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Select item 91063031.

Genome-wide CRISPR screens using isogenic cells reveal vulnerabilities conferred by loss of tumor suppressors

Xu Feng, Mengfan Tang, Merve Dede, Dan Su, Guangsheng Pei, Dadi Jiang, Chao Wang, Zhen Chen, Mi Li, Litong Nie, Yun Xiong, Siting Li, Jeong-Min Park, Huimin Zhang, Min Huang, Klaudia Szymonowicz, Zhongming Zhao, Traver Hart, Junjie Chen

Sci Adv. 2022 May; 8(19): eabm6638. Published online 2022 May 13. doi: 10.1126/sciadv.abm6638

PMCID:: PMC9106303

Abstract Article PDF–918K

Select item 90405562.

A protein interaction landscape of breast cancer

Minkyu Kim, Jisoo Park, Mehdi Bouhaddou, Kyumin Kim, Ajda Rojc, Maya Modak, Margaret Soucheray, Michael J. McGregor, Patrick O’Leary, Denise Wolf, Erica Stevenson, Tzeh Keong Foo, Dominique Mitchell, Kari A. Herrington, Denise P. Muñoz, Beril Tutuncuoglu, Kuei-Ho Chen, Fan Zheng, Jason F. Kreisberg, Morgan E. Diolaiti, John D. Gordan, Jean-Philippe Coppé, Danielle L. Swaney, Bing Xia, Laura van ’t Veer, Alan Ashworth, Trey Ideker, Nevan Krogan

Science. Author manuscript; available in PMC 2022 Apr 26.

Published in final edited form as: Science. 2021 Oct; 374(6563): eabf3066. Published online 2021 Oct 1. doi: 10.1126/science.abf3066

PMCID:: PMC9040556

Abstract Article PDF–2.2M

Select item 82519323.

Microdeletion of 9q22.3: A patient with minimal deletion size associated with a severe phenotype

Adam D. Ewing, Seth W. Cheetham, James J. McGill, Michael Sharkey, Rick Walker, Jennifer A. West, Malcolm J. West, Kim M. Summers

Am J Med Genet A. 2021 Jul; 185(7): 2070–2083. Published online 2021 May 7. doi: 10.1002/ajmg.a.62224

PMCID:: PMC8251932

Abstract Article PDF–5.5M

Select item 81650304.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 81080935.

DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity

Rajat Gupta, Kumar Somyajit, Takeo Narita, Elina Maskey, Andre Stanlie, Magdalena Kremer, Dimitris Typas, Michael Lammers, Niels Mailand, Andre Nussenzweig, Jiri Lukas, Chunaram Choudhary

Cell. Author manuscript; available in PMC 2021 May 10.

Published in final edited form as: Cell. 2018 May 3; 173(4): 972–988.e23. Published online 2018 Apr 12. doi: 10.1016/j.cell.2018.03.050

PMCID:: PMC8108093

Abstract Article PDF–3.5M

Select item 77267796.

Zika virus depletes neural stem cells and evades selective autophagy by suppressing the Fanconi anemia protein FANCC

Shashi Kant Tiwari, Jason W Dang, Nianwei Lin, Yue Qin, Shaobo Wang, Tariq M Rana

EMBO Rep. 2020 Dec 3; 21(12): e49183. Published online 2020 Oct 19. doi: 10.15252/embr.201949183

PMCID:: PMC7726779

Abstract Article PDF–4.5M

Select item 67156807.

