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Select item 111366661.

Hippo–YAP/TAZ signalling coordinates adipose plasticity and energy balance by uncoupling leptin expression from fat mass

Sungwoo Choi, Ju-Gyeong Kang, Yen T. H. Tran, Sun-Hye Jeong, Kun-Young Park, Hyemi Shin, Young Hoon Kim, Myungsun Park, Hahn Nahmgoong, Taejun Seol, Haeyon Jeon, Yeongmin Kim, Sanghee Park, Hee-joo Kim, Min-Seob Kim, Xiaoxu Li, Maroun Bou Sleiman, Eries Lee, Jinhyuk Choi, David Eisenbarth, Sang Heon Lee, Suhyeon Cho, David D. Moore, Johan Auwerx, Il-Young Kim, Jae Bum Kim, Jong-Eun Park, Dae-Sik Lim, Jae Myoung Suh

Nat Metab. 2024; 6(5): 847–860. Published online 2024 May 29. doi: 10.1038/s42255-024-01045-4

PMCID:: PMC11136666

Abstract Article PDF–18M

Select item 109176602.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 101580293.

S100 Calcium Binding Protein A16 Promotes Cell Proliferation by triggering LATS1 ubiquitin degradation mediated by CUL4A ligase to inhibit Hippo pathway in Glioma development

Yifang Hu, Rihua Zhang, Shan Lu, Wensong Zhang, Dan Wang, Yaoqi Ge, Feng Jiang, Xiaoxuan Qin, Yun Liu

Int J Biol Sci. 2023; 19(7): 2034–2052. Published online 2023 Apr 2. doi: 10.7150/ijbs.79924

PMCID:: PMC10158029

Abstract Article PDF–7.9M

Select item 101144984.

Regenerative reprogramming of the intestinal stem cell state via Hippo signaling suppresses metastatic colorectal cancer

Priscilla Cheung, Jordi Xiol, Michael T. Dill, Wei-Chien Yuan, Riccardo Panero, Jatin Roper, Fernando G. Osorio, Dejan Maglic, Qi Li, Basanta Gurung, Raffaele A. Calogero, Ömer H. Yilmaz, Junhao Mao, Fernando D. Camargo

Cell Stem Cell. Author manuscript; available in PMC 2023 Apr 19.

Published in final edited form as: Cell Stem Cell. 2020 Oct 1; 27(4): 590–604.e9. Published online 2020 Jul 29. doi: 10.1016/j.stem.2020.07.003

PMCID:: PMC10114498

Abstract Article PDF–2.4M

Select item 98169185.

A Stk4 -Foxp3-P65 Transcriptional Complex Promotes Treg Cell Activation and Homeostasis

Ye Cui, Mehdi Benamar, Klaus Schmitz-Abe, Varsha Poondi-Krishnan, Qian Chen, Bat-Erdene Jugder, Benoit Fatou, Jason Fong, Yuelin Zhong, Stuti Mehta, Altantsetseg Buyanbat, Beray Selver Eklioglu, Esra Karabiber, Safa Baris, Ayca Kiykim, Sevgi Keles, Emmanuel Stephen-Victor, Claudia Angelini, Louis-Marie Charbonnier, Talal A. Chatila

Sci Immunol. Author manuscript; available in PMC 2023 Jan 6.

Published in final edited form as: Sci Immunol. 2022 Sep 23; 7(75): eabl8357. Published online 2022 Sep 23. doi: 10.1126/sciimmunol.abl8357

PMCID:: PMC9816918

Abstract Article PDF–3.0M

Select item 97991476.

Maternal hepatocytes heterogeneously and dynamically exhibit developmental phenotypes partially via yes-associated protein 1 during pregnancy

Shashank Manohar Nambiar, Joonyong Lee, Jennifer Abla Yanum, Veronica Garcia, Huaizhou Jiang, Guoli Dai

Am J Physiol Gastrointest Liver Physiol. 2023 Jan 1; 324(1): G38–G50. Published online 2022 Oct 25. doi: 10.1152/ajpgi.00197.2022

PMCID:: PMC9799147

Abstract Article

Select item 97054397.

