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Select item 112511671.

MCM8 interacts with DDX5 to promote R-loop resolution

Canxin Wen, Lili Cao, Shuhan Wang, Weiwei Xu, Yongze Yu, Simin Zhao, Fan Yang, Zi-Jiang Chen, Shidou Zhao, Yajuan Yang, Yingying Qin

EMBO J. 2024 Jul; 43(14): 3044–3071. Published online 2024 Jun 10. doi: 10.1038/s44318-024-00134-0

PMCID:: PMC11251167

Abstract Article PDF–8.7M

Select item 110765932.

Complete male-to-female sex reversal in XY mice lacking the miR-17~92 cluster

Alicia Hurtado, Irene Mota-Gómez, Miguel Lao, Francisca M. Real, Johanna Jedamzick, Miguel Burgos, Darío G. Lupiáñez, Rafael Jiménez, Francisco J. Barrionuevo

Nat Commun. 2024; 15: 3809. Published online 2024 May 7. doi: 10.1038/s41467-024-47658-x

PMCID:: PMC11076593

Abstract Article PDF–4.4M

Select item 109594153.

FOXL2 interaction with different binding partners regulates the dynamics of ovarian development

Roberta Migale, Michelle Neumann, Richard Mitter, Mahmoud-Reza Rafiee, Sophie Wood, Jessica Olsen, Robin Lovell-Badge

Sci Adv. 2024 Mar 22; 10(12): eadl0788. Published online 2024 Mar 22. doi: 10.1126/sciadv.adl0788

PMCID:: PMC10959415

Abstract Article PDF–4.4M

Select item 109427714.

Origin, specification and differentiation of a rare supporting-like lineage in the developing mouse gonad

Chloé Mayère, Violaine Regard, Aitana Perea-Gomez, Corey Bunce, Yasmine Neirijnck, Cyril Djari, Natividad Bellido-Carreras, Pauline Sararols, Richard Reeves, Simon Greenaway, Michelle Simon, Pam Siggers, Diana Condrea, Françoise Kühne, Ivana Gantar, Furong Tang, Isabelle Stévant, Laura Batti, Norbert B. Ghyselinck, Dagmar Wilhelm, Andy Greenfield, Blanche Capel, Marie-Christine Chaboissier, Serge Nef

Sci Adv. 2022 May; 8(21): eabm0972. Published online 2022 May 25. doi: 10.1126/sciadv.abm0972

PMCID:: PMC10942771

Abstract Article PDF–6.7M

Select item 108798785.

Polycomb repressive complex 1 modulates granulosa cell proliferation in early folliculogenesis to support female reproduction

Meng Gao, Tuo Zhang, Tengxiang Chen, Ziqi Chen, Zijian Zhu, Yang Wen, Shaogang Qin, Yibing Bao, Ting Zhao, Hengxing Li, Longping Liu, Ming Hao, Jianbin Wang, Fengchao Wang, Haibin Wang, Bo Zhou, Hua Zhang, Guoliang Xia, Chao Wang

Theranostics. 2024; 14(4): 1371–1389. Published online 2024 Jan 27. doi: 10.7150/thno.89878

PMCID:: PMC10879878

Abstract Article PDF–13M

Select item 107535876.

Loss of NR5A1 in mouse Sertoli cells after sex determination changes cellular identity and induces cell death by anoikis

Sirine Souali-Crespo, Diana Condrea, Nadège Vernet, Betty Féret, Muriel Klopfenstein, Erwan Grandgirard, Violaine Alunni, Marie Cerciat, Matthieu Jung, Chloé Mayere, Serge Nef, Manuel Mark, Frédéric Chalmel, Norbert B. Ghyselinck

Development. 2023 Dec 15; 150(24): dev201710. Published online 2023 Dec 11. doi: 10.1242/dev.201710

PMCID:: PMC10753587

Abstract Article

Select item 104990287.

Induction of kidney-related gene programs through co-option of SALL1 in mole ovotestes

Magdalena Schindler, Marco Osterwalder, Izabela Harabula, Lars Wittler, Athanasia C. Tzika, Dina K. N. Dechmann, Martin Vingron, Axel Visel, Stefan A. Haas, Francisca M. Real

Development. 2023 Sep 1; 150(17): dev201562. Published online 2023 Sep 5. doi: 10.1242/dev.201562

PMCID:: PMC10499028

Abstract Article

Select item 104261548.