Two truncating variants in FANCC and breast cancer risk

Thilo Dörk, Paolo Peterlongo, Arto Mannermaa, Manjeet K. Bolla, Qin Wang, Joe Dennis, Thomas Ahearn, Irene L. Andrulis, Hoda Anton-Culver, Volker Arndt, Kristan J. Aronson, Annelie Augustinsson, Laura E. Beane Freeman, Matthias W. Beckmann, Alicia Beeghly-Fadiel, Sabine Behrens, Marina Bermisheva, Carl Blomqvist, Natalia V. Bogdanova, Stig E. Bojesen, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Federico Canzian, Tsun L. Chan, Jenny Chang-Claude, Stephen J. Chanock, Ji-Yeob Choi, Hans Christiansen, Christine L. Clarke, Fergus J. Couch, Kamila Czene, Mary B. Daly, Isabel dos-Santos-Silva, Miriam Dwek, Diana M. Eccles, Arif B. Ekici, Mikael Eriksson, D. Gareth Evans, Peter A. Fasching, Jonine Figueroa, Henrik Flyger, Lin Fritschi, Marike Gabrielson, Manuela Gago-Dominguez, Chi Gao, Susan M. Gapstur, Montserrat García-Closas, José A. García-Sáenz, Mia M. Gaudet, Graham G. Giles, Mark S. Goldberg, David E. Goldgar, Pascal Guénel, Lothar Haeberle, Christopher A. Haiman, Niclas Håkansson, Per Hall, Ute Hamann, Mikael Hartman, Jan Hauke, Alexander Hein, Peter Hillemanns, Frans B. L. Hogervorst, Maartje J. Hooning, John L. Hopper, Tony Howell, Dezheng Huo, Hidemi Ito, Motoki Iwasaki, Anna Jakubowska, Wolfgang Janni, Esther M. John, Audrey Jung, Rudolf Kaaks, Daehee Kang, Pooja Middha Kapoor, Elza Khusnutdinova, Sung-Won Kim, Cari M. Kitahara, Stella Koutros, Peter Kraft, Vessela N. Kristensen, Ava Kwong, Diether Lambrechts, Loic Le Marchand, Jingmei Li, Sara Lindström, Martha Linet, Wing-Yee Lo, Jirong Long, Artitaya Lophatananon, Jan Lubiński, Mehdi Manoochehri, Siranoush Manoukian, Sara Margolin, Elena Martinez, Keitaro Matsuo, Dimitris Mavroudis, Alfons Meindl, Usha Menon, Roger L. Milne, Nur Aishah Mohd Taib, Kenneth Muir, Anna Marie Mulligan, Susan L. Neuhausen, Heli Nevanlinna, Patrick Neven, William G. Newman, Kenneth Offit, Olufunmilayo I. Olopade, Andrew F. Olshan, Janet E. Olson, Håkan Olsson, Sue K. Park, Tjoung-Won Park-Simon, Julian Peto, Dijana Plaseska-Karanfilska, Esther Pohl-Rescigno, Nadege Presneau, Brigitte Rack, Paolo Radice, Muhammad U. Rashid, Gad Rennert, Hedy S. Rennert, Atocha Romero, Matthias Ruebner, Emmanouil Saloustros, Marjanka K. Schmidt, Rita K. Schmutzler, Michael O. Schneider, Minouk J. Schoemaker, Christopher Scott, Chen-Yang Shen, Xiao-Ou Shu, Jacques Simard, Susan Slager, Snezhana Smichkoska, Melissa C. Southey, John J. Spinelli, Jennifer Stone, Harald Surowy, Anthony J. Swerdlow, Rulla M. Tamimi, William J. Tapper, Soo H. Teo, Mary Beth Terry, Amanda E. Toland, Rob A. E. M. Tollenaar, Diana Torres, Gabriela Torres-Mejía, Melissa A. Troester, Thérèse Truong, Shoichiro Tsugane, Michael Untch, Celine M. Vachon, Ans M. W. van den Ouweland, Elke M. van Veen, Joseph Vijai, Camilla Wendt, Alicja Wolk, Jyh-Cherng Yu, Wei Zheng, Argyrios Ziogas, Elad Ziv, ABCTB Investigators, NBCS Collaborators, Alison M. Dunning, Paul D. P. Pharoah, Detlev Schindler, Peter Devilee, Douglas F. Easton

Sci Rep. 2019; 9: 12524. Published online 2019 Aug 29. doi: 10.1038/s41598-019-48804-y

PMCID:: PMC6715680

Abstract Article PDF–963K

Select item 61666828.

Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei

Domenico Fasci, Hugo van Ingen, Richard A. Scheltema, Albert J. R. Heck

Mol Cell Proteomics. 2018 Oct; 17(10): 2018–2033. Published online 2018 Jul 18. doi: 10.1074/mcp.RA118.000924

PMCID:: PMC6166682

Abstract Article PDF–3.8M

Select item 60462469.