Inactivation of LATS1/2 drives luminal-basal plasticity to initiate basal-like mammary carcinomas

Joseph G. Kern, Andrew M. Tilston-Lunel, Anthony Federico, Boting Ning, Amy Mueller, Grace B. Peppler, Eleni Stampouloglou, Nan Cheng, Randy L. Johnson, Marc E. Lenburg, Jennifer E. Beane, Stefano Monti, Xaralabos Varelas

Nat Commun. 2022; 13: 7198. Published online 2022 Nov 28. doi: 10.1038/s41467-022-34864-8

PMCID:: PMC9705439

Abstract Article PDF–6.2M

Select item 96553138.

Targeted Disruption of Lats1 and Lats2 in Mice Impairs Testis Development and Alters Somatic Cell Fate

Nour Abou Nader, Amélie Ménard, Adrien Levasseur, Guillaume St-Jean, Derek Boerboom, Gustavo Zamberlam, Alexandre Boyer

Int J Mol Sci. 2022 Nov; 23(21): 13585. Published online 2022 Nov 5. doi: 10.3390/ijms232113585

PMCID:: PMC9655313

Abstract Article PDF–4.1M

Select item 96297459.

Single-cell multiomics identifies clinically relevant mesenchymal stem-like cells and key regulators for MPNST malignancy

Lai Man Natalie Wu, Feng Zhang, Rohit Rao, Mike Adam, Kai Pollard, Sara Szabo, Xuezhao Liu, Katie A. Belcher, Zaili Luo, Sean Ogurek, Colleen Reilly, Xin Zhou, Li Zhang, Joshua Rubin, Long-sheng Chang, Mei Xin, Jiyang Yu, Mario Suva, Christine A. Pratilas, Steven Potter, Q. Richard Lu

Sci Adv. 2022 Nov; 8(44): eabo5442. Published online 2022 Nov 2. doi: 10.1126/sciadv.abo5442

PMCID:: PMC9629745

Abstract Article PDF–16M

Select item 958780510.

LATS1/2 control TGFB-directed epithelial-to-mesenchymal transition in the murine dorsal cranial neuroepithelium through YAP regulation

Idaliz M. Martínez Traverso, Jeffrey D. Steimle, Xiaolei Zhao, Jun Wang, James F. Martin

Development. 2022 Sep 15; 149(18): dev200860. Published online 2022 Sep 20. doi: 10.1242/dev.200860

PMCID:: PMC9587805

Abstract Article

Select item 956230111.

The Hippo pathway links adipocyte plasticity to adipose tissue fibrosis

Hongyu Shen, Xun Huang, Yiheng Zhao, Dongmei Wu, Kaili Xue, Jingfei Yao, Yushuang Wang, Nan Tang, Yifu Qiu

Nat Commun. 2022; 13: 6030. Published online 2022 Oct 13. doi: 10.1038/s41467-022-33800-0

PMCID:: PMC9562301

Abstract Article PDF–6.0M

Select item 952918812.

Transcription Factors YAP/TAZ and SRF Cooperate To Specify Renal Myofibroblasts in the Developing Mouse Kidney

Keri A. Drake, Christopher Chaney, Mohita Patel, Amrita Das, Julia Bittencourt, Martin Cohn, Thomas J. Carroll

J Am Soc Nephrol. 2022 Sep; 33(9): 1694–1707. Published online 2022 Sep. doi: 10.1681/ASN.2021121559

Correction in:: J Am Soc Nephrol. 2023 Mar; 34(3): 515–516.

PMCID:: PMC9529188

Abstract Article

Select item 924310713.