FAAP100 is required for the resolution of transcription-replication conflicts in primordial germ cells

Weiwei Xu, Yajuan Yang, Yongze Yu, Canxin Wen, Simin Zhao, Lili Cao, Shidou Zhao, Yingying Qin, Zi-Jiang Chen

BMC Biol. 2023; 21: 174. Published online 2023 Aug 15. doi: 10.1186/s12915-023-01676-1

PMCID:: PMC10426154

Abstract Article PDF–6.6M

Select item 104107179.

Steroidogenic factor 1 (SF-1; Nr5a1) regulates the formation of the ovarian reserve

Camilla H. K. Hughes, Olivia E. Smith, Marie-Charlotte Meinsohn, Mylène Brunelle, Nicolas Gévry, Bruce D. Murphy

Proc Natl Acad Sci U S A. 2023 Aug 8; 120(32): e2220849120. Published online 2023 Jul 26. doi: 10.1073/pnas.2220849120

PMCID:: PMC10410717

Abstract Article PDF–3.9M

Select item 1019393710.

CDYL reinforces male gonadal sex determination through epigenetically repressing Wnt4 transcription in mice

Naoki Okashita, Ryo Maeda, Makoto Tachibana

Proc Natl Acad Sci U S A. 2023 May 16; 120(20): e2221499120. Published online 2023 May 8. doi: 10.1073/pnas.2221499120

PMCID:: PMC10193937

Abstract Article PDF–1.9M

Select item 1016697811.

Forkhead box L2 is a target of miR‐133b and plays an important role in the pathogenesis of non‐small cell lung cancer

Juan Li, Lirong Gao, Anqi Wang, Huiwen Qian, Jianjie Zhu, Shundong Ji, Jun Chen, Zeyi Liu, Cheng Ji

Cancer Med. 2023 Apr; 12(8): 9826–9842. Published online 2023 Feb 27. doi: 10.1002/cam4.5746

PMCID:: PMC10166978

Abstract Article PDF–34M

Select item 1011289812.

Biased precursor ingression underlies the center-to-pole pattern of male sex determination in mouse

Corey Bunce, Lindsey Barske, Gloria Zhang, Blanche Capel

Development. 2023 Mar 1; 150(5): dev201060. Published online 2023 Mar 13. doi: 10.1242/dev.201060

PMCID:: PMC10112898

Abstract Article

Select item 1001770313.

Testicular macrophages are recruited during a narrow fetal time window and promote organ-specific developmental functions

Xiaowei Gu, Anna Heinrich, Shu-Yun Li, Tony DeFalco

Nat Commun. 2023; 14: 1439. Published online 2023 Mar 15. doi: 10.1038/s41467-023-37199-0

PMCID:: PMC10017703

Abstract Article PDF–16M

Select item 999099014.

Functional genomics analysis identifies loss of HNF1B function as a cause of Mayer–Rokitansky–Küster–Hauser syndrome

Ella Thomson, Minh Tran, Gorjana Robevska, Katie Ayers, Jocelyn van der Bergen, Prarthna Gopalakrishnan Bhaskaran, Eric Haan, Silvia Cereghini, Alla Vash-Margita, Miranda Margetts, Alison Hensley, Quan Nguyen, Andrew Sinclair, Peter Koopman, Emanuele Pelosi

Hum Mol Genet. 2023 Mar 15; 32(6): 1032–1047. Published online 2022 Oct 25. doi: 10.1093/hmg/ddac262

PMCID:: PMC9990990

Abstract Article PDF–2.2M

Select item 997132015.

DNA repair protein FANCD2 has both ubiquitination-dependent and ubiquitination-independent functions during germ cell development

Simin Zhao, Chengzi Huang, Yajuan Yang, Weiwei Xu, Yongze Yu, Canxin Wen, Lili Cao, Fei Gao, Yingying Qin, Zi-Jiang Chen, Ting Guo, Shidou Zhao

J Biol Chem. 2023 Mar; 299(3): 102905. Published online 2023 Jan 13. doi: 10.1016/j.jbc.2023.102905

PMCID:: PMC9971320

Abstract Article PDF–4.2M

Select item 989412216.

Turnover of mammal sex chromosomes in the Sry-deficient Amami spiny rat is due to male-specific upregulation of Sox9

Miho Terao, Yuya Ogawa, Shuji Takada, Rei Kajitani, Miki Okuno, Yuta Mochimaru, Kentaro Matsuoka, Takehiko Itoh, Atsushi Toyoda, Tomohiro Kono, Takamichi Jogahara, Shusei Mizushima, Asato Kuroiwa

Proc Natl Acad Sci U S A. 2022 Dec 6; 119(49): e2211574119. Published online 2022 Nov 28. doi: 10.1073/pnas.2211574119