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Select item 106136231.

Tumor-suppressive microRNA-152 inhibits the proliferation of Ewing’s sarcoma cells by targeting CDK5R1

Masanori Kawano, Kazuhiro Tanaka, Ichiro Itonaga, Tatsuya Iwasaki, Yuta Kubota, Hiroshi Tsumura

Sci Rep. 2023; 13: 18546. Published online 2023 Oct 29. doi: 10.1038/s41598-023-45833-6

PMCID:: PMC10613623

Abstract Article PDF–4.1M

Select item 100729062.

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong

Mol Cell. Author manuscript; available in PMC 2023 Apr 4.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015

PMCID:: PMC10072906

Abstract Article PDF–4.2M

Select item 92626143.

A dual-activity topoisomerase complex regulates mRNA translation and turnover

Shuaikun Su, Yutong Xue, Alexei Sharov, Yongqing Zhang, Seung Kyu Lee, Jennifer L Martindale, Wen Li, Wai Lim Ku, Keji Zhao, Supriyo De, Weiping Shen, Payel Sen, Myriam Gorospe, Dongyi Xu, Weidong Wang

Nucleic Acids Res. 2022 Jul 8; 50(12): 7013–7033. Published online 2022 Jun 24. doi: 10.1093/nar/gkac538

PMCID:: PMC9262614

Abstract Article PDF–3.6M

Select item 81650304.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 81398265.

Amphiphysin I cleavage by asparagine endopeptidase leads to tau hyperphosphorylation and synaptic dysfunction

Xingyu Zhang, Li Zou, Lanxia Meng, Min Xiong, Lina Pan, Guiqin Chen, Yongfa Zheng, Jing Xiong, Zhihao Wang, Duc M Duong, Zhaohui Zhang, Xuebing Cao, Tao Wang, Li Tang, Keqiang Ye, Zhentao Zhang

eLife. 2021; 10: e65301. Published online 2021 May 21. doi: 10.7554/eLife.65301

PMCID:: PMC8139826

Abstract Article PDF–8.4M

Select item 80955266.

Expression of Cyclin‐Dependent Kinase 5 mRNA and Protein in the Human Brain Following Acute Ischemic Stroke

Nicholas Mitsios, Roberta Pennucci, Jerzy Krupinski, Coral Sanfeliu, John Gaffney, Pat Kumar, Shant Kumar, Oriol Juan‐Babot, Mark Slevin

Brain Pathol. 2007 Jan; 17(1): 11–23. Published online 2007 Jan 22. doi: 10.1111/j.1750-3639.2006.00031.x

PMCID:: PMC8095526

Abstract Article PDF–1.6M

Select item 77915537.

Elevated CDK5R1 predicts worse prognosis in hepatocellular carcinoma based on TCGA data

Zhili Zeng, Zebiao Cao, Enxin Zhang, Haifu Huang, Ying Tang

Biosci Rep. 2021 Jan 29; 41(1): BSR20203594. Published online 2021 Jan 7. doi: 10.1042/BSR20203594

PMCID:: PMC7791553

Abstract Article PDF–1.3M

Select item 77580508.

In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators

Jennifer L. Franks, Raquel C. Martinez-Chacin, Xianxi Wang, Rochelle L. Tiedemann, Thomas Bonacci, Rajarshi Choudhury, Derek L. Bolhuis, Taylor P. Enrico, Ryan D. Mouery, Jeffrey S. Damrauer, Feng Yan, Joseph S. Harrison, M. Ben Major, Katherine A. Hoadley, Aussie Suzuki, Scott B. Rothbart, Nicholas G. Brown, Michael J. Emanuele

PLoS Biol. 2020 Dec; 18(12): e3000975. Published online 2020 Dec 11. doi: 10.1371/journal.pbio.3000975

PMCID:: PMC7758050

Abstract Article PDF–4.2M

Select item 67580849.

The Cyclin-Dependent Kinase 5 Activators p35 and p39 Interact with the α-Subunit of Ca²⁺/Calmodulin-Dependent Protein Kinase II and α-Actinin-1 in a Calcium-Dependent Manner

Rani Dhavan, Paul L. Greer, Maria A. Morabito, Lianna R. Orlando, Li-Huei Tsai

J Neurosci. 2002 Sep 15; 22(18): 7879–7891. doi: 10.1523/JNEUROSCI.22-18-07879.2002

PMCID:: PMC6758084

Abstract Article PDF–959K

Select item 674119910.

Identification of a Novel, Membrane-Associated Neuronal Kinase, Cyclin-Dependent Kinase 5/p35-Regulated Kinase

Sashi Kesavapany, Kwok-Fai Lau, Steven Ackerley, Steven J. Banner, Stephen J. A. Shemilt, Jonathan D. Cooper, P. Nigel Leigh, Christopher E. Shaw, Declan M. McLoughlin, Christopher C. J. Miller

J Neurosci. 2003 Jun 15; 23(12): 4975–4983. doi: 10.1523/JNEUROSCI.23-12-04975.2003

PMCID:: PMC6741199

Abstract Article PDF–479K

Select item 667126711.

