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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 99398352.

Sodium/(calcium + potassium) exchanger NCKX4 optimizes KLK4 activity in the enamel matrix microenvironment to regulate ECM modeling

Barry Chan, Ieong Cheng Cheng, Jalali Rozita, Ida Gorshteyn, Yulei Huang, Ida Shaffer, Chih Chang, Wu Li, Jonathan Lytton, Pamela Den Besten, Yan Zhang

Front Physiol. 2023; 14: 1116091. Published online 2023 Feb 6. doi: 10.3389/fphys.2023.1116091

PMCID:: PMC9939835

Abstract Article PDF–4.7M

Select item 96742173.

SOX9 and SOX10 control fluid homeostasis in the inner ear for hearing through independent and cooperative mechanisms

Irene Y. Y. Szeto, Daniel K. H. Chu, Peikai Chen, Ka Chi Chu, Tiffany Y. K. Au, Keith K. H. Leung, Yong-Heng Huang, Sarah L. Wynn, Angel C. Y. Mak, Ying-Shing Chan, Wood Yee Chan, Ralf Jauch, Bernd Fritzsch, Mai Har Sham, Robin Lovell-Badge, Kathryn S. E. Cheah

Proc Natl Acad Sci U S A. 2022 Nov 15; 119(46): e2122121119. Published online 2022 Nov 7. doi: 10.1073/pnas.2122121119

PMCID:: PMC9674217

Abstract Article PDF–2.7M

Select item 91803584.

Peroxisome Metabolism Contributes to PIEZO2-Mediated Mechanical Allodynia

Yi Gong, Fiza Laheji, Anna Berenson, April Qian, Sang-O Park, Rene Kok, Martin Selig, Ryan Hahn, Reza Sadjadi, Stephan Kemp, Florian Eichler

Cells. 2022 Jun; 11(11): 1842. Published online 2022 Jun 4. doi: 10.3390/cells11111842

PMCID:: PMC9180358

Abstract Article PDF–4.6M

Select item 80926595.

Odor sampling strategies in mice with genetically altered olfactory responses

Johannes Reisert, Glen J. Golden, Michele Dibattista, Alan Gelperin

PLoS One. 2021; 16(5): e0249798. Published online 2021 May 3. doi: 10.1371/journal.pone.0249798

PMCID:: PMC8092659

Abstract Article PDF–3.4M

Select item 79490856.

Calmodulin binds and modulates K⁺-dependent Na⁺/Ca²⁺-exchanger isoform 4, NCKX4

Stephanie Thibodeau, Weidong Yang, Sunita Sharma, Jonathan Lytton

J Biol Chem. 2021 Jan-Jun; 296: 100092. Published online 2020 Nov 23. doi: 10.1074/jbc.RA120.015037

PMCID:: PMC7949085

Abstract Article PDF–3.6M

Select item 73637067.

Sox21 Regulates Anapc10 Expression and Determines the Fate of Ectodermal Organ

Kan Saito, Frederic Michon, Aya Yamada, Hiroyuki Inuzuka, Satoko Yamaguchi, Emiko Fukumoto, Keigo Yoshizaki, Takashi Nakamura, Makiko Arakaki, Yuta Chiba, Masaki Ishikawa, Hideyuki Okano, Irma Thesleff, Satoshi Fukumoto

iScience. 2020 Jul 24; 23(7): 101329. Published online 2020 Jun 30. doi: 10.1016/j.isci.2020.101329

PMCID:: PMC7363706

Abstract Article PDF–9.9M

Select item 58113778.

Expression of potassium-dependent sodium-calcium exchanger in the murine lens

Alicia De Maria, Haiqing Zhao, Steven Bassnett

Exp Eye Res. Author manuscript; available in PMC 2019 Feb 1.

Published in final edited form as: Exp Eye Res. 2018 Feb; 167: 18–24. Published online 2017 Nov 9. doi: 10.1016/j.exer.2017.11.002

PMCID:: PMC5811377

Abstract Article PDF–756K

Select item 55155789.

