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Select item 114010341.

Proximity labeling reveals dynamic changes in the SQSTM1 protein network

Alejandro N. Rondón-Ortiz, Lushuang Zhang, Peter E.A. Ash, Avik Basu, Sambhavi Puri, Sophie J.F. van der Spek, Zihan Wang, Luke Dorrian, Andrew Emili, Benjamin Wolozin

J Biol Chem. 2024 Sep; 300(9): 107621. Published online 2024 Aug 3. doi: 10.1016/j.jbc.2024.107621

PMCID:: PMC11401034

Abstract Article PDF–5.4M

Select item 112969142.

DSBSO-Based XL-MS Analysis of Breast Cancer PDX Tissues to Delineate Protein Interaction Network in Clinical Samples

Fenglong Jiao, Clinton Yu, Andrew Wheat, Lijun Chen, Tung-Shing Mamie Lih, Hui Zhang, Lan Huang

J Proteome Res. Author manuscript; available in PMC 2024 Aug 3.

Published in final edited form as: J Proteome Res. 2024 Aug 2; 23(8): 3269–3279. Published online 2024 Feb 9. doi: 10.1021/acs.jproteome.3c00832

PMCID:: PMC11296914

Abstract Article PDF–1.7M

Select item 112143643.

CircUBE2D2 regulates HMGB1 through miR-885-5p to promote ovarian cancer malignancy

RuiXue Yan, SaiTian Zeng, FangYuan Gao, LingLing Li, XiYun Xiao

Clinics (Sao Paulo) 2024 Jan-Dec; 79: 100391. Published online 2024 Jun 6. doi: 10.1016/j.clinsp.2024.100391

PMCID:: PMC11214364

Abstract Article PDF–3.2M

Select item 111094834.

K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors

Anita Waltho, Oliver Popp, Christopher Lenz, Lukas Pluska, Mahil Lambert, Volker Dötsch, Philipp Mertins, Thomas Sommer

Life Sci Alliance. 2024 Aug; 7(8): e202402740. Published online 2024 May 21. doi: 10.26508/lsa.202402740

PMCID:: PMC11109483

Abstract Article PDF–2.9M

Select item 106964675.

Reduction of oligomer size modulates the competition between cluster formation and phase separation of the tumor suppressor SPOP

Nafiseh Sabri, Matthew J. Cuneo, Melissa R. Marzahn, Jihun Lee, Jill J. Bouchard, Ömer Güllülü, Sivaraja Vaithiyalingam, Madeleine B. Borgia, Jeremy Schmit, Tanja Mittag

J Biol Chem. 2023 Dec; 299(12): 105427. Published online 2023 Nov 4. doi: 10.1016/j.jbc.2023.105427

PMCID:: PMC10696467

Abstract Article PDF–5.1M

Select item 104917376.

The E3 ubiquitin ligase, CHIP/STUB1, inhibits aggregation of phosphorylated proteoforms of microtubule-associated protein tau (MAPT)

Cory M. Nadel, Aye C. Thwin, Matthew Callahan, Kanghyun Lee, Emily Connelly, Charles S. Craik, Daniel R. Southworth, Jason E. Gestwicki

J Mol Biol. Author manuscript; available in PMC 2023 Oct 23.

Published in final edited form as: J Mol Biol. 2023 Jun 1; 435(11): 168026. Published online 2023 Jun 16. doi: 10.1016/j.jmb.2023.168026

PMCID:: PMC10491737

Abstract Article PDF–2.0M

Select item 104695607.

Repression of TRIM13 by chromatin assembly factor CHAF1B is critical for AML development

Sarai T. Dean, Chiharu Ishikawa, Xiaoqin Zhu, Sean Walulik, Timothy Nixon, Jessica K. Jordan, Samantha Henderson, Michael Wyder, Nathan Salomonis, Mark Wunderlich, Kenneth D. Greis, Daniel T. Starczynowski, Andrew G. Volk

Blood Adv. 2023 Sep 12; 7(17): 4822–4837. Published online 2023 May 22. doi: 10.1182/bloodadvances.2022009438

PMCID:: PMC10469560

Abstract Article PDF–4.2M

Select item 104356678.

TRIM21-dependent target protein ubiquitination mediates cell-free Trim-Away

Tycho E.T. Mevissen, Anisa V. Prasad, Johannes C. Walter

Cell Rep. Author manuscript; available in PMC 2023 Oct 23.

Published in final edited form as: Cell Rep. 2023 Feb 28; 42(2): 112125. Published online 2023 Feb 18. doi: 10.1016/j.celrep.2023.112125

PMCID:: PMC10435667

Abstract Article PDF–2.3M

Select item 104258429.

Cryo‐EM structure of the chain‐elongating E3 ubiquitin ligase UBR5

Zuzana Hodáková, Irina Grishkovskaya, Hanna L Brunner, Derek L Bolhuis, Katarina Belačić, Alexander Schleiffer, Harald Kotisch, Nicholas G Brown, David Haselbach

EMBO J. 2023 Aug; 42(16): e113348. Published online 2023 Jul 6. doi: 10.15252/embj.2022113348

PMCID:: PMC10425842

Abstract Article PDF–3.0M

Select item 1040331610.

