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Select item 110374051.

MELK aggravates lung adenocarcinoma by regulating EZH2 ubiquitination and H3K27me3 histone methylation of LATS2

Hui Yu, Xianrong Xu, Lirong Zhu, Shengjie Chen, Jincheng He

J Cell Mol Med. 2024 Apr; 28(8): e18216. Published online 2024 Apr 23. doi: 10.1111/jcmm.18216

PMCID:: PMC11037405

Abstract Article PDF–12M

Select item 109424672.

Mitochondrial Raf1 Regulates Glutamine Catabolism

Ronald L. Shanderson, Ian D. Ferguson, Zurab Siprashvili, Luca Ducoli, Albert M. Li, Weili Miao, Suhas Srinivasan, Mary Grace Velasco, Yang Li, Jiangbin Ye, Paul A. Khavari

Version 1. bioRxiv. Preprint. 2024 Mar 9. doi: 10.1101/2024.03.08.581297

PMCID:: PMC10942467

Abstract Article PDF–6.5M

Select item 109168663.

Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma

Suzannah G. Miller, Maria Hoh, Christopher C. Ebmeier, Jian Wei Tay, Natalie G. Ahn

Mol Biol Cell. 2024 Mar 1; 35(3): ar31. Published online 2024 Jan 29. doi: 10.1091/mbc.E23-06-0255

PMCID:: PMC10916866

Abstract Article PDF–4.7M

Select item 104805354.

Mapping the MOB proteins’ proximity network reveals a unique interaction between human MOB3C and the RNase P complex

Islam E. Elkholi, Jonathan Boulais, Marie-Pier Thibault, Hong-Duc Phan, Amélie Robert, Lien B. Lai, Denis Faubert, Matthew J. Smith, Venkat Gopalan, Jean-Franҫois Côté

J Biol Chem. 2023 Sep; 299(9): 105123. Published online 2023 Aug 1. doi: 10.1016/j.jbc.2023.105123

PMCID:: PMC10480535

Abstract Article PDF–2.4M

Select item 100729065.

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong

Mol Cell. Author manuscript; available in PMC 2023 Apr 4.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015

PMCID:: PMC10072906

Abstract Article PDF–4.2M

Select item 97054396.

Inactivation of LATS1/2 drives luminal-basal plasticity to initiate basal-like mammary carcinomas

Joseph G. Kern, Andrew M. Tilston-Lunel, Anthony Federico, Boting Ning, Amy Mueller, Grace B. Peppler, Eleni Stampouloglou, Nan Cheng, Randy L. Johnson, Marc E. Lenburg, Jennifer E. Beane, Stefano Monti, Xaralabos Varelas

Nat Commun. 2022; 13: 7198. Published online 2022 Nov 28. doi: 10.1038/s41467-022-34864-8

PMCID:: PMC9705439

Abstract Article PDF–6.2M

Select item 93006237.

LATS kinases and SLUG regulate the transition to advanced stage in aggressive oral cancer cells

Emi Fujibayashi, Satomi Mukai, Kosuke Torigata, Yumi Ando, Toshihiro Uchihashi, Masami Nozaki, Susumu Tanaka, Masato Okada, Mikihiko Kogo, Hiroshi Nojima, Norikazu Yabuta

Sci Rep. 2022; 12: 12363. Published online 2022 Jul 20. doi: 10.1038/s41598-022-16667-5

PMCID:: PMC9300623

Abstract Article PDF–12M

Select item 92900728.

Pathological significance and prognostic role of LATS2 in prostate cancer

Tsuyoshi Matsuda, Yasuyoshi Miyata, Yuichiro Nakamura, Asato Otsubo, Yuta Mukae, Junki Harada, Kensuke Mitsunari, Tomohiro Matsuo, Kojiro Ohba, Bungo Furusato, Hideki Sakai

Prostate. 2021 Nov 1; 81(15): 1252–1260. Published online 2021 Sep 7. doi: 10.1002/pros.24226

PMCID:: PMC9290072

Abstract Article PDF–3.4M

Select item 92626149.

A dual-activity topoisomerase complex regulates mRNA translation and turnover

Shuaikun Su, Yutong Xue, Alexei Sharov, Yongqing Zhang, Seung Kyu Lee, Jennifer L Martindale, Wen Li, Wai Lim Ku, Keji Zhao, Supriyo De, Weiping Shen, Payel Sen, Myriam Gorospe, Dongyi Xu, Weidong Wang

Nucleic Acids Res. 2022 Jul 8; 50(12): 7013–7033. Published online 2022 Jun 24. doi: 10.1093/nar/gkac538

PMCID:: PMC9262614

Abstract Article PDF–3.6M

Select item 902294410.