The Na⁺/Ca²⁺, K⁺ exchanger NCKX4 is required for efficient cone-mediated vision

Frans Vinberg, Tian Wang, Alicia De Maria, Haiqing Zhao, Steven Bassnett, Jeannie Chen, Vladimir J Kefalov

eLife. 2017; 6: e24550. Published online 2017 Jun 26. doi: 10.7554/eLife.24550

PMCID:: PMC5515578

Abstract Article PDF–6.6M

Select item 529582110.

High-throughput discovery of novel developmental phenotypes

Mary E. Dickinson, Ann M. Flenniken, Xiao Ji, Lydia Teboul, Michael D. Wong, Jacqueline K. White, Terrence F. Meehan, Wolfgang J. Weninger, Henrik Westerberg, Hibret Adissu, Candice N. Baker, Lynette Bower, James M. Brown, L. Brianna Caddle, Francesco Chiani, Dave Clary, James Cleak, Mark J. Daly, James M. Denegre, Brendan Doe, Mary E. Dolan, Sarah M. Edie, Helmut Fuchs, Valerie Gailus-Durner, Antonella Galli, Alessia Gambadoro, Juan Gallegos, Shiying Guo, Neil R. Horner, Chih-wei Hsu, Sara J. Johnson, Sowmya Kalaga, Lance C. Keith, Louise Lanoue, Thomas N. Lawson, Monkol Lek, Manuel Mark, Susan Marschall, Jeremy Mason, Melissa L. McElwee, Susan Newbigging, Lauryl M.J. Nutter, Kevin A. Peterson, Ramiro Ramirez-Solis, Douglas J. Rowland, Edward Ryder, Kaitlin E. Samocha, John R. Seavitt, Mohammed Selloum, Zsombor Szoke-Kovacs, Masaru Tamura, Amanda G Trainor, Ilinca Tudose, Shigeharu Wakana, Jonathan Warren, Olivia Wendling, David B. West, Leeyean Wong, Atsushi Yoshiki, The International Mouse Phenotyping Consortium, Daniel G. MacArthur, Glauco P. Tocchini-Valentini, Xiang Gao, Paul Flicek, Allan Bradley, William C. Skarnes, Monica J. Justice, Helen E. Parkinson, Mark Moore, Sara Wells, Robert E. Braun, Karen L. Svenson, Martin Hrabe de Angelis, Yann Herault, Tim Mohun, Ann-Marie Mallon, R. Mark Henkelman, Steve D.M. Brown, David J. Adams, K.C. Kent Lloyd, Colin McKerlie, Arthur L. Beaudet, Maja Bucan, Stephen A. Murray

Nature. Author manuscript; available in PMC 2017 Mar 14.

Published in final edited form as: Nature. 2016 Sep 22; 537(7621): 508–514. Published online 2016 Sep 14. doi: 10.1038/nature19356

Correction in:: Nature. 2017 Nov 16; 551(7680): 398.

PMCID:: PMC5295821

Abstract Article PDF–3.0M

Select item 521508411.

Reduced Protein Expression of the Na⁺/Ca²⁺+K⁺-Exchanger (SLC24A4) in Apical Plasma Membranes of Maturation Ameloblasts of Fluorotic Mice

A. L. J. J. Bronckers, R. Jalali, J. Lytton

Calcif Tissue Int. 2017; 100(1): 80–86. Published online 2016 Oct 17. doi: 10.1007/s00223-016-0197-4

PMCID:: PMC5215084

Abstract Article PDF–2.1M

Select item 521462412.

Simultaneous Loss of NCKX4 and CNG Channel Desensitization Impairs Olfactory Sensitivity

Christopher H. Ferguson, Haiqing Zhao

J Neurosci. 2017 Jan 4; 37(1): 110–119. doi: 10.1523/JNEUROSCI.2527-16.2016

PMCID:: PMC5214624

Abstract Article PDF–1.9M

Select item 468148013.

Ameloblast Modulation and Transport of Cl⁻, Na⁺, and K⁺ during Amelogenesis

A.L.J.J. Bronckers, D. Lyaruu, R. Jalali, J.F. Medina, B. Zandieh-Doulabi, P.K. DenBesten

J Dent Res. 2015 Dec; 94(12): 1740–1747. doi: 10.1177/0022034515606900

PMCID:: PMC4681480

Abstract Article PDF–1.1M

Select item 452196614.