Structure of the human UBR5 E3 ubiquitin ligase

Feng Wang, Qing He, Wenhu Zhan, Ziqi Yu, Efrat Finkin-Groner, Xiaojing Ma, Gang Lin, Huilin Li

Structure. Author manuscript; available in PMC 2023 Aug 4.

Published in final edited form as: Structure. 2023 May 4; 31(5): 541–552.e4. Published online 2023 Apr 10. doi: 10.1016/j.str.2023.03.010

PMCID:: PMC10403316

Abstract Article PDF–1.7M

Select item 1035613711.

Dynamic regulation of inter-organelle communication by ubiquitylation controls skeletal muscle development and disease onset

Arian Mansur, Remi Joseph, Euri S Kim, Pierre M Jean-Beltran, Namrata D Udeshi, Cadence Pearce, Hanjie Jiang, Reina Iwase, Miroslav P Milev, Hashem A Almousa, Elyshia McNamara, Jeffrey Widrick, Claudio Perez, Gianina Ravenscroft, Michael Sacher, Philip A Cole, Steven A Carr, Vandana A Gupta

eLife. 2023; 12: e81966. Published online 2023 Jul 11. doi: 10.7554/eLife.81966

PMCID:: PMC10356137

Abstract Article PDF–12M

Select item 1028526912.

Inflammasome activation and metabolic remodelling in p16‐positive aging cells aggravates high‐fat diet‐induced lung fibrosis by inhibiting NEDD4L‐mediated K48‐polyubiquitin‐dependent degradation of SGK1

Xin Gu, Haoyu Meng, Chengyi Peng, Shiyu Lin, Baihong Li, Lin Zhao, Xue Yang, Guangyan Wang, Wenyuan Cai, Jiawen Zhou, Shuiyuan Liu, Peng Wu, Yingqiang Du, Jianliang Jin, Xiaoyan Wang

Clin Transl Med. 2023 Jun; 13(6): e1308. Published online 2023 Jun 21. doi: 10.1002/ctm2.1308

PMCID:: PMC10285269

Abstract Article PDF–20M

Select item 1028344013.

Stress granule homeostasis is modulated by TRIM21-mediated ubiquitination of G3BP1 and autophagy-dependent elimination of stress granules

Cuiwei Yang, Zhangshun Wang, Yingjin Kang, Qianqian Yi, Tong Wang, Yun Bai, Yanfen Liu

Autophagy. 2023; 19(7): 1934–1951. Published online 2023 Jan 24. doi: 10.1080/15548627.2022.2164427

PMCID:: PMC10283440

Abstract Article PDF–5.2M

Select item 1027947214.

HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways

Julie K. Monda, Xuezhen Ge, Moritz Hunkeler, Katherine A. Donovan, Michelle W. Ma, Cyrus Y. Jin, Marilyn Leonard, Eric S. Fischer, Eric J. Bennett

Cell Rep. Author manuscript; available in PMC 2023 Jun 19.

Published in final edited form as: Cell Rep. 2023 May 30; 42(5): 112496. Published online 2023 May 9. doi: 10.1016/j.celrep.2023.112496

PMCID:: PMC10279472

Abstract Article PDF–2.9M

Select item 1026673015.

Monitoring α-synuclein ubiquitination dynamics reveals key endosomal effectors mediating its trafficking and degradation

Dmitry Zenko, Jade Marsh, Andrew R. Castle, Rahel Lewin, Roman Fischer, George K. Tofaris

Sci Adv. 2023 Jun; 9(24): eadd8910. Published online 2023 Jun 14. doi: 10.1126/sciadv.add8910

PMCID:: PMC10266730

Abstract Article PDF–2.9M

Select item 1026281116.

TRIM7/RNF90 promotes autophagy via regulation of ATG7 ubiquitination during L. monocytogenes infection

Jie Wang, Xiao Qin, Yulu Huang, Qunmei Zhang, Jinyong Pei, Yi Wang, Idan Goren, Shujun Ma, Zhishan Song, Yanzi Liu, Hongxia Xing, Hui Wang, Bo Yang

Autophagy. 2023; 19(6): 1844–1862. Published online 2023 Jan 1. doi: 10.1080/15548627.2022.2162706

PMCID:: PMC10262811

Abstract Article PDF–7.7M

Select item 1023742217.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 1023410718.

The E2 ubiquitin-conjugating enzymes UBE2D1 and UBE2D2 regulate VEGFR2 dynamics and endothelial function

William R. Critchley, Gina A. Smith, Ian C. Zachary, Michael A. Harrison, Sreenivasan Ponnambalam

J Cell Sci. 2023 May 15; 136(10): jcs260657. Published online 2023 May 25. doi: 10.1242/jcs.260657

PMCID:: PMC10234107

Abstract Article

Select item 1020916919.

A ZFYVE21-Rubicon-RNF34 signaling complex promotes endosome-associated inflammasome activity in endothelial cells

Xue Li, Quan Jiang, Guiyu Song, Mahsa Nouri Barkestani, Qianxun Wang, Shaoxun Wang, Matthew Fan, Caodi Fang, Bo Jiang, Justin Johnson, Arnar Geirsson, George Tellides, Jordan S. Pober, Dan Jane-wit

Nat Commun. 2023; 14: 3002. Published online 2023 May 24. doi: 10.1038/s41467-023-38684-2