The Hippo pathway kinases LATS1 and 2 attenuate cellular responses to heavy metals through phosphorylating MTF1

Han Han, Hiroki J Nakaoka, Line Hofmann, Jeff Jiajing Zhou, Clinton Yu, Lisha Zeng, Junyu Nan, Gayoung Seo, Rebecca Elizabeth Vargas, Bing Yang, Ruxi Qi, Lee Bardwell, Dmitry A. Fishman, Ken W.Y. Cho, Lan Huang, Ray Luo, Rahul Warrior, Wenqi Wang

Nat Cell Biol. Author manuscript; available in PMC 2022 Jul 13.

Published in final edited form as: Nat Cell Biol. 2022 Jan; 24(1): 74–87. Published online 2022 Jan 13. doi: 10.1038/s41556-021-00813-8

PMCID:: PMC9022944

Abstract Article PDF–8.9M

Select item 884482711.

An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase

Zhifen Zhou, Yujing Li, Huimin Xu, Xiaowei Xie, Zibin He, Song Lin, Ruofei Li, Shouheng Jin, Jun Cui, Hai Hu, Feng Liu, Su Wu, Wenbin Ma, Zhou Songyang

iScience. 2022 Feb 18; 25(2): 103813. Published online 2022 Jan 25. doi: 10.1016/j.isci.2022.103813

PMCID:: PMC8844827

Abstract Article PDF–6.0M

Select item 881009212.

MicroRNA miR-4709-3p targets Large Tumor Suppressor Kinase 2 (LATS2) and induces obstructive renal fibrosis through Hippo signaling

Zexiang Jiang, Weiping Xia, Guoyu Dai, Bo Zhang, Yang Li, Xiang Chen

Bioengineered. 2021; 12(2): 12357–12371. Published online 2021 Dec 21. doi: 10.1080/21655979.2021.2002493

PMCID:: PMC8810092

Abstract Article PDF–3.2M

Select item 881002713.

Large tumor suppressor 2 is a prognostic biomarker and correlated with immune infiltrates in colorectal cancer

Chengwen Zhao, Jianping Chen, Yonghui Liu, Shaoqing Ju, Guihua Wang, Xudong Wang

Bioengineered. 2021; 12(2): 11648–11661. Published online 2021 Dec 19. doi: 10.1080/21655979.2021.1996513

PMCID:: PMC8810027

Abstract Article PDF–2.1M

Select item 880651614.

LncRNA MYLK-AS1 acts as an oncogene by epigenetically silencing large tumor suppressor 2 (LATS2) in gastric cancer

Juan Luo, Huifei Xiang

Bioengineered. 2021; 12(1): 3101–3112. Published online 2021 Jun 28. doi: 10.1080/21655979.2021.1944019

PMCID:: PMC8806516

Abstract Article PDF–2.6M

Select item 877564415.

Apoptosis in Type 2 Diabetes: Can It Be Prevented? Hippo Pathway Prospects

Agnieszka Kilanowska, Agnieszka Ziółkowska

Int J Mol Sci. 2022 Jan; 23(2): 636. Published online 2022 Jan 7. doi: 10.3390/ijms23020636

PMCID:: PMC8775644

Abstract Article PDF–834K

Select item 872667916.

Deathly triangle for pancreatic β-cells: Hippo pathway-MTORC1-autophagy

Amin Ardestani, Kathrin Maedler

Autophagy. 2021; 17(12): 4494–4496. Published online 2021 Sep 1. doi: 10.1080/15548627.2021.1972404

PMCID:: PMC8726679

Abstract Article PDF–379K

Select item 872560117.

Hippo signalling maintains ER expression and ER⁺ breast cancer growth

Shenghong Ma, Zhengming Wu, Feng Yang, Jianmin Zhang, Randy L. Johnson, Michael G. Rosenfeld, Kun-Liang Guan

Nature. Author manuscript; available in PMC 2022 Jan 4.

Published in final edited form as: Nature. 2021 Mar; 591(7848): E1–E10. Published online 2021 Mar 3. doi: 10.1038/s41586-020-03131-5

PMCID:: PMC8725601

Article PDF–1.6M

Select item 861614718.

RASSF1A-Mediated Suppression of Estrogen Receptor Alpha (ERα)-Driven Breast Cancer Cell Growth Depends on the Hippo-Kinases LATS1 and 2

Sven Roßwag, Jonathan P. Sleeman, Sonja Thaler

Cells. 2021 Nov; 10(11): 2868. Published online 2021 Oct 24. doi: 10.3390/cells10112868

PMCID:: PMC8616147

Abstract Article PDF–2.6M

Select item 855075919.

RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy

Tomasz Radaszkiewicz, Michaela Nosková, Kristína Gömöryová, Olga Vondálová Blanářová, Katarzyna Anna Radaszkiewicz, Markéta Picková, Ráchel Víchová, Tomáš Gybeľ, Karol Kaiser, Lucia Demková, Lucia Kučerová, Tomáš Bárta, David Potěšil, Zbyněk Zdráhal, Karel Souček, Vítězslav Bryja

eLife. 2021; 10: e65759. Published online 2021 Oct 27. doi: 10.7554/eLife.65759