Fanconi Anemia complementation group C protein in metabolic disorders

Manoj Nepal, Chi Ma, Guoxiang Xie, Wei Jia, Peiwen Fei

Aging (Albany NY) 2018 Jun; 10(6): 1506–1522. Published online 2018 Jun 21. doi: 10.18632/aging.101487

PMCID:: PMC6046246

Abstract Article PDF–4.0M

Select item 603987010.

LuTHy: a double‐readout bioluminescence‐based two‐hybrid technology for quantitative mapping of protein–protein interactions in mammalian cells

Philipp Trepte, Sabrina Kruse, Simona Kostova, Sheila Hoffmann, Alexander Buntru, Anne Tempelmeier, Christopher Secker, Lisa Diez, Aline Schulz, Konrad Klockmeier, Martina Zenkner, Sabrina Golusik, Kirstin Rau, Sigrid Schnoegl, Craig C Garner, Erich E Wanker

Mol Syst Biol. 2018 Jul; 14(7): e8071. Published online 2018 Jul 11. doi: 10.15252/msb.20178071

PMCID:: PMC6039870

Abstract Article PDF–2.1M

Select item 552553911.

Tumor suppressor RecQL5 controls recombination induced by DNA crosslinking agents

Yoshifumi Hosono, Takuya Abe, Masamichi Ishiai, M. Nurul Islam, Hiroshi Arakawa, Weidong Wang, Shunichi Takeda, Yutaka Ishii, Minoru Takata, Masayuki Seki, Takemi Enomoto

Biochim Biophys Acta. Author manuscript; available in PMC 2017 Jul 25.

Published in final edited form as: Biochim Biophys Acta. 2014 May; 1843(5): 1002–1012. Published online 2014 Jan 10. doi: 10.1016/j.bbamcr.2014.01.005

PMCID:: PMC5525539

Abstract Article PDF–1.6M

Select item 532576312.

HSP90 shapes the consequences of human genetic variation

Georgios I. Karras, Song Yi, Nidhi Sahni, Máté Fischer, Jenny Xie, Marc Vidal, Alan D. D'Andrea, Luke Whitesell, Susan Lindquist

Cell. Author manuscript; available in PMC 2018 Feb 23.

Published in final edited form as: Cell. 2017 Feb 23; 168(5): 856–866.e12. Published online 2017 Feb 16. doi: 10.1016/j.cell.2017.01.023

PMCID:: PMC5325763

Abstract Article PDF–2.4M

Select item 515473913.

HES1 is a novel interactor of the Fanconi anemia core complex

Cédric S. Tremblay, Feng F. Huang, Ouassila Habi, Caroline C. Huard, Chantal Godin, Georges Lévesque, Madeleine Carreau

Blood. Author manuscript; available in PMC 2016 Dec 13.

Published in final edited form as: Blood. 2008 Sep 1; 112(5): 2062–2070. Published online 2008 Jun 11. doi: 10.1182/blood-2008-04-152710

PMCID:: PMC5154739

Abstract Article PDF–1.1M

Select item 488219014.

Widespread expansion of protein interaction capabilities by alternative splicing

Xinping Yang, Jasmin Coulombe-Huntington, Shuli Kang, Gloria M. Sheynkman, Tong Hao, Aaron Richardson, Song Sun, Fan Yang, Yun A. Shen, Ryan R. Murray, Kerstin Spirohn, Bridget E. Begg, Miquel Duran-Frigola, Andrew MacWilliams, Samuel J. Pevzner, Quan Zhong, Shelly A. Wanamaker, Stanley Tam, Lila Ghamsari, Nidhi Sahni, Song Yi, Maria D. Rodriguez, Dawit Balcha, Guihong Tan, Michael Costanzo, Brenda Andrews, Charles Boone, Xianghong J. Zhou, Kourosh Salehi-Ashtiani, Benoit Charloteaux, Alyce A. Chen, Michael A. Calderwood, Patrick Aloy, Frederick P. Roth, David E. Hill, Lilia M. Iakoucheva, Yu Xia, Marc Vidal

Cell. Author manuscript; available in PMC 2017 Feb 11.

