabolism is lost in hepatocellular carcinoma and can be leveraged for metabolic imaging
Sui Seng Tee, Nathaniel Kim, Quinlan Cullen, Roozbeh Eskandari, Arsen Mamakhanyan, Rami M. Srouji, Rachel Chirayil, Sangmoo Jeong, Mojdeh Shakiba, Edward R. Kastenhuber, Shuibing Chen, Carlie Sigel, Scott W. Lowe, William R. Jarnagin, Craig B. Thompson, Andrea Schietinger, Kayvan R. Keshari
Sci Adv. 2022 Apr; 8(14): eabm7985. Published online 2022 Apr 6. doi: 10.1126/sciadv.abm7985
PMCID:
PMC8985914
AbstractArticlePDF–3.9M
6.
Dietary Fructose Improves Intestinal Cell Survival and Nutrient Absorption
Samuel R. Taylor, Shakti Ramsamooj, Roger J. Liang, Alyna Katti, Rita Pozovskiy, Neil Vasan, Seo-Kyoung Hwang, Navid Nahiyaan, Nancy J. Francoeur, Emma M. Schatoff, Jared L. Johnson, Manish A. Shah, Andrew J. Dannenberg, Robert P. Sebra, Lukas E. Dow, Lewis C. Cantley, Kyu Y. Rhee, Marcus D. Goncalves
Nature. Author manuscript; available in PMC 2022 Sep 1.
Published in final edited form as: Nature. 2021 Sep; 597(7875): 263–267. Published online 2021 Aug 18. doi: 10.1038/s41586-021-03827-2
PMCID:
PMC8686685
AbstractArticlePDF–4.5M
7.
Vasopressin mediates fructose-induced metabolic syndrome by activating the V1b receptor
Ana Andres-Hernando, Thomas J. Jensen, Masanari Kuwabara, David J. Orlicky, Christina Cicerchi, Nanxing Li, Carlos A. Roncal-Jimenez, Gabriela E. Garcia, Takuji Ishimoto, Paul S. Maclean, Petter Bjornstad, Laura Gabriela Sanchez-Lozada, Mehmet Kanbay, Takahiko Nakagawa, Richard J. Johnson, Miguel A. Lanaspa
JCI Insight. 2021 Jan 11; 6(1): e140848. Published online 2021 Jan 11. doi: 10.1172/jci.insight.140848
PMCID:
PMC7821599
AbstractArticlePDF–34M
8.
Sugar causes obesity and metabolic syndrome in mice independently of sweet taste
Ana Andres-Hernando, Masanari Kuwabara, David J. Orlicky, Aurelie Vandenbeuch, Christina Cicerchi, Sue C. Kinnamon, Thomas E. Finger, Richard J. Johnson, Miguel A. Lanaspa
Am J Physiol Endocrinol Metab. 2020 Aug 1; 319(2): E276–E290. Published online 2020 Jun 23. doi: 10.1152/ajpendo.00529.2019
PMCID:
PMC7473911
AbstractArticle
9.
Peroxisome-Deficiency and HIF-2α Signaling Are Negative Regulators of Ketohexokinase Expression
Tanja Eberhart, Miriam J. Schönenberger, Katharina M. Walter, Khanichi N. Charles, Phyllis L. Faust, Werner J. Kovacs
Front Cell Dev Biol. 2020; 8: 566. Published online 2020 Jul 8. doi: 10.3389/fcell.2020.00566
PMCID:
PMC7360681
AbstractArticlePDF–5.6M
10.
Deletion of fructokinase in the liver or in the intestine reveals differential effects on sugar-induced metabolic dysfunction
Ana Andres-Hernando, David J. Orlicky, Masanari Kuwabara, Takuji Ishimoto, Takahiko Nakagawa, Richard J. Johnson, Miguel A. Lanaspa
Cell Metab. Author manuscript; available in PMC 2021 Jul 7.
Published in final edited form as: Cell Metab. 2020 Jul 7; 32(1): 117–127.e3. Published online 2020 Jun 4. doi: 10.1016/j.cmet.2020.05.012
PMCID:
PMC7347444
AbstractArticlePDF–2.2M
11.
Fructose malabsorption induces cholecystokinin expression in the ileum and cecum by changing microbiota composition and metabolism
Xufei Zhang, Alexandra Grosfeld, Edek Williams, Daniel Vasiliauskas, Sharon Barretto, Lorraine Smith, Mahendra Mariadassou, Catherine Philippe, Fabienne Devime, Chloé Melchior, Guillaume Gourcerol, Nathalie Dourmap, Nicolas Lapaque, Pierre Larraufie, Hervé M. Blottière, Christine Herberden, Philippe Gerard, Jens F. Rehfeld, Ronaldo P. Ferraris, J. Christopher Fritton, Sandrine Ellero-Simatos, Veronique Douard
FASEB J. 2019 Jun; 33(6): 7126–7142. Published online 2019 Apr 2. doi: 10.1096/fj.201801526RR
PMCID:
PMC6988857
AbstractArticle
12.
High-fructose corn syrup enhances intestinal tumor growth in mice
Marcus D. Goncalves, Changyuan Lu, Jordan Tutnauer, Travis E. Hartman, Seo-Kyoung Hwang, Charles J Murphy, Chantal Pauli, Roxanne Morris, Sam Taylor, Kaitlyn Bosch, Sukjin Yang, Yumei Wang, Justin Van Riper, H Carl Lekaye, Jatin Roper, Young Kim, Qiuying Chen, Steven S. Gross, Kyu Y. Rhee, Lewis C. Cantley, Jihye Yun
Science. Author manuscript; available in PMC 2020 Mar 22.
