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Select item 112107541.

Activated Gab1 drives hepatocyte proliferation and anti-apoptosis in liver fibrosis via potential involvement of the HGF/c-Met signaling axis

Da-eun Nam, Soo-Jeung Park, Samson Omole, Eugene Um, Ramin M. Hakami, Young S. Hahn

PLoS One. 2024; 19(6): e0306345. Published online 2024 Jun 27. doi: 10.1371/journal.pone.0306345

PMCID:: PMC11210754

Abstract Article PDF–2.4M

Select item 100701072.

Epithelial Gab1 calibrates RIPK3-dependent necroptosis to prevent intestinal inflammation

Jiaqi Xu, Shihao Li, Wei Jin, Hui Zhou, Tingting Zhong, Xiaoqing Cheng, Yujuan Fu, Peng Xiao, Hongqiang Cheng, Di Wang, Yuehai Ke, Zhinong Jiang, Xue Zhang

JCI Insight. 2023 Mar 22; 8(6): e162701. Published online 2023 Mar 22. doi: 10.1172/jci.insight.162701

PMCID:: PMC10070107

Abstract Article PDF–24M

Select item 90674033.

Noncanonical imprinting sustains embryonic development and restrains placental overgrowth

Shogo Matoba, Chisayo Kozuka, Kento Miura, Kimiko Inoue, Mami Kumon, Ryoya Hayashi, Tatsuya Ohhata, Atsuo Ogura, Azusa Inoue

Genes Dev. 2022 Apr 1; 36(7-8): 483–494. doi: 10.1101/gad.349390.122

PMCID:: PMC9067403

Abstract Article PDF–9.6M

Select item 83132394.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

Select item 82450415.

Lacrimal gland budding requires PI3K-dependent suppression of EGF signaling

Qian Wang, Chenqi Tao, Abdul Hannan, Sungtae Yoon, Xuanyu Min, John Peregrin, Xiuxia Qu, Hongge Li, Honglian Yu, Jean Zhao, Xin Zhang

Sci Adv. 2021 Jul; 7(27): eabf1068. Published online 2021 Jun 30. doi: 10.1126/sciadv.abf1068

PMCID:: PMC8245041

Abstract Article PDF–1.8M

Select item 79387706.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 77163987.

S100a8 silencing attenuates inflammation, oxidative stress and apoptosis in BV2 cells induced by oxygen-glucose deprivation and reoxygenation by upregulating GAB1 expression

Wenguang Hu, Caimei Lin

Mol Med Rep. 2021 Jan; 23(1): 64. Published online 2020 Nov 19. doi: 10.3892/mmr.2020.11702

PMCID:: PMC7716398

Abstract Article PDF–1.3M

Select item 71953628.

Loss of H3K27me3 imprinting in the Sfmbt2 miRNA cluster causes enlargement of cloned mouse placentas

Kimiko Inoue, Narumi Ogonuki, Satoshi Kamimura, Hiroki Inoue, Shogo Matoba, Michiko Hirose, Arata Honda, Kento Miura, Masashi Hada, Ayumi Hasegawa, Naomi Watanabe, Yukiko Dodo, Keiji Mochida, Atsuo Ogura

Nat Commun. 2020; 11: 2150. Published online 2020 May 1. doi: 10.1038/s41467-020-16044-8

PMCID:: PMC7195362

Abstract Article PDF–2.8M

Select item 71899839.

Cholinergic Grb2-Associated-Binding Protein 1 Regulates Cognitive Function

Nan-Nan Lu, Chao Tan, Ning-He Sun, Ling-Xiao Shao, Xiu-Xiu Liu, Yin-Ping Gao, Rong-Rong Tao, Quan Jiang, Cheng-Kun Wang, Ji-Yun Huang, Kui Zhao, Guang-Fa Wang, Zhi-Rong Liu, Kohji Fukunaga, Ying-Mei Lu, Feng Han

Cereb Cortex. 2018 Jul; 28(7): 2391–2404. Published online 2017 Jun 7. doi: 10.1093/cercor/bhx141

PMCID:: PMC7189983

Abstract Article PDF–1.5M

Select item 698481110.

Gab1 mediates PDGF signaling and is essential to oligodendrocyte differentiation and CNS myelination

Liang Zhou, Chong-Yu Shao, Ya-Jun Xie, Na Wang, Si-Min Xu, Ben-Yan Luo, Zhi-Ying Wu, Yue Hai Ke, Mengsheng Qiu, Ying Shen

eLife. 2020; 9: e52056. Published online 2020 Jan 16. doi: 10.7554/eLife.52056

PMCID:: PMC6984811

Abstract Article PDF–7.1M

Select item 693862311.

Inhibition of microRNA-29a alleviates hyperoxia-induced bronchopulmonary dysplasia in neonatal mice via upregulation of GAB1

Yu Hu, Liang Xie, Jing Yu, Hongling Fu, Dan Zhou, Hanmin Liu

Mol Med. 2020; 26: 3. Published online 2019 Dec 31. doi: 10.1186/s10020-019-0127-9

PMCID:: PMC6938623

Abstract Article PDF–2.3M

Select item 681410312.

The multi-site docking protein Grb2-associated binder 1 (Gab1) enhances interleukin-6-induced MAPK-pathway activation in an SHP2-, Grb2-, and time-dependent manner

Hannes Bongartz, Karen Gille, Wiebke Hessenkemper, Katharina Mandel, Marc Lewitzky, Stephan M. Feller, Fred Schaper

Cell Commun Signal. 2019; 17: 135. Published online 2019 Oct 24. doi: 10.1186/s12964-019-0451-2

PMCID:: PMC6814103

Abstract Article PDF–3.8M

Select item 679525013.

