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Items: 1 to 20 of 31

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery
Kiren Baines, Kazuaki Yoshioka, Yoh Takuwa, Jon D. Lane
Autophagy Rep. 2022; 1(1): 88–118. Published online 2022 Apr 7. doi: 10.1080/27694127.2022.2042054
PMCID:
PMC9015699
AbstractArticlePDF–3.3M
3.
Extracellular cathepsin Z signals through the α5 integrin and augments NLRP3 inflammasome activation
Rhiannon I. Campden, Amy L. Warren, Catherine J. Greene, Jose A. Chiriboga, Corey R. Arnold, Devin Aggarwal, Neil McKenna, Christina F. Sandall, Justin A. MacDonald, Robin M. Yates
J Biol Chem. 2022 Jan; 298(1): 101459. Published online 2021 Dec 2. doi: 10.1016/j.jbc.2021.101459
PMCID:
PMC8753182
AbstractArticlePDF–1.9M
4.
Evaluation of novel cathepsin-X inhibitors in vitro and in vivo and their ability to improve cathepsin-B-directed antitumor therapy
Ana Mitrović, Janja Završnik, Georgy Mikhaylov, Damijan Knez, Urša Pečar Fonović, Petra Matjan Štefin, Miha Butinar, Stanislav Gobec, Boris Turk, Janko Kos
Cell Mol Life Sci. 2022 Jan; 79(1): 34. Published online 2022 Jan 6. doi: 10.1007/s00018-021-04117-w
PMCID:
PMC8738504
AbstractArticlePDF–8.2M
5.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
6.
Frontline Science: Multiple cathepsins promote inflammasome‐independent, particle‐induced cell death during NLRP3‐dependent IL‐1β activation
Gregory M. Orlowski, Shruti Sharma, Jeff D. Colbert, Matthew Bogyo, Stephanie A. Robertson, Hiroshi Kataoka, Francis K. Chan, Kenneth L. Rock
J Leukoc Biol. 2017 Jul; 102(1): 7–17. Published online 2017 Jan 13. doi: 10.1189/jlb.3HI0316-152R
PMCID:
PMC6608057
AbstractArticle
7.
Cysteine-type cathepsins promote the effector phase of acute cutaneous delayed-type hypersensitivity reactions
Johannes Schwenck, Andreas Maurer, Birgit Fehrenbacher, Roman Mehling, Philipp Knopf, Natalie Mucha, Dennis Haupt, Kerstin Fuchs, Christoph M. Griessinger, Daniel Bukala, Julia Holstein, Martin Schaller, Irene Gonzalez Menendez, Kamran Ghoreschi, Leticia Quintanilla-Martinez, Michael Gütschow, Stefan Laufer, Thomas Reinheckel, Martin Röcken, Hubert Kalbacher, Bernd J Pichler, Manfred Kneilling
Theranostics. 2019; 9(13): 3903–3917. Published online 2019 May 31. doi: 10.7150/thno.31037
PMCID:
PMC6587341
AbstractArticlePDF–1.7M
8.
Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors
Hyeonwoo Kim, Christiane D. Wrann, Mark Jedrychowski, Sara Vidoni, Yukiko Kitase, Kenichi Nagano, Chenhe Zhou, Joshua Chou, Virginia-Jeni A. Parkman, Scott J. Novick, Timothy S. Strutzenberg, Bruce D. Pascal, Phuong T. Le, Daniel J. Brooks, Alexander M. Roche, Kaitlyn K. Gerber, Laura Mattheis, Wenjing Chen, Hua Tu, Mary L. Bouxsein, Patrick R. Griffin, Roland Baron, Clifford J. Rosen, Lynda F. Bonewald, Bruce M. Spiegelman
Cell. Author manuscript; available in PMC 2019 Dec 13.
Published in final edited form as: Cell. 2018 Dec 13; 175(7): 1756–1768.e17. doi: 10.1016/j.cell.2018.10.025
Correction in:
Cell. 2019 Jul 11; 178(2): 507–508.
PMCID:
PMC6298040
AbstractArticlePDF–1.2M
9.
Lysosomal processing of progranulin
Xiaolai Zhou, Daniel H. Paushter, Tuancheng Feng, Lirong Sun, Thomas Reinheckel, Fenghua Hu
Mol Neurodegener. 2017; 12: 62. Published online 2017 Aug 23. doi: 10.1186/s13024-017-0205-9
PMCID:
PMC5569495
AbstractArticlePDF–1.0M
10.
STAT3 and STAT6 signaling pathways synergize to promote cathepsin secretion from macrophages via IRE1α activation
Dongyao Yan, Hao-Wei Wang, Robert L. Bowman, Johanna A. Joyce
Cell Rep. Author manuscript; available in PMC 2017 Aug 16.
Published in final edited form as: Cell Rep. 2016 Sep 13; 16(11): 2914–2927. doi: 10.1016/j.celrep.2016.08.035
PMCID:
PMC5559199
AbstractArticlePDF–1.0M
11.
