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Items: 1 to 20 of 134

1.
Cardiac-Specific Suppression of Valosin-Containing Protein Induces Progressive Heart Failure and Premature Mortality Correlating with Temporal Dysregulations in mTOR Complex 2 and Protein Phosphatase 1
Xiaonan Sun, Xicong Tang, Hongyu Qiu
Int J Mol Sci. 2024 Jun; 25(12): 6445. Published online 2024 Jun 11. doi: 10.3390/ijms25126445
PMCID:
PMC11203954
AbstractArticlePDF–2.9M
2.
DUSP1 interacts with and dephosphorylates VCP to improve mitochondrial quality control against endotoxemia-induced myocardial dysfunction
Hang Zhu, Jin Wang, Ting Xin, Shanshan Chen, Ruiying Hu, Yukun Li, Mingming Zhang, Hao Zhou
Cell Mol Life Sci. 2023 Aug; 80(8): 213. Published online 2023 Jul 18. doi: 10.1007/s00018-023-04863-z
PMCID:
PMC11072740
AbstractArticlePDF–16M
3.
Valosin-containing protein acts as a target and mediator of S-nitrosylation in the heart through distinct mechanisms
Xiaomeng Shi, Molly O'Connor, Hongyu Qiu
Redox Biol. 2024 Jun; 72: 103166. Published online 2024 Apr 26. doi: 10.1016/j.redox.2024.103166
PMCID:
PMC11061752
AbstractArticlePDF–4.9M
4.
Keratinocyte FABP5-VCP complex mediates recruitment of neutrophils in psoriasis
Jiaqing Hao, Jianyu Yu, Matthew S. Yorek, Chi-Li Yu, R. Marshall Pope, Michael S. Chimenti, Yiqin Xiong, Aloysius Klingelhutz, Ali Jabbari, Bing Li
Cell Rep. Author manuscript; available in PMC 2023 Dec 19.
Published in final edited form as: Cell Rep. 2023 Nov 28; 42(11): 113449. Published online 2023 Nov 15. doi: 10.1016/j.celrep.2023.113449
PMCID:
PMC10729729
AbstractArticlePDF–2.9M
5.
Inhibition of VCP modulates NF-κB signaling pathway to suppress multiple myeloma cell proliferation and osteoclast differentiation
Rongfang Wei, Yuhao Cao, Hongjie Wu, Xin Liu, Mingmei Jiang, Xian Luo, Zhendong Deng, Ze Wang, Mengying Ke, Yongqiang Zhu, Siqing Chen, Chunyan Gu, Ye Yang
Aging (Albany NY) 2023 Aug 30; 15(16): 8220–8236. Published online 2023 Aug 21. doi: 10.18632/aging.204965
PMCID:
PMC10497005
AbstractArticlePDF–1.5M
6.
Single-cell and spatial transcriptomics identify a macrophage population associated with skeletal muscle fibrosis
Gerald Coulis, Diego Jaime, Christian Guerrero-Juarez, Jenna M. Kastenschmidt, Philip K. Farahat, Quy Nguyen, Nicholas Pervolarakis, Katherine McLinden, Lauren Thurlow, Saba Movahedi, Brandon S. Hughes, Jorge Duarte, Andrew Sorn, Elizabeth Montoya, Izza Mozaffar, Morgan Dragan, Shivashankar Othy, Trupti Joshi, Chetan P. Hans, Virginia Kimonis, Adam L. MacLean, Qing Nie, Lindsay M. Wallace, Scott Q. Harper, Tahseen Mozaffar, Marshall W. Hogarth, Surajit Bhattacharya, Jyoti K. Jaiswal, David R. Golann, Qi Su, Kai Kessenbrock, Michael Stec, Melissa J. Spencer, Jesse R. Zamudio, S. Armando Villalta
Sci Adv. 2023 Jul; 9(27): eadd9984. Published online 2023 Jul 7. doi: 10.1126/sciadv.add9984
PMCID:
PMC10328414
AbstractArticlePDF–2.2M
7.