Dopaminergic and Glutamatergic Signaling Crosstalk in Huntington's Disease Neurodegeneration: The Role of p25/Cyclin-Dependent Kinase 5

Paola Paoletti, Ingrid Vila, Maria Rifé, José Miguel Lizcano, Jordi Alberch, Silvia Ginés

J Neurosci. 2008 Oct 1; 28(40): 10090–10101. doi: 10.1523/JNEUROSCI.3237-08.2008

PMCID:: PMC6671267

Abstract Article PDF–4.6M

Select item 667109512.

Cyclin-Dependent Kinase 5 Phosphorylation of Human Septin SEPT5 (hCDCrel-1) Modulates Exocytosis

Niranjana D. Amin, Ya-Li Zheng, Sashi Kesavapany, Jyotshnabala Kanungo, Tad Guszczynski, Ram K. Sihag, Parvathi Rudrabhatla, Wayne Albers, Philip Grant, Harish C. Pant

J Neurosci. 2008 Apr 2; 28(14): 3631–3643. doi: 10.1523/JNEUROSCI.0453-08.2008

PMCID:: PMC6671095

Abstract Article PDF–774K

Select item 636210613.

The Cyclin-Dependent Kinase 5 Inhibitor Peptide Inhibits Herpes Simplex Virus Type 1 Replication

Adrian Man, Mark Slevin, Eugen Petcu, Cornel Fraefel

Sci Rep. 2019; 9: 1260. Published online 2019 Feb 4. doi: 10.1038/s41598-018-37989-3

PMCID:: PMC6362106

Abstract Article PDF–1.2M

Select item 607334414.

Multiple Layers of CDK5R1 Regulation in Alzheimer’s Disease Implicate Long Non-Coding RNAs

Marco Spreafico, Barbara Grillo, Francesco Rusconi, Elena Battaglioli, Marco Venturin

Int J Mol Sci. 2018 Jul; 19(7): 2022. Published online 2018 Jul 11. doi: 10.3390/ijms19072022

PMCID:: PMC6073344

Abstract Article PDF–2.2M

Select item 589739615.

Cyclin-dependent kinase 5 mediates pleiotrophin-induced endothelial cell migration

Evgenia Lampropoulou, Ioanna Logoviti, Marina Koutsioumpa, Maria Hatziapostolou, Christos Polytarchou, Spyros S. Skandalis, Ulf Hellman, Manolis Fousteris, Sotirios Nikolaropoulos, Efrosini Choleva, Margarita Lamprou, Angeliki Skoura, Vasileios Megalooikonomou, Evangelia Papadimitriou

Sci Rep. 2018; 8: 5893. Published online 2018 Apr 12. doi: 10.1038/s41598-018-24326-x

PMCID:: PMC5897396

Abstract Article PDF–3.3M

Select item 582692616.

VIRMA mediates preferential m⁶A mRNA methylation in 3′UTR and near stop codon and associates with alternative polyadenylation

Yanan Yue, Jun Liu, Xiaolong Cui, Jie Cao, Guanzheng Luo, Zezhou Zhang, Tao Cheng, Minsong Gao, Xiao Shu, Honghui Ma, Fengqin Wang, Xinxia Wang, Bin Shen, Yizhen Wang, Xinhua Feng, Chuan He, Jianzhao Liu

Cell Discov. 2018; 4: 10. Published online 2018 Feb 27. doi: 10.1038/s41421-018-0019-0

PMCID:: PMC5826926

Abstract Article PDF–2.3M

Select item 553161117.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 549662018.

Early protection to stress mediated by CDK-dependent PI3,5P₂ signaling from the vacuole/lysosome

Natsuko Jin, Yui Jin, Lois S. Weisman

J Cell Biol. 2017 Jul 3; 216(7): 2075–2090. doi: 10.1083/jcb.201611144

PMCID:: PMC5496620

Abstract Article PDF–2.6M

Select item 546738919.

Mechanisms and Consequences of Dopamine Depletion-Induced Attenuation of the Spinophilin/Neurofilament Medium Interaction

Andrew C. Hiday, Michael C. Edler, Asma B. Salek, Cameron W. Morris, Morrent Thang, Tyler J. Rentz, Kristie L. Rose, Lisa M. Jones, Anthony J. Baucum, II

Neural Plast. 2017; 2017: 4153076. Published online 2017 May 28. doi: 10.1155/2017/4153076

PMCID:: PMC5467389

Abstract Article PDF–3.2M

Select item 515647620.

Computational study of the inhibitory mechanism of kinase CDK5 hyperactivity by peptide p5 and derivation of a pharmacophore

A. Cardone, M. Brady, R. Sriram, H. C. Pant, S. A. Hassan

J Comput Aided Mol Des. Author manuscript; available in PMC 2017 Jul 8.

Published in final edited form as: J Comput Aided Mol Des. 2016 Jun; 30(6): 513–521. Published online 2016 Jul 8. doi: 10.1007/s10822-016-9922-3

PMCID:: PMC5156476

Abstract Article PDF–929K

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