A role for cathepsin Z in neuroinflammation provides mechanistic support for an epigenetic risk factor in multiple sclerosis
Euan R. O. Allan, Rhiannon I. Campden, Benjamin W. Ewanchuk, Pankaj Tailor, Dale R. Balce, Neil T. McKenna, Catherine J. Greene, Amy L. Warren, Thomas Reinheckel, Robin M. Yates
J Neuroinflammation. 2017; 14: 103. Published online 2017 May 10. doi: 10.1186/s12974-017-0874-x
PMCID:
PMC5424360
AbstractArticlePDF–1.1M
12.
Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression
Alexandra Naba, Karl R. Clauser, D. R. Mani, Steven A. Carr, Richard O. Hynes
Sci Rep. 2017; 7: 40495. Published online 2017 Jan 10. doi: 10.1038/srep40495
PMCID:
PMC5223159
AbstractArticlePDF–2.3M
13.
Combined deletion of cathepsin protease family members reveals compensatory mechanisms in cancer
Leila Akkari, Vasilena Gocheva, Marsha L. Quick, Jemila C. Kester, Alison K. Spencer, Alfred L. Garfall, Robert L. Bowman, Johanna A. Joyce
Genes Dev. 2016 Jan 15; 30(2): 220–232. doi: 10.1101/gad.270439.115
PMCID:
PMC4719311
AbstractArticlePDF–1.1M
14.
Distinct functions of macrophage-derived and cancer cell-derived cathepsin Z combine to promote tumor malignancy via interactions with the extracellular matrix
Leila Akkari, Vasilena Gocheva, Jemila C. Kester, Karen E. Hunter, Marsha L. Quick, Lisa Sevenich, Hao-Wei Wang, Christoph Peters, Laura H. Tang, David S. Klimstra, Thomas Reinheckel, Johanna A. Joyce
Genes Dev. 2014 Oct 1; 28(19): 2134–2150. doi: 10.1101/gad.249599.114
PMCID:
PMC4180975
AbstractArticlePDF–2.3M
15.
Ferrous iron-dependent drug delivery enables controlled and selective release of therapeutic agents in vivo
Edgar Deu, Ingrid T. Chen, Erica M. W. Lauterwasser, Juan Valderramos, Hao Li, Laura E. Edgington, Adam R. Renslo, Matthew Bogyo
Proc Natl Acad Sci U S A. 2013 Nov 5; 110(45): 18244–18249. Published online 2013 Oct 21. doi: 10.1073/pnas.1312782110
PMCID:
PMC3831501
AbstractArticlePDF–1.0M
16.
Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates
Jeremy A. Miller, Jason Nathanson, Daniel Franjic, Sungbo Shim, Rachel A. Dalley, Sheila Shapouri, Kimberly A. Smith, Susan M. Sunkin, Amy Bernard, Jeffrey L. Bennett, Chang-Kyu Lee, Michael J. Hawrylycz, Allan R. Jones, David G. Amaral, Nenad Sestan, Fred H. Gage, Ed S. Lein
Development. 2013 Nov 15; 140(22): 4633–4644. doi: 10.1242/dev.097212
PMCID:
PMC3817946
AbstractArticle
17.
Induction of Premalignant Host Responses by Cathepsin X/Z-Deficiency in Helicobacter Pylori-Infected Mice
Sabine Krueger, Anja Bernhardt, Thomas Kalinski, Martin Baldensperger, Michael Zeh, Anne Teller, Daniela Adolf, Thomas Reinheckel, Albert Roessner, Doerthe Kuester
PLoS One. 2013; 8(7): e70242. Published online 2013 Jul 30. doi: 10.1371/journal.pone.0070242
PMCID:
PMC3728094
AbstractArticlePDF–18M
18.
Cathepsins L and Z Are Critical in Degrading Polyglutamine-containing Proteins within Lysosomes
Nidhi Bhutani, Rosanna Piccirillo, Raphael Hourez, Prasanna Venkatraman, Alfred L. Goldberg
J Biol Chem. 2012 May 18; 287(21): 17471–17482. Published online 2012 Mar 26. doi: 10.1074/jbc.M112.352781
PMCID:
PMC3366842
AbstractArticlePDF–2.4M
19.
Mice deficient in LMAN1 exhibit FV and FVIII deficiencies and liver accumulation of α1-antitrypsin
Bin Zhang, Chunlei Zheng, Min Zhu, Jiayi Tao, Matthew P. Vasievich, Andrea Baines, Jinoh Kim, Randy Schekman, Randal J. Kaufman, David Ginsburg
Blood. 2011 Sep 22; 118(12): 3384–3391. Prepublished online 2011 Jul 27. doi: 10.1182/blood-2011-05-352815
PMCID:
PMC3179404
AbstractArticle
20.
Overexpression of Cathepsin Z Contributes to Tumor Metastasis by Inducing Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma
Jian Wang, Leilei Chen, Yan Li, Xin-Yuan Guan
PLoS One. 2011; 6(9): e24967. Published online 2011 Sep 22. doi: 10.1371/journal.pone.0024967
PMCID:
PMC3178578
AbstractArticlePDF–2.1M

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