Critical roles for WDR72 in calcium transport and matrix protein removal during enamel maturation

Shih-Kai Wang, Yuanyuan Hu, Jie Yang, Charles E Smith, Stephanie M Nunez, Amelia S Richardson, Soumya Pal, Andrew C Samann, Jan C-C Hu, James P Simmer

Mol Genet Genomic Med. 2015 Jul; 3(4): 302–319. Published online 2015 Mar 29. doi: 10.1002/mgg3.143

PMCID:: PMC4521966

Abstract Article PDF–6.3M

Select item 416214915.

An Essential Role for the K⁺-dependent Na⁺/Ca²⁺-exchanger, NCKX4, in Melanocortin-4-receptor-dependent Satiety

Xiao-Fang Li, Jonathan Lytton

J Biol Chem. 2014 Sep 12; 289(37): 25445–25459. Published online 2014 Aug 5. doi: 10.1074/jbc.M114.564450

PMCID:: PMC4162149

Abstract Article PDF–3.9M

Select item 410754216.

STIM1 and SLC24A4 Are Critical for Enamel Maturation

S. Wang, M. Choi, A.S. Richardson, B.M. Reid, F. Seymen, M. Yildirim, E. Tuna, K. Gençay, J.P. Simmer, J.C. Hu

J Dent Res. 2014 Jul; 93(7 Suppl): 94S–100S. doi: 10.1177/0022034514527971

PMCID:: PMC4107542

Abstract Article PDF–1.1M

Select item 396495517.

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data

Gautier Koscielny, Gagarine Yaikhom, Vivek Iyer, Terrence F. Meehan, Hugh Morgan, Julian Atienza-Herrero, Andrew Blake, Chao-Kung Chen, Richard Easty, Armida Di Fenza, Tanja Fiegel, Mark Grifiths, Alan Horne, Natasha A. Karp, Natalja Kurbatova, Jeremy C. Mason, Peter Matthews, Darren J. Oakley, Asfand Qazi, Jack Regnart, Ahmad Retha, Luis A. Santos, Duncan J. Sneddon, Jonathan Warren, Henrik Westerberg, Robert J. Wilson, David G. Melvin, Damian Smedley, Steve D. M. Brown, Paul Flicek, William C. Skarnes, Ann-Marie Mallon, Helen Parkinson

Nucleic Acids Res. 2014 Jan 1; 42(Database issue): D802–D809. Published online 2013 Nov 3. doi: 10.1093/nar/gkt977

PMCID:: PMC3964955

Abstract Article PDF–5.7M

Select item 386779718.

Purinergic stimulation of K⁺-dependent Na⁺/Ca²⁺ exchanger isoform 4 requires dual activation by PKC and CaMKII

Xu Yang, Jonathan Lytton

Biosci Rep. 2013; 33(6): e00087. Prepublished online 2013 Nov 13. Published online 2013 Dec 19. doi: 10.1042/BSR20130099

PMCID:: PMC3867797

Abstract Article PDF–1.0M

Select item 357241019.

A conditional knockout resource for the genome–wide study of mouse gene function

William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley

Nature. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163

PMCID:: PMC3572410

Abstract Article PDF–1.1M

Select item 356727420.

Identification of Mutations in SLC24A4, Encoding a Potassium-Dependent Sodium/Calcium Exchanger, as a Cause of Amelogenesis Imperfecta

David A. Parry, James A. Poulter, Clare V. Logan, Steven J. Brookes, Hussain Jafri, Christopher H. Ferguson, Babra M. Anwari, Yasmin Rashid, Haiqing Zhao, Colin A. Johnson, Chris F. Inglehearn, Alan J. Mighell

Am J Hum Genet. 2013 Feb 7; 92(2): 307–312. doi: 10.1016/j.ajhg.2013.01.003

PMCID:: PMC3567274

Abstract Article PDF–594K

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