Inactivation of the Hippo tumor suppressor pathway promotes melanoma

Marc A. Vittoria, Nathan Kingston, Kristyna Kotynkova, Eric Xia, Rui Hong, Lee Huang, Shayna McDonald, Andrew Tilston-Lunel, Revati Darp, Joshua D. Campbell, Deborah Lang, Xiaowei Xu, Craig J. Ceol, Xaralabos Varelas, Neil J. Ganem

Nat Commun. 2022; 13: 3732. Published online 2022 Jun 29. doi: 10.1038/s41467-022-31399-w

PMCID:: PMC9243107

Abstract Article PDF–7.2M

Select item 908018914.

Molecular regulation of trophoblast stem cell self-renewal and giant cell differentiation by the Hippo components YAP and LATS1

Trishita Basak, Rupasri Ain

Stem Cell Res Ther. 2022; 13: 189. Published online 2022 May 7. doi: 10.1186/s13287-022-02844-w

PMCID:: PMC9080189

Abstract Article PDF–3.6M

Select item 899374215.

Skeletal muscle phenotyping of Hippo gene-mutated mice reveals that Lats1 deletion increases the percentage of type I muscle fibers

Fakhreddin Yaghoob Nezhad, Annett Riermeier, Martin Schönfelder, Lore Becker, Martin Hrabĕ de Angelis, Henning Wackerhage

Transgenic Res. 2022; 31(2): 227–237. Published online 2022 Jan 5. doi: 10.1007/s11248-021-00293-4

PMCID:: PMC8993742

Abstract Article PDF–3.8M

Select item 887642716.

Myofibroblast YAP/TAZ activation is a key step in organ fibrogenesis

Xiaolin He, Monica F. Tolosa, Tianzhou Zhang, Santosh Kumar Goru, Luisa Ulloa Severino, Paraish S. Misra, Caitríona M. McEvoy, Lauren Caldwell, Stephen G. Szeto, Feng Gao, Xiaolan Chen, Cassandra Atin, Victoria Ki, Noah Vukosa, Catherine Hu, Johnny Zhang, Christopher Yip, Adriana Krizova, Jeffrey L. Wrana, Darren A. Yuen

JCI Insight. 2022 Feb 22; 7(4): e146243. Published online 2022 Feb 22. doi: 10.1172/jci.insight.146243

PMCID:: PMC8876427

Abstract Article PDF–28M

Select item 845253217.

The aryl hydrocarbon receptor promotes differentiation during mouse preimplantational embryo development

Ana Nacarino-Palma, Francisco J. González-Rico, Claudia M. Rejano-Gordillo, Ana Ordiales-Talavero, Jaime M. Merino, Pedro M. Fernández-Salguero

Stem Cell Reports. 2021 Sep 14; 16(9): 2351–2363. Published online 2021 Sep 2. doi: 10.1016/j.stemcr.2021.08.002

PMCID:: PMC8452532

Abstract Article PDF–3.1M

Select item 831323918.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

Select item 815969819.

Deletion of Lats1/2 in adult kidney epithelia leads to renal cell carcinoma

Phoebe Carter, Ulrike Schnell, Christopher Chaney, Betty Tong, Xinchao Pan, Jianhua Ye, Glenda Mernaugh, Jennifer L. Cotton, Vitaly Margulis, Junhao Mao, Roy Zent, Bret M. Evers, Payal Kapur, Thomas J. Carroll

J Clin Invest. 2021 Jun 1; 131(11): e144108. Published online 2021 Jun 1. doi: 10.1172/JCI144108

PMCID:: PMC8159698

Abstract Article PDF–49M

Select item 809881420.

The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis

Shalini Menon, Dennis Goldfarb, Chris T. Ho, Erica W. Cloer, Nicholas P. Boyer, Christopher Hardie, Andrew J. Bock, Emma C. Johnson, Joel Anil, M. Ben Major, Stephanie L. Gupton

Mol Biol Cell. 2021 Feb 15; 32(4): 314–330. doi: 10.1091/mbc.E20-10-0622

PMCID:: PMC8098814

Abstract Article PDF–7.7M

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