PTP4A2 promotes lysophagy by dephosphorylation of VCP/p97 at Tyr805
Yunpeng Bai, Guimei Yu, Hong-Ming Zhou, Ovini Amarasinghe, Yuan Zhou, Peipei Zhu, Qinglin Li, Lujuan Zhang, Frederick Nguele Meke, Yiming Miao, Eli Chapman, W. Andy Tao, Zhong-Yin Zhang
Autophagy. 2023; 19(5): 1562–1581. Published online 2022 Nov 7. doi: 10.1080/15548627.2022.2140558
PMCID:
PMC10240998
AbstractArticlePDF–4.4M
8.
Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome
Brianna K. Unda, Leon Chalil, Sehyoun Yoon, Savannah Kilpatrick, Courtney Irwin, Sansi Xing, Nadeem Murtaza, Anran Cheng, Chad Brown, Alexandria Afonso, Elizabeth McCready, Gabriel M. Ronen, Jennifer Howe, Aurélie Caye-Eude, Alain Verloes, Brad W. Doble, Laurence Faivre, Antonio Vitobello, Stephen W. Scherer, Yu Lu, Peter Penzes, Karun K. Singh
Mol Psychiatry. 2023; 28(4): 1747–1769. Published online 2023 Jan 6. doi: 10.1038/s41380-022-01937-5
PMCID:
PMC10208958
AbstractArticlePDF–7.0M
9.
Rescue of neuropsychiatric phenotypes in a mouse model of 16p11.2 duplication syndrome by genetic correction of an epilepsy network hub
Marc P. Forrest, Marc Dos Santos, Nicolas H. Piguel, Yi-Zhi Wang, Nicole A. Hawkins, Vikram A. Bagchi, Leonardo E. Dionisio, Sehyoun Yoon, Dina Simkin, Maria Dolores Martin-de-Saavedra, Ruoqi Gao, Katherine E. Horan, Alfred L. George, Jr., Mark S. LeDoux, Jennifer A. Kearney, Jeffrey N. Savas, Peter Penzes
Nat Commun. 2023; 14: 825. Published online 2023 Feb 17. doi: 10.1038/s41467-023-36087-x
PMCID:
PMC9938216
AbstractArticlePDF–5.3M
10.
The p97-UBXD8 complex regulates ER-Mitochondria contact sites by altering membrane lipid saturation and composition
Rakesh Ganji, Joao A. Paulo, Yuecheng Xi, Ian Kline, Jiang Zhu, Christoph S. Clemen, Conrad C. Weihl, John G. Purdy, Steve P. Gygi, Malavika Raman
Nat Commun. 2023; 14: 638. Published online 2023 Feb 6. doi: 10.1038/s41467-023-36298-2
PMCID:
PMC9902492
AbstractArticlePDF–4.1M
11.
Valosin-containing protein (VCP/p97) inhibition reduces viral clearance and induces toxicity associated with muscular damage
Marta del Rio Oliva, Michael Basler
Cell Death Dis. 2022 Dec; 13(12): 1015. Published online 2022 Dec 1. doi: 10.1038/s41419-022-05461-w
PMCID:
PMC9715549
AbstractArticlePDF–2.3M
12.
DNA damage in embryonic neural stem cell determines FTLDs’ fate via early-stage neuronal necrosis
Hidenori Homma, Hikari Tanaka, Meihua Jin, Xiaocen Jin, Yong Huang, Yuki Yoshioka, Christian JF Bertens, Kohei Tsumaki, Kanoh Kondo, Hiroki Shiwaku, Kazuhiko Tagawa, Hiroyasu Akatsu, Naoki Atsuta, Masahisa Katsuno, Katsutoshi Furukawa, Aiko Ishiki, Masaaki Waragai, Gaku Ohtomo, Atsushi Iwata, Takanori Yokota, Haruhisa Inoue, Hiroyuki Arai, Gen Sobue, Masaki Sone, Kyota Fujita, Hitoshi Okazawa
Life Sci Alliance. 2021 Jul; 4(7): e202101022. Published online 2021 Jun 15. doi: 10.26508/lsa.202101022
PMCID:
PMC9715434
AbstractArticlePDF–4.7M
13.
The Deubiquitinating Enzyme USP48 Interacts with the Retinal Degeneration-Associated Proteins UNC119a and ARL3
Laura Sánchez-Bellver, Andrea Férriz-Gordillo, Marc Carrillo-Pz, Laura Rabanal, Francesc R. Garcia-Gonzalo, Gemma Marfany
Int J Mol Sci. 2022 Oct; 23(20): 12527. Published online 2022 Oct 19. doi: 10.3390/ijms232012527
PMCID:
PMC9603860
AbstractArticlePDF–3.4M
14.