Grb2-Associated Binder-1 Is Required for Neuregulin-1-Induced Peripheral Nerve Myelination

Yoon Kyung Shin, So Young Jang, So Young Park, Joo Youn Park, Jong Kuk Kim, Jong Phil Kim, Duk Joon Suh, Hye Jeong Lee, Hwan Tae Park

J Neurosci. 2014 May 28; 34(22): 7657–7662. doi: 10.1523/JNEUROSCI.4947-13.2014

PMCID:: PMC6795250

Abstract Article PDF–2.0M

Select item 639844814.

USP22 controls multiple signaling pathways that are essential for vasculature formation in the mouse placenta

Evangelia Koutelou, Li Wang, Andria C. Schibler, Hsueh-Ping Chao, Xianghong Kuang, Kevin Lin, Yue Lu, Jianjun Shen, Collene R. Jeter, Andrew Salinger, Marenda Wilson, Yi Chun Chen, Boyko S. Atanassov, Dean G. Tang, Sharon Y. R. Dent

Development. 2019 Feb 15; 146(4): dev174037. Published online 2019 Feb 22. doi: 10.1242/dev.174037

PMCID:: PMC6398448

Abstract Article

Select item 617692415.

LIF-dependent survival of embryonic stem cells is regulated by a novel palmitoylated Gab1 signalling protein

Linda Sutherland, Madeleine Ruhe, Daniela Gattegno-Ho, Karanjit Mann, Jennifer Greaves, Magdalena Koscielniak, Stephen Meek, Zen Lu, Martin Waterfall, Ryan Taylor, Anestis Tsakiridis, Helen Brown, Sutherland K. Maciver, Anagha Joshi, Michael Clinton, Luke H. Chamberlain, Austin Smith, Tom Burdon

J Cell Sci. 2018 Sep 15; 131(18): jcs222257. Published online 2018 Sep 20. doi: 10.1242/jcs.222257

PMCID:: PMC6176924

Abstract Article

Select item 587384416.

Modifier variant of METTL13 suppresses human GAB1–associated profound deafness

Rizwan Yousaf, Zubair M. Ahmed, Arnaud P.J. Giese, Robert J. Morell, Ayala Lagziel, Alain Dabdoub, Edward R. Wilcox, Sheikh Riazuddin, Thomas B. Friedman, Saima Riazuddin

J Clin Invest. 2018 Apr 2; 128(4): 1509–1522. Published online 2018 Mar 12. doi: 10.1172/JCI97350

PMCID:: PMC5873844

Abstract Article PDF–17M

Select item 581369817.

Basal Suppression of the Sonic Hedgehog Pathway by the G-Protein-Coupled Receptor Gpr161 Restricts Medulloblastoma Pathogenesis

Issei S. Shimada, Sun-Hee Hwang, Bandarigoda N. Somatilaka, Xin Wang, Patryk Skowron, Jiwoong Kim, Min Kim, John M. Shelton, Veena Rajaram, Zhenyu Xuan, Michael D. Taylor, Saikat Mukhopadhyay

Cell Rep. Author manuscript; available in PMC 2018 Feb 15.

Published in final edited form as: Cell Rep. 2018 Jan 30; 22(5): 1169–1184. doi: 10.1016/j.celrep.2018.01.018

PMCID:: PMC5813698

Abstract Article PDF–2.5M

Select item 557290918.

Increased levels of Gab1 and Gab2 adaptor proteins skew interleukin-4 (IL-4) signaling toward M2 macrophage-driven pulmonary fibrosis in mice

Xiaohong Guo, Tingting Li, Yun Xu, Xiayan Xu, Zhengyi Zhu, Yun Zhang, Jiaqi Xu, Kaihong Xu, Hongqiang Cheng, Xue Zhang, Yuehai Ke

J Biol Chem. 2017 Aug 25; 292(34): 14003–14015. Published online 2017 Jul 7. doi: 10.1074/jbc.M117.802066

PMCID:: PMC5572909

Abstract Article PDF–3.4M

Select item 511577019.

Molecular Characterization of Striated Muscle-Specific Gab1 Isoform as a Critical Signal Transducer for Neuregulin-1/ErbB Signaling in Cardiomyocytes

Taku Yasui, Takeshi Masaki, Yoh Arita, Tomohiko Ishibashi, Tadakatsu Inagaki, Makoto Okazawa, Toru Oka, Wataru Shioyama, Keiko Yamauchi-Takihara, Issei Komuro, Yasushi Sakata, Yoshikazu Nakaoka

PLoS One. 2016; 11(11): e0166710. Published online 2016 Nov 18. doi: 10.1371/journal.pone.0166710

PMCID:: PMC5115770

Abstract Article PDF–2.0M

Select item 509987320.

Scaffolding protein Gab1 regulates myeloid dendritic cell migration in allergic asthma

Yun Zhang, Yun Xu, Shuwan Liu, Xiaohong Guo, Dong Cen, Jiaqi Xu, Heyuan Li, Kaijun Li, Chunlai Zeng, Linrong Lu, Yiting Zhou, Huahao Shen, Hongqiang Cheng, Xue Zhang, Yuehai Ke

Cell Res. 2016 Nov; 26(11): 1226–1241. Published online 2016 Nov 4. doi: 10.1038/cr.2016.124

PMCID:: PMC5099873

Abstract Article PDF–5.8M

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