Published in final edited form as: Science. 2019 Mar 22; 363(6433): 1345–1349. doi: 10.1126/science.aat8515
PMCID:
PMC6487857
AbstractArticlePDF–717K
13.
Correction of gene model annotations improves isoform abundance estimates: the example of ketohexokinase ( Khk)
Christophe D. Chabbert, Tanja Eberhart, Ilaria Guccini, Wilhelm Krek, Werner J. Kovacs
Version 2. F1000Res. 2018; 7: 1956. Published online 2019 Apr 3. doi: 10.12688/f1000research.17082.2
PMCID:
PMC6464065
AbstractArticlePDF–4.8M
14.
Lacking Ketohexokinase-A Exacerbates Renal Injury in Streptozotocin-induced Diabetic Mice
Tomohito Doke, Takuji Ishimoto, Takahiro Hayasaki, Satsuki Ikeda, Masako Hasebe, Akiyoshi Hirayama, Tomoyoshi Soga, Noritoshi Kato, Tomoki Kosugi, Naotake Tsuboi, Miguel A. Lanaspa, Richard J. Johnson, Kenji Kadomatsu, Shoichi Maruyama
Metabolism. Author manuscript; available in PMC 2019 Aug 1.
Published in final edited form as: Metabolism. 2018 Aug; 85: 161–170. Published online 2018 Mar 29. doi: 10.1016/j.metabol.2018.03.020
PMCID:
PMC6394855
AbstractArticlePDF–1.0M
15.
Ketohexokinase C blockade ameliorates fructose-induced metabolic dysfunction in fructose-sensitive mice
Miguel A. Lanaspa, Ana Andres-Hernando, David J. Orlicky, Christina Cicerchi, Cholsoon Jang, Nanxing Li, Tamara Milagres, Masanari Kuwabara, Michael F. Wempe, Joshua D. Rabinowitz, Richard J. Johnson, Dean R. Tolan
J Clin Invest. 2018 Jun 1; 128(6): 2226–2238. Published online 2018 Apr 23. doi: 10.1172/JCI94427
PMCID:
PMC5983342
AbstractArticlePDF–8.7M
16.
High salt intake causes leptin resistance and obesity in mice by stimulating endogenous fructose production and metabolism
Miguel A. Lanaspa, Masanari Kuwabara, Ana Andres-Hernando, Nanxing Li, Christina Cicerchi, Thomas Jensen, David J. Orlicky, Carlos A. Roncal-Jimenez, Takuji Ishimoto, Takahiko Nakagawa, Bernardo Rodriguez-Iturbe, Paul S. MacLean, Richard J. Johnson
Proc Natl Acad Sci U S A. 2018 Mar 20; 115(12): 3138–3143. Published online 2018 Mar 5. doi: 10.1073/pnas.1713837115
Correction in:
Proc Natl Acad Sci U S A. 2018 Oct 2; 115(40): E9509.
PMCID:
PMC5866545
AbstractArticlePDF–1.3M
17.
Nutrient sensing by absorptive and secretory progenies of small intestinal stem cells
Kunihiro Kishida, Sarah C. Pearce, Shiyan Yu, Nan Gao, Ronaldo P. Ferraris
Am J Physiol Gastrointest Liver Physiol. 2017 Jun 1; 312(6): G592–G605. Published online 2017 Mar 23. doi: 10.1152/ajpgi.00416.2016
PMCID:
PMC5495913
AbstractArticle
18.
Protective role of fructokinase blockade in the pathogenesis of acute kidney injury in mice
Ana Andres-Hernando, Nanxing Li, Christina Cicerchi, Shinichiro Inaba, Wei Chen, Carlos Roncal-Jimenez, Myphuong T. Le, Michael F. Wempe, Tamara Milagres, Takuji Ishimoto, Mehdi Fini, Takahiko Nakagawa, Richard J. Johnson, Miguel A. Lanaspa
Nat Commun. 2017; 8: 14181. Published online 2017 Feb 13. doi: 10.1038/ncomms14181
PMCID:
PMC5316807
AbstractArticlePDF–3.2M
19.
Role of fructose and fructokinase in acute dehydration-induced vasopressin gene expression and secretion in mice
Zhilin Song (宋志林), Carlos A. Roncal-Jimenez, Miguel A. Lanaspa-Garcia, Sarah A. Oppelt, Masanari Kuwabara, Thomas Jensen, Tamara Milagres, Ana Andres-Hernando, Takuji Ishimoto, Gabriela E. Garcia, Ginger Johnson, Paul S. MacLean, Laura-Gabriela Sanchez-Lozada, Dean R. Tolan, Richard J. Johnson
J Neurophysiol. 2017 Feb 1; 117(2): 646–654. Published online 2016 Nov 16. doi: 10.1152/jn.00781.2016
PMCID:
PMC5288484
AbstractArticle
20.
Aging-associated renal disease in mice is fructokinase dependent
Carlos A. Roncal-Jimenez, Takuji Ishimoto, Miguel A. Lanaspa, Tamara Milagres, Ana Andres Hernando, Thomas Jensen, Makoto Miyazaki, Tomohito Doke, Takahiro Hayasaki, Takahiko Nakagawa, Shoichi Marumaya, David A. Long, Gabriela E. Garcia, Masanari Kuwabara, Laura G. Sánchez-Lozada, Duk-Hee Kang, Richard J. Johnson
Am J Physiol Renal Physiol. 2016 Oct 1; 311(4): F722–F730. Published online 2016 Jul 27. doi: 10.1152/ajprenal.00306.2016
PMCID:
PMC5142232
AbstractArticle

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