ALS-linked loss of Cyclin-F function affects HSP90
Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends
Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359
PMCID:
PMC9481933
AbstractArticlePDF–3.5M
15.
AAA-ATPase valosin-containing protein binds the transcription factor SREBP1 and promotes its proteolytic activation by rhomboid protease RHBDL4
Koji Shibuya, Ken Ebihara, Chihiro Ebihara, Nagisa Sawayama, Masayo Isoda, Daisuke Yamamuro, Manabu Takahashi, Shuichi Nagashima, Shun Ishibashi
J Biol Chem. 2022 Jun; 298(6): 101936. Published online 2022 Apr 14. doi: 10.1016/j.jbc.2022.101936
PMCID:
PMC9127370
AbstractArticlePDF–2.0M
16.
VCP suppresses proteopathic seeding in neurons
Jiang Zhu, Sara Pittman, Dhruva Dhavale, Rachel French, Jessica N. Patterson, Mohamed Salman Kaleelurrrahuman, Yuanzi Sun, Jaime Vaquer-Alicea, Gianna Maggiore, Christoph S. Clemen, William J. Buscher, Jan Bieschke, Paul Kotzbauer, Yuna Ayala, Marc I. Diamond, Albert A. Davis, Conrad Weihl
Mol Neurodegener. 2022; 17: 30. Published online 2022 Apr 12. doi: 10.1186/s13024-022-00532-0
PMCID:
PMC9004082
AbstractArticlePDF–7.0M
17.
Loss-of-function mutation in VCP mimics the characteristic pathology as in FTLD-TARDBP
Abubakar Wani, Conrad C. Weihl
Autophagy. 2021; 17(12): 4502–4503. Published online 2021 Oct 10. doi: 10.1080/15548627.2021.1985880
PMCID:
PMC8726662
AbstractArticlePDF–195K
18.
A p97/Valosin-Containing Protein Inhibitor Drug CB-5083 Has a Potent but Reversible Off-Target Effect on Phosphodiesterase-6
Henri Leinonen, Cheng Cheng, Marja Pitkänen, Christopher L. Sander, Jianye Zhang, Sama Saeid, Teemu Turunen, Alyaa Shmara, Lan Weiss, Lac Ta, Timothy Ton, Ari Koskelainen, Jesse D. Vargas, Virginia Kimonis, Krzysztof Palczewski
J Pharmacol Exp Ther. 2021 Jul; 378(1): 31–41. Published online 2021 Jul. doi: 10.1124/jpet.120.000486
PMCID:
PMC8456514
AbstractArticlePDF–1.5M
19.
Neuronal VCP loss of function recapitulates FTLD-TDP pathology
Abubakar Wani, Jiang Zhu, Jason D. Ulrich, Abdallah Eteleeb, Andrew D. Sauerbeck, Sydney J. Reitz, Khalid Arhzaouy, Chiseko Ikenaga, Carla M. Yuede, Sara K. Pittman, Feng Wang, Shan Li, Bruno A. Benitez, Carlos Cruchaga, Terrance T. Kummer, Oscar Harari, Tsui-Fen Chou, Rolf Schröder, Christoph S. Clemen, Conrad C. Weihl
Cell Rep. Author manuscript; available in PMC 2021 Aug 24.
Published in final edited form as: Cell Rep. 2021 Jul 20; 36(3): 109399. doi: 10.1016/j.celrep.2021.109399
PMCID:
PMC8383344
AbstractArticlePDF–1.9M
20.
Prediction and verification of the AD-FTLD common pathomechanism based on dynamic molecular network analysis
Meihua Jin, Xiaocen Jin, Hidenori Homma, Kyota Fujita, Hikari Tanaka, Shigeo Murayama, Hiroyasu Akatsu, Kazuhiko Tagawa, Hitoshi Okazawa
Commun Biol. 2021; 4: 961. Published online 2021 Aug 12. doi: 10.1038/s42003-021-02475-6
PMCID:
PMC8361101
AbstractArticlePDF–3.0M

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