Published in final edited form as: Cell. 2016 Feb 11; 164(4): 805–817. doi: 10.1016/j.cell.2016.01.029

PMCID:: PMC4882190

Abstract Article PDF–1.9M

Select item 488139115.

Fanconi anemia proteins function in mitophagy and immunity

Rhea Sumpter, Jr, Shyam Sirasanagandla, Álvaro F. Fernández, Yongjie Wei, Xiaonan Dong, Luis Franco, Zhongju Zou, Christophe Marchal, Ming Yeh Lee, D. Wade Clapp, Helmut Hanenberg, Beth Levine

Cell. Author manuscript; available in PMC 2017 May 5.

Published in final edited form as: Cell. 2016 May 5; 165(4): 867–881. Published online 2016 Apr 28. doi: 10.1016/j.cell.2016.04.006

PMCID:: PMC4881391

Abstract Article PDF–1.7M

Select item 473909116.

Fanconi anemia genes in lung adenocarcinoma- a pathway-wide study on cancer susceptibility

Shi-Yi Yang, Chia-Ni Hsiung, Yao-Jen Li, Gee-Chen Chang, Ying-Huang Tsai, Kuan-Yu Chen, Ming-Shyan Huang, Wu-Chou Su, Yuh-Min Chen, Chao A. Hsiung, Pan-Chyr Yang, Chien-Jen Chen, Pei-Ei Wu, Jyh-Cherng Yu, Chen-Yang Shen, Huan-Ming Hsu

J Biomed Sci. 2016; 23: 23. Published online 2016 Feb 3. doi: 10.1186/s12929-016-0240-9

PMCID:: PMC4739091

Abstract Article PDF–1.2M

Select item 461891017.

Hypermethylation of the FANCC and FANCL Promoter Regions in Sporadic Acute Leukaemia

C. J. Hess, N. Ameziane, G. J. Schuurhuis, A. Errami, F. Denkers, G. J. L. Kaspers, J. Cloos, H. Joenje, D. Reinhardt, G. J. Ossenkoppele, C. M. Zwaan, Q. Waisfisz

Cell Oncol. 2008; 30(4): 299–306. Published online 2008 Jul 1. doi: 10.3233/CLO-2008-0426

PMCID:: PMC4618910

Abstract PDF–272K

Select item 460562318.

The Fanconi Anemia C Protein Binds to and Regulates Stathmin-1 Phosphorylation

Audrey Magron, Sabine Elowe, Madeleine Carreau

PLoS One. 2015; 10(10): e0140612. Published online 2015 Oct 14. doi: 10.1371/journal.pone.0140612

PMCID:: PMC4605623

Abstract Article PDF–10M

Select item 432602719.

Fanconi Anemia Gene Editing by the CRISPR/Cas9 System

Mark J. Osborn, Richard Gabriel, Beau R. Webber, Anthony P. DeFeo, Amber N. McElroy, Jordan Jarjour, Colby G. Starker, John E. Wagner, J. Keith Joung, Daniel F. Voytas, Christof von Kalle, Manfred Schmidt, Bruce R. Blazar, Jakub Tolar

Hum Gene Ther. 2015 Feb 1; 26(2): 114–126. Published online 2014 Dec 29. doi: 10.1089/hum.2014.111

PMCID:: PMC4326027

Abstract Article PDF–865K

Select item 415799720.

Modularized Functions of the Fanconi Anemia Core Complex

Yaling Huang, Justin WC Leung, Megan Lowery, Nobuko Matsushita, Yucai Wang, Xi Shen, Do Huong, Minoru Takata, Junjie Chen, Lei Li

Cell Rep. Author manuscript; available in PMC 2015 Jun 26.

Published in final edited form as: Cell Rep. 2014 Jun 26; 7(6): 1849–1857. Published online 2014 Jun 5. doi: 10.1016/j.celrep.2014.04.029

PMCID:: PMC4157997

Abstract Article PDF–1.4M

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